PL376524A1 - Nowe hydroksyindole, ich zastosowanie jako inhibitorów fosfodiesterazy 4 i sposób ich wytwarzania - Google Patents

Nowe hydroksyindole, ich zastosowanie jako inhibitorów fosfodiesterazy 4 i sposób ich wytwarzania

Info

Publication number: PL376524A1
Authority: PL; Poland
Prior art keywords: hydroxyindoles; phosphodiesterase; inhibitors; novel; production
Prior art date: 2002-11-15

Application number

PL376524A

Other languages

English (en)

Inventor

Norbert Höfgen

Hildegard Kuss

Ute Egerland

Chris Rundfeldt

Helge Hartenhauer

Antje Gasparic

Original Assignee

Elbion Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-11-15

Filing date

2003-11-14

Publication date

2006-01-09

2003-11-14 Application filed by Elbion Ag filed Critical Elbion Ag

2006-01-09 Publication of PL376524A1 publication Critical patent/PL376524A1/pl

Links

MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 title 1
NLMQHXUGJIAKTH-UHFFFAOYSA-N 4-hydroxyindole Chemical class OC1=CC=CC2=C1C=CN2 NLMQHXUGJIAKTH-UHFFFAOYSA-N 0.000 title 1
102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 title 1
108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Rheumatology (AREA)
Virology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Cardiology (AREA)
Tropical Medicine & Parasitology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

PL376524A 2002-11-15 2003-11-14 Nowe hydroksyindole, ich zastosowanie jako inhibitorów fosfodiesterazy 4 i sposób ich wytwarzania PL376524A1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE10253426A DE10253426B4 (de)	2002-11-15	2002-11-15	Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung

Publications (1)

Publication Number	Publication Date
PL376524A1 true PL376524A1 (pl)	2006-01-09

Family

ID=32240098

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL376524A PL376524A1 (pl)	2002-11-15	2003-11-14	Nowe hydroksyindole, ich zastosowanie jako inhibitorów fosfodiesterazy 4 i sposób ich wytwarzania

Country Status (19)

Country	Link
US (2)	US7166637B2 (pl)
EP (1)	EP1562584A1 (pl)
JP (1)	JP2006508141A (pl)
KR (1)	KR20050075014A (pl)
CN (1)	CN1711082A (pl)
AR (1)	AR042053A1 (pl)
AU (1)	AU2003283400A1 (pl)
BR (1)	BR0316234A (pl)
CA (1)	CA2505988A1 (pl)
DE (1)	DE10253426B4 (pl)
HR (1)	HRP20050542A2 (pl)
MX (1)	MXPA05005138A (pl)
NO (1)	NO20052864L (pl)
PL (1)	PL376524A1 (pl)
RU (1)	RU2005118409A (pl)
TW (1)	TW200510306A (pl)
UA (1)	UA80567C2 (pl)
WO (1)	WO2004045607A1 (pl)
ZA (2)	ZA200503399B (pl)

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CL2008003651A1 (es)	2007-12-10	2009-06-19	Novartis Ag	Compuestos derivados de 3,5-diamino-6-cloropirazinamida sustituida; composicion farmaceutica; combinacion farmaceutica; y uso en el tratamiento de una condición inflamatoria o alergica, en particular una enfermedad inflamatoria u obstructiva de las vias respiratorias.
AU2009203693B2 (en)	2008-01-11	2012-06-07	Novartis Ag	Pyrimidines as kinase inhibitors
AU2009239430B2 (en)	2008-04-21	2015-01-22	Signum Biosciences, Inc.	Compounds, compositions and methods for making the same
CA2727196A1 (en)	2008-06-10	2009-12-17	Novartis Ag	Organic compounds
PL2391366T3 (pl)	2009-01-29	2013-04-30	Novartis Ag	Podstawione benzimidazole do leczenia gwiaździaków
US8389526B2 (en)	2009-08-07	2013-03-05	Novartis Ag	3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
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EA201200260A1 (ru)	2009-08-12	2012-09-28	Новартис Аг	Гетероциклические гидразоны и их применение для лечения рака и воспаления
NZ598220A (en)	2009-08-17	2014-02-28	Intellikine Llc	Heterocyclic compounds and uses thereof
CA2771432A1 (en)	2009-08-20	2011-02-24	Novartis Ag	Heterocyclic oxime compounds
US20110098311A1 (en)	2009-10-22	2011-04-28	Vertex Pharmaceuticals Incorported	Compositions for treatment of cystic fibrosis and other chronic diseases
US8247436B2 (en)	2010-03-19	2012-08-21	Novartis Ag	Pyridine and pyrazine derivative for the treatment of CF
WO2012034095A1 (en)	2010-09-09	2012-03-15	Irm Llc	Compounds and compositions as trk inhibitors
UY33597A (es)	2010-09-09	2012-04-30	Irm Llc	Compuestos y composiciones como inhibidores de la trk
US8372845B2 (en)	2010-09-17	2013-02-12	Novartis Ag	Pyrazine derivatives as enac blockers
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EP2968340A4 (en)	2013-03-15	2016-08-10	Intellikine Llc	COMBINING KINASE INHIBITORS AND USES THEREOF
TW201605450A (zh)	2013-12-03	2016-02-16	諾華公司	Ｍｄｍ２抑制劑與ＢＲＡＦ抑制劑之組合及其用途
CA2945212A1 (en)	2014-04-24	2015-10-29	Novartis Ag	Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
BR112016024484A2 (pt)	2014-04-24	2017-08-15	Novartis Ag	derivados de aminopiridina como inibidores de fosfatidilinositol 3-quinase
US9862711B2 (en)	2014-04-24	2018-01-09	Novartis Ag	Pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
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DE19917504A1 (de) *	1999-04-17	2000-10-19	Dresden Arzneimittel	Verwendung von Hydroxyindolen, die Inhibitoren der Phosphodiesterase 4 sind, zur Therapie chronisch obstruktiver Lungenerkrankungen
PL198983B1 (pl)	1998-04-28	2008-08-29	Elbion Ag	Nowe hydroksyindole, ich zastosowanie jako inhibitorów fosfodiesterazy 4 oraz sposoby ich wytwarzania
DE10053275A1 (de)	2000-10-27	2002-05-02	Dresden Arzneimittel	Neue 7-Azaindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
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DE10253426B4 (de) *	2002-11-15	2005-09-22	Elbion Ag	Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung

2002
- 2002-11-15 DE DE10253426A patent/DE10253426B4/de not_active Expired - Fee Related
2003
- 2003-11-13 US US10/714,568 patent/US7166637B2/en not_active Expired - Fee Related
- 2003-11-13 TW TW092131851A patent/TW200510306A/zh unknown
- 2003-11-14 PL PL376524A patent/PL376524A1/pl unknown
- 2003-11-14 UA UAA200504467A patent/UA80567C2/uk unknown
- 2003-11-14 JP JP2004552596A patent/JP2006508141A/ja not_active Withdrawn
- 2003-11-14 RU RU2005118409/04A patent/RU2005118409A/ru not_active Application Discontinuation
- 2003-11-14 AU AU2003283400A patent/AU2003283400A1/en not_active Abandoned
- 2003-11-14 AR ARP030104219A patent/AR042053A1/es not_active Application Discontinuation
- 2003-11-14 EP EP03775355A patent/EP1562584A1/de not_active Withdrawn
- 2003-11-14 CA CA002505988A patent/CA2505988A1/en not_active Abandoned
- 2003-11-14 WO PCT/EP2003/012742 patent/WO2004045607A1/de not_active Ceased
- 2003-11-14 CN CNA200380103190XA patent/CN1711082A/zh active Pending
- 2003-11-14 HR HR20050542A patent/HRP20050542A2/hr not_active Application Discontinuation
- 2003-11-14 KR KR1020057008684A patent/KR20050075014A/ko not_active Withdrawn
- 2003-11-14 MX MXPA05005138A patent/MXPA05005138A/es active IP Right Grant
- 2003-11-14 BR BR0316234-6A patent/BR0316234A/pt not_active IP Right Cessation
2005
- 2005-04-28 ZA ZA200503399A patent/ZA200503399B/en unknown
- 2005-06-13 NO NO20052864A patent/NO20052864L/no not_active Application Discontinuation
- 2005-09-01 ZA ZA200507002A patent/ZA200507002B/en unknown
2006
- 2006-11-30 US US11/606,696 patent/US20070093531A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AR042053A1 (es)	2005-06-08
AU2003283400A1 (en)	2004-06-15
EP1562584A1 (de)	2005-08-17
ZA200503399B (en)	2006-06-28
CA2505988A1 (en)	2004-06-03
US20070093531A1 (en)	2007-04-26
BR0316234A (pt)	2005-10-11
MXPA05005138A (es)	2005-07-22
HRP20050542A2 (en)	2005-08-31
JP2006508141A (ja)	2006-03-09
CN1711082A (zh)	2005-12-21
NO20052864L (no)	2005-06-13
UA80567C2 (en)	2007-10-10
ZA200507002B (en)	2006-06-28
DE10253426B4 (de)	2005-09-22
RU2005118409A (ru)	2006-01-20
WO2004045607A1 (de)	2004-06-03
US7166637B2 (en)	2007-01-23
TW200510306A (en)	2005-03-16
US20040147759A1 (en)	2004-07-29
DE10253426A1 (de)	2004-06-03
KR20050075014A (ko)	2005-07-19

Legal Events

Date	Code	Title	Description
2007-10-31	DISC	Decisions on discontinuance of the proceedings (taken after the publication of the particulars of the applications)

Publication	Publication Date	Title
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PL366690A1 (pl)	2005-10-03	Nowe pochodne 4,5,6,7-tetrabromobenzimidazolu oraz sposób ich otrzymywania
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PL373599A1 (pl)	2005-09-05	Sposób otrzymywania monoalkiloaminoketonów
PL376796A1 (pl)	2006-01-09	Sposób wytwarzania inhibitorów fosfodiesterazy-4
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