ITRM20010465A0 - Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam - Google Patents

Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam

Info

Publication number
ITRM20010465A0
ITRM20010465A0 IT2001RM000465A ITRM20010465A ITRM20010465A0 IT RM20010465 A0 ITRM20010465 A0 IT RM20010465A0 IT 2001RM000465 A IT2001RM000465 A IT 2001RM000465A IT RM20010465 A ITRM20010465 A IT RM20010465A IT RM20010465 A0 ITRM20010465 A0 IT RM20010465A0
Authority
IT
Italy
Prior art keywords
triazolylpurines
medicam
imidazopyridine
triazolyl
adenosine
Prior art date
Application number
IT2001RM000465A
Other languages
English (en)
Inventor
Giorgio Tarzia
Giovanni Piersanti
Patrizia Minetti
Cesare Assunta Di
Grazia Gallo
Fabrizio Giorgi
Luca Giorgi
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Priority to IT2001RM000465A priority Critical patent/ITRM20010465A1/it
Publication of ITRM20010465A0 publication Critical patent/ITRM20010465A0/it
Priority to KR1020047000173A priority patent/KR100884818B1/ko
Priority to DE60211343T priority patent/DE60211343T2/de
Priority to AU2002326146A priority patent/AU2002326146B2/en
Priority to AT02760555T priority patent/ATE325796T1/de
Priority to EP02760555A priority patent/EP1412354B1/en
Priority to ES02760555T priority patent/ES2263810T3/es
Priority to PT02760555T priority patent/PT1412354E/pt
Priority to JP2003517056A priority patent/JP4366186B2/ja
Priority to US10/484,491 priority patent/US7230102B2/en
Priority to PL368409A priority patent/PL217269B1/pl
Priority to HU0401987A priority patent/HU228985B1/hu
Priority to PCT/IT2002/000489 priority patent/WO2003011864A1/en
Priority to CA2451279A priority patent/CA2451279C/en
Priority to BR0211550-6A priority patent/BR0211550A/pt
Priority to DK02760555T priority patent/DK1412354T3/da
Priority to CNB028138481A priority patent/CN1271070C/zh
Priority to MXPA04000886A priority patent/MXPA04000886A/es
Priority to HK05100306.4A priority patent/HK1068334B/xx
Publication of ITRM20010465A1 publication Critical patent/ITRM20010465A1/it
Priority to US11/797,566 priority patent/US7528252B2/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32Nitrogen atom
    • C07D473/34Nitrogen atom attached in position 6, e.g. adenine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT2001RM000465A 2001-07-31 2001-07-31 Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam ITRM20010465A1 (it)

Priority Applications (20)

Application Number Priority Date Filing Date Title
IT2001RM000465A ITRM20010465A1 (it) 2001-07-31 2001-07-31 Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam
HK05100306.4A HK1068334B (en) 2001-07-31 2002-07-25 Derivatives of triazolyl-imidazopyridine and of the triazolylpurines useful as ligands of the adenosine a2a receptor and their use as medicaments
JP2003517056A JP4366186B2 (ja) 2001-07-31 2002-07-25 アデノシンA2a受容体のリガンドとして有用なトリアゾリル−イミダゾピリジンおよびトリアゾリルプリンの誘導体およびその薬物としての使用
PL368409A PL217269B1 (pl) 2001-07-31 2002-07-25 Pochodne triazoliloimidazopirydyny i triazolilopuryny, zawierająca je kompozycja farmaceutyczna, ich zastosowanie, sposób ich otrzymywania oraz związki pośrednie wykorzystywane w tym sposobie
AU2002326146A AU2002326146B2 (en) 2001-07-31 2002-07-25 Derivatives of triazolyl-imidazopyridine and of the triazolylpurines useful as ligands of the adenosine A2a receptor and their use as medicaments
AT02760555T ATE325796T1 (de) 2001-07-31 2002-07-25 Derivate von triazolyl-imidazopyridine und von triazolylpurine als ligande des adenosine a2a rezeptoren und ihre verwendung als medicamente
EP02760555A EP1412354B1 (en) 2001-07-31 2002-07-25 DERIVATIVES OF TRIAZOLYL-IMIDAZOPYRIDINE AND OF THE TRIAZOLYLPURINES USEFUL AS LIGANDS OF THE ADENOSINE A 2a? RECEPTOR AND THEIR USE AS MEDICAMENTS
ES02760555T ES2263810T3 (es) 2001-07-31 2002-07-25 Derivados de triazolil-imidazopiridina y de triazolilpurinas utiles como ligandos del receptor de adenosina a2a y su uso com medicamentos.
PT02760555T PT1412354E (pt) 2001-07-31 2002-07-25 Derivados de triazolil-imidazopiridina e de triazolilpurinas uteis como ligandos do receptor a2a da adenosina e sua utilizacao como medicamentos
KR1020047000173A KR100884818B1 (ko) 2001-07-31 2002-07-25 아데노신 A2a 수용체의 리간드로서 유용한트리아졸릴-이미다조피리딘 및 트리아졸릴퓨린의 유도체,및 약제로서 그의 용도
US10/484,491 US7230102B2 (en) 2001-07-31 2002-07-25 Derivatives of triazolyl-imidazopyridine and of the triazolylpurines useful as ligandsof the adenosine a2a receptor and their use as medicaments
DE60211343T DE60211343T2 (de) 2001-07-31 2002-07-25 Derivate von triazolyl-imidazopyridine und von triazolylpurine als ligande des adenosine a2a rezeptoren und ihre verwendung als medicamente
HU0401987A HU228985B1 (en) 2001-07-31 2002-07-25 Derivatives of triazolyl-imidazopyridine and of the triazolylpurines useful as ligands of the adenosine a2a receptor and their use as medicaments
PCT/IT2002/000489 WO2003011864A1 (en) 2001-07-31 2002-07-25 DERIVATIVES OF TRIAZOLYL-IMIDAZOPYRIDINE AND OF THE TRIAZOLYLPURINES USEFUL AS LIGANDS OF THE ADENOSINE A2a RECEPTOR AND THEIR USE AS MEDICAMENTS
CA2451279A CA2451279C (en) 2001-07-31 2002-07-25 Derivatives of triazolyl-imidazopyridine and of the triazolylpurines useful as ligands of the adenosine a2a receptor and their use as medicaments
BR0211550-6A BR0211550A (pt) 2001-07-31 2002-07-25 Derivados de triazolil-imidazopiridina e das triazolilpurinas úteis como ligandos do receptor a2a da adenosina, e seu uso como medicamentos
DK02760555T DK1412354T3 (da) 2001-07-31 2002-07-25 Derivater af triazolylimidazopyridin og af triazolylpurinerne, der er egnede som ligander for adenosin A2a?-receptoren og deres anvendelse som medikamenter
CNB028138481A CN1271070C (zh) 2001-07-31 2002-07-25 用作腺苷A2α受体的配体的三唑基-咪唑并吡啶和三唑基嘌呤类的衍生物及其作为药物的应用
MXPA04000886A MXPA04000886A (es) 2001-07-31 2002-07-25 Derivados de triazolil-imidazopiridina y triazolilpurinas empledos como ligandos del receptor de adenosina a2a y su uso como medicamentos.
US11/797,566 US7528252B2 (en) 2001-07-31 2007-05-04 Derivatives of triazoly-imidazopyridine useful as ligands of the adenosine A2a receptor and their use as medicaments

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2001RM000465A ITRM20010465A1 (it) 2001-07-31 2001-07-31 Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam

Publications (2)

Publication Number Publication Date
ITRM20010465A0 true ITRM20010465A0 (it) 2001-07-31
ITRM20010465A1 ITRM20010465A1 (it) 2003-01-31

Family

ID=11455703

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2001RM000465A ITRM20010465A1 (it) 2001-07-31 2001-07-31 Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam

Country Status (18)

Country Link
US (2) US7230102B2 (it)
EP (1) EP1412354B1 (it)
JP (1) JP4366186B2 (it)
KR (1) KR100884818B1 (it)
CN (1) CN1271070C (it)
AT (1) ATE325796T1 (it)
AU (1) AU2002326146B2 (it)
BR (1) BR0211550A (it)
CA (1) CA2451279C (it)
DE (1) DE60211343T2 (it)
DK (1) DK1412354T3 (it)
ES (1) ES2263810T3 (it)
HU (1) HU228985B1 (it)
IT (1) ITRM20010465A1 (it)
MX (1) MXPA04000886A (it)
PL (1) PL217269B1 (it)
PT (1) PT1412354E (it)
WO (1) WO2003011864A1 (it)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60206756T2 (de) * 2001-06-29 2006-07-13 CV Therapeutics, Inc., Palo Alto Purin derivate als a2b adenosin rezeptor antagonisten
ITRM20010465A1 (it) * 2001-07-31 2003-01-31 Sigma Tau Ind Farmaceuti Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam
ATE355291T1 (de) * 2001-12-18 2006-03-15 Cv Therapeutics Inc A2a adenosinrezeptorantagonisten
WO2005092893A1 (ja) 2004-03-26 2005-10-06 Dainippon Sumitomo Pharma Co., Ltd. 9置換−8−オキソアデニン化合物
CA2646891A1 (en) * 2006-03-23 2007-09-27 Novartis Ag Immunopotentiating compounds
EP2041135A4 (en) 2006-07-05 2010-12-01 Astrazeneca Ab As TLR7 MODULATORS, 8-OXOADENINE DERIVATIVES WORK
TW200831105A (en) 2006-12-14 2008-08-01 Astrazeneca Ab Novel compounds
EP2132209B8 (en) 2007-03-19 2014-04-16 AstraZeneca AB 9-substituted-8-oxo-adenine compounds as toll-like receptor (tlr7 ) modulators
EP2139894B1 (en) 2007-03-19 2011-10-26 AstraZeneca AB 9-substituted-8-oxo-adenine compounds as toll-like receptor (tlr7) modulators
AR065784A1 (es) * 2007-03-20 2009-07-01 Dainippon Sumitomo Pharma Co Derivados de 8-oxo adenina,medicamentos que los contienen y usos como agentes terapeuticos para enfermedades alergicas, antivirales o antibacterianas.
JP5401329B2 (ja) * 2007-03-20 2014-01-29 キュリス,インコーポレイテッド Hsp90インヒビターとしての縮合アミノピリジン
WO2008114819A1 (ja) 2007-03-20 2008-09-25 Dainippon Sumitomo Pharma Co., Ltd. 新規アデニン化合物
KR20100016289A (ko) * 2007-05-08 2010-02-12 아스트라제네카 아베 면역-조정 특성의 이미다조퀴놀린
UY31531A1 (es) 2007-12-17 2009-08-03 Sales derivadas de 8-oxoadenina composiciones farmacéuticas que las contienen y su uso en terapia como moduladores de receptor tipo toll (tlr)
WO2009091032A1 (ja) 2008-01-17 2009-07-23 Dainippon Sumitomo Pharma Co., Ltd. アデニン化合物の製造方法
US20110054168A1 (en) * 2008-01-17 2011-03-03 Ayumu Kurimoto Method for preparing adenine compound
TWI473614B (zh) * 2008-05-29 2015-02-21 Kyowa Hakko Kirin Co Ltd Anti-analgesic inhibitors
AU2009266889B2 (en) 2008-07-03 2013-05-02 Glaxosmithkline Llc Benzimidazoles and related analogs as sirtuin modulators
NZ590793A (en) * 2008-07-23 2012-07-27 Kyowa Hakko Kirin Co Ltd Therapeutic agent for migraine
HRP20150766T1 (hr) * 2009-03-20 2015-08-14 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Oksidirani derivati triazolilpurina, korisni kao ligandi adenozinskog receptora a2a, te namijenjeni upotrebi kao medikamenti
US20120295863A1 (en) * 2009-11-13 2012-11-22 Yun-Lian Lin Dual-Action Compounds Targeting Adenosine A2A Receptor and Adenosine Transporter for Prevention and Treatment of Neurodegenerative Diseases
JP2013512859A (ja) * 2009-12-03 2013-04-18 大日本住友製薬株式会社 トール様受容体(tlr)を介して作用するイミダゾキノリン
JP5714602B2 (ja) * 2010-11-24 2015-05-07 ヤマサ醤油株式会社 新規な2−アルキニル−n9−プロパギルアデニンおよびその医薬用途
JP5978225B2 (ja) 2010-12-16 2016-08-24 大日本住友製薬株式会社 治療に有用なイミダゾ[4,5−c]キノリン−1−イル誘導体
ES2627433T3 (es) 2010-12-17 2017-07-28 Sumitomo Dainippon Pharma Co., Ltd. Derivados de purina
CA2902833A1 (en) 2013-03-15 2014-09-18 Syngenta Participations Ag Microbicidally active imidazopyridine derivatives
CN105622495A (zh) * 2016-03-23 2016-06-01 叶芳 4-氯-3-硝基吡啶及其制备方法
ES2957548T3 (es) * 2016-04-15 2024-01-22 Univ Oxford Innovation Ltd Moduladores del receptor de adenosina para el tratamiento de los trastornos del ritmo circadiano
WO2025080645A1 (en) * 2023-10-10 2025-04-17 Regranion, Llc Methods and compositions for treating bullous pemphigoid
GB202319534D0 (en) * 2023-12-19 2024-01-31 Circadian Therapeutics Ltd Dosage regimen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU626983B2 (en) 1989-01-31 1992-08-13 Whitby Research, Inc. N6-substituted 9-methyladenines
US5670501A (en) * 1994-09-01 1997-09-23 Discovery Therapeutics, Inc. N-substituted 9-alkyladenines
AU1688599A (en) * 1998-01-05 1999-07-26 Eisai Co. Ltd. Purine derivatives and adenosine a2 receptor antagonists serving as preventives/remedies for diabetes
GB9915437D0 (en) * 1999-07-01 1999-09-01 Cerebrus Ltd Chemical compounds III
DE60206756T2 (de) * 2001-06-29 2006-07-13 CV Therapeutics, Inc., Palo Alto Purin derivate als a2b adenosin rezeptor antagonisten
ITRM20010465A1 (it) 2001-07-31 2003-01-31 Sigma Tau Ind Farmaceuti Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam

Also Published As

Publication number Publication date
PT1412354E (pt) 2006-09-29
CN1271070C (zh) 2006-08-23
PL217269B1 (pl) 2014-06-30
JP4366186B2 (ja) 2009-11-18
JP2005500355A (ja) 2005-01-06
BR0211550A (pt) 2004-07-13
CA2451279C (en) 2011-05-10
ITRM20010465A1 (it) 2003-01-31
WO2003011864A1 (en) 2003-02-13
DE60211343T2 (de) 2007-05-10
ATE325796T1 (de) 2006-06-15
US20040204428A1 (en) 2004-10-14
US7230102B2 (en) 2007-06-12
AU2002326146B2 (en) 2008-05-01
CA2451279A1 (en) 2003-02-13
MXPA04000886A (es) 2004-06-03
HK1068334A1 (en) 2005-04-29
EP1412354A1 (en) 2004-04-28
ES2263810T3 (es) 2006-12-16
EP1412354B1 (en) 2006-05-10
PL368409A1 (en) 2005-03-21
KR100884818B1 (ko) 2009-02-20
US7528252B2 (en) 2009-05-05
US20070249638A1 (en) 2007-10-25
DE60211343D1 (de) 2006-06-14
CN1525974A (zh) 2004-09-01
DK1412354T3 (da) 2006-09-18
KR20040023641A (ko) 2004-03-18
HUP0401987A2 (hu) 2005-01-28
HUP0401987A3 (en) 2012-12-28
HU228985B1 (en) 2013-07-29

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