PL371948A1 - Analogi himbacyny jako antagoniści receptora trombinowego - Google Patents

Analogi himbacyny jako antagoniści receptora trombinowego

Info

Publication number: PL371948A1
Authority: PL; Poland
Prior art keywords: himbacine; analogues; receptor antagonists; thrombin receptor; thrombin
Prior art date: 2001-10-18

Application number

PL02371948A

Other languages

English (en)

Inventor

Samuel Chackalamannil

Mariappan V. Chelliah

Martin C. Clasby

Yan Xia

Original Assignee

Schering Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-18

Filing date

2002-10-16

Publication date

2005-07-11

2002-10-16 Application filed by Schering Corporation filed Critical Schering Corporation

2005-07-11 Publication of PL371948A1 publication Critical patent/PL371948A1/pl

Links

FMPNFDSPHNUFOS-LPJDIUFZSA-N himbacine Chemical class C(/[C@@H]1[C@H]2CCCC[C@@H]2C[C@@H]2C(=O)O[C@H]([C@H]12)C)=C\[C@H]1CCC[C@H](C)N1C FMPNFDSPHNUFOS-LPJDIUFZSA-N 0.000 title 1
239000003856 thrombin receptor antagonist Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PL02371948A 2001-10-18 2002-10-16 Analogi himbacyny jako antagoniści receptora trombinowego PL371948A1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US33035901P	2001-10-18	2001-10-18

Publications (1)

Publication Number	Publication Date
PL371948A1 true PL371948A1 (pl)	2005-07-11

Family

ID=23289411

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL02371948A PL371948A1 (pl)	2001-10-18	2002-10-16	Analogi himbacyny jako antagoniści receptora trombinowego

Country Status (23)

Country	Link
US (2)	US7037920B2 (pl)
EP (1)	EP1436298B1 (pl)
JP (2)	JP4307260B2 (pl)
KR (1)	KR100960170B1 (pl)
CN (1)	CN100369917C (pl)
AR (1)	AR036832A1 (pl)
AT (1)	ATE525378T1 (pl)
AU (1)	AU2002335031C1 (pl)
BR (1)	BR0213967A (pl)
CA (1)	CA2463628A1 (pl)
CO (1)	CO5570668A2 (pl)
EC (1)	ECSP045064A (pl)
HU (1)	HUP0500443A3 (pl)
IL (1)	IL160918A0 (pl)
MX (1)	MXPA04003610A (pl)
MY (1)	MY139335A (pl)
NO (1)	NO329349B1 (pl)
NZ (1)	NZ531869A (pl)
PE (1)	PE20030808A1 (pl)
PL (1)	PL371948A1 (pl)
RU (1)	RU2319704C9 (pl)
WO (1)	WO2003033501A1 (pl)
ZA (1)	ZA200402849B (pl)

