PL369644A1 - Spiro-i dispiro-1,2,4-trioksolany jako środki przeciwmalaryczne - Google Patents

Spiro-i dispiro-1,2,4-trioksolany jako środki przeciwmalaryczne

Info

Publication number
PL369644A1
PL369644A1 PL04369644A PL36964404A PL369644A1 PL 369644 A1 PL369644 A1 PL 369644A1 PL 04369644 A PL04369644 A PL 04369644A PL 36964404 A PL36964404 A PL 36964404A PL 369644 A1 PL369644 A1 PL 369644A1
Authority
PL
Poland
Prior art keywords
group
dispiro
spiro
trioxolane
trioxalane
Prior art date
Application number
PL04369644A
Other languages
English (en)
Other versions
PL227294B1 (pl
Inventor
Jonathan L. Vennerstrom
Yuanqing Tang
Jacques Chollet
Yuxiang Dong
Hugues Matile
Maniyan Padmanilayam
William N. Charman
Original Assignee
Medicines For Malaria Venture
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medicines For Malaria Venture filed Critical Medicines For Malaria Venture
Publication of PL369644A1 publication Critical patent/PL369644A1/pl
Publication of PL227294B1 publication Critical patent/PL227294B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4747—Quinolines; Isoquinolines spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • C07D323/02—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Opisano środki i sposoby leczenia malarii, schistosomatozy i raka przy użyciu spiro- lub dispiro-1,2,4-trioksolanu. Preferowane 1,2,4-trioksołany posiadają grupę spiroadamantanową z jednej strony grupy trioksolanowej oraz grupę spirocykloheksylową z drugiej strony grupy trioksolanowej, przy czym pierścień spirocykloheksylowy jest korzystnie podstawiony w pozycji 4. W porównaniu do półsyntetycznych pochodnych artemizyniny, związki według wynalazku są strukturalnie proste, łatwe do otrzymania, nietoksyczne i wykazują silne działanie przeciwko pasożytom malarii.
PL369644A 2003-08-18 2004-08-18 Spiro-lub dispiro-1,2,4-trioksolan, kompozycja farmaceutyczna zawierajaca ten zwiazek i zastosowanie zwiazku PL227294B1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/642,721 US6825230B2 (en) 2002-06-21 2003-08-18 Spiro and dispiro 1,2,4-trixolane antimalarials
US10/642,721 2003-08-18

Publications (2)

Publication Number Publication Date
PL369644A1 true PL369644A1 (pl) 2005-02-21
PL227294B1 PL227294B1 (pl) 2017-11-30

Family

ID=31888549

Family Applications (2)

Application Number Title Priority Date Filing Date
PL04254821T PL1514871T3 (pl) 2003-08-18 2004-08-11 Dispiro 1,2,4 – trioksolanowe środki przeciwmalaryczne
PL369644A PL227294B1 (pl) 2003-08-18 2004-08-18 Spiro-lub dispiro-1,2,4-trioksolan, kompozycja farmaceutyczna zawierajaca ten zwiazek i zastosowanie zwiazku

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL04254821T PL1514871T3 (pl) 2003-08-18 2004-08-11 Dispiro 1,2,4 – trioksolanowe środki przeciwmalaryczne

Country Status (16)

Country Link
US (1) US6825230B2 (pl)
EP (2) EP2599779A1 (pl)
JP (1) JP2005060396A (pl)
KR (1) KR20050020946A (pl)
CN (1) CN1626530A (pl)
AU (1) AU2004203864B2 (pl)
CA (1) CA2478146C (pl)
CY (1) CY1117133T1 (pl)
DK (1) DK1514871T3 (pl)
ES (1) ES2560080T3 (pl)
HU (1) HUE028313T2 (pl)
MX (1) MXPA04008022A (pl)
PL (2) PL1514871T3 (pl)
PT (1) PT1514871E (pl)
SG (2) SG109559A1 (pl)
SI (1) SI1514871T1 (pl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080125441A1 (en) * 2002-06-21 2008-05-29 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US7371778B2 (en) * 2002-06-21 2008-05-13 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US6825230B2 (en) * 2002-06-21 2004-11-30 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trixolane antimalarials
EP1789380A1 (de) * 2004-07-23 2007-05-30 Justus-Liebig-Universität Giessen Aminoadamantan-derivate, verfahren zu ihrer herstellung und ihre verwendung
GB0421911D0 (en) * 2004-10-01 2004-11-03 Univ Cambridge Tech Methods and means
US8067620B2 (en) * 2005-05-04 2011-11-29 Medicines For Malaria Venture Mmv Dispiro 1,2,4-trioxolane antimalarials
EP1898901B1 (en) * 2005-05-18 2016-11-23 Sun Pharmaceutical Industries Limited Stable dosage forms of spiro and dispiro 1,2,4-trioxolane antimalarials
CN101472582A (zh) * 2006-05-17 2009-07-01 兰贝克赛实验室有限公司 联用合成青蒿素衍生物和双喹啉衍生物的抗疟疗法
BRPI0712208A2 (pt) * 2006-05-24 2012-03-13 Ranbaxy Laboratories Limited. processo de preparação de um composto
FR2924343A1 (fr) * 2007-12-04 2009-06-05 Palumed Sa Nouvelles utilisations therapeutiques de molecules duales contenant un derive peroxydique.
EP2340829B1 (en) * 2008-07-01 2015-08-05 National University Corporation Okayama University Novel antischistosomal agent
WO2010119425A1 (en) * 2009-04-17 2010-10-21 Ranbaxy Laboratories Limited A process for the preparation of 1, 2, 4-trioxolane antimalarials
WO2013008218A1 (en) 2011-07-14 2013-01-17 Ranbaxy Laboratories Limited Stable dosage forms of arterolane and piperaquine
WO2015123595A1 (en) 2014-02-14 2015-08-20 The Regents Of The University Of California Cyclic peroxides as prodrugs for selective delivery of agents
WO2019005977A1 (en) 2017-06-27 2019-01-03 The Regents Of The University Of California Trioxolane agents
EP4574143A1 (en) 2023-12-21 2025-06-25 Universität Regensburg Inhibitors of plasmodia remodeling enzymes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6486199B1 (en) * 2001-06-21 2002-11-26 Medicines For Malaria Venture Mmv International Centre Cointrin Spiro and dispiro 1,2,4-trioxolane antimalarials
US6825230B2 (en) * 2002-06-21 2004-11-30 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trixolane antimalarials

Also Published As

Publication number Publication date
EP1514871B1 (en) 2015-10-21
CA2478146A1 (en) 2006-02-17
DK1514871T3 (en) 2016-01-25
CY1117133T1 (el) 2017-04-05
PL1514871T3 (pl) 2016-05-31
SI1514871T1 (sl) 2016-02-29
ES2560080T3 (es) 2016-02-17
AU2004203864B2 (en) 2007-06-07
PL227294B1 (pl) 2017-11-30
CA2478146C (en) 2009-02-03
AU2004203864B9 (en) 2005-03-10
KR20050020946A (ko) 2005-03-04
EP2599779A1 (en) 2013-06-05
US6825230B2 (en) 2004-11-30
AU2004203864A1 (en) 2005-03-10
EP1514871A1 (en) 2005-03-16
CN1626530A (zh) 2005-06-15
SG139752A1 (en) 2008-02-29
JP2005060396A (ja) 2005-03-10
MXPA04008022A (es) 2005-06-08
HUE028313T2 (en) 2016-12-28
SG109559A1 (en) 2005-03-30
US20040039008A1 (en) 2004-02-26
PT1514871E (pt) 2016-02-08

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