PL373860A1 - Kwasy fosfonowe jako inhibitory proteazy seryny - Google Patents

Kwasy fosfonowe jako inhibitory proteazy seryny

Info

Publication number: PL373860A1
Authority: PL; Poland
Prior art keywords: inhibitors; phosphonic acid; acid compounds; serine proteases; proteases
Prior art date: 2001-10-19

Application number

PL02373860A

Other languages

English (en)

Other versions

PL209032B1 (pl

Inventor

Michael N. Greco

Harold R. Almond

Garavilla Lawrence De

Michael J. Hawkins

Bruce E. Maryanoff

Yun Qian

Donald Gilmore Walker

Sergio Cesco-Cancian

Christopher Norman Nilsen

Mitul N. Patel

Michael J. Humora

Original Assignee

Ortho-Mcneil Pharmaceutical, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-19

Filing date

2002-10-17

Publication date

2005-09-19

2002-10-17 Application filed by Ortho-Mcneil Pharmaceutical, Inc. filed Critical Ortho-Mcneil Pharmaceutical, Inc.

2005-09-19 Publication of PL373860A1 publication Critical patent/PL373860A1/pl

2011-07-29 Publication of PL209032B1 publication Critical patent/PL209032B1/pl

Links

102000012479 Serine Proteases Human genes 0.000 title 1
108010022999 Serine Proteases Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
150000003009 phosphonic acids Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3882—Arylalkanephosphonic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Immunology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Ophthalmology & Optometry (AREA)
Obesity (AREA)
Hematology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)

PL373860A 2001-10-19 2002-10-17 Kwas fosfonowy jako inhibitor proteazy seryny, sposób jego wytwarzania, kompozycja zawierająca ten związek, oraz jego zastosowanie PL209032B1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US33034301P	2001-10-19	2001-10-19

Publications (2)

Publication Number	Publication Date
PL373860A1 true PL373860A1 (pl)	2005-09-19
PL209032B1 PL209032B1 (pl)	2011-07-29

Family

ID=23289339

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL373860A PL209032B1 (pl)	2001-10-19	2002-10-17	Kwas fosfonowy jako inhibitor proteazy seryny, sposób jego wytwarzania, kompozycja zawierająca ten związek, oraz jego zastosowanie

Country Status (27)

Country	Link
US (1)	US20030195172A1 (pl)
EP (1)	EP1438316B1 (pl)
JP (1)	JP4423033B2 (pl)
KR (2)	KR101011175B1 (pl)
CN (1)	CN100506831C (pl)
AR (1)	AR037245A1 (pl)
AT (1)	ATE330961T1 (pl)
AU (1)	AU2002356818C1 (pl)
BR (1)	BR0213961A (pl)
CA (1)	CA2464111C (pl)
CY (1)	CY1105166T1 (pl)
DE (1)	DE60212675T2 (pl)
DK (1)	DK1438316T3 (pl)
ES (1)	ES2266634T3 (pl)
HU (1)	HUP0600339A2 (pl)
IL (2)	IL161476A0 (pl)
ME (1)	MEP48708A (pl)
MX (1)	MXPA04003707A (pl)
MY (1)	MY133586A (pl)
NO (1)	NO20042057L (pl)
NZ (1)	NZ532372A (pl)
PL (1)	PL209032B1 (pl)
PT (1)	PT1438316E (pl)
RS (1)	RS50944B (pl)
RU (1)	RU2311421C2 (pl)
WO (1)	WO2003035654A1 (pl)
ZA (1)	ZA200403824B (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7459461B2 (en)	2001-10-19	2008-12-02	Ortho-Mcneil Pharmaceutical, Inc.	Phosphonic acid compounds as inhibitors of serine proteases
US7601847B2 (en)	2004-10-26	2009-10-13	Wyeth	Preparation and purification of 4-(indazol-3-yl)phenols
AU2005310490B2 (en)	2004-12-02	2012-01-19	Daiichi Sankyo Company, Limited	7-membered ring compound, process for producing the same, and medicinal use thereof
JP4728350B2 (ja) *	2005-01-06	2011-07-20	シェーリングコーポレイション	ケトンアミドの調製
JP2009523423A (ja) *	2006-01-12	2009-06-25	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	キマーゼによるｓｌｐｉの処理
JP5117382B2 (ja)	2006-05-31	2013-01-16	第一三共株式会社	７員環化合物の製造方法
PA8799601A1 (es) *	2007-10-16	2009-05-15	Janssen Pharmaceutica Nv	Proceso para sintetizar compuestos de acido fosfonico y fosfinico
EP2879449A4 (en)	2012-07-24	2015-08-19	Fujitsu Ltd	WIRELESS DEVICE, WIRELESS BASE STATION, WIRELESS COMMUNICATION SYSTEM AND WIRELESS COMMUNICATION PROCESS
CN107353305A (zh) *	2017-07-12	2017-11-17	浙江普洛得邦制药有限公司	一种噁唑烷酮类抗菌药物的三羟甲基氨基甲烷盐及其晶型a、制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5508273A (en) *	1993-12-30	1996-04-16	Ortho Pharmaceutical Corporation	Substituted phosphonic acids and derivatives useful in treating bone wasting diseases
CA2226414A1 (en) *	1995-07-17	1997-02-06	Cephalon, Inc.	Phosphorous-containing cysteine and serine protease inhibitors
DE19750002A1 (de) *	1997-11-12	1999-05-20	Solvay Pharm Gmbh	Phosphonsäure-substituierte Benzazepinon-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

2002
- 2002-10-17 PT PT02802153T patent/PT1438316E/pt unknown
- 2002-10-17 DK DK02802153T patent/DK1438316T3/da active
- 2002-10-17 NZ NZ532372A patent/NZ532372A/en not_active IP Right Cessation
- 2002-10-17 KR KR1020047005810A patent/KR101011175B1/ko not_active Expired - Fee Related
- 2002-10-17 JP JP2003538169A patent/JP4423033B2/ja not_active Expired - Fee Related
- 2002-10-17 RS YUP-333/04A patent/RS50944B/sr unknown
- 2002-10-17 RU RU2004111784/04A patent/RU2311421C2/ru not_active IP Right Cessation
- 2002-10-17 KR KR1020107011999A patent/KR20100074322A/ko not_active Withdrawn
- 2002-10-17 AU AU2002356818A patent/AU2002356818C1/en not_active Ceased
- 2002-10-17 AT AT02802153T patent/ATE330961T1/de active
- 2002-10-17 DE DE60212675T patent/DE60212675T2/de not_active Expired - Lifetime
- 2002-10-17 WO PCT/US2002/033206 patent/WO2003035654A1/en not_active Ceased
- 2002-10-17 ME MEP-487/08A patent/MEP48708A/xx unknown
- 2002-10-17 IL IL16147602A patent/IL161476A0/xx unknown
- 2002-10-17 BR BR0213961-8A patent/BR0213961A/pt not_active Application Discontinuation
- 2002-10-17 HU HU0600339A patent/HUP0600339A2/hu unknown
- 2002-10-17 MX MXPA04003707A patent/MXPA04003707A/es active IP Right Grant
- 2002-10-17 US US10/273,208 patent/US20030195172A1/en not_active Abandoned
- 2002-10-17 PL PL373860A patent/PL209032B1/pl not_active IP Right Cessation
- 2002-10-17 CN CNB028250982A patent/CN100506831C/zh not_active Expired - Fee Related
- 2002-10-17 CA CA2464111A patent/CA2464111C/en not_active Expired - Fee Related
- 2002-10-17 ES ES02802153T patent/ES2266634T3/es not_active Expired - Lifetime
- 2002-10-17 EP EP02802153A patent/EP1438316B1/en not_active Expired - Lifetime
- 2002-10-21 MY MYPI20023912A patent/MY133586A/en unknown
- 2002-10-21 AR ARP020103969A patent/AR037245A1/es unknown
2004
- 2004-04-18 IL IL161476A patent/IL161476A/en not_active IP Right Cessation
- 2004-05-18 ZA ZA200403824A patent/ZA200403824B/en unknown
- 2004-05-18 NO NO20042057A patent/NO20042057L/no not_active Application Discontinuation
2006
- 2006-08-23 CY CY20061101180T patent/CY1105166T1/el unknown

Also Published As

Publication number	Publication date
WO2003035654A1 (en)	2003-05-01
KR20100074322A (ko)	2010-07-01
PL209032B1 (pl)	2011-07-29
HUP0600339A2 (en)	2006-08-28
AU2002356818C1 (en)	2009-10-22
BR0213961A (pt)	2004-08-31
CN1604904A (zh)	2005-04-06
RU2311421C2 (ru)	2007-11-27
IL161476A0 (en)	2004-09-27
IL161476A (en)	2009-09-01
CA2464111A1 (en)	2003-05-01
MXPA04003707A (es)	2005-04-08
CN100506831C (zh)	2009-07-01
HK1065802A1 (en)	2005-03-04
CA2464111C (en)	2013-03-12
ATE330961T1 (de)	2006-07-15
MEP48708A (en)	2011-02-10
KR20040060941A (ko)	2004-07-06
CY1105166T1 (el)	2010-03-03
RU2004111784A (ru)	2005-10-20
MY133586A (en)	2007-11-30
KR101011175B1 (ko)	2011-01-26
DE60212675T2 (de)	2007-06-28
PT1438316E (pt)	2006-10-31
EP1438316B1 (en)	2006-06-21
EP1438316A1 (en)	2004-07-21
NO20042057L (no)	2004-05-18
AU2002356818B2 (en)	2009-02-26
ES2266634T3 (es)	2007-03-01
DK1438316T3 (da)	2006-10-16
RS50944B (sr)	2010-08-31
RS33304A (sr)	2006-12-15
ZA200403824B (en)	2005-09-13
JP4423033B2 (ja)	2010-03-03
NZ532372A (en)	2007-07-27
DE60212675D1 (de)	2006-08-03
JP2005537217A (ja)	2005-12-08
US20030195172A1 (en)	2003-10-16
AR037245A1 (es)	2004-11-03

Legal Events

Date	Code	Title	Description
2012-01-31	RECP	Rectifications of patent specification
2013-11-29	LAPS	Decisions on the lapse of the protection rights	Effective date: 20121017

Publication	Publication Date	Title
IL155202A0 (en)	2003-11-23	Biaryl compounds as serine protease inhibitors
NO20042080L (no)	2004-07-16	Inhibitorer for post-prolin spaltningsproteaser
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