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US6346510B1 (en)	1995-10-23	2002-02-12	The Children's Medical Center Corporation	Therapeutic antiangiogenic endostatin compositions
US7235567B2 (en) *	2000-06-15	2007-06-26	Schering Corporation	Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist
US7488742B2 (en) *	2000-06-15	2009-02-10	Schering Corporation	Thrombin receptor antagonists
JP4558331B2 (ja)	2002-04-16	2010-10-06	シェーリングコーポレイション	三環式トロンビンレセプターアンタゴニスト
US20070243632A1 (en) *	2003-07-08	2007-10-18	Coller Barry S	Methods for measuring platelet reactivity of patients that have received drug eluting stents
ATE536889T1 (de)	2003-07-08	2011-12-15	Accumetrics Inc	Kontrollierte thrombozyten-aktivierung zur überwachung der behandlung von adp-antagonisten
MY143987A (en) *	2004-05-28	2011-07-29	Schering Corp	Constrained himbacine analogs as thrombin receptor antagonists
JP2008510726A (ja) *	2004-08-20	2008-04-10	エントレメッドインコーポレイテッド	プロテイナーゼ活性化受容体アンタゴニストを含む組成物および方法
AU2005294265A1 (en) *	2004-10-06	2006-04-20	University Of Rochester	Treatment of pulmonary hypertension using an agent that inhibits a tissue factor pathway
EP1802609A2 (en) *	2004-10-08	2007-07-04	Schering Corporation	Thrombin receptor antagonists
CN101137636A (zh) *	2005-01-14	2008-03-05	先灵公司	Himbacine类似物的外型选择性合成
AR052870A1 (es) *	2005-01-14	2007-04-11	Schering Corp	Sintesis de analogos de himbacina
EP2206697B1 (en)	2005-01-14	2011-10-26	Schering Corporation	Exo- and diastereo-selective syntheses of himbacine analogs
US7776889B2 (en) *	2005-03-31	2010-08-17	Schering Corporation	Spirocyclic thrombin receptor antagonists
US7595169B2 (en) *	2005-04-27	2009-09-29	Accumetrics, Inc.	Method for determining percent platelet aggregation
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WO2007075809A2 (en) *	2005-12-22	2007-07-05	Schering Corporation	Oxazoloisoquinoline derivatives as thrombin receptor antagonists
BRPI0620641A2 (pt) *	2005-12-22	2011-11-16	Schering Corp	usos de compostos antagonistas de receptor de trombina na profilaxia de complicações de cirurgia cardiopulmonar
KR20080104352A (ko) *	2006-03-29	2008-12-02	쉐링 코포레이션	트롬빈 수용체 길항제로서 유용한 모노사이클릭 및 비사이클릭 힘바신 유도체
US8003803B2 (en) *	2006-04-13	2011-08-23	Schering Corporation	Fused ring thrombin receptor antagonists
EP2032560B1 (en)	2006-06-29	2013-05-01	Merck Sharp & Dohme Corp.	Substituted bicyclic and tricyclic thrombin receptor antagonists
AR061727A1 (es) *	2006-06-30	2008-09-17	Schering Corp	Sintesis de dietil [[ 5- ( 3-fluorofenil) -piridin -2il] metil] fosfonato
TWI367112B (en) *	2006-06-30	2012-07-01	Schering Corp	Immediate-release tablet formulations of a thrombin receptor antagonist
TWI343262B (en) *	2006-09-26	2011-06-11	Schering Corp	Rapidly disintegrating lyophilized oral formulations of a thrombin receptor antagonist
CN101553484A (zh) *	2006-10-04	2009-10-07	先灵公司	以喜巴辛的被改质三环单位为基础的凝血酶受体拮抗剂
