PL368315A1 - Zastosowanie pochodnych tiazolu do wytwarzania leku przeznaczonego do ochrony mitochondriów - Google Patents

Zastosowanie pochodnych tiazolu do wytwarzania leku przeznaczonego do ochrony mitochondriów

Info

Publication number: PL368315A1
Authority: PL; Poland
Prior art keywords: sup; hydrogen atom; alkyl; medicine; independently represent
Prior art date: 2001-07-26

Application number

PL02368315A

Other languages

English (en)

Other versions

PL206706B1 (pl

Inventor

Michel Auguet

De Lassauniere Pierre-Etienne Chabrier

Jeremiah Harnett

Original Assignee

Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-26

Filing date

2002-07-25

Publication date

2005-03-21

2002-07-25 Application filed by Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) filed Critical Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.)

2005-03-21 Publication of PL368315A1 publication Critical patent/PL368315A1/pl

2010-09-30 Publication of PL206706B1 publication Critical patent/PL206706B1/pl

Links

239000003814 drug Substances 0.000 title abstract 3
210000003470 mitochondria Anatomy 0.000 title abstract 2
150000007979 thiazole derivatives Chemical class 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
125000000217 alkyl group Chemical group 0.000 abstract 6
125000003545 alkoxy group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
206010016654 Fibrosis Diseases 0.000 abstract 1
230000007882 cirrhosis Effects 0.000 abstract 1
208000019425 cirrhosis of liver Diseases 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Toxicology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Oncology (AREA)
Orthopedic Medicine & Surgery (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Communicable Diseases (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Gastroenterology & Hepatology (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Detergent Compositions (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Cleaning By Liquid Or Steam (AREA)
Accessory Of Washing/Drying Machine, Commercial Washing/Drying Machine, Other Washing/Drying Machine (AREA)

PL368315A 2001-07-26 2002-07-25 Zastosowanie pochodnych tiazolu do wytwarzania leku przeznaczonego do ochrony mitochondriów PL206706B1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0109979A FR2827772B1 (fr)	2001-07-26	2001-07-26	Utilisation de derives de thiazoles pour preparer un medicament destine a proteger les mitochondries

Publications (2)

Publication Number	Publication Date
PL368315A1 true PL368315A1 (pl)	2005-03-21
PL206706B1 PL206706B1 (pl)	2010-09-30

Family

ID=8865922

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL368315A PL206706B1 (pl)	2001-07-26	2002-07-25	Zastosowanie pochodnych tiazolu do wytwarzania leku przeznaczonego do ochrony mitochondriów

Country Status (25)

Country	Link
US (3)	US7345066B2 (pl)
EP (1)	EP1414447B1 (pl)
JP (1)	JP4491229B2 (pl)
KR (1)	KR20040030843A (pl)
CN (1)	CN1533276B (pl)
AT (1)	ATE333876T1 (pl)
AU (1)	AU2002341008B8 (pl)
BR (1)	BR0211423A (pl)
CA (1)	CA2455635C (pl)
CY (1)	CY1106212T1 (pl)
DE (1)	DE60213424T2 (pl)
DK (1)	DK1414447T3 (pl)
ES (1)	ES2268099T3 (pl)
FR (1)	FR2827772B1 (pl)
HU (2)	HU228783B1 (pl)
IL (2)	IL159548A0 (pl)
IS (1)	IS2366B (pl)
MX (1)	MXPA04000752A (pl)
NO (1)	NO334797B1 (pl)
NZ (1)	NZ530368A (pl)
PL (1)	PL206706B1 (pl)
PT (1)	PT1414447E (pl)
RU (1)	RU2297832C2 (pl)
TW (1)	TWI309568B (pl)
WO (1)	WO2003009843A1 (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7291641B2 (en) *	1999-10-11	2007-11-06	Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.)	Derivatives of heterocycles with 5 members, their preparation and their use as medicaments
US7101917B2 (en)	2003-04-14	2006-09-05	Hoffmann-La Roche Inc.	Mitochrondrial permeability transition pore affinity labels and modulators
WO2008067863A2 (en) *	2006-10-24	2008-06-12	Congenia S.R.L.	Phenyl substituted maleimides as medicaments for blocking degenerative tissue damages by inhibiting mpt
KR100970814B1 (ko) *	2009-06-01	2010-07-16	주식회사 동아지질	석션 드레인 공법에 사용되는 배수재 연결구
JP6958860B2 (ja)	2017-11-07	2021-11-02	学校法人自治医科大学	ミトコンドリアの機能障害の改善剤、及びミトコンドリアの機能障害に起因する疾患又は症状の予防又は治療薬、並びにそれらの用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4914207A (en) *	1989-05-09	1990-04-03	Pfizer Inc.	Arylthiazolylimidazoles
DK0550631T3 (da) *	1990-09-25	1997-01-20	Rhone Poulenc Rorer Int	Forbindelser med blodtrykssænkende virkning og virkning mod iskæmi
HU9502843D0 (en) *	1995-09-29	1995-11-28	Livigene Ltd	Pharmaceutical composition
FR2764889B1 (fr) *	1997-06-20	2000-09-01	Sod Conseils Rech Applic	Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
DE69819349T2 (de) *	1997-08-29	2004-07-22	Tularik Ltd.	1-amino-7-isochinolin-derivate als serin protease inhibitoren
US6518292B1 (en) *	1999-03-12	2003-02-11	Bristol-Myers Squibb Co.	Heterocyclic aromatic compounds usefuls as growth hormone secretagogues
CA2375920A1 (en) *	1999-06-14	2000-12-21	Eli Lilly And Company	Compounds
CA2381215A1 (en) *	1999-08-06	2001-02-15	Takeda Chemical Industries, Ltd.	P38map kinase inhibitors
TWI283577B (en) *	1999-10-11	2007-07-11	Sod Conseils Rech Applic	Pharmaceutical composition of imidazole derivatives acting as modulators of sodium channels and the use thereof
FR2800615B1 (fr) *	1999-11-05	2002-05-03	Sod Conseils Rech Applic	Produit comprenant au moins une substance inhibitrice des no synthases en association avec au moins une substance inhibitrice des phospholipases a2

