PL365958A1 - Trójpierścieniowe związki 2-pirydynowe użyteczne jako inhibitory odwrotnej transkryptazy HIV - Google Patents

Trójpierścieniowe związki 2-pirydynowe użyteczne jako inhibitory odwrotnej transkryptazy HIV

Info

Publication number: PL365958A1
Authority: PL; Poland
Prior art keywords: tricyclic; reverse transcriptase; compounds useful; transcriptase inhibitors; hiv reverse
Prior art date: 2000-07-20

Application number

PL01365958A

Other languages

English (en)

Inventor

James D. Rodgers

Haisheng Wang

Mona Patel

Argyrios Arvanitis

Anthony J. Cocuzza

Original Assignee

Bristol-Myers Squibb Pharma Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-20

Filing date

2001-07-20

Publication date

2005-01-24

2001-07-20 Application filed by Bristol-Myers Squibb Pharma Company filed Critical Bristol-Myers Squibb Pharma Company

2005-01-24 Publication of PL365958A1 publication Critical patent/PL365958A1/pl

Links

108010078851 HIV Reverse Transcriptase Proteins 0.000 title 1
UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical class OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 title 1
239000003419 rna directed dna polymerase inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
Engineering & Computer Science (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PL01365958A 2000-07-20 2001-07-20 Trójpierścieniowe związki 2-pirydynowe użyteczne jako inhibitory odwrotnej transkryptazy HIV PL365958A1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US21953200P	2000-07-20	2000-07-20
US28485601P	2001-04-19	2001-04-19

Publications (1)

Publication Number	Publication Date
PL365958A1 true PL365958A1 (pl)	2005-01-24

Family

ID=26913986

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL01365958A PL365958A1 (pl)	2000-07-20	2001-07-20	Trójpierścieniowe związki 2-pirydynowe użyteczne jako inhibitory odwrotnej transkryptazy HIV

Country Status (23)

Country	Link
US (1)	US6596729B2 (pl)
EP (1)	EP1303515A2 (pl)
JP (1)	JP2004532793A (pl)
KR (1)	KR20030065454A (pl)
CN (1)	CN1464878A (pl)
AR (1)	AR031861A1 (pl)
AU (1)	AU2001280641A1 (pl)
BG (1)	BG107439A (pl)
BR (1)	BR0112606A (pl)
CA (1)	CA2418194A1 (pl)
EE (1)	EE200300027A (pl)
HU (1)	HUP0302862A2 (pl)
IL (1)	IL153683A0 (pl)
IS (1)	IS6690A (pl)
LT (1)	LT2003003A (pl)
LV (1)	LV13024B (pl)
MX (1)	MXPA03000434A (pl)
NO (1)	NO20030248L (pl)
PL (1)	PL365958A1 (pl)
SI (1)	SI21139A (pl)
SK (1)	SK392003A3 (pl)
WO (1)	WO2002008226A2 (pl)
YU (1)	YU3203A (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8101629B2 (en)	2001-08-13	2012-01-24	Janssen Pharmaceutica N.V.	Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
JO3429B1 (ar)	2001-08-13	2019-10-20	Janssen Pharmaceutica Nv	مشتقات برميدينات مثبطة فيروس الايدز
US7638522B2 (en)	2001-08-13	2009-12-29	Janssen Pharmaceutica N.V.	Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
TW200306192A (en)	2002-01-18	2003-11-16	Bristol Myers Squibb Co	Tricyclic 2-pyrimidone compounds useful as HIV reverse transcriptase inhibitors
AR039540A1 (es) *	2002-05-13	2005-02-23	Tibotec Pharm Ltd	Compuestos microbicidas con contenido de pirimidina o triazina
CN102702111B (zh)	2002-08-09	2014-12-17	詹森药业有限公司	制备4-[[4-[[4-(2-氰基乙烯基)-2,6-二甲基苯基]氨基]-2-嘧啶基]氨基]苄腈的方法
PL227577B1 (pl) *	2003-02-07	2017-12-29	Janssen Pharmaceutica Nv	Zastosowanie pochodnych pirymidyny do wytwarzania leku do zapobiegania zakażeniu wirusem HIV oraz kompozycja farmaceutyczna
MXPA06013314A (es) *	2004-05-17	2007-02-02	Tibotec Pharm Ltd	1-heterociclil-1,5-dihidro-pirido[3,2-b]indol-2-onas.

