PL363238A1 - Związki heterocykliloalkilo-indolowe i-azaindolowe jako ligandy receptora 5-hydroksytryptaminowego-6 - Google Patents
Związki heterocykliloalkilo-indolowe i-azaindolowe jako ligandy receptora 5-hydroksytryptaminowego-6Info
- Publication number
- PL363238A1 PL363238A1 PL01363238A PL36323801A PL363238A1 PL 363238 A1 PL363238 A1 PL 363238A1 PL 01363238 A PL01363238 A PL 01363238A PL 36323801 A PL36323801 A PL 36323801A PL 363238 A1 PL363238 A1 PL 363238A1
- Authority
- PL
- Poland
- Prior art keywords
- heterocyclylalkylindole
- hydroxytryptamine
- ligands
- azaindole compounds
- azaindole
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25768400P | 2000-12-22 | 2000-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL363238A1 true PL363238A1 (pl) | 2004-11-15 |
Family
ID=22977310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL01363238A PL363238A1 (pl) | 2000-12-22 | 2001-12-11 | Związki heterocykliloalkilo-indolowe i-azaindolowe jako ligandy receptora 5-hydroksytryptaminowego-6 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6613781B2 (pl) |
| EP (1) | EP1355900B1 (pl) |
| JP (1) | JP2004520325A (pl) |
| KR (1) | KR20030062440A (pl) |
| CN (1) | CN1492863A (pl) |
| AR (1) | AR034284A1 (pl) |
| AT (1) | ATE327232T1 (pl) |
| BR (1) | BR0116481A (pl) |
| CA (1) | CA2432661A1 (pl) |
| DE (1) | DE60119982T2 (pl) |
| DK (1) | DK1355900T3 (pl) |
| EA (1) | EA200300716A1 (pl) |
| ES (1) | ES2264994T3 (pl) |
| HU (1) | HUP0400682A2 (pl) |
| IL (1) | IL156518A0 (pl) |
| MX (1) | MXPA03005433A (pl) |
| NO (1) | NO20032841L (pl) |
| PL (1) | PL363238A1 (pl) |
| WO (1) | WO2002051832A2 (pl) |
| ZA (1) | ZA200305625B (pl) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2294932C2 (ru) * | 2001-06-07 | 2007-03-10 | Ф.Хоффманн-Ля Рош Аг | Новые производные индола со сродством к рецептору 5-ht6 |
| US20030225121A1 (en) * | 2001-12-20 | 2003-12-04 | Wyeth | Heterocyclylalkylindole or-azaindole compounds as 5-hydroxytryptamine-6 ligands |
| ATE401072T1 (de) * | 2002-02-12 | 2008-08-15 | Organon Nv | 1-arylsulfonyl-3-substituierte indol und indolinederivate verwendbar zur behandlung von erkrankungen des zentralnervensystem |
| TW200401641A (en) * | 2002-07-18 | 2004-02-01 | Wyeth Corp | 1-Heterocyclylalkyl-3-sulfonylindole or-indazole derivatives as 5-hydroxytryptamine-6 ligands |
| ATE401307T1 (de) * | 2002-11-28 | 2008-08-15 | Suven Life Sciences Ltd | N-arylsulfonyl-2-substituierte indole mit affinität zum serotonin rezeptor, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen |
| BRPI0406883A (pt) * | 2003-01-22 | 2006-01-03 | Lilly Co Eli | Composto, composição farmacêutica, método de tratar um distúrbio, e, uso de um composto |
| CN100422171C (zh) * | 2003-02-14 | 2008-10-01 | 惠氏公司 | 作为5-羟色胺-6配体的杂环-3-磺酰基吲唑 |
| WO2004074286A1 (en) * | 2003-02-14 | 2004-09-02 | Wyeth | Heterocyclyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands |
| ES2222828B1 (es) | 2003-07-30 | 2006-04-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de 1-sulfonilindoles, su preparacion y su aplicacion como medicamentos. |
| WO2005012311A1 (en) * | 2003-07-31 | 2005-02-10 | Wyeth | N-sulfonylheterocyclopyrrolylalkylamine compounds as 5-hydroxytryptamine-6 ligands |
| US7998981B2 (en) * | 2005-08-12 | 2011-08-16 | Suven Life Sciences Limited | Aminoaryl sulphonamide derivatives as functional 5-HT6 ligands |
| CA2619010C (en) * | 2005-08-15 | 2013-10-01 | Wyeth | Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands |
| WO2007031838A1 (en) | 2005-09-16 | 2007-03-22 | Ranbaxy Laboratories Limited | Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors |
| EP1842541A1 (en) * | 2006-03-29 | 2007-10-10 | G.I.M.-Gesellschaft Für Innovative Medizin Gmbh Nfg Ohg | Plant components and extracts and uses thereof |
| BRPI0709718A2 (pt) * | 2006-04-05 | 2011-03-29 | Wyeth Corp | composto; método para tratamento de um transtorno do sistema nervoso central relacionado a ou afetado pelo receptor 5-ht6 em um paciente necessitado; composição farmacêutica; e proceso para a preparação do composto |
| WO2007120596A1 (en) * | 2006-04-12 | 2007-10-25 | Wyeth | DIHYDRO[1,4]DIOXINO[2,3-e]INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS |
| SI2124944T1 (sl) | 2007-03-14 | 2012-05-31 | Ranbaxy Lab Ltd | Derivati pirazolo b piridina kot inhibitorji fosfodiesteraze |
| KR20100031578A (ko) * | 2007-05-24 | 2010-03-23 | 메모리 파마슈티칼스 코포레이션 | 5-ｈｔ6 수용체 친화성을 갖는 4'-치환된 화합물 |
| US20100016297A1 (en) * | 2008-06-24 | 2010-01-21 | Memory Pharmaceuticals Corporation | Alkyl-substituted 3' compounds having 5-ht6 receptor affinity |
| US20100022581A1 (en) * | 2008-07-02 | 2010-01-28 | Memory Pharmaceuticals Corporation | Pyrrolidine-substituted azaindole compounds having 5-ht6 receptor affinity |
| US20100029629A1 (en) * | 2008-07-25 | 2010-02-04 | Memory Pharmaceuticals Corporation | Acyclic compounds having 5-ht6 receptor affinity |
| US20100056531A1 (en) * | 2008-08-22 | 2010-03-04 | Memory Pharmaceuticals Corporation | Alkyl-substituted 3' compounds having 5-ht6 receptor affinity |
| CN104725295B (zh) | 2013-12-20 | 2019-05-24 | 广东东阳光药业有限公司 | 芳杂环类衍生物及其在药物上的应用 |
| AU2015286049B2 (en) | 2014-07-08 | 2018-03-01 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4208417A (en) | 1978-06-29 | 1980-06-17 | Pharmindustrie | Indole derivatives and their use as anxiolytics |
| FR2701026B1 (fr) | 1993-02-02 | 1995-03-31 | Adir | Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| IT1271352B (it) | 1993-04-08 | 1997-05-27 | Boehringer Ingelheim Italia | Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale |
| US6100291A (en) | 1998-03-16 | 2000-08-08 | Allelix Biopharmaceuticals Inc. | Pyrrolidine-indole compounds having 5-HT6 affinity |
| US6133287A (en) * | 1998-03-24 | 2000-10-17 | Allelix Biopharmaceuticals Inc. | Piperidine-indole compounds having 5-HT6 affinity |
| AR015035A1 (es) * | 1998-04-29 | 2001-04-11 | American Home Prod | Agentes serotonergicos, composicion farmaceutica que los contiene y su uso para la manufactura de un medicamento |
| US6251893B1 (en) | 1998-06-15 | 2001-06-26 | Nps Allelix Corp. | Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity |
| US6066637A (en) | 1998-06-19 | 2000-05-23 | American Home Products Corporation | Indolyl derivatives as serotonergic agents |
| US6191141B1 (en) | 1999-08-12 | 2001-02-20 | Nps Allelix Corp. | Azaindoles having serotonin receptor affinity |
| KR100823908B1 (ko) * | 2000-10-20 | 2008-04-21 | 바이오비트럼 에이비(피유비엘) | 2-, 3-, 4-, 또는 5-치환-ｎ1-(벤젠술포닐)인돌 및 이의치료 용도 |
-
2001
- 2001-12-11 ES ES01993251T patent/ES2264994T3/es not_active Expired - Lifetime
- 2001-12-11 CA CA002432661A patent/CA2432661A1/en not_active Abandoned
- 2001-12-11 JP JP2002552927A patent/JP2004520325A/ja active Pending
- 2001-12-11 KR KR10-2003-7008333A patent/KR20030062440A/ko not_active Withdrawn
- 2001-12-11 PL PL01363238A patent/PL363238A1/pl unknown
- 2001-12-11 CN CNA018228232A patent/CN1492863A/zh active Pending
- 2001-12-11 BR BR0116481-3A patent/BR0116481A/pt not_active IP Right Cessation
- 2001-12-11 IL IL15651801A patent/IL156518A0/xx unknown
- 2001-12-11 AT AT01993251T patent/ATE327232T1/de not_active IP Right Cessation
- 2001-12-11 EA EA200300716A patent/EA200300716A1/ru unknown
- 2001-12-11 EP EP01993251A patent/EP1355900B1/en not_active Expired - Lifetime
- 2001-12-11 DK DK01993251T patent/DK1355900T3/da active
- 2001-12-11 WO PCT/US2001/047938 patent/WO2002051832A2/en not_active Ceased
- 2001-12-11 DE DE60119982T patent/DE60119982T2/de not_active Expired - Fee Related
- 2001-12-11 HU HU0400682A patent/HUP0400682A2/hu unknown
- 2001-12-11 MX MXPA03005433A patent/MXPA03005433A/es active IP Right Grant
- 2001-12-20 US US10/028,487 patent/US6613781B2/en not_active Expired - Fee Related
- 2001-12-21 AR ARP010106003A patent/AR034284A1/es unknown
-
2003
- 2003-06-20 NO NO20032841A patent/NO20032841L/no not_active Application Discontinuation
- 2003-07-21 ZA ZA200305625A patent/ZA200305625B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK1355900T3 (da) | 2006-09-11 |
| AR034284A1 (es) | 2004-02-18 |
| KR20030062440A (ko) | 2003-07-25 |
| WO2002051832A3 (en) | 2002-09-06 |
| ATE327232T1 (de) | 2006-06-15 |
| JP2004520325A (ja) | 2004-07-08 |
| DE60119982T2 (de) | 2006-12-21 |
| ES2264994T3 (es) | 2007-02-01 |
| IL156518A0 (en) | 2004-01-04 |
| BR0116481A (pt) | 2004-01-06 |
| US6613781B2 (en) | 2003-09-02 |
| US20020128477A1 (en) | 2002-09-12 |
| DE60119982D1 (de) | 2006-06-29 |
| WO2002051832A2 (en) | 2002-07-04 |
| MXPA03005433A (es) | 2003-09-10 |
| CN1492863A (zh) | 2004-04-28 |
| NO20032841L (no) | 2003-08-20 |
| NO20032841D0 (no) | 2003-06-20 |
| ZA200305625B (en) | 2004-10-21 |
| HUP0400682A2 (hu) | 2004-06-28 |
| EP1355900A2 (en) | 2003-10-29 |
| EA200300716A1 (ru) | 2003-12-25 |
| EP1355900B1 (en) | 2006-05-24 |
| CA2432661A1 (en) | 2002-07-04 |
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