PL3733665T3 - Związki zawierające ugrupowanie 2-okso-1,3,4-tiadiazynan-3-ylowe mające aktywność agonisty receptora EP4 - Google Patents
Związki zawierające ugrupowanie 2-okso-1,3,4-tiadiazynan-3-ylowe mające aktywność agonisty receptora EP4Info
- Publication number
- PL3733665T3 PL3733665T3 PL18893819.5T PL18893819T PL3733665T3 PL 3733665 T3 PL3733665 T3 PL 3733665T3 PL 18893819 T PL18893819 T PL 18893819T PL 3733665 T3 PL3733665 T3 PL 3733665T3
- Authority
- PL
- Poland
- Prior art keywords
- thiadiazinan
- oxo
- containing compounds
- receptor agonist
- agonist activity
- Prior art date
Links
- -1 2-oxo-1,3,4-thiadiazinan-3-yl moiety Chemical group 0.000 title 1
- 101150109738 Ptger4 gene Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017248173 | 2017-12-25 | ||
| PCT/JP2018/047450 WO2019131582A1 (ja) | 2017-12-25 | 2018-12-25 | 含窒素６員環化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3733665T3 true PL3733665T3 (pl) | 2023-02-06 |
Family
ID=67063663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18893819.5T PL3733665T3 (pl) | 2017-12-25 | 2018-12-25 | Związki zawierające ugrupowanie 2-okso-1,3,4-tiadiazynan-3-ylowe mające aktywność agonisty receptora EP4 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10988468B2 (pl) |
| EP (1) | EP3733665B1 (pl) |
| JP (1) | JP6896106B2 (pl) |
| KR (1) | KR102446027B1 (pl) |
| CN (1) | CN111511736B (pl) |
| AU (1) | AU2018396402C1 (pl) |
| CA (1) | CA3086662C (pl) |
| ES (1) | ES2929799T3 (pl) |
| MX (1) | MX2020006307A (pl) |
| PH (1) | PH12020500556A1 (pl) |
| PL (1) | PL3733665T3 (pl) |
| PT (1) | PT3733665T (pl) |
| WO (1) | WO2019131582A1 (pl) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111511736B (zh) * | 2017-12-25 | 2023-03-24 | 旭化成制药株式会社 | 含氮6元环化合物 |
| WO2020227592A1 (en) | 2019-05-09 | 2020-11-12 | The Feinstein Institutes For Medical Research | Thiosemicarbazates and uses thereof |
| US11883461B2 (en) | 2019-05-09 | 2024-01-30 | The Feinstein Institutes For Medical Research | HMGB1 antagonist treatment of severe sepsis |
| EP3965792A4 (en) | 2019-05-09 | 2023-01-18 | The Feinstein Institutes for Medical Research | HMGB1 ANTAGONIST |
| CN111440141A (zh) * | 2020-05-20 | 2020-07-24 | 安徽泽升科技有限公司 | 一种羟甲基取代芳杂环类化合物的制备方法 |
| CN111718353B (zh) * | 2020-08-04 | 2023-02-10 | 许昌恒生制药有限公司 | 一种磷酸西格列汀的制备方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002024647A1 (en) | 2000-09-21 | 2002-03-28 | Ono Pharmaceutical Co., Ltd. | Ep4 receptor agonists containing 8-azaprostaglandin derivatives as the active ingredient |
| PT1339678E (pt) * | 2000-11-27 | 2007-11-30 | Pfizer Prod Inc | Agonistas selectivos do receptor ep4 no tratamento de osteoporose |
| RU2296122C2 (ru) | 2001-07-16 | 2007-03-27 | Ф.Хоффманн-Ля Рош Аг | Производные 2-пирролидона в качестве простаноидных агонистов и фармацевтическая композиция |
| NZ530885A (en) | 2001-07-23 | 2007-09-28 | Ono Pharmaceutical Co | Remedies for diseases with bone mass loss having EP4 agonist as the active ingredient |
| JP4550417B2 (ja) | 2001-10-23 | 2010-09-22 | メルク セローノ ソシエテ アノニム | プロスタグランジンｅｐ２及び／又はｅｐ４受容体のリガンドとしてのポリアゾリジノン化合物 |
| US7053085B2 (en) | 2003-03-26 | 2006-05-30 | Merck & Co. Inc. | EP4 receptor agonist, compositions and methods thereof |
| RU2311409C2 (ru) | 2003-01-10 | 2007-11-27 | Ф.Хоффманн-Ля Рош Аг | Производные 2-пиперидона в качестве агонистов простагландина |
| US6747037B1 (en) | 2003-06-06 | 2004-06-08 | Allergan, Inc. | Piperidinyl prostaglandin E analogs |
| EP1707208A4 (en) | 2003-12-05 | 2010-03-17 | Ono Pharmaceutical Co | PROMOTER OF BLOOD FLOW IN THE TISSUES OF THE HORSE TAIL |
| EP1782830A4 (en) | 2004-08-10 | 2009-07-29 | Ono Pharmaceutical Co | PREVENTION AND / OR REMEDY FOR LOWER URINARY TRACT DISEASES CONTAINING AN EP4 AGONIST |
| EP1847533B1 (en) | 2005-01-27 | 2013-08-14 | Asahi Kasei Pharma Corporation | Six-membered heterocyclic compound and the use thereof |
| US7531533B2 (en) | 2005-01-27 | 2009-05-12 | Asahi Kasei Pharma Corporation | 6-Membered heterocyclic compound and use thereof |
| RU2420316C2 (ru) | 2005-06-03 | 2011-06-10 | Оно Фармасьютикал Ко., Лтд. | Агент для регенерации и/или защиты нервов |
| EP1912977A4 (en) * | 2005-08-03 | 2009-10-21 | Merck Frosst Canada Ltd | EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS |
| EP1912957A4 (en) * | 2005-08-03 | 2009-05-13 | Merck Frosst Canada Ltd | EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS |
| EP3235817B1 (en) | 2013-03-15 | 2018-12-12 | Cayman Chemical Company, Incorporated | Lactam compounds as ep4 receptor-selective agonists for use in the treatment of ep4-mediated diseases and conditions |
| CN111511736B (zh) * | 2017-12-25 | 2023-03-24 | 旭化成制药株式会社 | 含氮6元环化合物 |
-
2018
- 2018-12-25 CN CN201880083367.0A patent/CN111511736B/zh active Active
- 2018-12-25 US US16/333,510 patent/US10988468B2/en active Active
- 2018-12-25 MX MX2020006307A patent/MX2020006307A/es unknown
- 2018-12-25 PT PT188938195T patent/PT3733665T/pt unknown
- 2018-12-25 AU AU2018396402A patent/AU2018396402C1/en active Active
- 2018-12-25 JP JP2019561689A patent/JP6896106B2/ja active Active
- 2018-12-25 CA CA3086662A patent/CA3086662C/en active Active
- 2018-12-25 ES ES18893819T patent/ES2929799T3/es active Active
- 2018-12-25 WO PCT/JP2018/047450 patent/WO2019131582A1/ja not_active Ceased
- 2018-12-25 KR KR1020207014350A patent/KR102446027B1/ko active Active
- 2018-12-25 PH PH1/2020/500556A patent/PH12020500556A1/en unknown
- 2018-12-25 PL PL18893819.5T patent/PL3733665T3/pl unknown
- 2018-12-25 EP EP18893819.5A patent/EP3733665B1/en active Active
-
2021
- 2021-03-04 US US17/192,614 patent/US11667630B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR102446027B1 (ko) | 2022-09-21 |
| WO2019131582A1 (ja) | 2019-07-04 |
| US20200347046A1 (en) | 2020-11-05 |
| JP6896106B2 (ja) | 2021-06-30 |
| JPWO2019131582A1 (ja) | 2021-01-14 |
| AU2018396402A1 (en) | 2020-07-09 |
| US20210188837A1 (en) | 2021-06-24 |
| MX2020006307A (es) | 2020-09-17 |
| CA3086662C (en) | 2022-01-25 |
| CN111511736B (zh) | 2023-03-24 |
| AU2018396402B2 (en) | 2020-10-29 |
| US10988468B2 (en) | 2021-04-27 |
| RU2020120817A3 (pl) | 2022-01-27 |
| EP3733665A1 (en) | 2020-11-04 |
| CA3086662A1 (en) | 2019-07-04 |
| EP3733665A4 (en) | 2021-06-02 |
| EP3733665B1 (en) | 2022-09-28 |
| ES2929799T3 (es) | 2022-12-01 |
| RU2020120817A (ru) | 2022-01-27 |
| PH12020500556A1 (en) | 2021-04-19 |
| BR112020012405A2 (pt) | 2020-11-24 |
| CN111511736A (zh) | 2020-08-07 |
| PT3733665T (pt) | 2022-10-21 |
| US11667630B2 (en) | 2023-06-06 |
| AU2018396402C1 (en) | 2021-03-18 |
| KR20200073265A (ko) | 2020-06-23 |
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