AU2007305269A1 (en) *	2006-10-04	2008-04-10	Schering Corporation	Bicyclic and tricyclic derivatives as thrombin receptor antagonists
EP2120879A2 (en) *	2006-12-22	2009-11-25	Schering Corporation	Disintegration promoters in solid dose wet granulation formulations
BRPI0809095A2 (pt) *	2007-03-23	2014-09-09	Schering Corp	Redução de eventos adversos após intervenção percutânea através de uso de um antagonista de receptor de trombina
KR20100017576A (ko) *	2007-05-03	2010-02-16	아큐메트릭스, 인크.	트롬빈 수용체 길항제에 의한 혈소판 응집 억제의 측정 방법
CN101981034B (zh)	2008-02-05	2013-08-14	赛诺菲-安万特	作为par1抑制剂的三唑并哒嗪、其制备及其制备药物的用途
CN102099340A (zh)	2008-05-19	2011-06-15	先灵公司	作为因子ixa抑制剂的杂环化合物
HRP20131049T1 (hr)	2009-06-04	2013-12-06	Merck Sharp & Dohme Corp.	Aktivni metabolit antagonista trombinskog receptora
AU2010259003A1 (en)	2009-06-08	2011-11-10	Merck Sharp & Dohme Corp.	A thrombin receptor antagonist and clopidogrel fixed dose tablet
WO2011017296A1 (en)	2009-08-04	2011-02-10	Schering Corporation	4, 5, 6-trisubstituted pyrimidine derivatives as factor ixa inhibitors
WO2013134012A1 (en)	2012-03-06	2013-09-12	Merck Sharp & Dohme Corp.	Preparation and use of bicyclic himbacine derivatives as par-receptor antagonists
US20160200715A1 (en)	2013-08-22	2016-07-14	Merck Sharp & Dohme Corp.	Preparation and use of 7a-heterocycle substituted- 6,6-difluoro bicyclic himbacine derivatives as par-1 receptor antagonists
US9808473B2 (en)	2013-08-22	2017-11-07	Merck Sharp & Dohme Corp.	Preparation and use of 3-pyridyl substituted-6,6-difluoro bicyclic himbacine derivatives as par-1 receptor antagonists
US9701669B2 (en)	2013-08-22	2017-07-11	Merck Sharp & Dohme Corp.	Preparation and use of 7a-amide substituted- 6,6-difluoro bicyclic himbacine derivatives as PAR-1 receptor antagonists
WO2015160636A1 (en)	2014-04-16	2015-10-22	Merck Sharp & Dohme Corp.	Factor ixa inhibitors
CN104610330A (zh) *	2015-02-25	2015-05-13	成都安斯利生物医药有限公司	一种制备(e)-3-丙烯酸乙酯频呐硼酸酯的方法
ES3048448T3 (en)	2020-07-22	2025-12-10	Janssen Pharmaceutica Nv	Compounds useful as factor xia inhibitors
US11845748B2 (en)	2021-03-18	2023-12-19	Janssen Pharmaceutica Nv	Bicyclic pyridine N-oxide derivatives useful as a factor XIa inhibitors
US11919881B2 (en)	2021-03-18	2024-03-05	Janssen Pharmaceutica Nv	Substituted pyridine N-oxide derivatives useful as a factor XIa inhibitors
US11814364B2 (en)	2021-03-18	2023-11-14	Janssen Pharmaceutica Nv	Pyridine N-oxide derivatives useful as factor XIa inhibitors
US11897880B2 (en)	2021-04-30	2024-02-13	Janssen Pharmaceutica Nv	7,8-dihydrobenzo[e]pyrido[3,4-c]azocine-2,5(3H,6H)-dione derivatives useful as a factor XIa inhibitors
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US12286429B2 (en)	2021-07-22	2025-04-29	Janssen Pharmaceutica Nv	5-oxo-1,2,3,5,8,8a-hexahydroindolizine-3-carboxamide derivatives useful as a factor XIa inhibitors

