PL369183A1 - Związki oksazolidynonowe i izoksazolinowe jako środki przeciwbakteryjne - Google Patents

Związki oksazolidynonowe i izoksazolinowe jako środki przeciwbakteryjne

Info

Publication number
PL369183A1
PL369183A1 PL02369183A PL36918302A PL369183A1 PL 369183 A1 PL369183 A1 PL 369183A1 PL 02369183 A PL02369183 A PL 02369183A PL 36918302 A PL36918302 A PL 36918302A PL 369183 A1 PL369183 A1 PL 369183A1
Authority
PL
Poland
Prior art keywords
isoxazoline
oxazolidinone
antibacterial agents
antibacterial
agents
Prior art date
Application number
PL02369183A
Other languages
English (en)
Inventor
Michael Barry Gravestock
Neil James Hales
Michael Lingard Swain
Sheila Irene Hauck
Stuart Dennett Mills
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0121942A external-priority patent/GB0121942D0/en
Priority claimed from GB0215420A external-priority patent/GB0215420D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PL369183A1 publication Critical patent/PL369183A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
PL02369183A 2001-09-11 2002-09-09 Związki oksazolidynonowe i izoksazolinowe jako środki przeciwbakteryjne PL369183A1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0121942A GB0121942D0 (en) 2001-09-11 2001-09-11 Chemical compounds
GB0215420A GB0215420D0 (en) 2002-07-04 2002-07-04 Chemical compounds

Publications (1)

Publication Number Publication Date
PL369183A1 true PL369183A1 (pl) 2005-04-18

Family

ID=26246531

Family Applications (1)

Application Number Title Priority Date Filing Date
PL02369183A PL369183A1 (pl) 2001-09-11 2002-09-09 Związki oksazolidynonowe i izoksazolinowe jako środki przeciwbakteryjne

Country Status (25)

