PL368388A1 - Podstawione glicyną tieno [2,3-d] pirymidyny o połączonej aktywności agonistycznej wobec LH i FSH - Google Patents

Podstawione glicyną tieno [2,3-d] pirymidyny o połączonej aktywności agonistycznej wobec LH i FSH

Info

Publication number: PL368388A1
Authority: PL; Poland
Prior art keywords: sup; alkyl; hydroxy; glycine; pyrimidines
Prior art date: 2001-09-04

Application number

PL02368388A

Other languages

English (en)

Inventor

Robert Gerard Jules Marie Hanssen

Cornelis Marius Timmers

Jan Kelder

Original Assignee

Akzo Nobel N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-09-04

Filing date

2002-08-29

Publication date

2005-03-21

2002-08-29 Application filed by Akzo Nobel N.V. filed Critical Akzo Nobel N.V.

2005-03-21 Publication of PL368388A1 publication Critical patent/PL368388A1/pl

Links

-1 Glycine-substituted thieno [2,3-d]pyrimidines Chemical class 0.000 title abstract 2
230000001270 agonistic effect Effects 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 6
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
125000001072 heteroaryl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
102000008175 FSH Receptors Human genes 0.000 abstract 1
108010060374 FSH Receptors Proteins 0.000 abstract 1
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 1
239000004471 Glycine Substances 0.000 abstract 1
102000023108 LH Receptors Human genes 0.000 abstract 1
108010011942 LH Receptors Proteins 0.000 abstract 1
230000003213 activating effect Effects 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000035558 fertility Effects 0.000 abstract 1
125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
230000001105 regulatory effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1
DDWBRNXDKNIQDY-UHFFFAOYSA-N thieno[2,3-d]pyrimidine Chemical class N1=CN=C2SC=CC2=C1 DDWBRNXDKNIQDY-UHFFFAOYSA-N 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PL02368388A 2001-09-04 2002-08-29 Podstawione glicyną tieno [2,3-d] pirymidyny o połączonej aktywności agonistycznej wobec LH i FSH PL368388A1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP01203328		2001-09-04

Publications (1)

Publication Number	Publication Date
PL368388A1 true PL368388A1 (pl)	2005-03-21

Family

ID=8180877

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL02368388A PL368388A1 (pl)	2001-09-04	2002-08-29	Podstawione glicyną tieno [2,3-d] pirymidyny o połączonej aktywności agonistycznej wobec LH i FSH

Country Status (27)

Country	Link
US (1)	US7375109B2 (pl)
EP (1)	EP1427734B1 (pl)
JP (1)	JP4263094B2 (pl)
KR (1)	KR100891630B1 (pl)
CN (1)	CN1261437C (pl)
AR (1)	AR036408A1 (pl)
AT (1)	ATE309251T1 (pl)
AU (1)	AU2002333750B2 (pl)
BR (1)	BR0212173A (pl)
CA (1)	CA2457212C (pl)
CY (1)	CY1106052T1 (pl)
DE (1)	DE60207280T2 (pl)
DK (1)	DK1427734T3 (pl)
EC (1)	ECSP044990A (pl)
ES (1)	ES2252540T3 (pl)
HR (1)	HRP20040194A2 (pl)
HU (1)	HUP0401443A3 (pl)
IL (2)	IL160194A0 (pl)
IS (1)	IS2419B (pl)
MX (1)	MXPA04002046A (pl)
NO (1)	NO328792B1 (pl)
NZ (1)	NZ531375A (pl)
PE (1)	PE20030467A1 (pl)
PL (1)	PL368388A1 (pl)
RU (1)	RU2294331C2 (pl)
WO (1)	WO2003020727A1 (pl)
ZA (1)	ZA200401459B (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6890923B2 (en) *	2002-12-16	2005-05-10	Astrazeneca Ab	Compounds
KR100666484B1 (ko) *	2005-02-04	2007-01-09	삼성전자주식회사	반도체 메모리 장치의 입출력 회로 및 입출력 방법
JP5718233B2 (ja)	2008-10-20	2015-05-13	ザガバメントオブザユナイテッドステイツオブアメリカアズリプレゼンテッドバイザセクレタリーオブザデパートメントオブヘルスアンドヒューマンサービシーズ	甲状腺刺激ホルモン受容体（ｔｓｈｒ）の低分子量アゴニスト
CN101762915B (zh) *	2008-12-24	2013-04-17	北京京东方光电科技有限公司	Tft-lcd阵列基板及其驱动方法
JP5965387B2 (ja)	2010-04-08	2016-08-03	アメリカ合衆国	Ｔｓｈ受容体用のインバースアゴニストおよびニュートラルアンタゴニスト
SMT202200255T1 (it)	2012-09-28	2022-07-21	Takeda Pharmaceuticals Co	Forma cristallina di 1-(4-1-(2,6-difluorobenzil)-5-dimetilamminometil-3-(6-metossipiridazin-3-il)-2,4-diosso-1,2,3,4-tetraidrotieno(2,3-d)-pirimidin-6il)fenil)-3-metossiurea
JP2022551316A (ja)	2019-10-10	2022-12-08	ミオバントサイエンシズゲーエムベーハー	Ｎ－（４－（１－（２，６－ジフルオロベンジル）－５－（（ジメチルアミノ）メチル）－３－（６－メトキシ－３－ピリダジニル）－２，４－ジオキソ－１，２，３，４－テトラヒドロチエノ［２，３－ｄ］ピリミジン－６－イル）フェニル）－Ｎ’－メトキシ尿素の結晶形
WO2021069700A1 (en)	2019-10-10	2021-04-15	Myovant Sciences Gmbh	Crystalline solvated forms of n-(4-(1-(2,6-difluorobenzyl)-5- ((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4- tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-n'-methoxyurea

