PL367429A1 - Zabezpieczone 3,5-dihydroksy-2,2-dimetylowaleronitryle do syntezy epotilonów i ich pochodnych oraz sposób ich wytwarzania i zastosowania - Google Patents

Zabezpieczone 3,5-dihydroksy-2,2-dimetylowaleronitryle do syntezy epotilonów i ich pochodnych oraz sposób ich wytwarzania i zastosowania

Info

Publication number: PL367429A1
Authority: PL; Poland
Prior art keywords: epothilones; synthesis; production; valeronitriles; dihydroxy
Prior art date: 2001-08-03

Application number

PL02367429A

Other languages

English (en)

Inventor

Jürgen Westermann

Orlin Petrov

Johannes Platzek

Original Assignee

Schering Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-03

Filing date

2002-08-05

Publication date

2005-02-21

2002-08-05 Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft

2005-02-21 Publication of PL367429A1 publication Critical patent/PL367429A1/pl

Links

230000015572 biosynthetic process Effects 0.000 title abstract 3
229930013356 epothilone Natural products 0.000 title abstract 3
HESCAJZNRMSMJG-KKQRBIROSA-N epothilone A Chemical class C/C([C@@H]1C[C@@H]2O[C@@H]2CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 HESCAJZNRMSMJG-KKQRBIROSA-N 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title abstract 3
238000003786 synthesis reaction Methods 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
150000003883 epothilone derivatives Chemical class 0.000 abstract 2
239000013067 intermediate product Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/16—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same carbon atom of an acyclic carbon skeleton
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/002—Nitriles (-CN)
- C12P13/004—Cyanohydrins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/11—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton
- C07C255/12—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/11—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton
- C07C255/13—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
- C07C255/20—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Analytical Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

PL02367429A 2001-08-03 2002-08-05 Zabezpieczone 3,5-dihydroksy-2,2-dimetylowaleronitryle do syntezy epotilonów i ich pochodnych oraz sposób ich wytwarzania i zastosowania PL367429A1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE10138347A DE10138347A1 (de)	2001-08-03	2001-08-03	Geschützte 3,5-Dihydroxy-2,2-dimethyl-valeronitrile für die Synthese von Epothilonen- und Derivaten und Verfahren zur Herstellung

Publications (1)

Publication Number	Publication Date
PL367429A1 true PL367429A1 (pl)	2005-02-21

Family

ID=7694414

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL02367429A PL367429A1 (pl)	2001-08-03	2002-08-05	Zabezpieczone 3,5-dihydroksy-2,2-dimetylowaleronitryle do syntezy epotilonów i ich pochodnych oraz sposób ich wytwarzania i zastosowania

Country Status (20)

Country	Link
US (2)	US7034165B2 (pl)
EP (1)	EP1412323B1 (pl)
JP (1)	JP4620346B2 (pl)
KR (1)	KR100876036B1 (pl)
CN (1)	CN100482641C (pl)
AR (1)	AR036206A1 (pl)
AT (1)	ATE444283T1 (pl)
AU (1)	AU2002333336B2 (pl)
BR (1)	BR0211651A (pl)
CA (1)	CA2455797C (pl)
DE (2)	DE10138347A1 (pl)
ES (1)	ES2331468T3 (pl)
IL (1)	IL159726A0 (pl)
MX (1)	MXPA04001060A (pl)
NO (1)	NO20040911L (pl)
PE (1)	PE20030327A1 (pl)
PL (1)	PL367429A1 (pl)
RU (1)	RU2303590C2 (pl)
WO (1)	WO2003014068A1 (pl)
ZA (1)	ZA200401722B (pl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1386922B1 (en)	1996-12-03	2012-04-11	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereof, analogues and uses thereof
US6204388B1 (en) *	1996-12-03	2001-03-20	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
US6867305B2 (en)	1996-12-03	2005-03-15	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
US7368568B2 (en) *	2001-08-03	2008-05-06	Bayer Schering Pharma Ag	Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for production and the use
WO2003029195A1 (en)	2001-09-28	2003-04-10	Sumika Fine Chemicals Co., Ltd.	Intermediates for epothilone derivative and process for producing these
ATE350383T1 (de)	2002-08-23	2007-01-15	Sloan Kettering Inst Cancer	Synthese von epothilonen, zwischenprodukte dafür, analoga und deren verwendungen
US6921769B2 (en)	2002-08-23	2005-07-26	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
US7649006B2 (en)	2002-08-23	2010-01-19	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
EP2634252B1 (en)	2005-02-11	2018-12-19	University of Southern California	Method of expressing proteins with disulfide bridges
US8008256B2 (en) *	2006-05-01	2011-08-30	University Of Southern California	Combination therapy for treatment of cancer
US8802394B2 (en)	2008-11-13	2014-08-12	Radu O. Minea	Method of expressing proteins with disulfide bridges with enhanced yields and activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE267197T1 (de) *	1996-11-18	2004-06-15	Biotechnolog Forschung Gmbh	Epothilon d, dessen herstellung und dessen verwendung als cytostatisches mittel bzw. als pflanzenschutzmittel
DE19701758A1 (de) *	1997-01-20	1998-07-23	Wessjohann Ludgar A Dr	Epothilone-Synthesebausteine
US6603015B2 (en) *	1999-03-29	2003-08-05	University Of Kansas	Synthesis of epothilones
US6211412B1 (en) *	1999-03-29	2001-04-03	The University Of Kansas	Synthesis of epothilones
WO2003029195A1 (en) *	2001-09-28	2003-04-10	Sumika Fine Chemicals Co., Ltd.	Intermediates for epothilone derivative and process for producing these

