PL372370A1 - Drobnoustroje jako nośnik sekwencji nukleotydów kodujących antygeny komórkowe do leczenia nowotworów - Google Patents

Drobnoustroje jako nośnik sekwencji nukleotydów kodujących antygeny komórkowe do leczenia nowotworów

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Publication number
PL372370A1
PL372370A1 PL03372370A PL37237003A PL372370A1 PL 372370 A1 PL372370 A1 PL 372370A1 PL 03372370 A PL03372370 A PL 03372370A PL 37237003 A PL37237003 A PL 37237003A PL 372370 A1 PL372370 A1 PL 372370A1
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PL
Poland
Prior art keywords
tumors
microorganisms
carriers
treatment
nucleotide sequences
Prior art date
Application number
PL03372370A
Other languages
English (en)
Inventor
Ulf R. Rapp
Werner Goebel
Ivaylo Gentschev
Joachim Fensterle
Original Assignee
Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh
Publication of PL372370A1 publication Critical patent/PL372370A1/pl

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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A61K39/001148—Regulators of development
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001154—Enzymes
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    • A61K39/0011—Cancer antigens
    • A61K39/001166—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/42—Salmonella
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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PL03372370A 2002-02-28 2003-02-13 Drobnoustroje jako nośnik sekwencji nukleotydów kodujących antygeny komórkowe do leczenia nowotworów PL372370A1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10208653A DE10208653A1 (de) 2002-02-28 2002-02-28 Mikroorganismus als Träger von Nukleotidsequenzen kodierend für Zellantigene zur Behandlung von Tumoren

Publications (1)

Publication Number Publication Date
PL372370A1 true PL372370A1 (pl) 2005-07-25

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PL03372370A PL372370A1 (pl) 2002-02-28 2003-02-13 Drobnoustroje jako nośnik sekwencji nukleotydów kodujących antygeny komórkowe do leczenia nowotworów

Country Status (19)

Country Link
US (1) US20060105423A1 (pl)
EP (1) EP1478756A2 (pl)
JP (1) JP2005518795A (pl)
KR (1) KR20040104464A (pl)
CN (1) CN1650014A (pl)
AU (1) AU2003206664A1 (pl)
BR (1) BRPI0308119A2 (pl)
CA (1) CA2513190A1 (pl)
DE (1) DE10208653A1 (pl)
HR (1) HRP20040785A2 (pl)
IL (1) IL163672A0 (pl)
MX (1) MXPA04008287A (pl)
NO (1) NO20043926L (pl)
NZ (1) NZ535312A (pl)
PL (1) PL372370A1 (pl)
RS (1) RS75604A (pl)
RU (1) RU2319741C2 (pl)
WO (1) WO2003072789A2 (pl)
ZA (1) ZA200407528B (pl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8221739B2 (en) * 2004-04-29 2012-07-17 Botanic Oil Innovations, Inc. Method of cancer treatment
DK2119450T3 (da) 2005-11-29 2013-05-06 Actogenix Nv Induktion af mucosal tolerance over for pankreatisk ø-beta-celle-autoantigener
KR100818144B1 (ko) * 2006-02-15 2008-03-31 고려대학교 산학협력단 인터페론감마를 발현하는 살모넬라 균주 및 이를 함유하는항암 치료용 조성물
US20100129406A1 (en) * 2006-09-01 2010-05-27 Anza Therapeutics, Inc. Holin-enhanced vaccines and reagents, and methods of use thereof
EP1921149A1 (en) 2006-11-13 2008-05-14 AEterna Zentaris GmbH Microorganisms as carriers of nucleotide sequences coding for antigens and protein toxins, process of manufacturing and uses thereof
CN103933563B (zh) 2007-01-25 2016-09-28 英特瑞克斯顿阿克图比奥帝克斯有限公司 使用遗传修饰的乳杆菌通过抗原的粘膜递送治疗免疫疾病
KR101104077B1 (ko) 2008-10-14 2012-01-11 건국대학교 산학협력단 Ｅｇｒ－１의 발현을 증가시키는 활성을 갖는 신규한 엔터로박테리아속에 속하는 신규균주 및 그 균주를 포함하는 조성물의 항암제로서의 용도
KR101346620B1 (ko) * 2011-11-30 2014-01-06 전남대학교산학협력단 신규 박테리아 용해 단백질 및 그의 용도
RU2551238C9 (ru) * 2013-08-02 2016-04-10 Федеральное государственное бюджетное учреждение "Медико-генетический научный центр" Российской академии медицинских наук Способ индукции апоптоза клеток злокачественной опухоли колоректального рака и средство для его осуществления
US11576936B2 (en) 2016-12-07 2023-02-14 Salspera, Llc Methods of synergistic treatment of cancer
CN111936166B (zh) * 2018-02-09 2024-10-22 国家科学与技术研究理事会(Conicet) 用于药物递送的免疫调节和免疫刺激多肽
WO2020232389A1 (en) * 2019-05-16 2020-11-19 City Of Hope Compositions and methods for targeting tumor-associated extracellular matrix components to improve drug delivery

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU1445193C (ru) * 1987-04-22 1996-03-20 Институт биоорганической химии им.М.М.Шемякина и Ю.А.Овчинникова РАН РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pGA 23 - ПРОМЕЖУТОЧНЫЙ ПРОДУКТ ДЛЯ КОНСТРУИРОВАНИЯ РЕКОМБИНАНТНОЙ ПЛАЗМИДНОЙ ДНК pTNF 311Δ,-/,, РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pTNF 311Δ,-/,, КОДИРУЮЩАЯ ПОЛИПЕПТИД СО СВОЙСТВАМИ ФАКТОРА НЕКРОЗА ОПУХОЛИ ЧЕЛОВЕКА И ШТАММ БАКТЕРИЙ ESCHERICHIA COLI - ПРОДУЦЕНТ ПОЛИПЕПТИДА СО СВОЙСТВАМИ ФАКТОРА НЕКРОЗА ОПУХОЛИ ЧЕЛОВЕКА
RU1438241C (ru) * 1987-04-22 1996-03-20 Институт биоорганической химии им.М.М.Шемякина и Ю.А.Овчинникова РАН Рекомбинантная плазмидная днк ртnf 33, кодирующая полипептид со свойствами фактора некроза опухоли человека, и штамм бактерий escherichia coli - продуцент полипептида со свойствами фактора некроза опухоли человека
RU1438240C (ru) * 1987-04-22 1996-03-20 Институт биоорганической химии им.М.М.Шемякина и Ю.А.Овчинникова РАН РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК РТNF 22, СОДЕРЖАЩАЯ ПОЛУСИНТЕТИЧЕСКИЙ ГЕН ФАКТОРА НЕКРОЗА ОПУХОЛИ ЧЕЛОВЕКА - ПРОМЕЖУТОЧНАЯ ПЛАЗМИДА ДЛЯ КОНСТРУИРОВАНИЯ РЕКОМБИНАНТНОЙ ПЛАЗМИДНОЙ ДНК pTNF 31, КОДИРУЮЩАЯ ПОЛИПЕПТИД СО СВОЙСТВАМИ ФАКТОРА НЕКРОЗА ОПУХОЛИ ЧЕЛОВЕКА, И ШТАММ БАКТЕРИЙ ESCHERICHIA COLI - ПРОДУЦЕНТ ПОЛИПЕПТИДА СО СВОЙСТВАМИ ФАКТОРА НЕКРОЗА ОПУХОЛИ ЧЕЛОВЕКА
US5156841A (en) * 1988-08-26 1992-10-20 United States Of America Anti-tumor vaccine
ZA941645B (en) * 1994-03-09 1995-01-13 South To South Co Operation In Antibodies specifically reactive against human prostate specific antigen.
US6051237A (en) * 1994-11-08 2000-04-18 The Trustees Of The University Of Pennsylvania Specific immunotherapy of cancer using a live recombinant bacterial vaccine vector
JP3976685B2 (ja) * 2000-11-22 2007-09-19 ユニバーシティ オブ メリーランド， ボルチモア タンパク質分泌のためのＣｌｙＡ溶血素の使用

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KR20040104464A (ko) 2004-12-10
HRP20040785A2 (en) 2004-12-31
AU2003206664A1 (en) 2003-09-09
US20060105423A1 (en) 2006-05-18
NO20043926L (no) 2004-09-20
RU2004128929A (ru) 2005-04-10
RS75604A (sr) 2006-12-15
DE10208653A1 (de) 2003-09-18
JP2005518795A (ja) 2005-06-30
NZ535312A (en) 2008-03-28
EP1478756A2 (de) 2004-11-24
BRPI0308119A2 (pt) 2016-06-28
WO2003072789A3 (de) 2004-02-12
CA2513190A1 (en) 2003-09-04
CN1650014A (zh) 2005-08-03
MXPA04008287A (es) 2006-04-27
RU2319741C2 (ru) 2008-03-20
ZA200407528B (en) 2006-06-28
WO2003072789A2 (de) 2003-09-04
IL163672A0 (en) 2005-12-18

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