Country Link
US (2) US7396847B2 (pl)
EP (1) EP1427711B1 (pl)
JP (1) JP2005507386A (pl)
KR (1) KR20040044886A (pl)
CN (1) CN1639136A (pl)
AR (1) AR036778A1 (pl)
AT (1) ATE299502T1 (pl)
AU (1) AU2002329393B2 (pl)
BR (1) BR0212458A (pl)
CA (1) CA2459766A1 (pl)
CO (1) CO5560609A2 (pl)
DE (1) DE60205030T2 (pl)
DK (1) DK1427711T3 (pl)
ES (1) ES2244802T3 (pl)
HU (1) HUP0401005A3 (pl)
IL (1) IL160739A0 (pl)
IS (1) IS7175A (pl)
MX (1) MXPA04002303A (pl)
NO (1) NO327010B1 (pl)
NZ (1) NZ531621A (pl)
PL (1) PL369183A1 (pl)
PT (1) PT1427711E (pl)
RU (1) RU2004111285A (pl)
SI (1) SI1427711T1 (pl)
WO (1) WO2003022824A1 (pl)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6667299B1 (en) * 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
EP1443930A1 (en) 2001-10-25 2004-08-11 AstraZeneca AB Isoxazoline derivatives useful as antimicrobials
CN1649866A (zh) 2002-02-28 2005-08-03 阿斯特拉曾尼卡有限公司 3－环状基－5－(含氮5－元环)甲基－噁唑烷酮衍生物及其作为抗菌药物的用途
CN1653064A (zh) 2002-02-28 2005-08-10 阿斯特拉曾尼卡有限公司 噁唑烷酮衍生物、其制备方法以及包含它们的药用组合物
PL373888A1 (pl) * 2002-04-25 2005-09-19 Basf Aktiengesellschaft 3-Heteroarylo-podstawione 5-metoksymetyloizoksazoliny jako herbicydy
TW200420573A (en) 2002-09-26 2004-10-16 Rib X Pharmaceuticals Inc Bifunctional heterocyclic compounds and methods of making and using same
MXPA05005651A (es) * 2002-11-28 2005-07-27 Astrazeneca Ab Derivados de oxazolidinona y/o isoxazolina como agentes antibacterianos.
GB0227701D0 (en) * 2002-11-28 2003-01-08 Astrazeneca Ab Chemical compounds
WO2004048350A2 (en) * 2002-11-28 2004-06-10 Astrazeneca Ab Oxazolidinones as antibacterial agents
GB0229526D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
GB0229522D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
GB0229521D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
GB0304723D0 (en) * 2003-03-01 2003-04-02 Astrazeneca Ab Chemical compounds
TW200500360A (en) * 2003-03-01 2005-01-01 Astrazeneca Ab Hydroxymethyl compounds
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
EP1656370B1 (en) 2003-06-03 2012-08-15 Rib-X Pharmaceuticals, Inc. Biaryl heterocyclic compounds and methods of making and using the same
WO2005012271A2 (en) * 2003-07-29 2005-02-10 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
ES2536001T3 (es) * 2003-07-29 2015-05-19 Melinta Therapeutics, Inc. Procedimiento para la síntesis de biariloxazolidinonas
AR046782A1 (es) 2003-12-17 2005-12-21 Rib X Pharmaceuticals Inc Compuestos heterociclicos de biarilo halogenados, composiciones farmaceuticas que los contienen, metodos para su elaboracion y su uso como medicamentos.
KR100854211B1 (ko) 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
EP1723159B1 (en) 2004-02-27 2019-06-12 Melinta Therapeutics, Inc. Macrocyclic compounds and methods of making and using the same
GB0411596D0 (en) * 2004-05-25 2004-06-30 Astrazeneca Ab Chemical process
US20080064689A1 (en) * 2004-05-25 2008-03-13 Astrazeneca Ab 3-[4-(6-Pyridin-3-Yl)-3-Phenyl] -5-(1H-1,2,3-Triazol-1-Ylmethyl)-1,3-Oxazolidin-2-Ones as Antibacterial Agents
WO2005116024A1 (en) * 2004-05-25 2005-12-08 Astrazeneca Ab 3- (4- (2-dihydroisoxazol-3-ylpyridin-5-yl) phenyl) -5-triazol-1-ylmethyloxazolidin-2-one derivaives as mao inhibitors for the treatment of bacterial infections
DOP2005000123A (es) 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
WO2006038100A1 (en) * 2004-10-08 2006-04-13 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
EP1874782A1 (en) 2005-04-15 2008-01-09 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
JP5534497B2 (ja) 2005-06-08 2014-07-02 メリンタ セラピューティクス，インコーポレイテッド トリアゾール類の合成方法
EP3290427A1 (en) 2005-08-24 2018-03-07 Melinta Therapeutics, Inc. Triazole compounds and methods of making and using the same
EP1934237A2 (en) 2005-08-24 2008-06-25 Rib-X Pharmaceuticals, Inc. Triazole compounds and methods of making and using the same
RU2659792C1 (ru) 2008-10-10 2018-07-04 Мерк Шарп Энд Домэ Корп. Оксазолидиноны и способ их очистки
MY156354A (en) 2009-02-03 2016-02-15 Merck Sharp & Dohme Crystalline form of r)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate
US8580767B2 (en) 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
KR101561964B1 (ko) 2013-11-15 2015-10-20 한국과학기술연구원 옥사졸리디논 화합물 및 이를 포함하는 c형 간염 예방 또는 치료용 약학 조성물
JP6610905B2 (ja) * 2015-02-27 2019-11-27 オーピーバイオファクトリー株式会社 カケロマイシンおよびその誘導体の製造方法
CN106083994B (zh) * 2016-04-18 2019-12-06 南京曼杰生物科技有限公司 取代的噁唑烷酮水溶性衍生物及其应用
US20170333305A1 (en) * 2016-05-23 2017-11-23 Microban Products Company Topical skin product having retention property
US11452719B2 (en) 2017-12-13 2022-09-27 Merck Sharp & Dohme Llc Pharmaceutical compositions of tedizolid phosphate
CN113149924B (zh) * 2021-03-29 2023-11-03 苏州大学 一种异噁唑啉的简单制备方法
CN113831517A (zh) * 2021-09-09 2021-12-24 万凯新材料股份有限公司 抗菌及抗紫外聚酯的制备方法

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5043443A (en) * 1988-07-29 1991-08-27 Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives
SK283420B6 (sk) 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
GB9521508D0 (en) 1995-10-20 1995-12-20 Zeneca Ltd Chemical compounds
GB9601666D0 (en) 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9604301D0 (en) 1996-02-29 1996-05-01 Zeneca Ltd Chemical compounds
GB9609919D0 (en) 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
GB9614236D0 (en) 1996-07-06 1996-09-04 Zeneca Ltd Chemical compounds
GB9614238D0 (en) 1996-07-06 1996-09-04 Zeneca Ltd Chemical compounds
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
EP1007525A1 (en) 1997-08-29 2000-06-14 Zeneca Limited Aminometyl oxooxazolidinyl benzene derivatives
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
AU1694099A (en) 1997-12-26 1999-07-19 Cheil Jedang Corporation Cephem derivatives and a method for producing the compounds and an antibacterialcomposition containing the compounds
WO1999064417A2 (en) 1998-06-05 1999-12-16 Astrazeneca Ab Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
GB9812019D0 (en) 1998-06-05 1998-07-29 Zeneca Ltd Chemical compounds
US6288234B1 (en) 1998-06-08 2001-09-11 Advanced Medicine, Inc. Multibinding inhibitors of microsomal triglyceride transferase protein
GB9821938D0 (en) 1998-10-09 1998-12-02 Zeneca Ltd Chemical compounds
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB9928499D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical processes and intermediates
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
AU5889701A (en) * 2000-06-05 2001-12-17 Dong A Pharm Co Ltd Novel oxazolidinone derivatives and a process for the preparation thereof
DE10034625A1 (de) 2000-07-17 2002-01-31 Bayer Ag Heterocyclisch substituierte Thienyl-Phenyl-Oxazolidinone
DE10034624A1 (de) 2000-07-17 2002-01-31 Bayer Ag Aryl-substituierte Thienyl-1,3-oxazolidin-2-one als Cytokin-Inhibitoren
US20020115669A1 (en) * 2000-08-31 2002-08-22 Wiedeman Paul E. Oxazolidinone chemotherapeutic agents
YU52403A (sh) 2000-12-26 2006-03-03 Dr.Reddy's Research Foundation Heterociklična jedinjenja koja imaju antibakterijsko dejstvo, postupak za njihovo dobijanje i farmaceutske smeše koje ih sadrže
GB0108764D0 (en) 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compounds
GB0108793D0 (en) 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compounds
GB0108794D0 (en) 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compound
DE60212959T2 (de) 2001-04-07 2007-02-15 Astrazeneca Ab Eine sulfonimid-gruppe enthaltende oxazolidinone als antibiotika
GB0113300D0 (en) 2001-06-01 2001-07-25 Astrazeneca Ab Purification process
GB0113297D0 (en) 2001-06-01 2001-07-25 Astrazeneca Ab Chemical Process
GB0113299D0 (en) 2001-06-01 2001-07-25 Astrazeneca Ab Chemical process & intermediates
GB0113298D0 (en) 2001-06-01 2001-07-25 Astrazeneca Ab Purification process and intermediates
US7049443B2 (en) 2001-07-12 2006-05-23 Pharmacia & Upjohn Company Amide-containing compound having improved solubility and method of improving the solubility of an amide-containing compound
GB0118407D0 (en) 2001-07-27 2001-09-19 Cipla Ltd Oxazolidinone derivatives as antibacterial agents
WO2003031441A1 (en) 2001-10-04 2003-04-17 Morphochen Aktiengesellschaft Für Kombinatorische Chemie Multiple action compounds
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
EP1443930A1 (en) 2001-10-25 2004-08-11 AstraZeneca AB Isoxazoline derivatives useful as antimicrobials
GB2396350A (en) 2001-10-25 2004-06-23 Astrazeneca Ab Aryl substituted oxazolidinones with antibacterial activity
CN1653064A (zh) 2002-02-28 2005-08-10 阿斯特拉曾尼卡有限公司 噁唑烷酮衍生物、其制备方法以及包含它们的药用组合物
CN1649866A (zh) 2002-02-28 2005-08-03 阿斯特拉曾尼卡有限公司 3－环状基－5－(含氮5－元环)甲基－噁唑烷酮衍生物及其作为抗菌药物的用途
JP2003335762A (ja) 2002-05-20 2003-11-28 Meiji Seika Kaisha Ltd 新規ビフェニル誘導体
TW200420573A (en) 2002-09-26 2004-10-16 Rib X Pharmaceuticals Inc Bifunctional heterocyclic compounds and methods of making and using same
MXPA05005651A (es) * 2002-11-28 2005-07-27 Astrazeneca Ab Derivados de oxazolidinona y/o isoxazolina como agentes antibacterianos.

