PL370379A1 - N-Tlenek prukaloprydu, sposób jego wytwarzania i zastosowanie oraz zawierająca go kompozycja i sposób jej wytwarzania - Google Patents

N-Tlenek prukaloprydu, sposób jego wytwarzania i zastosowanie oraz zawierająca go kompozycja i sposób jej wytwarzania

Info

Publication number
PL370379A1
PL370379A1 PL370379A PL37037903A PL370379A1 PL 370379 A1 PL370379 A1 PL 370379A1 PL 370379 A PL370379 A PL 370379A PL 37037903 A PL37037903 A PL 37037903A PL 370379 A1 PL370379 A1 PL 370379A1
Authority
PL
Poland
Prior art keywords
prucalopride
oxide
compositions
novel
concerned
Prior art date
Application number
PL370379A
Other languages
English (en)
Other versions
PL214274B1 (pl
Inventor
Joannes Adrianus Jacobus Schuurkes
Willy Joannes Carolus Van Laerhoven
Original Assignee
Movetis N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Movetis N.V. filed Critical Movetis N.V.
Publication of PL370379A1 publication Critical patent/PL370379A1/pl
Publication of PL214274B1 publication Critical patent/PL214274B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Niniejszy wynalazek dotyczy nowej pochodnej benzamidu i jej farmaceutycznie dopuszczalnych soli addycyjnych z kwasami, kompozycji farmaceutycznych zawierających ten nowy związek, sposobów wytwarzania wymienionych związków i kompozycji oraz ich zastosowania jako leków w leczeniu zaburzeń ruchliwości układu pokarmowego.
PL370379A 2002-01-16 2003-01-13 N-Tlenek prukaloprydu, sposób jego wytwarzania i zastosowanie oraz zawierająca go kompozycja i sposób jej wytwarzania PL214274B1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02075157 2002-01-16
PCT/EP2003/000276 WO2003059906A1 (en) 2002-01-16 2003-01-13 Prucalopride-n-oxide

Publications (2)

Publication Number Publication Date
PL370379A1 true PL370379A1 (pl) 2005-05-16
PL214274B1 PL214274B1 (pl) 2013-07-31

Family

ID=8185531

Family Applications (1)

Application Number Title Priority Date Filing Date
PL370379A PL214274B1 (pl) 2002-01-16 2003-01-13 N-Tlenek prukaloprydu, sposób jego wytwarzania i zastosowanie oraz zawierająca go kompozycja i sposób jej wytwarzania

Country Status (18)

Country Link
US (2) US20050085510A1 (pl)
EP (1) EP1467991B1 (pl)
JP (1) JP2005514458A (pl)
KR (1) KR101023433B1 (pl)
CN (1) CN1330646C (pl)
AT (1) ATE295845T1 (pl)
AU (1) AU2003206722B2 (pl)
CA (1) CA2471729C (pl)
DE (1) DE60300683T2 (pl)
ES (1) ES2242940T3 (pl)
IL (1) IL163025A (pl)
MX (1) MXPA04006888A (pl)
NO (1) NO326580B1 (pl)
NZ (1) NZ533041A (pl)
PL (1) PL214274B1 (pl)
RU (1) RU2301806C2 (pl)
WO (1) WO2003059906A1 (pl)
ZA (1) ZA200405654B (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR058022A1 (es) * 2005-08-22 2008-01-23 Solvay Pharm Bv Derivados de benzooxazoles, composiciones farmaceuticas y su uso para el tratamiento de desordenes del sistema nervioso.
ATE417834T1 (de) * 2005-08-22 2009-01-15 Solvay Pharm Bv N-oxide als prodrugs von piperazin- und piperidinderivaten
US7750013B2 (en) 2005-08-22 2010-07-06 Solvay Pharmaceuticals, B.V. N-oxides as prodrugs of piperazine and piperidine derivatives
US20070294778A1 (en) * 2006-03-16 2007-12-20 Adam Rich Zebrafish model for assessing gastrointestinal motility
WO2017137910A1 (en) 2016-02-11 2017-08-17 Symed Labs Limited Processes for the preparation of highly pure prucalopride succinate and its intermediates
CN112500398A (zh) * 2020-12-24 2021-03-16 艾希尔（深圳）药物研发有限公司 一种普鲁卡必利氧化物的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8716587D0 (en) * 1987-07-14 1987-08-19 Shell Int Research Preparing thiophene derivatives
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
RU2154064C2 (ru) * 1994-09-27 2000-08-10 Жансен Фармасетика Н.В. N-замещенные пиперидинилбензоаты, их n-оксидные формы, фармацевтически приемлемые соли присоединения кислот и стереохимически изомерные формы, способы их получения, фармацевтическая композиция на их основе и промежуточный продукт
TW490465B (en) * 1994-11-24 2002-06-11 Janssen Pharmaceutica Nv Enterokinetic benzamide, the preparation process and the pharmaceutical compositions thereof
TW382017B (en) * 1995-12-27 2000-02-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives
NZ330263A (en) * 1996-02-15 1999-06-29 Janssen Pharmaceutica Nv Esters of 3-hydroxy-piperidinemethanol derivatives to improve gastric emptying
TW445263B (en) * 1996-02-29 2001-07-11 Janssen Pharmaceutica Nv Novel esters of 1,4-disubstituted piperidine derivatives
KR20010080025A (ko) * 1998-11-23 2001-08-22 디르크 반테 소화불량 치료용 의약의 제조를 위한 프루칼로프라이드의용도
TW592709B (en) * 1999-04-29 2004-06-21 Janssen Pharmaceutica Nv Prucalopride oral solution

Also Published As

Publication number Publication date
NZ533041A (en) 2006-04-28
US20080125464A1 (en) 2008-05-29
ATE295845T1 (de) 2005-06-15
AU2003206722B2 (en) 2008-01-24
US20050085510A1 (en) 2005-04-21
DE60300683D1 (de) 2005-06-23
EP1467991B1 (en) 2005-05-18
EP1467991A1 (en) 2004-10-20
DE60300683T2 (de) 2006-04-27
KR101023433B1 (ko) 2011-03-25
MXPA04006888A (es) 2004-12-06
CN1615308A (zh) 2005-05-11
WO2003059906A1 (en) 2003-07-24
CA2471729C (en) 2010-03-23
HK1075894A1 (zh) 2005-12-30
NO326580B1 (no) 2009-01-12
CN1330646C (zh) 2007-08-08
AU2003206722A1 (en) 2003-07-30
US8063069B2 (en) 2011-11-22
RU2004124844A (ru) 2006-01-20
CA2471729A1 (en) 2003-07-24
RU2301806C2 (ru) 2007-06-27
KR20040074981A (ko) 2004-08-26
PL214274B1 (pl) 2013-07-31
ES2242940T3 (es) 2005-11-16
IL163025A (en) 2010-06-16
JP2005514458A (ja) 2005-05-19
NO20043397L (no) 2004-08-16
ZA200405654B (en) 2005-09-28

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