PL367618A1 - Pochodne 5-fluorowco-tryptaminy stosowane jako ligandy 5-HT6 i/lub 5-HT7 receptorów serotoniny - Google Patents

Pochodne 5-fluorowco-tryptaminy stosowane jako ligandy 5-HT6 i/lub 5-HT7 receptorów serotoniny

Info

Publication number: PL367618A1
Authority: PL; Poland
Prior art keywords: sub; ligands; halo; derivatives used; serotonin receptors
Prior art date: 2001-06-21

Application number

PL02367618A

Other languages

English (en)

Inventor

Cesare Maria Assunta Di

Patrizia Minetti

Giorgio Tarzia

Gilberto Spadoni

Original Assignee

Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-21

Filing date

2002-06-17

Publication date

2005-03-07

2002-06-17 Application filed by Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. filed Critical Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.

2005-03-07 Publication of PL367618A1 publication Critical patent/PL367618A1/pl

Links

239000003446 ligand Substances 0.000 title abstract 2
102000040125 5-hydroxytryptamine receptor family Human genes 0.000 title 1
108091032151 5-hydroxytryptamine receptor family Proteins 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
239000004480 active ingredient Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000002295 serotoninergic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)

PL02367618A 2001-06-21 2002-06-17 Pochodne 5-fluorowco-tryptaminy stosowane jako ligandy 5-HT6 i/lub 5-HT7 receptorów serotoniny PL367618A1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2001RM000356A ITRM20010356A1 (it)	2001-06-21	2001-06-21	"5-alogeno derivati della triptamina utili come ligandi del recettore5-ht6 e/o 5-ht7 della serotonina.
PCT/IT2002/000398 WO2003000252A1 (en)	2001-06-21	2002-06-17	5-halo-tryptamine derivatives used as ligands of the 5-ht6 and/or 5-ht7 serotonin receptors

Publications (1)

Publication Number	Publication Date
PL367618A1 true PL367618A1 (pl)	2005-03-07

Family

ID=11455609

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL02367618A PL367618A1 (pl)	2001-06-21	2002-06-17	Pochodne 5-fluorowco-tryptaminy stosowane jako ligandy 5-HT6 i/lub 5-HT7 receptorów serotoniny

Country Status (21)

Country	Link
US (1)	US7098233B2 (pl)
EP (1)	EP1404317B1 (pl)
JP (2)	JP4683839B2 (pl)
KR (1)	KR100885308B1 (pl)
CN (1)	CN100482223C (pl)
AT (1)	ATE416767T1 (pl)
AU (1)	AU2002317482B2 (pl)
BR (1)	BR0210538A (pl)
CA (1)	CA2455296C (pl)
CY (1)	CY1108879T1 (pl)
CZ (1)	CZ20033314A3 (pl)
DE (1)	DE60230270D1 (pl)
DK (1)	DK1404317T3 (pl)
ES (1)	ES2319107T3 (pl)
HU (1)	HUP0400250A3 (pl)
IT (1)	ITRM20010356A1 (pl)
MX (1)	MXPA03011510A (pl)
PL (1)	PL367618A1 (pl)
PT (1)	PT1404317E (pl)
SK (1)	SK287828B6 (pl)
WO (1)	WO2003000252A1 (pl)