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19975054I2 (de)	1987-08-08	2000-04-13	Akzo Nobel Nv	Kontrazeptives Implantat
DE19632423A1 (de) *	1996-08-12	1998-02-19	Merck Patent Gmbh	Thienopyrimidine
TW564247B (en) *	1999-04-08	2003-12-01	Akzo Nobel Nv	Bicyclic heteraromatic compound

2002
- 2002-08-29 DE DE60207280T patent/DE60207280T2/de not_active Expired - Lifetime
- 2002-08-29 NZ NZ531375A patent/NZ531375A/en not_active IP Right Cessation
- 2002-08-29 US US10/488,483 patent/US7375109B2/en not_active Expired - Lifetime
- 2002-08-29 AU AU2002333750A patent/AU2002333750B2/en not_active Ceased
- 2002-08-29 WO PCT/EP2002/009648 patent/WO2003020727A1/en not_active Ceased
- 2002-08-29 JP JP2003524997A patent/JP4263094B2/ja not_active Expired - Fee Related
- 2002-08-29 MX MXPA04002046A patent/MXPA04002046A/es active IP Right Grant
- 2002-08-29 BR BR0212173-5A patent/BR0212173A/pt not_active IP Right Cessation
- 2002-08-29 RU RU2004110036/04A patent/RU2294331C2/ru not_active IP Right Cessation
- 2002-08-29 ES ES02797646T patent/ES2252540T3/es not_active Expired - Lifetime
- 2002-08-29 KR KR1020047003096A patent/KR100891630B1/ko not_active Expired - Fee Related
- 2002-08-29 AT AT02797646T patent/ATE309251T1/de not_active IP Right Cessation
- 2002-08-29 HU HU0401443A patent/HUP0401443A3/hu unknown
- 2002-08-29 CN CNB02817240XA patent/CN1261437C/zh not_active Expired - Fee Related
- 2002-08-29 IL IL16019402A patent/IL160194A0/xx unknown
- 2002-08-29 EP EP02797646A patent/EP1427734B1/en not_active Expired - Lifetime
- 2002-08-29 HR HR20040194A patent/HRP20040194A2/hr not_active Application Discontinuation
- 2002-08-29 PL PL02368388A patent/PL368388A1/pl not_active Application Discontinuation
- 2002-08-29 CA CA2457212A patent/CA2457212C/en not_active Expired - Fee Related
- 2002-08-29 DK DK02797646T patent/DK1427734T3/da active
- 2002-09-02 AR ARP020103310A patent/AR036408A1/es unknown
- 2002-09-03 PE PE2002000839A patent/PE20030467A1/es not_active Application Discontinuation
2004
- 2004-02-03 IL IL160194A patent/IL160194A/en not_active IP Right Cessation
- 2004-02-13 IS IS7152A patent/IS2419B/is unknown
- 2004-02-23 ZA ZA200401459A patent/ZA200401459B/en unknown
- 2004-02-26 EC EC2004004990A patent/ECSP044990A/es unknown
- 2004-03-03 NO NO20040922A patent/NO328792B1/no not_active IP Right Cessation
2005
- 2005-12-22 CY CY20051101587T patent/CY1106052T1/el unknown