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2002
- 2002-10-16 KR KR1020047005435A patent/KR100960170B1/ko not_active Expired - Fee Related
- 2002-10-16 WO PCT/US2002/032936 patent/WO2003033501A1/en not_active Ceased
- 2002-10-16 JP JP2003536240A patent/JP4307260B2/ja not_active Expired - Fee Related
- 2002-10-16 RU RU2004115114/04A patent/RU2319704C9/ru not_active IP Right Cessation
- 2002-10-16 AR ARP020103876A patent/AR036832A1/es unknown
- 2002-10-16 CA CA002463628A patent/CA2463628A1/en not_active Abandoned
- 2002-10-16 IL IL16091802A patent/IL160918A0/xx not_active IP Right Cessation
- 2002-10-16 PE PE2002001022A patent/PE20030808A1/es not_active Application Discontinuation
- 2002-10-16 HU HU0500443A patent/HUP0500443A3/hu unknown
- 2002-10-16 NZ NZ531869A patent/NZ531869A/en not_active IP Right Cessation
- 2002-10-16 PL PL02371948A patent/PL371948A1/pl not_active Application Discontinuation
- 2002-10-16 US US10/271,715 patent/US7037920B2/en not_active Expired - Fee Related
- 2002-10-16 AU AU2002335031A patent/AU2002335031C1/en not_active Ceased
- 2002-10-16 AT AT02801732T patent/ATE525378T1/de not_active IP Right Cessation
- 2002-10-16 BR BR0213967-7A patent/BR0213967A/pt not_active IP Right Cessation
- 2002-10-16 CN CNB028206665A patent/CN100369917C/zh not_active Expired - Fee Related
- 2002-10-16 MY MYPI20023859A patent/MY139335A/en unknown
- 2002-10-16 EP EP02801732A patent/EP1436298B1/en not_active Expired - Lifetime
- 2002-10-16 MX MXPA04003610A patent/MXPA04003610A/es active IP Right Grant
2004
- 2004-04-15 EC EC2004005064A patent/ECSP045064A/es unknown
- 2004-04-15 ZA ZA200402849A patent/ZA200402849B/xx unknown
- 2004-04-16 CO CO04034781A patent/CO5570668A2/es not_active Application Discontinuation
- 2004-05-14 NO NO20042021A patent/NO329349B1/no not_active IP Right Cessation
2005
- 2005-12-19 US US11/311,083 patent/US20060106050A1/en not_active Abandoned
2008
- 2008-09-17 JP JP2008238716A patent/JP2009029820A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
WO2003033501A1 (en)	2003-04-24
JP4307260B2 (ja)	2009-08-05
EP1436298B1 (en)	2011-09-21
CA2463628A1 (en)	2003-04-24
CO5570668A2 (es)	2005-10-31
NZ531869A (en)	2006-11-30
AU2002335031B2 (en)	2005-06-30
BR0213967A (pt)	2005-08-30
AR036832A1 (es)	2004-10-06
ZA200402849B (en)	2005-01-14
MXPA04003610A (es)	2004-07-27
HUP0500443A3 (en)	2009-12-28
AU2002335031C1 (en)	2006-11-16
RU2319704C2 (ru)	2008-03-20
US7037920B2 (en)	2006-05-02
CN1571789A (zh)	2005-01-26
CN100369917C (zh)	2008-02-20
JP2009029820A (ja)	2009-02-12
RU2004115114A (ru)	2005-10-27
IL160918A0 (en)	2004-08-31
ATE525378T1 (de)	2011-10-15
JP2005529841A (ja)	2005-10-06
KR20050036845A (ko)	2005-04-20
EP1436298A1 (en)	2004-07-14
MY139335A (en)	2009-09-30
HUP0500443A2 (hu)	2005-08-29
US20030203927A1 (en)	2003-10-30
NO329349B1 (no)	2010-10-04
KR100960170B1 (ko)	2010-05-26
RU2319704C9 (ru)	2008-08-20
ECSP045064A (es)	2004-05-28
PE20030808A1 (es)	2003-09-22
NO20042021L (no)	2004-05-14
US20060106050A1 (en)	2006-05-18

Legal Events

Date	Code	Title	Description
2011-10-31	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)

Publication	Publication Date	Title
IL160918A0 (en)	2004-08-31	Himbacine analogues as thrombin receptor antagonists
IL153308A0 (en)	2003-07-06	Thrombin receptor antagonists
IL174538A0 (en)	2006-08-01	Thrombin receptor antagonists
IL164585A0 (en)	2005-12-18	Tricyclic thrombin receptor antagonists
EP1553075A4 (en)	2009-11-04	LPA Receptor Antagonists
IL165841A0 (en)	2006-01-15	Mchir antagonists
SI1562595T1 (sl)	2008-10-31	Diaril etri kot antagonisti opiodnega receptorja
AU2003261392A8 (en)	2004-02-23	M3muscarinic acetylcholine receptor antagonists
PL376509A1 (pl)	2005-12-27	Antagoniści IL-15
EP1351933A4 (en)	2005-09-07	ANTAGONISTS OF IL-8 RECEPTORS
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