PL368409A1 - Pochodne triazolilo-imidazopirydyny i triazolilopuryn użyteczne jako ligandy receptora adenyzowego A2a oraz ich zastosowanie jako leków - Google Patents

Pochodne triazolilo-imidazopirydyny i triazolilopuryn użyteczne jako ligandy receptora adenyzowego A2a oraz ich zastosowanie jako leków

Info

Publication number: PL368409A1
Authority: PL; Poland
Prior art keywords: linear; branched; alkyl; aryl; alkenyl
Prior art date: 2001-07-31

Application number

PL02368409A

Other languages

English (en)

Other versions

PL217269B1 (pl

Inventor

Giorgio Tarzia

Giovanni Piersanti

Patrizia Minetti

Cesare Maria Assunta Di

Grazia Gallo

Fabrizio Giorgi

Luca Giorgi

Original Assignee

Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-31

Filing date

2002-07-25

Publication date

2005-03-21

2002-07-25 Application filed by Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. filed Critical Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.

2005-03-21 Publication of PL368409A1 publication Critical patent/PL368409A1/pl

2014-06-30 Publication of PL217269B1 publication Critical patent/PL217269B1/pl

Links

239000003814 drug Substances 0.000 title abstract 2
OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title 2
239000002126 C01EB10 - Adenosine Substances 0.000 title 1
229960005305 adenosine Drugs 0.000 title 1
239000003446 ligand Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
125000005915 C6-C14 aryl group Chemical group 0.000 abstract 4
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
125000003342 alkenyl group Chemical group 0.000 abstract 3
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
125000003302 alkenyloxy group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
125000006727 (C1-C6) alkenyl group Chemical group 0.000 abstract 1
102000007471 Adenosine A2A receptor Human genes 0.000 abstract 1
108010085277 Adenosine A2A receptor Proteins 0.000 abstract 1
125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 abstract 1
101100294115 Caenorhabditis elegans nhr-4 gene Chemical group 0.000 abstract 1
208000018737 Parkinson disease Diseases 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Psychology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PL368409A 2001-07-31 2002-07-25 Pochodne triazoliloimidazopirydyny i triazolilopuryny, zawierająca je kompozycja farmaceutyczna, ich zastosowanie, sposób ich otrzymywania oraz związki pośrednie wykorzystywane w tym sposobie PL217269B1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT2001RM000465A ITRM20010465A1 (it)	2001-07-31	2001-07-31	Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam

Publications (2)

Publication Number	Publication Date
PL368409A1 true PL368409A1 (pl)	2005-03-21
PL217269B1 PL217269B1 (pl)	2014-06-30

Family

ID=11455703

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL368409A PL217269B1 (pl)	2001-07-31	2002-07-25	Pochodne triazoliloimidazopirydyny i triazolilopuryny, zawierająca je kompozycja farmaceutyczna, ich zastosowanie, sposób ich otrzymywania oraz związki pośrednie wykorzystywane w tym sposobie

Country Status (18)

Country	Link
US (2)	US7230102B2 (pl)
EP (1)	EP1412354B1 (pl)
JP (1)	JP4366186B2 (pl)
KR (1)	KR100884818B1 (pl)
CN (1)	CN1271070C (pl)
AT (1)	ATE325796T1 (pl)
AU (1)	AU2002326146B2 (pl)
BR (1)	BR0211550A (pl)
CA (1)	CA2451279C (pl)
DE (1)	DE60211343T2 (pl)
DK (1)	DK1412354T3 (pl)
ES (1)	ES2263810T3 (pl)
HU (1)	HU228985B1 (pl)
IT (1)	ITRM20010465A1 (pl)
MX (1)	MXPA04000886A (pl)
PL (1)	PL217269B1 (pl)
PT (1)	PT1412354E (pl)
WO (1)	WO2003011864A1 (pl)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE307132T1 (de) *	2001-06-29	2005-11-15	Cv Therapeutics Inc	Purin derivate als a2b adenosin rezeptor antagonisten
ITRM20010465A1 (it) *	2001-07-31	2003-01-31	Sigma Tau Ind Farmaceuti	Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam
AU2002357295A1 (en) *	2001-12-18	2003-06-30	Cv Therapeutics, Inc.	A2a adenosine receptor antagonists
BRPI0509258A8 (pt)	2004-03-26	2019-01-22	Astrazeneca Ab	composto de 8-oxoadenina 9-substituída
CA2646891A1 (en) *	2006-03-23	2007-09-27	Novartis Ag	Immunopotentiating compounds
JP2009542645A (ja)	2006-07-05	2009-12-03	アストラゼネカ・アクチエボラーグ	Ｔｌｒ７のモジュレーターとして作用する８−オキソアデニン誘導体
TW200831105A (en)	2006-12-14	2008-08-01	Astrazeneca Ab	Novel compounds
EP2132209B8 (en)	2007-03-19	2014-04-16	AstraZeneca AB	9-substituted-8-oxo-adenine compounds as toll-like receptor (tlr7 ) modulators
JP5329444B2 (ja)	2007-03-19	2013-10-30	アストラゼネカ・アクチエボラーグ	Ｔｏｌｌ様受容体（ｔｌｒ７）モジュレーターとしての９−置換−８−オキソ−アデニン化合物
EP2138497A4 (en)	2007-03-20	2012-01-04	Dainippon Sumitomo Pharma Co	NEW ADENINE CONNECTION
TW200902018A (en) *	2007-03-20	2009-01-16	Dainippon Sumitomo Pharma Co	Novel adenine compound
EA019103B1 (ru) *	2007-03-20	2014-01-30	Кьюрис, Инк.	Конденсированный аминопиридин в качестве ингибиторов hsp90
BRPI0811125A2 (pt) *	2007-05-08	2017-05-09	Astrazeneca Ab	imidazoquinolinas com propriedades imunomoduladoras
UY31531A1 (es)	2007-12-17	2009-08-03		Sales derivadas de 8-oxoadenina composiciones farmacéuticas que las contienen y su uso en terapia como moduladores de receptor tipo toll (tlr)
US20110054168A1 (en) *	2008-01-17	2011-03-03	Ayumu Kurimoto	Method for preparing adenine compound
US8865896B2 (en)	2008-01-17	2014-10-21	Astrazeneca Aktiebolag	Method for preparing adenine compound
TWI473614B (zh) *	2008-05-29	2015-02-21	Kyowa Hakko Kirin Co Ltd	Anti-analgesic inhibitors
BRPI0914006A2 (pt)	2008-07-03	2015-10-27	Sirtris Pharmaceuticals Inc	benzimidazóis e análogos relacionados como moduladores de sirtuína
NZ590793A (en) *	2008-07-23	2012-07-27	Kyowa Hakko Kirin Co Ltd	Therapeutic agent for migraine
SI2408775T1 (sl) *	2009-03-20	2015-08-31	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Oksidirani derivati triazolilpurinov, ki so uprabni kot ligandi receptorja adenozina A2A, in njihova uporaba kot zdravila
US20120295863A1 (en) *	2009-11-13	2012-11-22	Yun-Lian Lin	Dual-Action Compounds Targeting Adenosine A2A Receptor and Adenosine Transporter for Prevention and Treatment of Neurodegenerative Diseases
JP2013512859A (ja) *	2009-12-03	2013-04-18	大日本住友製薬株式会社	トール様受容体（ｔｌｒ）を介して作用するイミダゾキノリン
WO2012070601A1 (ja) *	2010-11-24	2012-05-31	ヤマサ醤油株式会社	新規な２－アルキニル－ｎ９－プロパギルアデニンおよびその医薬用途
CN103370317B (zh)	2010-12-16	2015-10-07	阿斯利康(瑞典)有限公司	可用于治疗的咪唑并[4,5-c]喹啉-1-基衍生物
WO2012080730A1 (en)	2010-12-17	2012-06-21	Astrazeneca Ab	Purine derivatives
AR095604A1 (es)	2013-03-15	2015-10-28	Syngenta Participations Ag	Derivados de imidazopiridina útiles como microbicidas
CN105622495A (zh) *	2016-03-23	2016-06-01	叶芳	4-氯-3-硝基吡啶及其制备方法
EP3280414B1 (en) *	2016-04-15	2023-08-23	Oxford University Innovation Limited	Adenosine receptor modulators for the treatment of circadian rhythm disorders
CN122341368A (zh) *	2023-10-10	2026-07-03	瑞格拉尼昂有限责任公司	用于治疗大疱性类天疱疮的方法和组合物
GB202319534D0 (en) *	2023-12-19	2024-01-31	Circadian Therapeutics Ltd	Dosage regimen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR910700253A (ko) *	1989-01-31	1991-03-14	로버트 제이, 바란	N_6-치환-9-메틸아데닌: 신규한 부류의 아데노신 수용체 길항질
US5670501A (en)	1994-09-01	1997-09-23	Discovery Therapeutics, Inc.	N-substituted 9-alkyladenines
US6579868B1 (en) *	1998-01-05	2003-06-17	Eisai Co., Ltd.	Purine derivatives and adenosine A2 receptor antagonists serving as preventives/remedies for diabetes
GB9915437D0 (en)	1999-07-01	1999-09-01	Cerebrus Ltd	Chemical compounds III
ATE307132T1 (de) *	2001-06-29	2005-11-15	Cv Therapeutics Inc	Purin derivate als a2b adenosin rezeptor antagonisten
ITRM20010465A1 (it)	2001-07-31	2003-01-31	Sigma Tau Ind Farmaceuti	Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam

2001
- 2001-07-31 IT IT2001RM000465A patent/ITRM20010465A1/it unknown
2002
- 2002-07-25 EP EP02760555A patent/EP1412354B1/en not_active Expired - Lifetime
- 2002-07-25 AT AT02760555T patent/ATE325796T1/de active
- 2002-07-25 JP JP2003517056A patent/JP4366186B2/ja not_active Expired - Fee Related
- 2002-07-25 ES ES02760555T patent/ES2263810T3/es not_active Expired - Lifetime
- 2002-07-25 CN CNB028138481A patent/CN1271070C/zh not_active Expired - Fee Related
- 2002-07-25 WO PCT/IT2002/000489 patent/WO2003011864A1/en not_active Ceased
- 2002-07-25 MX MXPA04000886A patent/MXPA04000886A/es active IP Right Grant
- 2002-07-25 HU HU0401987A patent/HU228985B1/hu not_active IP Right Cessation
- 2002-07-25 PL PL368409A patent/PL217269B1/pl unknown
- 2002-07-25 AU AU2002326146A patent/AU2002326146B2/en not_active Ceased
- 2002-07-25 PT PT02760555T patent/PT1412354E/pt unknown
- 2002-07-25 KR KR1020047000173A patent/KR100884818B1/ko not_active Expired - Fee Related
- 2002-07-25 US US10/484,491 patent/US7230102B2/en not_active Expired - Fee Related
- 2002-07-25 BR BR0211550-6A patent/BR0211550A/pt not_active IP Right Cessation
- 2002-07-25 DE DE60211343T patent/DE60211343T2/de not_active Expired - Lifetime
- 2002-07-25 DK DK02760555T patent/DK1412354T3/da active
- 2002-07-25 CA CA2451279A patent/CA2451279C/en not_active Expired - Fee Related
2007
- 2007-05-04 US US11/797,566 patent/US7528252B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2263810T3 (es)	2006-12-16
CA2451279A1 (en)	2003-02-13
US7230102B2 (en)	2007-06-12
US20040204428A1 (en)	2004-10-14
PT1412354E (pt)	2006-09-29
WO2003011864A1 (en)	2003-02-13
BR0211550A (pt)	2004-07-13
ITRM20010465A1 (it)	2003-01-31
EP1412354A1 (en)	2004-04-28
HU228985B1 (en)	2013-07-29
DK1412354T3 (da)	2006-09-18
PL217269B1 (pl)	2014-06-30
HUP0401987A2 (hu)	2005-01-28
ITRM20010465A0 (it)	2001-07-31
HUP0401987A3 (en)	2012-12-28
MXPA04000886A (es)	2004-06-03
ATE325796T1 (de)	2006-06-15
JP4366186B2 (ja)	2009-11-18
DE60211343T2 (de)	2007-05-10
US20070249638A1 (en)	2007-10-25
AU2002326146B2 (en)	2008-05-01
EP1412354B1 (en)	2006-05-10
CN1271070C (zh)	2006-08-23
CA2451279C (en)	2011-05-10
CN1525974A (zh)	2004-09-01
DE60211343D1 (de)	2006-06-14
US7528252B2 (en)	2009-05-05
KR100884818B1 (ko)	2009-02-20
KR20040023641A (ko)	2004-03-18
HK1068334A1 (en)	2005-04-29
JP2005500355A (ja)	2005-01-06

Publication	Publication Date	Title
ATE325796T1 (de)	2006-06-15	Derivate von triazolyl-imidazopyridine und von triazolylpurine als ligande des adenosine a2a rezeptoren und ihre verwendung als medicamente
TW200716528A (en)	2007-05-01	Cyclopropanecarboxamide derivatives
HUP0401047A2 (hu)	2004-09-28	Triazolo[4,5-d]pirimidin-származékok, alkalmazásuk purinergikus receptor-antagonistákként és a vegyületet tartalmazó gyógyszerkészítmények
MY139357A (en)	2009-09-30	Novel benzoimidazole derivatives useful as antiproliferative agents
UY25679A1 (es)	2000-03-31	Derivados de quinolin-2-ona inhibidores de la farnesil proteína transferasa útiles como agentes contra el cáncer
GEP20084357B (en)	2008-04-29	Pyrimidine derivatives for the treatment of abnormal cell growth
YU55603A (sh)	2006-05-25	Derivati purina kao antagonisti purinergiskog receptora
MXPA04000577A (es)	2004-04-20	Derivados de dolastatina 10.
MXPA04001240A (es)	2004-06-03	Analogos antitumorales.
TW200517109A (en)	2005-06-01	Substituted pyridinones
MXPA05010621A (es)	2005-11-23	Pirimidinonas sustituidas.
PL353337A1 (pl)	2003-11-17	Podstawione tien-3-ylosulfonyloamino(tio)karbonylotriazolin(ti)ony
HUP0204418A2 (hu)	2003-04-28	NHE-1 inhibitor hatású N-[(helyettesített öttagú, di- vagy triaza-, kétszeresen telítetlen gyűrű)-karbonil]-guanidin-származékok és alkalmazásuk
MY139612A (en)	2009-10-30	Benzoxazine derivatives as 5-th6 modulators and uses thereof
ATE233754T1 (de)	2003-03-15	Diphenyl-piperidin derivate
MY136824A (en)	2008-11-28	Substituted benzoxazinones and uses thereof
MXPA04000407A (es)	2004-03-18	Derivados de fenilacetamido-tiazol, procedimiento para su preparacion y uso como agentes antitumorales.
MY138466A (en)	2009-06-30	Aminoalkoxyndoles as 5-ht6-receptor ligands for the treatment of cns-disorders
PT1022276E (pt)	2003-10-31	Derivados de epoxissuccinamida
YU64400A (sh)	2003-01-31	Aril fuzirana azapoliciklična jedinjenja
NZ515407A (en)	2004-03-26	4-Phenyl-pyrimidine derivatives
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