PL363756A1 - Sposób wytwarzania flukonazolu oraz jego odmian krystalicznych - Google Patents

Sposób wytwarzania flukonazolu oraz jego odmian krystalicznych

Info

Publication number: PL363756A1
Authority: PL; Poland
Prior art keywords: sub; sup; fluconazole; crystal modifications; preparing
Prior art date: 2001-03-23

Application number

PL01363756A

Other languages

English (en)

Other versions

PL211572B1 (pl

Inventor

Janos Kreidl

Laszlo Czibula

Csaba Szantay

Jenone Farkas

Juhasz Ida Deutschne

Istvan Hegedus

Papp Eva Werkne

Bagdy Judit Nagyne

Agnes Piller

Original Assignee

Richter Gedeon Vegyeszeti Gyar Rt.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-23

Filing date

2001-03-23

Publication date

2004-11-29

2001-03-23 Application filed by Richter Gedeon Vegyeszeti Gyar Rt. filed Critical Richter Gedeon Vegyeszeti Gyar Rt.

2004-11-29 Publication of PL363756A1 publication Critical patent/PL363756A1/pl

2012-05-31 Publication of PL211572B1 publication Critical patent/PL211572B1/pl

Links

229960004884 fluconazole Drugs 0.000 title abstract 3
239000013078 crystal Substances 0.000 title abstract 2
RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 title abstract 2
238000012986 modification Methods 0.000 title abstract 2
230000004048 modification Effects 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
239000007864 aqueous solution Substances 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical compound [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 abstract 1
-1 fluconazole monohydrate Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Liquid Crystal (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PL363756A 2001-03-23 2001-03-23 Sposób wytwarzania monohydratu i krystalicznej odmiany flukonazolu PL211572B1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/HU2001/000033 WO2002076955A1 (en)	2001-03-23	2001-03-23	Process for preparing fluconazole and its crystal modifications

Publications (2)

Publication Number	Publication Date
PL363756A1 true PL363756A1 (pl)	2004-11-29
PL211572B1 PL211572B1 (pl)	2012-05-31

Family

ID=10974115

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL363756A PL211572B1 (pl)	2001-03-23	2001-03-23	Sposób wytwarzania monohydratu i krystalicznej odmiany flukonazolu

Country Status (14)

Country	Link
US (1)	US7094904B2 (pl)
EP (1)	EP1373227B1 (pl)
JP (1)	JP2004524348A (pl)
AT (1)	ATE309226T1 (pl)
BG (1)	BG66152B1 (pl)
CA (1)	CA2439310C (pl)
CZ (1)	CZ304213B6 (pl)
DE (1)	DE60114889T2 (pl)
ES (1)	ES2252209T3 (pl)
HR (1)	HRP20030854B1 (pl)
HU (1)	HU226886B1 (pl)
PL (1)	PL211572B1 (pl)
SK (1)	SK287354B6 (pl)
WO (1)	WO2002076955A1 (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2011101862A1 (en)	2010-02-17	2011-08-25	Fdc Limited	Stabilized fluconazole polymorph iii formulation
CN102276543A (zh) *	2011-07-13	2011-12-14	王健祥	一种氟康唑的精制方法
CN107935947A (zh) *	2018-01-04	2018-04-20	苏州天马药业有限公司	一种氟康唑晶型ⅲ的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2078719B (en) *	1980-06-02	1984-04-26	Ici Ltd	Heterocyclic compounds
EP0069442B1 (en) *	1981-06-06	1985-02-20	Pfizer Limited	Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them
GB2099818A (en) *	1981-06-06	1982-12-15	Pfizer Ltd	Triazoles
ES8604938A1 (es) *	1985-11-19	1986-03-01	Inke Sa	Procedimiento para la obtencion del 2-(2,4-difluorofenil)- 1,3-bis(1h-1,2,4-triazol-1-il)-propan-2-ol
ES8604940A1 (es) *	1985-11-19	1986-03-01	Inke Sa	Procedimiento para la obtencion del 2-(2,4-difluorofenil)- 1,3-bis(1h-1,2,4-triazol-1-il)-propan-2-ol.
ES8604939A1 (es) *	1985-11-19	1986-03-01	Inke Sa	Procedimiento para la obtencion del 2-(2,4-difluorofenil)- 1,3-bis(1h-1,2,4-triazol-1-il)-propan-2-ol
ES8605753A1 (es) *	1985-12-06	1986-04-16	Lazlo Int Sa	Procedimiento de sintesis de un alcohol terciario
GB8618846D0 (en) *	1986-08-01	1986-09-10	Smithkline Beckman Corp	Chemical process
IT1249211B (it) *	1990-06-08	1995-02-20	Ind Chimica Srl	Processo per la preparazione di triazolil isopropanoli in particolare fluconazolo
TW218017B (pl) *	1992-04-28	1993-12-21	Takeda Pharm Industry Co Ltd
GB2270521A (en) *	1992-09-09	1994-03-16	Pfizer	Crystalline monohydrate of 2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
HU212424B (en) *	1993-09-23	1996-06-28	Richter Gedeon Vegyeszet	New propan-2-ol derivatives substituted with triazole or imidazole and process for producing them
HU212458B (en) *	1993-09-23	1996-06-28	Richter Gedeon Vegyeszet	New silyloxypropane derivatives substituted with triazole or imidazole pharmaceutical compositions containing them and process for producing them
CA2139079C (en) *	1994-12-23	1996-05-28	K.S. Keshava Murthy	Commercial process for the manufacture of fluconazole and intermediates useful in the manufacture thereof
JP2000511875A (ja) *	1996-06-19	2000-09-12	ドクター・レディーズ・リサーチ・ファウンデーション	抗糖尿病活性を増強されたトログリタゾンの新規な多形型及びそれらの製造方法
KR100194945B1 (ko) *	1997-01-29	1999-06-15	서치영	플루코나졸의 제조방법