Also Published As

Publication number	Publication date
PE20030467A1 (es)	2003-05-26
US20040180907A1 (en)	2004-09-16
RU2004110036A (ru)	2005-10-10
ECSP044990A (es)	2004-04-28
US7375109B2 (en)	2008-05-20
DE60207280D1 (de)	2005-12-15
WO2003020727A1 (en)	2003-03-13
CY1106052T1 (el)	2011-04-06
EP1427734B1 (en)	2005-11-09
JP2005504784A (ja)	2005-02-17
EP1427734A1 (en)	2004-06-16
HUP0401443A3 (en)	2008-05-28
DK1427734T3 (da)	2006-03-06
CN1261437C (zh)	2006-06-28
JP4263094B2 (ja)	2009-05-13
NO328792B1 (no)	2010-05-18
HRP20040194A2 (en)	2004-08-31
BR0212173A (pt)	2004-07-20
AU2002333750B2 (en)	2008-02-21
IL160194A0 (en)	2004-07-25
NZ531375A (en)	2005-06-24
NO20040922L (no)	2004-03-03
RU2294331C2 (ru)	2007-02-27
KR20040029135A (ko)	2004-04-03
ATE309251T1 (de)	2005-11-15
CN1551883A (zh)	2004-12-01
CA2457212A1 (en)	2003-03-13
IS7152A (is)	2004-02-13
AR036408A1 (es)	2004-09-08
ZA200401459B (en)	2004-11-22
CA2457212C (en)	2011-02-15
ES2252540T3 (es)	2006-05-16
DE60207280T2 (de)	2006-05-18
IS2419B (is)	2008-10-15
KR100891630B1 (ko)	2009-04-03
HUP0401443A2 (hu)	2004-11-29
MXPA04002046A (es)	2004-07-16
IL160194A (en)	2009-06-15

Legal Events

Date	Code	Title	Description
2011-07-29	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)

Publication	Publication Date	Title
BG103785A (en)	2000-06-30	Pyrrolo[2,3-d]pyrimidines and their application as tyrosine kinase inhibitors
TW340846B (en)	1998-09-21	Pyrimidinedione, pyrimidinetrione, triazinedione, tetrahydro-quinazolinedione derivatives as a1 adrenergic receptor antagonists
WO2004065392A8 (en)	2004-10-07	Condensed pyridines and pyrimidines and their use as alk-5 receptor ligands
CA2227991A1 (en)	1997-02-13	1,2,4-triazolo¬1,5-c\|pyrimidine heterocyclic analogues having antagonistic activity on adenosine a2a receptor
DK1646389T3 (da)	2009-01-05	Pyrimidin-2,4-dionderivater som gonadotropinfrigörende hormonreceptorantagonister
MXPA06000716A (es)	2006-03-30	Derivados de quinolina y quinazolina que tienen afinidad hacia receptores del tipo 5ht1.
CA2525214A1 (en)	2004-12-09	Macrocyclic quinazoline derivatives as antiproliferative agents
EP1465631A4 (en)	2005-03-30	SELECTIVE PYRIMIDINE A2B ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE
MXPA04003795A (es)	2004-07-30	Compuestos de pirimidina y composiciones farmaceuticas que contienen los compuestos.
DK1348707T3 (da)	2010-12-13	Pyrazolo[4,3-d]pyrimidiner, fremgangsmåder til deres fremstilling samt deres terapeutiske anvendelse
CA2132297A1 (en)	1993-09-30	Pyrido[2,3-d]pyrimidine derivatives as phosphodiesterase inhibitors
YU55603A (sh)	2006-05-25	Derivati purina kao antagonisti purinergiskog receptora
EP1167367A4 (en)	2002-04-24	THIENOPYRIMIDINE COMPOUNDS AND SALTS THEREOF, AND PROCESS FOR THE PREPARATION THEREOF
BR0012157A (pt)	2002-04-02	Derivado de quinazolina, derivado de pirimidina, processo para a preparação de um derivado de quinazolina, composição farmacêutica, uso de um derivado de quinazolina, e, método para a prevenção ou tratamento de doenças ou condições médicas pela célula t um em animal de sangue quente em necessidade de tal tratamento
BR0009558A (pt)	2002-02-19	Composto derivado bicìclico heteroaromático, composição farmacêutica, e, uso de compostos derivados bicìclicos heteroaromáticos
MXPA02004448A (es)	2004-09-10	Derivados de imidazopiridina como inhibidores de la fosfodiesterasa vii.
PT1427733E (pt)	2007-02-28	Tieno ( 2,3-d) pirimidinas com actividade agonista de lh e fsh combinada
IS2419B (is)	2008-10-15	Glýsín-setin þíeno[2,3-d]pýrimidín með sameinaða LH og FSH gerandefnisvirkni
CA2479363A1 (en)	2003-10-02	Thiopyrimidine and isothiazolopyrimidine kinase inhibitors
AU2413995A (en)	1996-02-09	Bicyclic amidine derivatives as inhibitors of nitric oxide synthetase
CA2461060A1 (en)	2003-03-27	Method for preparing pyrimidinone compound and pharmaceutically acceptable salts thereof
CA2375671A1 (en)	2000-12-07	4-phenyl-pyrimidine derivatives
IL174678A0 (en)	2006-08-20	Arylindenophyridines and arylindenophyrimidines and their use as adenosine a2a receptor antagonist
MXPA04003278A (es)	2004-07-23	Derivados de 5-metoxi-8-aril-?1,2,4?triazolo?1,5-a?piridina como antagonistas del receptor de adenosina.
CA2543431A1 (en)	2005-05-19	Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines