PL372084A1 - Związek pochodnej 8-azaprostaglandyny i środek zawierający ten związek jako składnik aktywny - Google Patents

Związek pochodnej 8-azaprostaglandyny i środek zawierający ten związek jako składnik aktywny

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Publication number
PL372084A1
PL372084A1 PL03372084A PL37208403A PL372084A1 PL 372084 A1 PL372084 A1 PL 372084A1 PL 03372084 A PL03372084 A PL 03372084A PL 37208403 A PL37208403 A PL 37208403A PL 372084 A1 PL372084 A1 PL 372084A1
Authority
PL
Poland
Prior art keywords
compounds
active ingredient
drugs containing
azaprostaglandin derivative
azaprostaglandin
Prior art date
Application number
PL03372084A
Other languages
English (en)
Inventor
Kousuke Tani
Kaoru Kobayashi
Toru Maruyama
Tohru Kambe
Mikio Ogawa
Tsutomu Shiroya
Original Assignee
Ono Pharmaceutical Co, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co, Ltd. filed Critical Ono Pharmaceutical Co, Ltd.
Publication of PL372084A1 publication Critical patent/PL372084A1/pl

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    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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PL03372084A 2002-03-05 2003-03-04 Związek pochodnej 8-azaprostaglandyny i środek zawierający ten związek jako składnik aktywny PL372084A1 (pl)

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JP2002058487 2002-03-05
JP2002216567 2002-07-25
JP2003013447 2003-01-22

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PL372084A1 true PL372084A1 (pl) 2005-07-11

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PL03372084A PL372084A1 (pl) 2002-03-05 2003-03-04 Związek pochodnej 8-azaprostaglandyny i środek zawierający ten związek jako składnik aktywny

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US (3) US7402605B2 (pl)
EP (1) EP1481976B1 (pl)
JP (2) JP4547912B2 (pl)
KR (1) KR100704215B1 (pl)
CN (1) CN1653046A (pl)
AU (1) AU2003211574A1 (pl)
BR (1) BR0308166A (pl)
CA (1) CA2477715A1 (pl)
IL (1) IL163866A0 (pl)
MX (1) MXPA04008596A (pl)
NO (1) NO20043702L (pl)
NZ (1) NZ535024A (pl)
PL (1) PL372084A1 (pl)
RU (1) RU2306309C2 (pl)
TW (1) TW200305425A (pl)
WO (1) WO2003074483A1 (pl)