2001
- 2001-03-23 DE DE60114889T patent/DE60114889T2/de not_active Expired - Lifetime
- 2001-03-23 JP JP2002576215A patent/JP2004524348A/ja active Pending
- 2001-03-23 CA CA002439310A patent/CA2439310C/en not_active Expired - Fee Related
- 2001-03-23 SK SK1239-2003A patent/SK287354B6/sk not_active IP Right Cessation
- 2001-03-23 ES ES01921683T patent/ES2252209T3/es not_active Expired - Lifetime
- 2001-03-23 HR HR20030854A patent/HRP20030854B1/xx not_active IP Right Cessation
- 2001-03-23 CZ CZ2003-2575A patent/CZ304213B6/cs not_active IP Right Cessation
- 2001-03-23 HU HU0500796A patent/HU226886B1/hu unknown
- 2001-03-23 EP EP01921683A patent/EP1373227B1/en not_active Expired - Lifetime
- 2001-03-23 WO PCT/HU2001/000033 patent/WO2002076955A1/en not_active Ceased
- 2001-03-23 PL PL363756A patent/PL211572B1/pl not_active IP Right Cessation
- 2001-03-23 AT AT01921683T patent/ATE309226T1/de not_active IP Right Cessation
2003
- 2003-09-11 BG BG108172A patent/BG66152B1/bg unknown
- 2003-09-22 US US10/667,201 patent/US7094904B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2252209T3 (es)	2006-05-16
HRP20030854A9 (hr)	2011-09-30
SK287354B6 (sk)	2010-08-09
CZ304213B6 (cs)	2014-01-08
CZ20032575A3 (cs)	2003-12-17
PL211572B1 (pl)	2012-05-31
DE60114889D1 (de)	2005-12-15
US20040106804A1 (en)	2004-06-03
BG66152B1 (bg)	2011-08-31
HRP20030854A2 (en)	2005-08-31
EP1373227B1 (en)	2005-11-09
CA2439310A1 (en)	2002-10-03
WO2002076955A1 (en)	2002-10-03
SK12392003A3 (sk)	2004-02-03
CA2439310C (en)	2009-09-29
EP1373227A1 (en)	2004-01-02
HUP0500796A2 (hu)	2005-12-28
JP2004524348A (ja)	2004-08-12
HU226886B1 (en)	2010-01-28
HRP20030854B1 (en)	2011-11-30
ATE309226T1 (de)	2005-11-15
US7094904B2 (en)	2006-08-22
DE60114889T2 (de)	2006-07-20
BG108172A (en)	2004-07-30
HUP0500796A3 (en)	2007-06-28

Legal Events

Date	Code	Title	Description
2015-05-29	LAPS	Decisions on the lapse of the protection rights	Effective date: 20140323

Publication	Publication Date	Title
IL152348A0 (en)	2003-05-29	Oxidation process for preparing the intermediate 6.alpha.-difluoro-11.beta., 17.alpha.-dihydroxy-16.alpha.-methyl-androst-1,4-dien-3-one 17.beta.-carboxylic acid
AU2001237347A1 (en)	2001-08-14	Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
PL367298A1 (pl)	2005-02-21	Sposób wytwarzania beraprostu i jego soli
BG106939A (en)	2003-03-31	Method for the preparation of citalopram
HRP20030854A2 (en)	2005-08-31	Process for preparing fluconazole and its crystal modifications
HU0203193D0 (pl)	2002-10-28
IL154466A0 (en)	2003-09-17	Process for preparing a substituted imidazopyridine compound
IL156768A0 (en)	2004-02-08	Process for preparing (+/-) trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidine
AU2002304846A1 (en)	2002-10-08	Method of producing 1-hydroxy-1,1-diphosphonic acid compounds
ZA200005110B (en)	2001-05-22	Process for preparing intermediates.
MXPA04003086A (es)	2004-09-06	Proceso para sintesis estereoselectiva de 2-hidroximetil-cromanos.
PL378179A1 (pl)	2006-03-06	Sposób wytwarzania podstawionych pochodnych imidazolu i związki pośrednie stosowane w sposobie
AU4436796A (en)	1996-07-31	Process for producing 3,5-diaryl pyrazolene
DE60004669D1 (de)	2003-09-25	Indolocarbazolalkaloide aus einer marinen actinomycete
MXPA03008727A (es)	2004-07-30	Procedimiento para la preparacion de derivados de imidazol tetrasubstituidos y estructuras cristalinas novedosas de los mismos.
IL158530A0 (en)	2004-05-12	Method for producing 1,3-disubstituted 2-nitroguanidines
ZA200208986B (en)	2003-11-04	Process for the preparation of pesticidal compounds.
DK1320527T3 (da)	2008-12-01	Fremgangsmåde til fremstilling af 1-substituerede 5-chlor-4-methylpytrazoler
TW358087B (en)	1999-05-11	Method for preparing carbamoylmethylurea derivatives
AU2000275433A1 (en)	2002-04-15	Process for the preparation of alkyl n-alkylanthranilate
AU2001250386A1 (en)	2001-09-24	Method for producing 1,1' binaphthalenylidene-4,4'-diones