PL374094A1 - Sposób wytwarzania 2,2-dichloro-lub dibromofenylooctanów alkilu - Google Patents

Sposób wytwarzania 2,2-dichloro-lub dibromofenylooctanów alkilu

Info

Publication number
PL374094A1
PL374094A1 PL03374094A PL37409403A PL374094A1 PL 374094 A1 PL374094 A1 PL 374094A1 PL 03374094 A PL03374094 A PL 03374094A PL 37409403 A PL37409403 A PL 37409403A PL 374094 A1 PL374094 A1 PL 374094A1
Authority
PL
Poland
Prior art keywords
sub
formula
dichloro
alkyl
nitrile
Prior art date
Application number
PL03374094A
Other languages
English (en)
Other versions
PL215180B1 (pl
Inventor
Sylvia Krich
Bernhard Holub
Original Assignee
Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg filed Critical Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg
Publication of PL374094A1 publication Critical patent/PL374094A1/pl
Publication of PL215180B1 publication Critical patent/PL215180B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/18—Preparation of carboxylic acid esters by conversion of a group containing nitrogen into an ester group
    • C07C67/22—Preparation of carboxylic acid esters by conversion of a group containing nitrogen into an ester group from nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Przedmiotem wynalazku jest ulepszony sposób wytwarzania 2,2-dichloro- lub dibromofenylooctanów alkilu o wzorze (I), w którym X oznacza Cl lub Br, n oznacza liczbę całkowitą od 1 do 5, R oznacza atom wodoru, C<sub>1</sub>-C<sub>8</sub> alkil, aryl, heteroaryl, C<sub>1</sub>-C<sub>8</sub>alkoksy, arylooksy lub atom fluorowca i R1 oznacza C<sub>1</sub>-C<sub>8</sub> alkil. Według powyższego sposobu, 2,2-dichloro- lub dibromofenyloacetonitryl o wzorze (II), w roztworze 0,8 do 2 moli wody na mol nitrylu o wzorze (II), poddaje się reakcji z roztworem 1 do 8 moli alkoholu o wzorze R10H (III) na mol nitrylu o wzorze (II) oraz w obecności roztworu 1 do 3 moli HCl lub HBr na mol nitrylu o wzorze (II), ewentualnie w obecności obojętnego, w warunkach reakcji, rozpuszczalnika, z wytworzeniem odpowiednich 2,2-dichloro- lub dibromofenylooctanów alkilu o wzorze (I), przy czym temperatura reakcji w pierwszym etapie wynosiła pomiędzy 30 i 60°C, a w drugim etapie pomiędzy 60 i 100°C. Reakcję prowadzi się jednokrotnie, mieszaninę reakcyjną ochładza się do temperatury pomiędzy 20 i 40°C i rozcieńczono wodą, uzyskując 2,2-dichloro- lub dibromofenylooctan alkilu o wzorze (I).
PL374094A 2002-04-04 2003-03-10 Sposób wytwarzania 2,2-dichloro- lub dibromofenylooctanów alkilu PL215180B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0052302A AT500469B1 (de) 2002-04-04 2002-04-04 Verbessertes verfahren zur herstellung von 2,2-dichlorophenylessigsäurealkylestern

Publications (2)

Publication Number Publication Date
PL374094A1 true PL374094A1 (pl) 2005-09-19
PL215180B1 PL215180B1 (pl) 2013-10-31

Family

ID=28679361

Family Applications (1)

Application Number Title Priority Date Filing Date
PL374094A PL215180B1 (pl) 2002-04-04 2003-03-10 Sposób wytwarzania 2,2-dichloro- lub dibromofenylooctanów alkilu

Country Status (13)

Country Link
US (1) US20050131246A1 (pl)
EP (1) EP1490322B1 (pl)
JP (1) JP4686129B2 (pl)
CN (1) CN100516015C (pl)
AT (1) AT500469B1 (pl)
AU (1) AU2003212321B2 (pl)
BR (2) BR0308929A (pl)
CA (1) CA2479643C (pl)
ES (1) ES2549401T3 (pl)
IL (1) IL163964A (pl)
PL (1) PL215180B1 (pl)
RU (1) RU2320639C2 (pl)
WO (1) WO2003084918A1 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102911057B (zh) * 2011-08-04 2016-01-27 浙江九洲药业股份有限公司 一种酮洛芬乙酯的制备方法
CN109020834A (zh) * 2018-08-30 2018-12-18 南平铭正医药化学有限公司 一种2,2-二氯苯乙腈的制备方法
CN109485566B (zh) * 2018-11-23 2019-10-11 宁波江润化工有限公司 一种氧代苯乙酸酯的新合成方法
CN118791400B (zh) * 2024-06-05 2025-02-18 辽宁众辉生物科技有限公司 一种(e)-2-(2-氯甲基苯基)-2-甲氧亚胺基乙酸甲酯的新合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2827977A1 (de) * 1978-06-26 1980-01-17 Bayer Ag Verfahren zur herstellung von mandelsaeureestern
NL8104287A (nl) * 1981-09-17 1983-04-18 Stamicarbon De bereiding van derivaten van dichloorazijnzure esters.
NL8104286A (nl) * 1981-09-17 1983-04-18 Stamicarbon Werkwijze voor de bereiding van 2,2-dichloorfenylazijnzure esters.
NL9100979A (nl) * 1991-06-07 1993-01-04 Dsm Nv Werkwijze voor de alpha-chlorering van fenylacetonitrillen.

Also Published As

Publication number Publication date
WO2003084918A1 (de) 2003-10-16
US20050131246A1 (en) 2005-06-16
PL215180B1 (pl) 2013-10-31
BRPI0308929B1 (pt) 2019-04-24
EP1490322B1 (de) 2015-07-29
AT500469A1 (de) 2006-01-15
IL163964A (en) 2011-02-28
CA2479643A1 (en) 2003-10-16
RU2004132213A (ru) 2005-04-20
IL163964A0 (en) 2005-12-18
CN1642898A (zh) 2005-07-20
AU2003212321A1 (en) 2003-10-20
JP2006508024A (ja) 2006-03-09
BR0308929A (pt) 2005-01-04
CA2479643C (en) 2011-01-25
CN100516015C (zh) 2009-07-22
ES2549401T3 (es) 2015-10-27
JP4686129B2 (ja) 2011-05-18
RU2320639C2 (ru) 2008-03-27
AU2003212321B2 (en) 2009-05-28
EP1490322A1 (de) 2004-12-29
AT500469B1 (de) 2007-04-15

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