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JP4754820B2 (ja) * 2002-06-10 2011-08-24 メルク セローノ ソシエテ アノニム プロスタグランジン作動薬としてのγラクタムおよびその使用
WO2004019938A1 (en) * 2002-08-28 2004-03-11 Merck Frosst Canada & Co. Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma
WO2004037813A1 (en) * 2002-10-25 2004-05-06 Merck Frosst Canada & Co. Pyrrolidin-2-on derivatives as ep4 receptor agonists
US20070167403A1 (en) * 2003-04-03 2007-07-19 Yoshifumi Takenobu Remedy for spinal canal stenosis
WO2005009468A1 (ja) 2003-07-25 2005-02-03 Ono Pharmaceutical Co., Ltd. 軟骨関連疾患治療剤
EP1682127B1 (en) * 2003-11-14 2009-07-29 Vertex Pharmaceuticals Incorporated Thiazoles and oxazoles useful as modulators of atp-binding cassette transporters
US7833995B2 (en) 2003-12-05 2010-11-16 Ono Pharmaceutical Co., Ltd. Blood flow promoters for cauda equina tissues
WO2005072743A1 (ja) * 2004-01-30 2005-08-11 Ono Pharmaceutical Co., Ltd. 気管支拡張剤
JP2006008568A (ja) * 2004-06-24 2006-01-12 Cyclochem:Kk IgE抗体抑制剤および食品
JP4893999B2 (ja) * 2004-10-22 2012-03-07 小野薬品工業株式会社 吸入用医薬組成物
US7547685B2 (en) 2004-11-08 2009-06-16 Allergan, Inc. Therapeutic substituted pyrrolidone compounds
WO2006063048A2 (en) * 2004-12-06 2006-06-15 Avigen, Inc. Ibudilast for treating neuropathic pain and associated syndromes
BRPI0605926A2 (pt) 2005-01-14 2009-05-26 Allergan Inc ciclopentanos substituìdos ou ciclopentanonas como agentes terapêuticos
CN101137622A (zh) * 2005-03-10 2008-03-05 阿勒根公司 作为治疗剂的取代的γ内酰胺
CA2610692C (en) * 2005-06-03 2014-11-25 Ono Pharmaceutical Co., Ltd. Ep2 agonists which may have an ep3 agonistic effect for regeneration and/or protection of nerves
WO2007005176A1 (en) * 2005-06-29 2007-01-11 Allergan, Inc. Pyrrolidinones for the treatment of glaucoma and ocular hypertension
US7893107B2 (en) * 2005-11-30 2011-02-22 Allergan, Inc. Therapeutic methods using prostaglandin EP4 agonist components
US7323591B2 (en) 2006-01-10 2008-01-29 Allergan, Inc. Substituted cyclopentanes or cyclopentanones as therapeutic agents
US20070232660A1 (en) * 2006-04-04 2007-10-04 Allergan, Inc. Therapeutic and delivery methods of prostaglandin ep4 agonists
US7557095B2 (en) * 2006-05-12 2009-07-07 Allergan, Inc. Therapeutic compounds
US7507833B2 (en) * 2006-08-10 2009-03-24 Allergan, Inc. Therapeutic N-aryl or N-heteroaryl pyrazolidine and pyrazolidinone derivatives
WO2008021975A2 (en) * 2006-08-11 2008-02-21 Allergan, Inc. Therapeutic lactams
WO2008028032A2 (en) 2006-09-01 2008-03-06 Allergan, Inc. Therapeutic substituted hydantoins and related compounds
JP5271272B2 (ja) 2006-11-16 2013-08-21 ジェンムス ファーマ インコーポレイティド A型インフルエンザウィルス感染の治療のための薬剤としてのep2およびep4作動薬
KR20080055355A (ko) * 2006-12-15 2008-06-19 에스케이케미칼주식회사 보관안정성이 우수한 클로피도그렐 함유 포접 복합체
WO2008076703A1 (en) * 2006-12-18 2008-06-26 Allergan, Inc. Methods and compositions for treating gastrointestinal disorders
US20080181876A1 (en) * 2007-01-30 2008-07-31 Johnson Kirk W Methods for treating acute and subchronic pain
WO2008094912A2 (en) * 2007-01-31 2008-08-07 Allergan, Inc. Substituted gamma lactams as therapeutic agents
BRPI0807600A2 (pt) * 2007-02-15 2014-07-22 Allergan Inc Gama-lactamas para o tratamento de glaucoma ou pressão intraocular elevada
NZ578988A (en) 2007-02-16 2012-03-30 Ono Pharmaceutical Co Therapeutic agent for urinary excretion disorder
US7589213B2 (en) * 2007-04-27 2009-09-15 Old David W Therapeutic substituted lactams
