PL372944A1 - 2,4-Dipodstawione pochodne pirymidyno-5-karboksyamidu jako modulatory kanału potasowego KCNQ - Google Patents
2,4-Dipodstawione pochodne pirymidyno-5-karboksyamidu jako modulatory kanału potasowego KCNQInfo
- Publication number
- PL372944A1 PL372944A1 PL02372944A PL37294402A PL372944A1 PL 372944 A1 PL372944 A1 PL 372944A1 PL 02372944 A PL02372944 A PL 02372944A PL 37294402 A PL37294402 A PL 37294402A PL 372944 A1 PL372944 A1 PL 372944A1
- Authority
- PL
- Poland
- Prior art keywords
- potassium channel
- channel modulators
- carboxamide derivatives
- kcnq potassium
- disubstituted pyrimidine
- Prior art date
Links
- 102000012359 KCNQ Potassium Channels Human genes 0.000 title 1
- 108010022282 KCNQ Potassium Channels Proteins 0.000 title 1
- QDXGKRWDQCEABB-UHFFFAOYSA-N pyrimidine-5-carboxamide Chemical class NC(=O)C1=CN=CN=C1 QDXGKRWDQCEABB-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26980001P | 2001-02-20 | 2001-02-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL372944A1 true PL372944A1 (pl) | 2005-08-08 |
Family
ID=23028698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL02372944A PL372944A1 (pl) | 2001-02-20 | 2002-02-14 | 2,4-Dipodstawione pochodne pirymidyno-5-karboksyamidu jako modulatory kanału potasowego KCNQ |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20020183335A1 (pl) |
| EP (1) | EP1361879A1 (pl) |
| JP (1) | JP2005508833A (pl) |
| CA (1) | CA2438231A1 (pl) |
| CZ (1) | CZ20032233A3 (pl) |
| HU (1) | HUP0303841A2 (pl) |
| MX (1) | MXPA03007395A (pl) |
| NO (1) | NO20033683L (pl) |
| PL (1) | PL372944A1 (pl) |
| WO (1) | WO2002066036A1 (pl) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1438053B1 (de) * | 2001-10-17 | 2008-09-10 | Boehringer Ingelheim Pharma GmbH & Co.KG | Pyrimidinderivate, arzneimittel enthaltend diese verbindungen, deren verwendung und verfahren zu ihrer herstellung |
| EP1453516A2 (de) | 2001-10-17 | 2004-09-08 | Boehringer Ingelheim Pharma GmbH & Co.KG | 5-substituierte 4-amino-2-phenylamino-pyrimdinderivate und ihre verwendung als beta-amyloid modulatoren |
| US7205307B2 (en) | 2002-02-14 | 2007-04-17 | Icagen, Inc. | Pyrimidines as novel openers of potassium ion channels |
| US7176310B1 (en) * | 2002-04-09 | 2007-02-13 | Ucb Sa | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents |
| EP1534687B1 (en) * | 2002-08-21 | 2006-09-27 | Glaxo Group Limited | 2-phenylamino-4-trifluoromethyl-5-(benzyl- or pyridin-4-ylmethyl)carbamoylpyrimidine derivatives as selective cb2 cannabinoid receptor modulators |
| UY27939A1 (es) | 2002-08-21 | 2004-03-31 | Glaxo Group Ltd | Compuestos |
| US7459460B2 (en) * | 2003-05-28 | 2008-12-02 | Bristol-Myers Squibb Company | Trisubstituted heteroaromatic compounds as calcium sensing receptor modulators |
| PE20051029A1 (es) * | 2003-07-02 | 2005-12-07 | Vertex Pharma | Pirimidinas moduladoras de canales ionicos regulados por voltaje |