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3700673A (en) *	1971-02-12	1972-10-24	Morton Norwich Products Inc	3-4-dihydrobenzo(b) (1,7)naphthyridin-1(2h)-ones
GB9023289D0 (en)	1990-10-25	1990-12-05	Ici Plc	Herbicides
IL102764A0 (en)	1991-08-16	1993-01-31	Merck & Co Inc	Quinazoline derivatives,and pharmaceutical compositions containing them
AU2436792A (en) *	1991-08-16	1993-03-16	Merck & Co., Inc.	Quinazoline derivatives as inhibitors of hiv reverse transcriptase
DE4320347A1 (de)	1993-06-19	1994-12-22	Boehringer Mannheim Gmbh	Quinazolin-Derivate und diese enthaltende Arzneimittel
AU1046895A (en)	1993-11-05	1995-05-23	Merck & Co., Inc.	New quinazolines as inhibitors of hiv reverse transcriptase
DE4344452A1 (de)	1993-12-24	1995-06-29	Hoechst Ag	Aza-4-iminochinoline, Verfahren zu ihrer Herstellung und ihre Verwendung
ID18046A (id)	1996-08-20	1998-02-19	Takeda Chemical Industries Ltd	Senyawa siklik campuran, pembuatan dan penngunaannya.
WO1998014436A1 (en)	1996-10-02	1998-04-09	Dupont Pharmaceuticals Company	4,4-disubstituted-1,4-dihydro-2h-3,1-benzoxazin-2-ones useful as hiv reverse transcriptase inhibitors and intermediates and processes for making the same
HRP980143A2 (en)	1997-04-09	1999-02-28	Soo Sung Ko	4,4-disubstituted-3,4-dihydro-2 (1h)-quinazolinones useful as hiv reverse transcriptase inhibitors
US6593337B1 (en)	1999-10-19	2003-07-15	Bristol-Myers Squibb Pharma Company	Tricyclic compounds useful as HIV reverse transcriptase inhibitors

2001
- 2001-07-19 US US09/908,995 patent/US6596729B2/en not_active Expired - Lifetime
- 2001-07-20 CN CN01815629A patent/CN1464878A/zh active Pending
- 2001-07-20 AR ARP010103492A patent/AR031861A1/es unknown
- 2001-07-20 JP JP2002514132A patent/JP2004532793A/ja active Pending
- 2001-07-20 YU YU3203A patent/YU3203A/sh unknown
- 2001-07-20 SI SI200120050A patent/SI21139A/sl not_active IP Right Cessation
- 2001-07-20 IL IL15368301A patent/IL153683A0/xx unknown
- 2001-07-20 MX MXPA03000434A patent/MXPA03000434A/es unknown
- 2001-07-20 BR BR0112606-7A patent/BR0112606A/pt not_active Application Discontinuation
- 2001-07-20 KR KR10-2003-7000800A patent/KR20030065454A/ko not_active Withdrawn
- 2001-07-20 HU HU0302862A patent/HUP0302862A2/hu unknown
- 2001-07-20 SK SK39-2003A patent/SK392003A3/sk unknown
- 2001-07-20 EP EP01959047A patent/EP1303515A2/en not_active Withdrawn
- 2001-07-20 CA CA002418194A patent/CA2418194A1/en not_active Abandoned
- 2001-07-20 WO PCT/US2001/022827 patent/WO2002008226A2/en not_active Ceased
- 2001-07-20 AU AU2001280641A patent/AU2001280641A1/en not_active Abandoned
- 2001-07-20 PL PL01365958A patent/PL365958A1/pl not_active Application Discontinuation
- 2001-07-20 EE EEP200300027A patent/EE200300027A/xx unknown
2003
- 2003-01-06 BG BG107439A patent/BG107439A/bg unknown
- 2003-01-15 LT LT2003003A patent/LT2003003A/xx not_active Application Discontinuation
- 2003-01-17 IS IS6690A patent/IS6690A/is unknown
- 2003-01-17 NO NO20030248A patent/NO20030248L/no not_active Application Discontinuation
- 2003-02-18 LV LVP-03-16A patent/LV13024B/en unknown