2000
- 2000-07-13 HU HU0500484A patent/HU228783B1/hu unknown
2001
- 2001-07-26 FR FR0109979A patent/FR2827772B1/fr not_active Expired - Lifetime
2002
- 2002-07-18 TW TW091116026A patent/TWI309568B/zh not_active IP Right Cessation
- 2002-07-25 PL PL368315A patent/PL206706B1/pl unknown
- 2002-07-25 DE DE60213424T patent/DE60213424T2/de not_active Expired - Lifetime
- 2002-07-25 CA CA2455635A patent/CA2455635C/fr not_active Expired - Fee Related
- 2002-07-25 RU RU2004105653/15A patent/RU2297832C2/ru not_active IP Right Cessation
- 2002-07-25 HU HU0500557A patent/HU229425B1/hu not_active IP Right Cessation
- 2002-07-25 JP JP2003515236A patent/JP4491229B2/ja not_active Expired - Fee Related
- 2002-07-25 AT AT02774830T patent/ATE333876T1/de active
- 2002-07-25 BR BR0211423-2A patent/BR0211423A/pt not_active Application Discontinuation
- 2002-07-25 ES ES02774830T patent/ES2268099T3/es not_active Expired - Lifetime
- 2002-07-25 NZ NZ530368A patent/NZ530368A/en not_active IP Right Cessation
- 2002-07-25 MX MXPA04000752A patent/MXPA04000752A/es active IP Right Grant
- 2002-07-25 DK DK02774830T patent/DK1414447T3/da active
- 2002-07-25 AU AU2002341008A patent/AU2002341008B8/en not_active Ceased
- 2002-07-25 CN CN028145097A patent/CN1533276B/zh not_active Expired - Fee Related
- 2002-07-25 WO PCT/FR2002/002660 patent/WO2003009843A1/fr not_active Ceased
- 2002-07-25 PT PT02774830T patent/PT1414447E/pt unknown
- 2002-07-25 IL IL15954802A patent/IL159548A0/xx unknown
- 2002-07-25 EP EP02774830A patent/EP1414447B1/fr not_active Expired - Lifetime
- 2002-07-25 US US10/483,823 patent/US7345066B2/en not_active Expired - Fee Related
- 2002-07-25 KR KR10-2004-7000996A patent/KR20040030843A/ko not_active Ceased
2003
- 2003-12-24 IL IL159548A patent/IL159548A/en not_active IP Right Cessation
2004
- 2004-01-09 IS IS7100A patent/IS2366B/is unknown
- 2004-01-21 NO NO20040280A patent/NO334797B1/no not_active IP Right Cessation
2006
- 2006-10-23 CY CY20061101513T patent/CY1106212T1/el unknown
2007
- 2007-02-20 US US11/708,526 patent/US20070185174A1/en not_active Abandoned
- 2007-08-16 US US11/894,004 patent/US20080039451A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CN1533276B (zh)	2010-06-30
ATE333876T1 (de)	2006-08-15
JP2005500337A (ja)	2005-01-06
NO334797B1 (no)	2014-05-26
DE60213424D1 (de)	2006-09-07
CY1106212T1 (el)	2011-06-08
FR2827772B1 (fr)	2006-04-28
PT1414447E (pt)	2006-12-29
IL159548A (en)	2009-11-18
WO2003009843A1 (fr)	2003-02-06
BR0211423A (pt)	2004-08-17
MXPA04000752A (es)	2004-04-20
IL159548A0 (en)	2004-06-01
HU0500484D0 (en)	2005-07-28
AU2002341008B2 (en)	2007-03-08
EP1414447B1 (fr)	2006-07-26
HK1069326A1 (en)	2005-05-20
HUP0500484A3 (en)	2005-09-28
DE60213424T2 (de)	2007-08-23
TWI309568B (en)	2009-05-11
HU229425B1 (en)	2013-12-30
NO20040280L (no)	2004-01-21
EP1414447A1 (fr)	2004-05-06
FR2827772A1 (fr)	2003-01-31
CN1533276A (zh)	2004-09-29
US20070185174A1 (en)	2007-08-09
NZ530368A (en)	2005-04-29
AU2002341008B8 (en)	2007-08-09
HU228783B1 (en)	2013-05-28
CA2455635C (fr)	2011-05-31
ES2268099T3 (es)	2007-03-16
US20080039451A1 (en)	2008-02-14
IS7100A (is)	2004-01-09
RU2297832C2 (ru)	2007-04-27
DK1414447T3 (da)	2006-11-27
KR20040030843A (ko)	2004-04-09
AU2002341008A1 (en)	2003-02-17
US20040248885A1 (en)	2004-12-09
JP4491229B2 (ja)	2010-06-30
US7345066B2 (en)	2008-03-18
RU2004105653A (ru)	2005-04-10
HUP0500557A2 (hu)	2005-09-28
PL206706B1 (pl)	2010-09-30
HUP0500557A3 (en)	2006-02-28
IS2366B (is)	2008-06-15
CA2455635A1 (fr)	2003-02-06