US20080287402A1 (en) * 2007-05-03 2008-11-20 Johnson Kirk W Use of a glial attenuator to prevent amplified pain responses caused by glial priming
AU2008246579A1 (en) * 2007-05-08 2008-11-13 National University Corporation, Hamamatsu University School Of Medicine Cytotoxic T cell activator comprising EP4 agonist
SI2264009T1 (sl) 2008-03-12 2019-05-31 Ube Industries, Ltd. Spojina piridilaminoocetne kisline
US7956055B2 (en) 2008-03-25 2011-06-07 Allergan, Inc. Substituted gamma lactams as therapeutic agents
MY150518A (en) * 2008-04-24 2014-01-30 Allergan Inc Substituted gamma lactams as therapeutic agents
EP2291346A2 (en) 2008-05-15 2011-03-09 Allergan, Inc. Therapeutic substituted cyclopentanes
EP2149552A1 (de) 2008-07-30 2010-02-03 Bayer Schering Pharma AG 5,6 substituierte Benzamid-Derivate als Modulatoren des EP2-Rezeptors
EP2149551A1 (de) 2008-07-30 2010-02-03 Bayer Schering Pharma AG N-(Indol-3-ylalkyl)-(hetero)arylamidderivate als Modulatoren des EP2-Rezeptors
EP2149554A1 (de) 2008-07-30 2010-02-03 Bayer Schering Pharma Aktiengesellschaft Indolylamide als Modulatoren des EP2-Rezeptors
PT2343292E (pt) 2008-09-10 2014-11-04 Kaken Pharma Co Ltd Novo derivado de prostaglandina i2
HUE026742T2 (en) 2009-03-30 2016-07-28 Ube Industries A pharmaceutical composition for the treatment or prevention of glaucoma
BRPI1013152B1 (pt) 2009-06-10 2019-06-18 Ono Pharmaceutical Co., Ltd. Composto, composição farmacêutica e medicamento que tem atividade de contração muscular destrusora e atividade muscular relaxante dos esfincteres uretais
GB2474120B (en) * 2009-10-01 2011-12-21 Amira Pharmaceuticals Inc Compounds as Lysophosphatidic acid receptor antagonists
GB2474748B (en) 2009-10-01 2011-10-12 Amira Pharmaceuticals Inc Polycyclic compounds as lysophosphatidic acid receptor antagonists
CN102917703B (zh) 2010-03-08 2015-08-19 科研制药株式会社 新型ep4激动剂
CN103596947A (zh) 2011-04-05 2014-02-19 艾米拉医药股份有限公司 用于治疗纤维化、疼痛、癌症和呼吸、过敏性、神经系统疾病或心血管疾病的基于3-或5-联苯-4-基异噁唑的化合物
TW201326154A (zh) 2011-11-28 2013-07-01 拜耳知識產權公司 作為ep2受體拮抗劑之新穎2h-吲唑
US9440919B2 (en) 2012-07-19 2016-09-13 Cayman Chemical Company, Inc. Difluorolactam compositions for EP4-mediated osteo related diseases and conditions
AU2013309872B2 (en) 2012-08-31 2017-09-14 Ono Pharmaceutical Co., Ltd. Amine salt and crystals thereof
WO2014144610A1 (en) 2013-03-15 2014-09-18 Cayman Chemical Company, Inc. Lactam compounds as ep4 receptor-selective agonists for use in the treatment of ep4-mediated diseases and conditions
ES2635635T3 (es) 2013-03-15 2017-10-04 Cayman Chemical Company, Incorporated Compuestos de difluorolactama como agonistas selectivos del receptor EP4 para su uso en el tratamiento de enfermedades y afecciones mediadas por EP4
HK1220457A1 (zh) 2013-03-28 2017-05-05 宇部兴产株式会社 取代联芳基化合物
EP3021879A2 (en) 2013-07-19 2016-05-25 Cayman Chemical Company, Incorporated Methods, systems, and compositions for promoting bone growth
US9540357B1 (en) 2014-07-31 2017-01-10 Allergan, Inc. 15-aryl prostaglandins as EP4 agonists, and methods of use thereof
TWI739666B (zh) * 2015-01-09 2021-09-11 日商小野藥品工業股份有限公司 醫藥組成物
CA3015494C (en) * 2016-03-30 2021-10-26 Ayuvis Research, Inc. Novel compositions and therapeutic methods
GB202211232D0 (en) 2022-08-02 2022-09-14 Heptares Therapeutics Ltd Prostaglandin EP4 receptor agonist compounds

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS511461A (en) 1974-06-24 1976-01-08 Tanabe Seiyaku Co 88 azapurosutansanjudotainoseiho
GB1529852A (en) 1975-03-21 1978-10-25 Labaz 8-azaprostaglandins and process for the preparation thereof
NL7604330A (nl) 1975-04-28 1976-11-01 Syntex Inc Werkwijze voor de bereiding van 8-azaprostaan- zuurderivaten.
DE2556326A1 (de) 1975-12-13 1977-06-23 Hoechst Ag Neue pyrrolidone und verfahren zu ihrer herstellung
IL49325A (en) 1976-03-31 1979-11-30 Labaz 8-aza-11-deoxy-pge1 derivatives,their preparation and pharmaceutical compositions containing them
DE2619638A1 (de) 1976-05-04 1977-11-17 Hoechst Ag Pyrrolidone und verfahren zu ihrer herstellung
EP0471201A1 (de) 1990-07-21 1992-02-19 Hoechst Aktiengesellschaft Neue Oxazolidinon-Derivate und ihre Verwendung als Dotierstoffe in Flüssigkristallmischungen
US5280034A (en) * 1991-08-23 1994-01-18 E. R. Squibb & Sons, Inc. Bis-heterocyclic prostaglandin analogs
IT1254373B (it) 1992-05-29 1995-09-14 Eteroprostanoidi, procedimento per la loro preparazione e loro impiegoterapeutico.
US5362879A (en) * 1993-04-15 1994-11-08 Bristol-Myers Squibb Company 4-5-diphenyloxazole derivatives as inhibitors of blood platelet aggregation
TW401408B (en) * 1995-07-21 2000-08-11 Fujisawa Pharmaceutical Co Heterocyclic compounds having prostaglandin I2 agonism
EA005293B1 (ru) * 1999-12-22 2004-12-30 Пфайзер Продактс Инк. Производные пирролидин-2-она и их применение при лечении остеопороза
ATE327751T1 (de) 2000-01-31 2006-06-15 Pfizer Prod Inc Verwendung von aktivatoren des prostaglandinrezeptores 4 zur behandlung von akuter oder chronischer niereninsuffizienz
US20010056060A1 (en) 2000-02-07 2001-12-27 Cameron Kimberly O. Treatment of osteoporsis with EP2/EP4 receptor selective agonists
WO2002024647A1 (en) * 2000-09-21 2002-03-28 Ono Pharmaceutical Co., Ltd. Ep4 receptor agonists containing 8-azaprostaglandin derivatives as the active ingredient
EA200300379A1 (ru) * 2000-11-27 2003-08-28 Пфайзер Продактс Инк. Селективные агонисты рецептора ep4 в лечении остеопороза
RU2296122C2 (ru) 2001-07-16 2007-03-27 Ф.Хоффманн-Ля Рош Аг Производные 2-пирролидона в качестве простаноидных агонистов и фармацевтическая композиция
RU2288913C2 (ru) * 2001-07-16 2006-12-10 Ф.Хоффманн-Ля Рош Аг Аналоги простагландинов, способ их получения и фармацевтическая композиция, обладающая селективной агонистической активностью в отношении рецептора ep4
IL159996A0 (en) 2001-07-23 2004-06-20 Ono Pharmaceutical Co Remedies for diseases with bone mass loss having ep4 agonist as the active ingredient
WO2003047513A2 (en) * 2001-12-03 2003-06-12 Merck & Co., Inc. Method for treating ocular hypertension
JP2005519879A (ja) * 2001-12-03 2005-07-07 メルク エンド カムパニー インコーポレーテッド Ep4受容体作動剤とその組成物および方法
JP4893999B2 (ja) * 2004-10-22 2012-03-07 小野薬品工業株式会社 吸入用医薬組成物

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