Also Published As

Publication number	Publication date
AU2001280641A1 (en)	2002-02-05
SI21139A (sl)	2003-08-31
SK392003A3 (en)	2003-10-07
LT2003003A (en)	2003-11-25
LV13024B (en)	2003-10-20
US6596729B2 (en)	2003-07-22
CN1464878A (zh)	2003-12-31
US20020107261A1 (en)	2002-08-08
BR0112606A (pt)	2004-06-29
AR031861A1 (es)	2003-10-08
KR20030065454A (ko)	2003-08-06
MXPA03000434A (es)	2003-06-24
IS6690A (is)	2003-01-17
BG107439A (bg)	2003-09-30
JP2004532793A (ja)	2004-10-28
NO20030248L (no)	2003-03-17
WO2002008226A3 (en)	2002-06-20
EP1303515A2 (en)	2003-04-23
IL153683A0 (en)	2003-07-06
EE200300027A (et)	2004-10-15
HUP0302862A2 (hu)	2003-12-29
YU3203A (sh)	2006-01-16
WO2002008226A2 (en)	2002-01-31
CA2418194A1 (en)	2002-01-31
NO20030248D0 (no)	2003-01-17

Legal Events

Date	Code	Title	Description
2008-08-29	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)

Publication	Publication Date	Title
IL149219A0 (en)	2002-11-10	Tricyclic compounds useful as hiv reverse transcriptase inhibitors
HUS2200038I1 (hu)	2022-08-28	HIV-gátló pirimidinszármazékok
IL181957A0 (en)	2009-02-11	Pyrimidine-4-one derivatives as ldl-pla2 inhibitors
GB0107758D0 (en)	2001-05-16	Anti-cancer compounds
IL152872A0 (en)	2003-06-24	Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors
AU6623201A (en)	2002-02-05	Colchinol derivatives as angiogenesis inhibitors
SG89376A1 (en)	2002-06-18	Nominal shift machining
MXPA03000066A (es)	2003-10-15	Derivados glutamida.substituidos con ciclopentilo como inhibidores de endopeptidasa neutral.
MXPA03004262A (es)	2003-09-22	Derivados de (dihidro)isoquinolina como inhibidores de fosfodiesterasa.
AU2003243765A8 (en)	2004-01-19	2,4-disubstituted-pyridine n-oxides useful as hiv reverse transcriptase inhibitors
PL371418A1 (pl)	2005-06-13	Tricykliczne związki 2-pirymidonu jako inhibitoryodwrotnej transkryptazy wirusa HIV
AU6989501A (en)	2001-12-24	Hiv integrase inhibitors
MXPA03009482A (es)	2004-02-12	Compuestos triciclicos utiles como inhibidores de la transcriptasa inversa del virus de inmunodeficiencia humana (vih).
IL152819A0 (en)	2003-06-24	Non-nucleoside reverse transcriptase inhibitors
EE200300027A (et)	2004-10-15	HIV pöördtranskriptaasi inhibiitoritena kasutatavad tritsüklilised 2-püridooniühendid
IL157543A (en)	2010-11-30	Cyclopropaheterocycles as non-nucleoside reverse transcriptase inhibitors
AU2001249161A1 (en)	2001-10-03	Asymmetric synthesis of quinazolin-2-ones useful as hiv reverse transcriptase inhibitors
IL155573A0 (en)	2003-11-23	Novel compounds for use as hiv protease inhibitors
AU4719799A (en)	2000-01-17	Substituted quinolin-2(1h)-ones useful as hiv reverse transcriptase inhibitors
HK1059568A (en)	2004-07-09	Tricyclic compounds useful as hiv reverse transcriptase inhibitors
AU5588400A (en)	2000-12-18	1,4-benzodiazepin-2-ones useful as hiv reverse transcriptase inhibitors
HK1069825A (en)	2005-06-03	Tricyclic 2-pyrimidone compounds useful as hiv reverse transcriptase inhibitors
ZA200206528B (en)	2003-03-13	Pyrimidine-4-one derivatives as LDL-PLA2 inhibitors.
ZA200004558B (en)	2001-11-30	Inhibitors of HIV reverse transcriptase.
SI1294720T1 (sl)	2006-08-31	Nenukleozidni inhibitorji reverzne transkriptaze