PL371216A1 - Pochodne izochinoliny - Google Patents

Pochodne izochinoliny

Info

Publication number: PL371216A1
Authority: PL; Poland
Prior art keywords: isoquinoline derivatives; isoquinoline; derivatives
Prior art date: 2002-03-06

Application number

PL03371216A

Other languages

English (en)

Inventor

Matthias Wiesner

Simon Goodman

Horst Kessler

Georgette Thumshirn

Dirk Weber

Dirk Gottschling

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-06

Filing date

2003-02-07

Publication date

2005-06-13

2003-02-07 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2005-06-13 Publication of PL371216A1 publication Critical patent/PL371216A1/pl

Links

125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Oncology (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Communicable Diseases (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Diabetes (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

PL03371216A 2002-03-06 2003-02-07 Pochodne izochinoliny PL371216A1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE10209692A DE10209692A1 (de)	2002-03-06	2002-03-06	Isochinolinderivate

Publications (1)

Publication Number	Publication Date
PL371216A1 true PL371216A1 (pl)	2005-06-13

Family

ID=27762712

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL03371216A PL371216A1 (pl)	2002-03-06	2003-02-07	Pochodne izochinoliny

Country Status (15)

Country	Link
US (1)	US7060707B2 (pl)
EP (1)	EP1480971A1 (pl)
JP (1)	JP2005525363A (pl)
KR (1)	KR20040089704A (pl)
CN (1)	CN1639150A (pl)
AR (1)	AR038869A1 (pl)
AU (1)	AU2003218980A1 (pl)
BR (1)	BR0308195A (pl)
CA (1)	CA2478618A1 (pl)
DE (1)	DE10209692A1 (pl)
MX (1)	MXPA04008469A (pl)
PL (1)	PL371216A1 (pl)
RU (1)	RU2004129734A (pl)
WO (1)	WO2003074512A1 (pl)
ZA (1)	ZA200408027B (pl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100735639B1 (ko) *	2004-12-29	2007-07-04	한미약품 주식회사	암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 및 이의제조방법
CN101360736A (zh) *	2005-11-23	2009-02-04	阿斯利康(瑞典)有限公司	L-丙氨酸衍生物
JP2009539815A (ja) *	2006-06-09	2009-11-19	アストラゼネカアクチボラグ	固形腫瘍の治療用のａ５ｂ１アンタゴニストとしてのＮ−（ベンゾイル）−Ｏ−［２−（ピリジン−２−イルアミノ）エチル］−Ｌ−チロシン誘導体と関連化合物
WO2008093065A1 (en) *	2007-01-29	2008-08-07	Astrazeneca Ab	L-ALANINE DERIVATIVES AS α5βL ANTAGONISTS
WO2008125811A1 (en) *	2007-04-11	2008-10-23	Astrazeneca Ab	N-[HETEROARYLCARBONYL]-S-THIENYL-L-ALANINE DERIVATIVES AS α5β1 ANTAGONISTS
CN101318994B (zh) *	2007-06-04	2012-03-28	北京大学	取代-四氢异喹啉-3-羧酸化合物、其制备方法及应用
CN101318995B (zh) *	2007-06-04	2011-04-20	北京大学	取代四氢异喹啉化合物、其制备方法及用途
CN102127145B (zh) *	2007-06-04	2012-07-04	北京大学	取代四氢异喹啉化合物、其制备方法及用途
CN102225965B (zh) *	2007-06-04	2013-03-27	北京大学	取代-四氢异喹啉-3-羧酸化合物、其制备方法及应用
CN101497651B (zh) *	2008-01-30	2012-06-27	首都医科大学	具有溶血栓活性的化合物、其制备方法、其应用
US8883823B2 (en)	2012-07-16	2014-11-11	Fibrogen, Inc.	Crystalline forms of a prolyl hydroxylase inhibitor
IL296484B2 (en)	2013-06-06	2025-03-01	Fibrogen Inc	Pharmaceutical formulations of HIF hydroxylase inhibitor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1999011658A1 (en) *	1997-08-29	1999-03-11	Proteus Molecular Design Ltd.	Meta-benzamidine derivatives as serin protease inhibitors
US6740682B2 (en)	1997-08-29	2004-05-25	Tularik Limited	Meta-benzamidine derivatives as serine protease inhibitors
CA2375920A1 (en) *	1999-06-14	2000-12-21	Eli Lilly And Company	Compounds
DE19932796A1 (de)	1999-07-14	2001-01-18	Merck Patent Gmbh	Diacylhydrazinderivate