Publication	Publication Date	Title
NO20013379L (no)	2001-07-06	4-okso-1,4-dihydro-3-kinolinkarboksamider som antivirusmidler
HUP0303037A2 (hu)	2004-03-01	Alzheimer-kór kezelésére alkalmas vegyületek és ezeket tartalmazó gyógyszerkészítmények
DK1389617T3 (da)	2007-05-07	Heterocyclisk forbindelse og antitumormiddel indeholdende denne som den aktive bestanddel
DK1054874T3 (da)	2002-12-30	Substituerede aminophenylisoxazolinderivater, der er anvendelige som antimokrobielle midler
TW200420542A (en)	2004-10-16	A compound having TGF β inhibition activity and a medicinal composition containing the same
MXPA05006196A (es)	2006-01-27	Compuestos y metodos para el tratamiento o prevencion de infecciones por flavivirus.
AP1541A (en)	2006-01-11	New thiadazoles and oxadiazoles and their use as phosphodiesterase - 7 inhibitors.
NO20015172L (no)	2002-01-23	1-metyl-erytromycin-derivater
WO2005046672A3 (fr)	2005-09-15	Utilisation d’inhibiteurs de glucosidase pour une therapie de la mucoviscidose
TW200613297A (en)	2006-05-01	Pyrazole derivatives
IL159548A0 (en)	2004-06-01	Use of thiazole derivatives for preparing a medicine for protecting mitochondria
ES2184467T3 (es)	2003-04-01	Derivados de la piperacina para la inhibicion de la replicacion del virus de la inmunodeficiencia humana.
DK0700914T3 (da)	2000-07-31	Campththecinderivater, deres fremstilling og antitumormidler
DE60003452D1 (de)	2003-07-24	Silizium-enthaltende ascorbinsäurederivate
MXPA04000371A (es)	2004-05-04	6- (2-tolil) - triazolopirimidinas substituidas.
EA200600608A1 (ru)	2006-10-27	Производные имидазопиридина как ингибиторы индуцируемой no-синтазы
MY120618A (en)	2005-11-30	Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives.
CO5210951A1 (es)	2002-10-30	Mezclas fungicidas sinergicas de una azolopirimidina y una fenoxiamida inhibidora de la biosisntesis de melanina
EP1908755A4 (en)	2009-06-24	THERAPEUTIC AGENT AGAINST RESTENOSIS
MY126230A (en)	2006-09-29	Fungicidal mixtures
TW200508211A (en)	2005-03-01	2-naphthylimino-1,3-thiazine derivatives
DE60006368D1 (de)	2003-12-11	Hsv primase-inhibitoren
BR0116412A (pt)	2003-12-30	Inibidores de pró-colagénio c-proteinase
NO20053117L (no)	2005-06-24	Cyklopenta[c]isoksazol-3-aminer anvendt som materialbeskyttelsesmidler..
TW200621740A (en)	2006-07-01	Compound for treating hepatitis B and composition thereof