2001
- 2001-08-03 DE DE10138347A patent/DE10138347A1/de not_active Withdrawn
2002
- 2002-08-02 PE PE2002000703A patent/PE20030327A1/es not_active Application Discontinuation
- 2002-08-02 AR ARP020102939A patent/AR036206A1/es unknown
- 2002-08-05 MX MXPA04001060A patent/MXPA04001060A/es active IP Right Grant
- 2002-08-05 AU AU2002333336A patent/AU2002333336B2/en not_active Expired - Fee Related
- 2002-08-05 JP JP2003519018A patent/JP4620346B2/ja not_active Expired - Fee Related
- 2002-08-05 ES ES02794553T patent/ES2331468T3/es not_active Expired - Lifetime
- 2002-08-05 CA CA2455797A patent/CA2455797C/en not_active Expired - Fee Related
- 2002-08-05 WO PCT/EP2002/008730 patent/WO2003014068A1/de not_active Ceased
- 2002-08-05 AT AT02794553T patent/ATE444283T1/de not_active IP Right Cessation
- 2002-08-05 US US10/211,236 patent/US7034165B2/en not_active Expired - Fee Related
- 2002-08-05 EP EP02794553A patent/EP1412323B1/de not_active Expired - Lifetime
- 2002-08-05 DE DE50213889T patent/DE50213889D1/de not_active Expired - Lifetime
- 2002-08-05 PL PL02367429A patent/PL367429A1/pl unknown
- 2002-08-05 RU RU2004106532/04A patent/RU2303590C2/ru not_active IP Right Cessation
- 2002-08-05 KR KR1020047001709A patent/KR100876036B1/ko not_active Expired - Fee Related
- 2002-08-05 BR BR0211651-0A patent/BR0211651A/pt not_active IP Right Cessation
- 2002-08-05 CN CNB028152395A patent/CN100482641C/zh not_active Expired - Fee Related
- 2002-08-05 IL IL15972602A patent/IL159726A0/xx unknown
2004
- 2004-03-02 ZA ZA200401722A patent/ZA200401722B/en unknown
- 2004-03-02 NO NO20040911A patent/NO20040911L/no not_active Application Discontinuation
2005
- 2005-07-26 US US11/188,991 patent/US7358382B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP4620346B2 (ja)	2011-01-26
CN1538954A (zh)	2004-10-20
US20030149281A1 (en)	2003-08-07
EP1412323B1 (de)	2009-09-30
EP1412323A1 (de)	2004-04-28
JP2004537591A (ja)	2004-12-16
DE50213889D1 (de)	2009-11-12
BR0211651A (pt)	2004-07-13
ZA200401722B (en)	2004-10-08
RU2303590C2 (ru)	2007-07-27
DE10138347A1 (de)	2003-02-27
MXPA04001060A (es)	2004-05-20
CA2455797A1 (en)	2003-02-20
RU2004106532A (ru)	2005-07-27
KR100876036B1 (ko)	2008-12-26
US20050267306A1 (en)	2005-12-01
HK1070350A1 (zh)	2005-06-17
CN100482641C (zh)	2009-04-29
ATE444283T1 (de)	2009-10-15
IL159726A0 (en)	2004-06-20
ES2331468T3 (es)	2010-01-05
US7034165B2 (en)	2006-04-25
WO2003014068A1 (de)	2003-02-20
PE20030327A1 (es)	2003-04-10
US7358382B2 (en)	2008-04-15
AU2002333336B2 (en)	2008-05-29
KR20040022229A (ko)	2004-03-11
AR036206A1 (es)	2004-08-18
CA2455797C (en)	2010-11-16
NO20040911L (no)	2004-03-02