2002
- 2002-03-06 DE DE10209692A patent/DE10209692A1/de not_active Withdrawn
2003
- 2003-02-07 EP EP03714735A patent/EP1480971A1/de not_active Withdrawn
- 2003-02-07 JP JP2003572980A patent/JP2005525363A/ja not_active Withdrawn
- 2003-02-07 RU RU2004129734/04A patent/RU2004129734A/ru not_active Application Discontinuation
- 2003-02-07 PL PL03371216A patent/PL371216A1/pl unknown
- 2003-02-07 CA CA002478618A patent/CA2478618A1/en not_active Abandoned
- 2003-02-07 MX MXPA04008469A patent/MXPA04008469A/es not_active Application Discontinuation
- 2003-02-07 US US10/506,820 patent/US7060707B2/en not_active Expired - Fee Related
- 2003-02-07 CN CNA038051753A patent/CN1639150A/zh active Pending
- 2003-02-07 BR BR0308195-8A patent/BR0308195A/pt not_active IP Right Cessation
- 2003-02-07 AU AU2003218980A patent/AU2003218980A1/en not_active Abandoned
- 2003-02-07 KR KR10-2004-7013809A patent/KR20040089704A/ko not_active Withdrawn
- 2003-02-07 WO PCT/EP2003/001248 patent/WO2003074512A1/de not_active Ceased
- 2003-03-05 AR ARP030100724A patent/AR038869A1/es not_active Application Discontinuation
2004
- 2004-10-05 ZA ZA200408027A patent/ZA200408027B/en unknown

Also Published As

Publication number	Publication date
RU2004129734A (ru)	2005-07-10
DE10209692A1 (de)	2003-09-18
ZA200408027B (en)	2005-07-05
US20050090525A1 (en)	2005-04-28
EP1480971A1 (de)	2004-12-01
CA2478618A1 (en)	2003-09-12
KR20040089704A (ko)	2004-10-21
WO2003074512A1 (de)	2003-09-12
MXPA04008469A (es)	2004-12-06
AR038869A1 (es)	2005-02-02
CN1639150A (zh)	2005-07-13
AU2003218980A1 (en)	2003-09-16
JP2005525363A (ja)	2005-08-25
US7060707B2 (en)	2006-06-13
BR0308195A (pt)	2005-01-04

Legal Events

Date	Code	Title	Description
2010-03-31	DISC	Decisions on discontinuance of the proceedings (taken after the publication of the particulars of the applications)

Publication	Publication Date	Title
AP1850A (en)	2008-05-26	Spiroindolineplperidine derivatives
EG24050A (en)	2008-04-13	Heterocylocarboxamide derivatives
PL374718A1 (pl)	2005-10-31	Azolidynono-winylowe pochodne skondensowanego benzenu
IL166121A0 (en)	2006-01-15	Indole-3-sulphur derivatives
EP1522540A4 (en)	2011-08-10	AZAARENE DERIVATIVES
PL376475A1 (pl)	2005-12-27	Pochodne N-podstawionej 2-oksodihydropirydyny
HRP20041031A2 (en)	2005-06-30	Quinolinone derivatives
GB0317665D0 (en)	2003-09-03	Qinazoline derivatives
PL1682493T3 (pl)	2009-06-30	Pochodne amidoacetonitrylu
ZA200500471B (en)	2006-07-26	N-biarylmethyl aminocycloalkanecarboxamide derivatives
PL1606277T3 (pl)	2008-10-31	Pochodne imidazol-4-iloetynylo-pirydyny
AU2003227712A1 (en)	2003-12-02	Tetrahydroisoquinoline derivatives
PL373697A1 (pl)	2005-09-05	Pochodne izochinoliny
PL376997A1 (pl)	2006-01-23	Pochodne tetrahydrochinoliny
IL165572A0 (en)	2006-01-15	1-Ä(indoÜ-3-yl)carbonylÜpiperazine derivatives
IL175189A0 (en)	2006-09-05	N-thiazol-2-yl-benzamide derivatives
PL377318A1 (pl)	2006-01-23	Pochodne tetrahydrochinoliny
AU2003222659A8 (en)	2003-11-03	23-o-substituted 5-o-mycaminosyltylonide derivatives
EG24415A (en)	2009-05-25	Quinoline derivatives
EP1531854A4 (en)	2006-06-28	O-DERIVATED NOCATHIACIN DERIVATIVES
GB0319793D0 (en)	2003-09-24	Pyridinylmorpholine derivatives
GB0213488D0 (en)	2002-07-24	2-Naphthamide derivatives
AU2003243397A8 (en)	2003-12-19	Homo-camptothecin derivatives
AU2003290095A8 (en)	2004-07-14	Quinolizidine derivatives
GB0219894D0 (en)	2002-10-02	Dihydropyridinone derivatives