PL370478A1 - Pochodne aminoindazolu jako inhibitory kinaz białkowych - Google Patents

Pochodne aminoindazolu jako inhibitory kinaz białkowych

Info

Publication number: PL370478A1
Authority: PL; Poland
Prior art keywords: protein; kinase inhibitors; aminoindazole derivatives; aminoindazole; derivatives
Prior art date: 2002-03-11

Application number

PL03370478A

Other languages

English (en)

Inventor

Gilles Dutruc-Rosset

Dominique Lesuisse

Thomas Rooney

Franck Halley

Original Assignee

Aventis Pharma S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-11

Filing date

2003-03-07

Publication date

2005-05-30

2003-03-07 Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.

2005-05-30 Publication of PL370478A1 publication Critical patent/PL370478A1/pl

Links

YDTDKKULPWTHRV-UHFFFAOYSA-N 1H-indazol-3-amine Chemical class C1=CC=C2C(N)=NNC2=C1 YDTDKKULPWTHRV-UHFFFAOYSA-N 0.000 title 1
229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
239000003909 protein kinase inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Immunology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Hematology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Virology (AREA)
Endocrinology (AREA)
Psychology (AREA)
Communicable Diseases (AREA)
Emergency Medicine (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Child & Adolescent Psychology (AREA)
Molecular Biology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PL03370478A 2002-03-11 2003-03-07 Pochodne aminoindazolu jako inhibitory kinaz białkowych PL370478A1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0202997A FR2836915B1 (fr)	2002-03-11	2002-03-11	Derives d'aminoindazoles, procede de preparation et intermediaires de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant

Publications (1)

Publication Number	Publication Date
PL370478A1 true PL370478A1 (pl)	2005-05-30

Family

ID=27763685

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL03370478A PL370478A1 (pl)	2002-03-11	2003-03-07	Pochodne aminoindazolu jako inhibitory kinaz białkowych

Country Status (30)