Legal Events

Date	Code	Title	Description
2009-12-31	DISC	Decisions on discontinuance of the proceedings (taken after the publication of the particulars of the applications)

Publication	Publication Date	Title
MXPA03010909A (es)	2004-02-17	Derivados de epotilona.
HUP0103019A3 (en)	2002-01-28	Amide derivatives useful as inhibitors of the production of cytokines, process for producing them and pharmaceutical compositions containing them
BG105177A (en)	2001-11-30	Novel substituted pyrazole derivatives
MY141853A (en)	2010-07-16	1-amino-2-oxy-substituted tetrahydronaphtalene derivatives, methods for the production thereof, and their use as antiphlogistics
AU2003233010A1 (en)	2003-12-19	Process for the preparation of 3,3,4,4-tetrafluoropyrrolidine and derivatives thereof
PL376524A1 (pl)	2006-01-09	Nowe hydroksyindole, ich zastosowanie jako inhibitorów fosfodiesterazy 4 i sposób ich wytwarzania
IL157723A0 (en)	2004-03-28	5-phenylpyrimidine, methods and intermediate products for the production thereof and use of the same for controlling pathogenic fungi
MY134480A (en)	2007-12-31	4-pyrrolidino-phenyl-benzyl ether derivatives
ZA200404752B (en)	2005-04-26	6-aminomorphinane derivatives method for the production and use thereof
MXPA04001060A (es)	2004-05-20	3,5 dihidroxi-2,2-dimetil-valeronitrilos protegidos para la sintesis de epotilonas y sus derivados y metodos para su elaboracion y uso de los mismos.
AU2003262062A1 (en)	2004-04-19	Cu-CONTAINING STEEL PRODUCT OF EXCELLENT SURFACE PROPERTY AND PROCESS FOR PRODUCING THE SAME
AU2002333336A1 (en)	2003-06-19	Protected 3.5-dihydroxy -2.2-dimethyl-valeronitriles for the synthesis of epothilones and derivatives and method for the production and use thereof
TWI318211B (en)	2009-12-11	Novel derivatives of 4a, 5, 9, 10, 11, 12-hexahydrobenzofuro [3a, 2, 2] [2] -benzazepine, method for the production thereof and use thereof in the production of medicaments
MXPA04000954A (es)	2004-04-20	3,5-dibidroxi-2,2-dimetil-valeroamidas protegidas para la sintesis de epotilonas y derivados, un procedimiento para su preparacion y el empleo de las mismas.
MXPA01002408A (es)	2003-08-20	Productos alimenticios tipo granola y metodo para fabricarlos.
WO2005047278A3 (de)	2005-07-21	Substituierte dihydrochinazoline ii
MY140061A (en)	2009-11-30	Improved method for the production of ramipril
WO2001049651A3 (de)	2002-05-23	Aminomethyl-phenyl-cyclohexanonderivate
AU2003274145A1 (en)	2005-05-05	Machine for the production of an anchovy fillet substitute or similar from surimi, production method thereof and product thus produced
MXPA05008440A (es)	2005-10-19	Procedimiento para la preparacion de aminoacidos aromaticos biciclicos e intermediarios de los mismos.
MXPA03002047A (es)	2004-05-04	Fenilciclohexanocarboxamidas substituidas y su uso.
AU4291901A (en)	2001-09-24	Process for the production of 2-hydroxyethylmaleimide and the product obtained by the process
IL166358A0 (en)	2006-01-16	Microbiological method for the production of 7 alpha-substituted 11 alpha-hydroxysteroids
ZA200501008B (en)	2006-12-27	A new process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods for preparing same
AU2002340805A1 (en)	2003-06-19	Protected 3.5-dihydroxy-2.2-dimethyl-valeroamides for the synthesis of epothilone and derivatives and method for the production and use thereof