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CN102816103B (zh) *	2012-08-20	2014-05-07	冉瑞琼	硫化天冬氨酸修饰的退黑素衍生物及其应用
US9008769B2 (en)	2012-12-21	2015-04-14	Backbeat Medical, Inc.	Methods and systems for lowering blood pressure through reduction of ventricle filling
US9370662B2 (en)	2013-12-19	2016-06-21	Backbeat Medical, Inc.	Methods and systems for controlling blood pressure by controlling atrial pressure
CN104529865B (zh) *	2014-12-12	2017-02-01	广东东阳光药业有限公司	苄胺类衍生物及其在药物上的应用
RU2017145976A (ru)	2015-06-12	2019-07-15	Аксовант Сайенсиз Гмбх	Производные диарил- и арилгетероарилмочевины, применимые для профилактики и лечения нарушения поведения во время REM-фазы сна
TW201720439A (zh)	2015-07-15	2017-06-16	Axovant Sciences Gmbh	用於預防及治療與神經退化性疾病相關的幻覺之作為５－ｈｔ２ａ血清素受體的二芳基及芳基雜芳基脲衍生物
US10342982B2 (en)	2015-09-11	2019-07-09	Backbeat Medical, Inc.	Methods and systems for treating cardiac malfunction
US10485658B2 (en)	2016-04-22	2019-11-26	Backbeat Medical, Inc.	Methods and systems for controlling blood pressure
CN108926565A (zh) *	2017-05-26	2018-12-04	中国科学院上海生命科学研究院	五羟色胺受体亚型6小分子激活剂及拮抗剂在防治阿尔茨海默症中的应用
CA3148256A1 (en) *	2018-06-21	2019-12-26	Robert John Petcavich	Method of inducing dendritic and synaptic genesis in neurodegenerative chronic diseases
GB201907871D0 (en) *	2019-06-03	2019-07-17	Small Pharma Ltd	Therapeutic compositions
PL4084791T3 (pl) *	2020-02-18	2025-04-22	Gilgamesh Pharmaceuticals, Inc.	Specyficzne tryptaminy do zastosowania w leczeniu zaburzeń nastroju
US11759452B2 (en)	2020-05-08	2023-09-19	Psilera Inc.	Compositions of matter and pharmaceutical compositions
JP7766623B2 (ja)	2020-05-19	2025-11-10	サイビンアイアールエルリミテッド	重水素化トリプタミン誘導体および使用方法
EP3902541B1 (en) *	2020-06-02	2022-09-14	Small Pharma Ltd	Therapeutic compositions comprising deuterated or partially deuterated n,n-dimethyltryptamine compounds
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2001
- 2001-06-21 IT IT2001RM000356A patent/ITRM20010356A1/it unknown
2002
- 2002-06-17 CZ CZ20033314A patent/CZ20033314A3/cs unknown
- 2002-06-17 SK SK38-2004A patent/SK287828B6/sk not_active IP Right Cessation
- 2002-06-17 CA CA2455296A patent/CA2455296C/en not_active Expired - Fee Related
- 2002-06-17 KR KR1020037016564A patent/KR100885308B1/ko not_active Expired - Fee Related
- 2002-06-17 EP EP02745793A patent/EP1404317B1/en not_active Expired - Lifetime
- 2002-06-17 HU HU0400250A patent/HUP0400250A3/hu unknown
- 2002-06-17 ES ES02745793T patent/ES2319107T3/es not_active Expired - Lifetime
- 2002-06-17 JP JP2003506898A patent/JP4683839B2/ja not_active Expired - Fee Related
- 2002-06-17 BR BR0210538-1A patent/BR0210538A/pt not_active Application Discontinuation
- 2002-06-17 AU AU2002317482A patent/AU2002317482B2/en not_active Ceased
- 2002-06-17 AT AT02745793T patent/ATE416767T1/de active
- 2002-06-17 DE DE60230270T patent/DE60230270D1/de not_active Expired - Lifetime
- 2002-06-17 PT PT02745793T patent/PT1404317E/pt unknown
- 2002-06-17 WO PCT/IT2002/000398 patent/WO2003000252A1/en not_active Ceased
- 2002-06-17 CN CNB02814337XA patent/CN100482223C/zh not_active Expired - Fee Related
- 2002-06-17 DK DK02745793T patent/DK1404317T3/da active
- 2002-06-17 US US10/481,433 patent/US7098233B2/en not_active Expired - Fee Related
- 2002-06-17 PL PL02367618A patent/PL367618A1/pl not_active IP Right Cessation
- 2002-06-17 MX MXPA03011510A patent/MXPA03011510A/es active IP Right Grant
2009
- 2009-03-06 CY CY20091100260T patent/CY1108879T1/el unknown
2010
- 2010-09-13 JP JP2010204733A patent/JP2011016835A/ja active Pending

Also Published As

Publication number	Publication date
PT1404317E (pt)	2009-02-23
ES2319107T3 (es)	2009-05-04
US7098233B2 (en)	2006-08-29
SK287828B6 (sk)	2011-11-04
ITRM20010356A0 (it)	2001-06-21
JP4683839B2 (ja)	2011-05-18
CN100482223C (zh)	2009-04-29
KR100885308B1 (ko)	2009-02-24
DE60230270D1 (de)	2009-01-22
DK1404317T3 (da)	2009-02-23
CA2455296A1 (en)	2003-01-03
JP2004534816A (ja)	2004-11-18
JP2011016835A (ja)	2011-01-27
MXPA03011510A (es)	2004-03-18
CN1535146A (zh)	2004-10-06
HK1068792A1 (zh)	2005-05-06
EP1404317B1 (en)	2008-12-10
SK382004A3 (en)	2004-05-04
ITRM20010356A1 (it)	2002-12-23
AU2002317482B2 (en)	2007-08-16
CZ20033314A3 (cs)	2004-08-18
US20040235899A1 (en)	2004-11-25
ATE416767T1 (de)	2008-12-15
CY1108879T1 (el)	2014-07-02
CA2455296C (en)	2010-08-17
HUP0400250A2 (hu)	2004-08-30
KR20040032113A (ko)	2004-04-14
BR0210538A (pt)	2004-06-22
EP1404317A1 (en)	2004-04-07
HUP0400250A3 (en)	2008-03-28
WO2003000252A1 (en)	2003-01-03

Legal Events

Date	Code	Title	Description
2012-11-30	VOID	Decisions declaring the decisions on the grant of the patent lapsed

Publication	Publication Date	Title
PL367618A1 (pl)	2005-03-07	Pochodne 5-fluorowco-tryptaminy stosowane jako ligandy 5-HT6 i/lub 5-HT7 receptorów serotoniny
SE9903998D0 (sv)	1999-11-03	New compounds
CA2449874A1 (en)	2002-12-12	New indole derivatives with 5-ht6 receptor affinity
CA2414018A1 (en)	2001-12-13	2-aminocarbonyl-9h-purine derivatives
TR200200579T2 (tr)	2002-12-23	Amino-tirazolpiridin türevleri.
CA2411008A1 (en)	2001-12-13	Derivatives of 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
SE0201659D0 (sv)	2002-05-31	Modified release pharmaceutical formulation
HRP20040090A2 (en)	2004-12-31	Arylsulfonyl derivatives with 5-ht<sub>6</sub> receptor affinity
SE9903997D0 (sv)	1999-11-03	New compounds
PT992509E (pt)	2004-12-31	Novos derivados macrolidos
NO20050666L (no)	2005-03-11	2,7-substituerte indoler og deres anvendelse som 5-HT6 modulatorer
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