| WO2005053662A1 (en) * | 2003-12-01 | 2005-06-16 | Kudos Pharmaceuticals Limited | Dna damage repair inhibitors for treatment of cancer |
| GB0402356D0 (en) * | 2004-02-03 | 2004-03-10 | Glaxo Group Ltd | Novel compounds |
| GB0404105D0 (en) * | 2004-02-24 | 2004-03-31 | Glaxo Group Ltd | Novel compounds |
| TWI357901B (en) | 2004-03-12 | 2012-02-11 | Lundbeck & Co As H | Substituted morpholine and thiomorpholine derivati |
| US7560464B2 (en) | 2004-04-13 | 2009-07-14 | Icagen, Inc. | Polycyclic pyrimidines as potassium ion channel modulators |
| DE602005015742D1 (de) * | 2004-10-22 | 2009-09-10 | Janssen Pharmaceutica Nv | Aromatische amide als hemmer der c-fms-kinase |
| EP1809290A2 (en) * | 2004-11-03 | 2007-07-25 | Vertex Pharmaceuticals Incorporated | Pyrimidine derivatives as ion channel modulators and methods of use |
| WO2006092143A1 (en) * | 2005-03-03 | 2006-09-08 | H. Lundbeck A/S | Substituted pyridine derivatives |
| UA92340C2 (en) * | 2005-03-03 | 2010-10-25 | Х. Луннбек А/С | Substituted pyridine derivatives |
| JP2008534472A (ja) * | 2005-03-22 | 2008-08-28 | ノイロサーチ アクティーゼルスカブ | カリウムチャンネル調節剤としてのピラゾリル−ピリミジン及びその医学的使用 |
| DE102005038947A1 (de) * | 2005-05-18 | 2006-11-30 | Grünenthal GmbH | Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln |
| JP5388574B2 (ja) * | 2005-05-31 | 2014-01-15 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネルのモジュレーターとして有用なヘテロ環式類 |
| AU2006322461A1 (en) * | 2005-09-09 | 2007-06-14 | H. Lundbeck A/S | Pyrimidine derivatives and their use as KCNQ potassium channels openers |
| US7683058B2 (en) | 2005-09-09 | 2010-03-23 | H. Lundbeck A/S | Substituted pyrimidine derivatives |
| JP2010519328A (ja) | 2007-02-26 | 2010-06-03 | ファイザー・プロダクツ・インク | Ｈ−ｐｇｄｓの阻害剤としてのニコチンアミド誘導体およびプロスタグランジンｄ２が媒介する疾患の治療のためのそれらの使用 |
| CN102036981B (zh) | 2008-03-18 | 2015-04-08 | 默沙东公司 | 取代的4-羟基嘧啶-5-甲酰胺 |
| TWI504395B (zh) | 2009-03-10 | 2015-10-21 | Substituted 3-amino-2-mercaptoquinoline as a KCNQ2 / 3 modifier | |
| TW201038565A (en) | 2009-03-12 | 2010-11-01 | Gruenenthal Gmbh | Substituted 2-mercapto-3-aminopyridines as KCNQ2/3 modulators |
| TWI475020B (zh) * | 2009-03-12 | 2015-03-01 | The substituted nicotine amide as a KCNQ2 / 3 modifier | |
| TWI461197B (zh) | 2009-03-12 | 2014-11-21 | 2-mercaptoquinoline-3-carboxamide as a KCNQ2 / 3 modifier | |
| AU2011275393B2 (en) * | 2010-07-08 | 2014-04-10 | Pfizer Inc. | Piperidinyl pyrimidine amides as Kv7 potassium channel openers |
| WO2012025237A1 (en) | 2010-08-27 | 2012-03-01 | Grünenthal GmbH | Substituted 2-amino-quinoline-3-carboxamides as kcnq2/3 modulators |
| WO2012025239A1 (en) | 2010-08-27 | 2012-03-01 | Grünenthal GmbH | Substituted 2-oxo- and 2-thioxo-dihydroquinoline-3-carboxamides as kcnq2/3 modulators |
| AR082732A1 (es) | 2010-08-27 | 2012-12-26 | Gruenenthal Gmbh | 2-oxiquinolina-3-carboxamidas sustituidas como moduladores de kcnq2/3 |