Country	Link
US (1)	US6949579B2 (pl)
EP (1)	EP1487804B1 (pl)
JP (2)	JP4648630B2 (pl)
KR (1)	KR101068770B1 (pl)
CN (2)	CN101962365A (pl)
AR (1)	AR038915A1 (pl)
AU (1)	AU2003242809B8 (pl)
BR (1)	BR0308373A (pl)
CA (1)	CA2478542C (pl)
FR (1)	FR2836915B1 (pl)
GT (1)	GT200300057A (pl)
HR (1)	HRP20040824B1 (pl)
IL (2)	IL163831A0 (pl)
JO (1)	JO2326B1 (pl)
MA (1)	MA27230A1 (pl)
ME (2)	ME00058B (pl)
MX (1)	MXPA04007478A (pl)
MY (1)	MY138269A (pl)
NO (1)	NO329384B1 (pl)
NZ (1)	NZ535147A (pl)
PA (1)	PA8568301A1 (pl)
PE (1)	PE20040155A1 (pl)
PL (1)	PL370478A1 (pl)
RS (1)	RS52396B (pl)
RU (1)	RU2345070C2 (pl)
SV (1)	SV2003001494A (pl)
TW (1)	TWI329103B (pl)
UY (1)	UY27713A1 (pl)
WO (1)	WO2003078403A2 (pl)
ZA (1)	ZA200406687B (pl)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2836914B1 (fr)	2002-03-11	2008-03-14	Aventis Pharma Sa	Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
MXPA04011417A (es) *	2002-05-17	2005-02-14	Pharmacia Italia Spa	Derivados de aminoindazol activos como inhibidores de cinasa, procedimiento para su preparacion y composiciones farmaceuticas que los comprenden.
JP4648703B2 (ja) *	2002-09-05	2011-03-09	アベンティス・ファーマ・ソシエテ・アノニム	医薬としての新規なアミノインダゾール誘導体及びこれらを含む医薬組成物
BR0316950A (pt) *	2002-12-02	2006-01-17	Hoffmann La Roche	Derivados de indazol como antagonistas de crf
FR2848554A1 (fr) *	2002-12-12	2004-06-18	Aventis Pharma Sa	Nouveaux derives d'aminoindazoles a titre de medicaments et compositions pharmaceutiques les renfermant
BR0316606A (pt) *	2002-12-12	2005-10-11	Aventis Pharma Sa	Derivados de aminoindazóis e sua utilização como inibidores de quinases
US7135575B2 (en)	2003-03-03	2006-11-14	Array Biopharma, Inc.	P38 inhibitors and methods of use thereof
US7994196B2 (en)	2004-02-12	2011-08-09	Mitsubishi Tanabe Pharma Corporation	Indazole compound and pharmaceutical use thereof
FR2871158A1 (fr) *	2004-06-04	2005-12-09	Aventis Pharma Sa	Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
EP1773781A2 (en)	2004-08-03	2007-04-18	Wyeth	Indazoles useful in treating cardiovascular diseases
JP2009507843A (ja) *	2005-09-09	2009-02-26	シェーリングコーポレイション	アザ縮合サイクリン依存性キナーゼ阻害剤
RS52298B (sr)	2006-01-31	2012-12-31	Array Biopharma Inc.	Inhibitori kinaze i postupak njihove upotrebe
EP2061767B1 (de)	2006-08-08	2014-12-17	Sanofi	Arylaminoaryl-alkyl-substituierte Imidazolidin-2,4-dione, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und ihre Verwendung
MX2009006401A (es)	2006-12-20	2009-06-23	Nerviano Medical Sciences Srl	Derivados de indazol como inhibidores de cinasa para el tratamiento del cancer.
DE102007022565A1 (de) *	2007-05-14	2008-11-20	Merck Patent Gmbh	Heterocyclische Indazolderivate
PT2176231T (pt) *	2007-07-20	2016-12-09	Nerviano Medical Sciences Srl	Derivados de indazol substituídos activos como inibidores de quinases
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
JP5693239B2 (ja)	2008-01-23	2015-04-01	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	４−ピリジノン化合物および癌についてのその使用
UY31968A (es)	2008-07-09	2010-01-29	Sanofi Aventis	Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos
WO2010068601A1 (en)	2008-12-08	2010-06-17	Sanofi-Aventis	A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
US8354399B2 (en) *	2008-12-18	2013-01-15	Nerviano Medical Sciences S.R.L.	Substituted indazole derivatives active as kinase inhibitors
LT2899191T (lt)	2009-04-30	2017-10-25	Glaxo Group Limited	Oksazolo pakeistieji indazolai kaip pi3-kinazės inhibitoriai
KR20120060207A (ko)	2009-08-26	2012-06-11	사노피	신규한 결정성 헤테로방향족 플루오로글리코시드 수화물, 이들 화합물을 포함하는 약제 및 이들의 용도
WO2011090738A2 (en)	2009-12-29	2011-07-28	Dana-Farber Cancer Institute, Inc.	Type ii raf kinase inhibitors
WO2011107494A1 (de)	2010-03-03	2011-09-09	Sanofi	Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8987275B2 (en) *	2010-03-16	2015-03-24	Dana-Farber Cancer Institute, Inc.	Indazole compounds and their uses
EP2582709B1 (de)	2010-06-18	2018-01-24	Sanofi	Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en)	2010-06-21	2013-09-10	Sanofi	Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
WO2012080729A2 (en)	2010-12-14	2012-06-21	Electrophoretics Limited	CASEIN KINASE 1δ (CK1δ) INHIBITORS
US8828994B2 (en)	2011-03-08	2014-09-09	Sanofi	Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120056A1 (de)	2011-03-08	2012-09-13	Sanofi	Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8895547B2 (en)	2011-03-08	2014-11-25	Sanofi	Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
WO2012120058A1 (de)	2011-03-08	2012-09-13	Sanofi	Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120051A1 (de)	2011-03-08	2012-09-13	Sanofi	Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2766349B1 (de)	2011-03-08	2016-06-01	Sanofi	Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683702B1 (de)	2011-03-08	2014-12-24	Sanofi	Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683704B1 (de)	2011-03-08	2014-12-17	Sanofi	Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683699B1 (de)	2011-03-08	2015-06-24	Sanofi	Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2567959B1 (en)	2011-09-12	2014-04-16	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013037390A1 (en)	2011-09-12	2013-03-21	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