Also Published As

Publication number Publication date
KR20040044886A (ko) 2004-05-31
ATE299502T1 (de) 2005-07-15
PT1427711E (pt) 2005-11-30
HUP0401005A2 (hu) 2004-08-30
HK1065789A1 (en) 2005-03-04
BR0212458A (pt) 2004-10-19
DK1427711T3 (da) 2005-10-17
HUP0401005A3 (en) 2007-11-28
AU2002329393B2 (en) 2008-06-12
US20100137243A1 (en) 2010-06-03
RU2004111285A (ru) 2005-10-10
NO20041428L (no) 2004-06-08
NZ531621A (en) 2005-06-24
US7396847B2 (en) 2008-07-08
AR036778A1 (es) 2004-10-06
EP1427711A1 (en) 2004-06-16
EP1427711B1 (en) 2005-07-13
DE60205030D1 (de) 2005-08-18
NO327010B1 (no) 2009-04-06
MXPA04002303A (es) 2004-06-29
ES2244802T3 (es) 2005-12-16
CN1639136A (zh) 2005-07-13
DE60205030T2 (de) 2006-04-20
SI1427711T1 (sl) 2005-12-31
IL160739A0 (en) 2004-08-31
CA2459766A1 (en) 2003-03-20
JP2005507386A (ja) 2005-03-17
US20050107435A1 (en) 2005-05-19
CO5560609A2 (es) 2005-09-30
IS7175A (is) 2004-03-10
WO2003022824A1 (en) 2003-03-20

Similar Documents

Publication Publication Date Title
IL160739A0 (en) Oxazolidinone and/or isoxazoline as antibacterial agents
GB0303836D0 (en) Oxazolidinones and their use as antibacterial agents
IL168747A0 (en) Oxazolidinone and/or isoxazoline derivatives as antibacterial agents
AU6937001A (en) Oxazolidinone derivatives as antimicrobials
PT2311466E (pt) Compostos antimicrobianos e métodos para a sua utilização
AU2002319320A1 (en) Substituted isoxazoles and the use thereof as antibiotics
IL159434A0 (en) New derivatives of oxazolidinones as antibacterial agents
AU2003292422A1 (en) Oxazolidinone derivatives and their use as antibacterial agents
EG23929A (en) Isoxazolines derivatives and their use as antidepressants
GB0118407D0 (en) Oxazolidinone derivatives as antibacterial agents
EP1511753A4 (en) ANTIMICROBIAL MEDIUM AND ITS USE
AU4754001A (en) Novel benzosultam oxazolidinone antibacterial agents
HUP0401586A3 (en) Antibacterial agent
GB0106428D0 (en) Antibacterial composition
AU2002241175A1 (en) Oxazolidinones and their use as antibacterial agents
GB2383999B (en) Anti-bacterial treatment
AP2004003064A0 (en) Dithiocarbamate derivatives and their use as antibacterial agents.
GB0102641D0 (en) Antibacterial agents
GB0115197D0 (en) Antibacterial Agents
GB0110705D0 (en) Antibacterial Agents
GB0123792D0 (en) Antibacterial agents
GB0100949D0 (en) Antibacterial agents
AU2002355666A1 (en) Oxazolidinone derivatives as antibacterial agents
GB0109914D0 (en) Novel antimicrobial agents
GB0109913D0 (en) Novel antimicrobial agents

Legal Events

Date Code Title Description
REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)