| CA2807886A1 (en) | 2010-09-01 | 2012-03-08 | Gruenenthal Gmbh | Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as kcnq2/3 modulators |
| US9168259B2 (en) | 2010-10-20 | 2015-10-27 | Grünenthal GmbH | Substituted 6-amino-nicotinamides as KCNQ2/3 modulators |
| AU2011317855B2 (en) | 2010-10-20 | 2015-04-30 | Grunenthal Gmbh | Substituted 6-amino-nicotinamides as KCNQ2/3 modulators |
| LT2888233T (lt) | 2012-04-18 | 2017-01-10 | Grünenthal GmbH | Pakeistieji 6-amino-nikotinamidai, turintys oh-turinčią grupę, kaip kcnq2/3 moduliatoriai |
| JP2015516969A (ja) * | 2012-04-18 | 2015-06-18 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | Ｋｃｎｑ２／３調節因子としての置換４−アミノベンズアミド |
| MX2015006689A (es) | 2012-11-28 | 2015-08-20 | Grünenthal GmbH | Carboxamidas especificas como moduladores de kcnq2/3. |
| US9248122B2 (en) | 2012-11-28 | 2016-02-02 | Grünenthal GmbH | Heteroquinoline-3-carboxamides as KCNQ2/3 modulators |
| EP2925316A1 (en) * | 2012-11-28 | 2015-10-07 | Grünenthal GmbH | Substituted amino-arylcarboxamides as kcnq2/3 modulators |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5852028A (en) * | 1995-12-18 | 1998-12-22 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
| US5935966A (en) * | 1995-09-01 | 1999-08-10 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
| US5811428A (en) * | 1995-12-18 | 1998-09-22 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxamides and related compounds and methods for treating inflammatory conditions |
| TW550258B (en) * | 1999-05-31 | 2003-09-01 | Hoffmann La Roche | 4-phenyl-pyrimidine derivatives |
| BR0012934A (pt) * | 1999-08-04 | 2003-07-29 | Icagen Inc | Processos para a redução de dor e de ansiedade |
| IL157313A0 (en) * | 2001-02-20 | 2004-02-19 | Bristol Myers Squibb Co | Modulators of kcnq potassium channels and uses thereof |
-
2002
- 2002-02-14 HU HU0303841A patent/HUP0303841A2/hu unknown
- 2002-02-14 CA CA002438231A patent/CA2438231A1/en not_active Abandoned
- 2002-02-14 MX MXPA03007395A patent/MXPA03007395A/es unknown
- 2002-02-14 JP JP2002565594A patent/JP2005508833A/ja active Pending
- 2002-02-14 EP EP02709517A patent/EP1361879A1/en not_active Withdrawn
- 2002-02-14 PL PL02372944A patent/PL372944A1/pl not_active Application Discontinuation
- 2002-02-14 WO PCT/US2002/004305 patent/WO2002066036A1/en not_active Ceased
- 2002-02-14 CZ CZ20032233A patent/CZ20032233A3/cs unknown
- 2002-02-14 US US10/075,521 patent/US20020183335A1/en not_active Abandoned
-
2003
- 2003-08-19 NO NO20033683A patent/NO20033683L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1361879A1 (en) | 2003-11-19 |
| MXPA03007395A (es) | 2003-12-04 |
| CA2438231A1 (en) | 2002-08-29 |
| HUP0303841A2 (hu) | 2004-03-01 |
| US20020183335A1 (en) | 2002-12-05 |
| NO20033683L (no) | 2003-10-17 |
| NO20033683D0 (no) | 2003-08-19 |
| WO2002066036A1 (en) | 2002-08-29 |
| CZ20032233A3 (cs) | 2004-12-15 |
| JP2005508833A (ja) | 2005-04-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |