PL3689140T3 - Zwierzęta inne niż ludzie eksprymujące humanizowany kompleks CD3 - Google Patents

Zwierzęta inne niż ludzie eksprymujące humanizowany kompleks CD3

Info

Publication number
PL3689140T3
PL3689140T3 PL20160251.3T PL20160251T PL3689140T3 PL 3689140 T3 PL3689140 T3 PL 3689140T3 PL 20160251 T PL20160251 T PL 20160251T PL 3689140 T3 PL3689140 T3 PL 3689140T3
Authority
PL
Poland
Prior art keywords
complex
human animals
animals expressing
expressing humanized
humanized
Prior art date
Application number
PL20160251.3T
Other languages
English (en)
Inventor
Kara L. OLSON
Eric Smith
Ka-Man Venus Lai
Andrew J. Murphy
Gavin Thurston
Dayong Guo
Original Assignee
Regeneron Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54849703&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3689140(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.
Publication of PL3689140T3 publication Critical patent/PL3689140T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0337—Animal models for infectious diseases
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PL20160251.3T 2014-11-24 2015-11-23 Zwierzęta inne niż ludzie eksprymujące humanizowany kompleks CD3 PL3689140T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462083653P 2014-11-24 2014-11-24
US201562106999P 2015-01-23 2015-01-23

Publications (1)

Publication Number Publication Date
PL3689140T3 true PL3689140T3 (pl) 2022-09-05

Family

ID=54849703

Family Applications (2)

Application Number Title Priority Date Filing Date
PL15808501T PL3223605T3 (pl) 2014-11-24 2015-11-23 Zwierzęta inne niż ludzie eksprymujące humanizowany kompleks CD3
PL20160251.3T PL3689140T3 (pl) 2014-11-24 2015-11-23 Zwierzęta inne niż ludzie eksprymujące humanizowany kompleks CD3

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL15808501T PL3223605T3 (pl) 2014-11-24 2015-11-23 Zwierzęta inne niż ludzie eksprymujące humanizowany kompleks CD3

Country Status (25)

Country Link
US (4) US20170164588A1 (pl)
EP (3) EP4088572A1 (pl)
JP (5) JP7018314B2 (pl)
KR (2) KR20240055876A (pl)
CN (2) CN113016720B (pl)
AU (2) AU2015353705C9 (pl)
BR (1) BR112017010793A2 (pl)
CA (1) CA2967823A1 (pl)
CY (2) CY1123714T1 (pl)
DK (2) DK3223605T3 (pl)
ES (2) ES2923775T3 (pl)
HR (2) HRP20201938T1 (pl)
HU (2) HUE052603T2 (pl)
IL (2) IL286414B2 (pl)
LT (2) LT3223605T (pl)
MA (1) MA50679A (pl)
MX (1) MX2017006802A (pl)
PL (2) PL3223605T3 (pl)
PT (2) PT3689140T (pl)
RS (2) RS61080B1 (pl)
RU (2) RU2020122439A (pl)
SG (1) SG11201703800PA (pl)
SI (2) SI3689140T1 (pl)
SM (2) SMT202100181T1 (pl)
WO (1) WO2016085889A1 (pl)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA50679A (fr) * 2014-11-24 2021-03-17 Regeneron Pharma Animaux non humains exprimant un complexe cd3 humanisé
RU2728412C2 (ru) 2014-12-05 2020-07-29 Регенерон Фармасьютикалз, Инк. Животные, отличные от человека, имеющие гуманизированный ген кластера дифференцировки 47
CN107257624B (zh) 2014-12-09 2021-07-13 瑞泽恩制药公司 具有人源化分化簇274基因的非人动物
US11612149B2 (en) 2015-07-10 2023-03-28 Chugai Seiyaku Kabushiki Kaisha Non-human animal having human CD3 gene substituted for endogenous CD3 gene
PT3376857T (pt) 2015-11-20 2021-05-27 Regeneron Pharma Animais não humanos com um gene humanizado 3 de ativação de linfócitos
DK3422845T3 (da) * 2016-02-29 2021-08-30 Regeneron Pharma Gnavere med et humaniseret tmprss-gen
EP3502250B1 (en) * 2016-08-22 2024-04-24 Chugai Seiyaku Kabushiki Kaisha Gene-modified rodent expressing human gpc3 polypeptide
IL319209A (en) * 2017-06-27 2025-04-01 Regeneron Pharma Non-human animals containing a humanized ASGR1 locus
ES2961713T3 (es) 2017-09-29 2024-03-13 Regeneron Pharma Roedores que expresan el complejo C1Q humanizado
JP7361031B2 (ja) 2017-11-30 2023-10-13 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物
WO2019114768A1 (en) * 2017-12-12 2019-06-20 Biocytogen Jiangsu Co., Ltd. GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD3e
SG11202008620VA (en) 2018-03-26 2020-10-29 Regeneron Pharma Humanized rodents for testing therapeutic agents
US10463029B1 (en) * 2018-06-07 2019-11-05 Regeneron Pharmaceuticals, Inc. Rodent model of steel syndrome
JP7634994B2 (ja) 2018-07-16 2025-02-25 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Ｄｉｔｒａの非ヒト動物モデルおよびその使用
CN109355309B (zh) * 2018-10-18 2021-02-05 江苏集萃药康生物科技股份有限公司 一种cd3e基因修饰人源化动物模型的构建方法
WO2021018198A1 (en) * 2019-07-29 2021-02-04 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric il33
CN114276433A (zh) * 2020-04-01 2022-04-05 百奥赛图(北京)医药科技股份有限公司 Cd38基因人源化的非人动物及其构建方法和应用
EP4139347A4 (en) * 2020-04-24 2024-06-05 Memorial Sloan Kettering Cancer Center Anti-cd3 antibodies and uses thereof
EP4240833A4 (en) * 2020-11-06 2025-02-19 BioVentures, LLC T cells and bifunctional protein against human papillomavirus
CN112458117B (zh) * 2021-02-02 2021-05-04 百奥赛图(北京)医药科技股份有限公司 Cd155基因人源化的非人动物的构建方法及应用
CN114621971A (zh) * 2021-02-19 2022-06-14 百奥赛图(北京)医药科技股份有限公司 经遗传修饰的非人动物及其构建方法和应用
KR20250151441A (ko) 2023-02-17 2025-10-21 리제너론 파마슈티칼스 인코포레이티드 Cd3/taa 이중특이적 항체에 대해 반응성인 유도된 nk 세포
TW202520975A (zh) 2023-08-09 2025-06-01 英商劍橋企業有限公司 基因改造之囓齒動物及囓齒動物細胞以及其等用途

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0517895B1 (en) * 1990-12-14 1996-11-20 Cell Genesys, Inc. Chimeric chains for receptor-associated signal transduction pathways
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
FR2827302B1 (fr) * 2001-07-13 2003-10-10 Genoway Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations
CA2474486C (en) 2002-01-23 2013-05-14 The University Of Utah Research Foundation Targeted chromosomal mutagenesis using zinc finger nucleases
EP1344824A1 (en) * 2002-03-11 2003-09-17 Institut de la Santé et de la Recherche Médicale Mutated gene coding for a LAT protein and the biological applications thereof
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
UA94211C2 (ru) * 2004-06-03 2011-04-26 Новиммюн С.А. Выделенное полностью человеческое моноклональное cd3 антитело
AU2005295269B2 (en) 2004-10-19 2010-05-13 Regeneron Pharmaceuticals, Inc. Method for generating an animal homozygous for a genetic modification
HUE040467T2 (hu) * 2007-04-03 2019-03-28 Amgen Res Munich Gmbh Keresztfaj-specifikus kötõdomén
SG195609A1 (en) * 2007-04-03 2013-12-30 Amgen Res Munich Gmbh Cross-species-specific binding domain
PL2155788T3 (pl) * 2007-04-03 2013-02-28 Amgen Res Munich Gmbh Swoiste międzygatunkowe bispecyficzne czynniki wiążące
US8632768B2 (en) * 2008-05-30 2014-01-21 University Of Louisville Research Foundation, Inc. Human facilitating cells
AU2009299791B2 (en) * 2008-10-01 2016-02-25 Amgen Research (Munich) Gmbh Cross-species-specific PSCAxCD3, CD19xCD3, C-METxCD3, EndosialinxCD3, EpCAMxC D3, IGF-1RxCD3 or FAPalpha xCD3 bispecific single chain antibody
WO2010085660A2 (en) * 2009-01-23 2010-07-29 Roger Williams Hospital Viral vectors encoding multiple highly homologous non-viral polypeptides and the use of same
RU2425880C2 (ru) * 2009-07-30 2011-08-10 Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН Способ получения трансгенных мышей
PL2460403T3 (pl) 2009-07-31 2019-11-29 Smc Global Asset Inc Mysi model stłuszczeniowego zapalenia wątroby-raka wątroby
US8883496B2 (en) * 2009-12-21 2014-11-11 Regeneron Phamaceuticals, Inc. Humanized FcgR mice
TW201125583A (en) * 2009-12-23 2011-08-01 Bioalliance Cv Anti-EpCAM antibodies that induce apoptosis of cancer cells and methods using same
PT3272214T (pt) 2011-10-28 2020-03-04 Regeneron Pharma Ratinhos geneticamente modificados que expressam moléculas quiméricas de complexo principal de histocompatibilidade (mhc) ii
PT2818478T (pt) 2011-10-28 2017-05-12 Regeneron Pharma Il-6 e recetor de il-6 humanizados
KR101964776B1 (ko) * 2011-10-28 2019-04-04 리제너론 파아마슈티컬스, 인크. 유전자 변형된 ｔ 세포 수용체 마우스
PT2770821T (pt) 2011-10-28 2017-12-18 Regeneron Pharma Ratinhos de complexo principal de histocompatibilidade principal modificados geneticamente
WO2014028776A1 (en) * 2012-08-15 2014-02-20 Zyngenia, Inc. Monovalent and multivalent multispecific complexes and uses thereof
CA2882684A1 (en) * 2012-08-21 2014-02-27 Glaxo Group Limited Compositions comprising a single variable domain and camostat mesylate (cm)
WO2014042251A1 (ja) 2012-09-13 2014-03-20 中外製薬株式会社 遺伝子ノックイン非ヒト動物
JOP20200236A1 (ar) 2012-09-21 2017-06-16 Regeneron Pharma الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
WO2014056783A1 (en) * 2012-10-08 2014-04-17 Roche Glycart Ag Fc-free antibodies comprising two fab-fragments and methods of use
SG11201502685XA (en) 2012-11-05 2015-05-28 Regeneron Pharma Genetically modified non-human animals and methods of use thereof
TWI682941B (zh) 2013-02-01 2020-01-21 美商再生元醫藥公司 含嵌合恆定區之抗體
SI2958938T1 (sl) 2013-02-20 2019-08-30 Regeneron Pharmaceuticals, Inc. Miši, ki izražajo humanizirane koreceptorje za celice T
RS57963B1 (sr) 2013-02-22 2019-01-31 Regeneron Pharma Miševi koji eksprimiraju humanizovani glavni kompleks histokompatibilnosti
US20150342163A1 (en) 2013-02-22 2015-12-03 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex mice
CN103509122B (zh) * 2013-09-23 2015-04-15 武汉友芝友生物制药有限公司 一种cd3抗原及其制备方法和用途
SMT201900067T1 (it) 2013-09-23 2019-02-28 Regeneron Pharma Animali non umani aventi un gene di proteina regolatoria del segnale umanizzato
BR112016011003A2 (pt) 2013-11-19 2017-12-05 Regeneron Pharma animal roedor geneticamente modificado, célula tronco embrionária de camundongo, embrião de camundongo, e, métodos para fabricar um animal roedor e para enxertar células humanas em um camundongo
TWI701042B (zh) 2014-03-19 2020-08-11 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
JP6652931B2 (ja) 2014-04-08 2020-02-26 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ヒト化Ｆｃγ受容体を有する非ヒト動物
NO2785538T3 (pl) 2014-05-07 2018-08-04
SG10202002187WA (en) 2014-05-19 2020-04-29 Regeneron Pharma Genetically modified non-human animals expressing human epo
US10390522B2 (en) 2014-06-19 2019-08-27 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized programmed cell death 1 gene
MA50679A (fr) * 2014-11-24 2021-03-17 Regeneron Pharma Animaux non humains exprimant un complexe cd3 humanisé

Also Published As

Publication number Publication date
WO2016085889A1 (en) 2016-06-02
SI3689140T1 (sl) 2022-10-28
BR112017010793A2 (pt) 2017-12-26
EP4088572A1 (en) 2022-11-16
JP7018314B2 (ja) 2022-02-10
US20240306616A1 (en) 2024-09-19
DK3689140T3 (da) 2022-08-01
EP3223605B1 (en) 2020-10-14
MX2017006802A (es) 2018-01-30
AU2015353705C1 (en) 2022-08-11
JP7591094B2 (ja) 2024-11-27
HUE052603T2 (hu) 2021-05-28
JP2023101757A (ja) 2023-07-21
AU2022202578B2 (en) 2025-06-05
JP2017536126A (ja) 2017-12-07
LT3689140T (lt) 2022-08-25
RU2017122038A (ru) 2018-12-26
SMT202200438T1 (it) 2023-01-13
RU2726446C2 (ru) 2020-07-14
AU2022202578A1 (en) 2022-05-12
ES2923775T3 (es) 2022-09-30
CN107105633A (zh) 2017-08-29
CN113016720A (zh) 2021-06-25
IL286414A (en) 2021-10-31
ES2844000T3 (es) 2021-07-21
RS63410B1 (sr) 2022-08-31
AU2015353705C9 (en) 2022-09-01
EP3689140B1 (en) 2022-05-11
US20210100229A1 (en) 2021-04-08
EP3689140A1 (en) 2020-08-05
JP7269214B2 (ja) 2023-05-08
RU2020122439A (ru) 2020-09-24
RS61080B1 (sr) 2020-12-31
EP3223605A1 (en) 2017-10-04
CY1125424T1 (el) 2025-05-09
LT3223605T (lt) 2021-01-11
PL3223605T3 (pl) 2021-04-19
US20170164588A1 (en) 2017-06-15
CY1123714T1 (el) 2022-03-24
HRP20220904T1 (hr) 2022-10-14
JP2022066476A (ja) 2022-04-28
KR20170120090A (ko) 2017-10-30
DK3223605T3 (da) 2020-11-16
SI3223605T1 (sl) 2021-03-31
EP3223605B9 (en) 2021-08-18
IL286414B1 (en) 2023-12-01
CA2967823A1 (en) 2016-06-02
US20200275642A1 (en) 2020-09-03
HRP20201938T1 (hr) 2021-02-05
SG11201703800PA (en) 2017-06-29
US12419282B2 (en) 2025-09-23
PT3223605T (pt) 2020-12-24
JP2021035397A (ja) 2021-03-04
KR20240055876A (ko) 2024-04-29
SMT202100181T1 (it) 2021-05-07
IL252202A0 (en) 2017-07-31
JP7524240B2 (ja) 2024-07-29
CN107105633B (zh) 2021-02-12
AU2015353705B2 (en) 2022-01-20
US10932455B2 (en) 2021-03-02
IL286414B2 (en) 2024-04-01
RU2017122038A3 (pl) 2019-07-17
IL252202B (en) 2021-10-31
CN113016720B (zh) 2023-02-21
PT3689140T (pt) 2022-07-27
US11937587B2 (en) 2024-03-26
JP2024114974A (ja) 2024-08-23
KR102659123B1 (ko) 2024-04-22
AU2015353705A1 (en) 2017-06-08
HUE059417T2 (hu) 2022-11-28
MA50679A (fr) 2021-03-17

Similar Documents

Publication Publication Date Title
IL286414A (en) Non-human animals expressing a cd3 complex of human origin
HUS2500051I1 (hu) Humanizált vagy kiméra CD3 ellenanyagok
PL3130606T3 (pl) Przeciwciała dwuswoiste aktywujące układ odpornościowy
PT3101131T (pt) Anticorpo antitranstirretina humanizado
PT3116908T (pt) Anticorpos kir3dl2 humanizados
IL246497B (en) Non-human animals with human fc–gamma receptors
SG11201610594WA (en) Anti-il4-il 13 bispecific antibodies
IL272676B (en) Bispecific antibodies against il-4 and il-13
GB201409990D0 (en) Loungers for pets