ES2882807T3 (es)	2011-09-16	2021-12-02	Novartis Ag	Heterociclil carboxamidas N-sustituidas
WO2013045413A1 (en)	2011-09-27	2013-04-04	Sanofi	6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US9382239B2 (en)	2011-11-17	2016-07-05	Dana-Farber Cancer Institute, Inc.	Inhibitors of c-Jun-N-terminal kinase (JNK)
EP2797880B1 (en) *	2011-12-27	2017-03-01	Bio-Pharm Solutions Co., Ltd.	Phenyl carbamate compounds for use in preventing or treating epilepsy
EP2909194A1 (en)	2012-10-18	2015-08-26	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinase 7 (cdk7)
WO2014063054A1 (en)	2012-10-19	2014-04-24	Dana-Farber Cancer Institute, Inc.	Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof
USRE48175E1 (en)	2012-10-19	2020-08-25	Dana-Farber Cancer Institute, Inc.	Hydrophobically tagged small molecules as inducers of protein degradation
EP3057956B1 (en)	2013-10-18	2021-05-05	Dana-Farber Cancer Institute, Inc.	Polycyclic inhibitors of cyclin-dependent kinase 7 (cdk7)
WO2015058126A1 (en)	2013-10-18	2015-04-23	Syros Pharmaceuticals, Inc.	Heteroaromatic compounds useful for the treatment of prolferative diseases
CN103739550B (zh) *	2014-01-02	2016-06-01	中国药科大学	2,3-二甲基-6-脲-2h-吲唑类化合物及其制备方法与应用
EP3097091A1 (en) *	2014-01-24	2016-11-30	AbbVie Inc.	6-phenyl- or 6-(pyridin-3-yl)indazole derivatives and methods of use
TWI672141B (zh)	2014-02-20	2019-09-21	美商醫科泰生技	投予ｒｏｓ１突變癌細胞之分子
US9862688B2 (en)	2014-04-23	2018-01-09	Dana-Farber Cancer Institute, Inc.	Hydrophobically tagged janus kinase inhibitors and uses thereof
WO2015164614A1 (en)	2014-04-23	2015-10-29	Dana-Farber Cancer Institute, Inc.	Janus kinase inhibitors and uses thereof
KR101731624B1 (ko) *	2014-07-01	2017-05-04	광주과학기술원	세포 리프로그래밍 유도용 조성물
ES2904544T3 (es) *	2014-08-19	2022-04-05	Shanghai Haihe Pharmaceutical Co Ltd	Compuestos de indazol como inhibidores de la cinasa FGFR, preparación y uso de los mismos
CN107207471B (zh)	2014-12-02	2020-06-26	伊尼塔公司	用于治疗神经母细胞瘤的组合
EP3233840B1 (en)	2014-12-16	2018-11-21	Eudendron S.r.l.	Heterocyclic derivatives modulating activity of certain protein kinases
JP6854762B2 (ja)	2014-12-23	2021-04-07	ダナ−ファーバーキャンサーインスティテュート，インコーポレイテッド	サイクリン依存性キナーゼ７（ｃｄｋ７）の阻害剤
USRE50776E1 (en)	2015-03-27	2026-02-03	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinases
CN106279119B (zh) *	2015-05-27	2020-06-16	上海海和药物研究开发有限公司	一种新型激酶抑制剂的制备及其应用
WO2016201370A1 (en)	2015-06-12	2016-12-15	Dana-Farber Cancer Institute, Inc.	Combination therapy of transcription inhibitors and kinase inhibitors
GB201511382D0 (en)	2015-06-29	2015-08-12	Imp Innovations Ltd	Novel compounds and their use in therapy
AU2016319125B2 (en)	2015-09-09	2021-04-08	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinases
WO2017068064A1 (en) *	2015-10-22	2017-04-27	Selvita S.A.	Pyridone derivatives and their use as kinase inhibitors
CN105467027B (zh) *	2015-11-18	2021-09-21	北京万全德众医药生物技术有限公司	一种用气相色谱法分离测定米诺膦酸中间体有关物质的方法
AU2016370846B2 (en)	2015-12-18	2022-08-25	Ignyta, Inc.	Combinations for the treatment of cancer
KR102718538B1 (ko)	2017-07-19	2024-10-21	이그니타, 인코포레이티드	엔트렉티닙을 포함하는 약학적 조성물
AU2018312349A1 (en)	2017-08-01	2020-02-06	Theravance Biopharma R&D Ip, Llc	Pyrazolo and triazolo bicyclic compounds as JAK kinase inhibitors
CN111225662B (zh)	2017-10-17	2022-11-22	伊尼塔公司	药物组合物和剂型
CN110117278B (zh) *	2018-02-07	2022-07-19	石家庄以岭药业股份有限公司	烷氧基苯并五元(六元)杂环胺类化合物及其药物用途
EP3810132A4 (en)	2018-06-25	2022-06-22	Dana-Farber Cancer Institute, Inc.	TAIRE FAMILY KINASE INHIBITORS AND RELATED USES
AU2019318209B2 (en)	2018-08-10	2025-09-25	Diapin Therapeutics, Llc	Tri-peptides and treatment of metabolic, cardiovascular and inflammatory disorders
CN112955450A (zh) *	2018-10-24	2021-06-11	百时美施贵宝公司	经取代的吲哚和吲唑化合物
ES2963696T3 (es)	2018-10-24	2024-04-01	Bristol Myers Squibb Co	Compuestos diméricos de indol sustituidos
US12281126B2 (en)	2018-12-28	2025-04-22	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinase 7 and uses thereof
CN113498352A (zh)	2019-01-23	2021-10-12	施万生物制药研发Ip有限责任公司	作为jak抑制剂的咪唑并[1,5-a]吡啶、1,2,4-三唑并[4,3-a]吡啶和咪唑并[1,5-a]吡嗪
EP3965888B1 (en)	2019-05-09	2024-08-21	Bristol-Myers Squibb Company	Substituted benzimidazolone compounds
WO2021067326A1 (en)	2019-10-01	2021-04-08	Bristol-Myers Squibb Company	Substituted bicyclic heteroaryl compounds
CN114829350B (zh)	2019-10-04	2024-05-28	百时美施贵宝公司	经取代的咔唑化合物
ES3056809T3 (en) *	2019-12-04	2026-02-24	Syngenta Crop Protection Ag	Pesticidally active fused bicyclic heteroaromatic amino compounds
WO2023122782A2 (en) *	2021-12-23	2023-06-29	The Katholieke Universiteit Leuven	Indoles, indazoles, and related analogs for inhibiting yap/taz-tead
WO2024052685A1 (en)	2022-09-09	2024-03-14	MyricX Pharma Limited	Cytotoxic imidazo[1,2-a]pyridine compounds and their use in therapy
WO2025175264A1 (en) *	2024-02-17	2025-08-21	Padarn Therapeutics, Inc.	Inhibitors of cdk2

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3133081A (en) *		1964-05-12		J-aminoindazole derivatives
US2971842A (en) *	1956-03-21	1961-02-14	Gen Aniline & Film Corp	Light sensitive layers for photomechanical reproduction
DE1280878B (de) *	1961-11-30	1968-10-24	Smith Kline French Lab	3-Aminoindazole
GB965511A (en) *	1961-11-30	1964-07-29	Smith Kline French Lab	Improvements in or relating to 3-aminoindazole derivatives
BE626284A (pl) *	1962-04-28
DE1301319B (de) *	1965-09-08	1969-08-21	Siegfried Ag	3,5-Diaminoindazol, dessen Salze, sowie Verfahren zu deren Herstellung
US3720671A (en) *	1970-10-05	1973-03-13	Ciba Geigy Ag	Polycyclic dyestuffs
FR2111641A2 (en) *	1970-10-09	1972-06-09	Geigy Ag J R	Polycyclic cpds as dispersion dyestuffs for - hydrophobic organic fibres
DE2458965C3 (de) *	1974-12-13	1979-10-11	Bayer Ag, 5090 Leverkusen	3-Amino-indazol-N-carbonsäure-Derivate, Verfahren zu ihrer Herstellung sowie sie enthaltende Arzneimittel
JPS51143010A (en) *	1975-06-04	1976-12-09	Kao Corp	Stable bleaching detergent composition
SU742430A1 (ru) *	1978-11-09	1980-06-25	Предприятие П/Я А-7850	Способ получени 3-амино-5-нитроиндазола
EP0090972B1 (en) *	1982-03-17	1990-05-30	Asahi Kasei Kogyo Kabushiki Kaisha	Indazole derivatives
JPS58159473A (ja) *	1982-03-17	1983-09-21	Asahi Chem Ind Co Ltd	ベンゼン環置換基を有する新規な１位置換インダゾ−ル誘導体およびその製造法
KR940021073A (ko) *	1993-03-02	1994-10-17	미야베 요시가즈	알쯔하이머병의 예방 또는 치료제, 그 스크리닝 방법 및 인간 유래의 타우 단백질 키나아제 i
KR100423899B1 (ko) *	2000-05-10	2004-03-24	주식회사 엘지생명과학	세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸

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Also Published As

Publication number	Publication date
SV2003001494A (es)	2003-07-10
RS79504A (sr)	2006-12-15
AR038915A1 (es)	2005-02-02
JP4648630B2 (ja)	2011-03-09
FR2836915A1 (fr)	2003-09-12
JP2005530711A (ja)	2005-10-13
ZA200406687B (en)	2005-10-26
MY138269A (en)	2009-05-29
TW200403226A (en)	2004-03-01
MA27230A1 (fr)	2005-02-01
HRP20040824A2 (en)	2005-06-30
HRP20040824B1 (hr)	2013-05-31
WO2003078403A2 (fr)	2003-09-25
CA2478542C (fr)	2012-02-21
RU2004129780A (ru)	2005-04-10
PA8568301A1 (es)	2005-02-04
FR2836915B1 (fr)	2008-01-11
CN1656078A (zh)	2005-08-17
JP5315287B2 (ja)	2013-10-16
CA2478542A1 (fr)	2003-09-25
MEP16108A (en)	2010-06-10
US20040014802A1 (en)	2004-01-22
GT200300057A (es)	2006-10-19
US6949579B2 (en)	2005-09-27
NO329384B1 (no)	2010-10-11
IL163831A0 (en)	2005-12-18
EP1487804A2 (fr)	2004-12-22
RS52396B (sr)	2013-02-28
MXPA04007478A (es)	2004-11-10
KR20040091121A (ko)	2004-10-27
EP1487804B1 (fr)	2014-02-26
NZ535147A (en)	2007-08-31
JO2326B1 (en)	2006-06-28
UY27713A1 (es)	2003-09-30
IL163831A (en)	2010-12-30
AU2003242809B2 (en)	2010-03-18
NO20044137L (no)	2004-11-25
PE20040155A1 (es)	2004-04-18
KR101068770B1 (ko)	2011-09-30
CN101962365A (zh)	2011-02-02
AU2003242809A1 (en)	2003-09-29
JP2010222357A (ja)	2010-10-07
RU2345070C2 (ru)	2009-01-27
TWI329103B (en)	2010-08-21
WO2003078403A3 (fr)	2004-04-22
AU2003242809B8 (en)	2010-04-15
BR0308373A (pt)	2005-01-11
ME00058B (me)	2010-10-10

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