PL374447A1 - Sposób wytwarzania farmaceutycznie aktywnego związku (granisetronu) - Google Patents
Sposób wytwarzania farmaceutycznie aktywnego związku (granisetronu)Info
- Publication number
- PL374447A1 PL374447A1 PL03374447A PL37444703A PL374447A1 PL 374447 A1 PL374447 A1 PL 374447A1 PL 03374447 A PL03374447 A PL 03374447A PL 37444703 A PL37444703 A PL 37444703A PL 374447 A1 PL374447 A1 PL 374447A1
- Authority
- PL
- Poland
- Prior art keywords
- granisetron
- preparing
- compound
- formula
- active compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- MFWNKCLOYSRHCJ-BTTYYORXSA-N granisetron Chemical compound C1=CC=C2C(C(=O)N[C@H]3C[C@H]4CCC[C@@H](C3)N4C)=NN(C)C2=C1 MFWNKCLOYSRHCJ-BTTYYORXSA-N 0.000 title abstract 3
- 229960003727 granisetron Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000012442 inert solvent Substances 0.000 abstract 2
- 230000011987 methylation Effects 0.000 abstract 2
- 238000007069 methylation reaction Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 229940100198 alkylating agent Drugs 0.000 abstract 1
- 239000002168 alkylating agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000017858 demethylation Effects 0.000 abstract 1
- 238000010520 demethylation reaction Methods 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Otolaryngology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200200713A ES2197001B1 (es) | 2002-03-26 | 2002-03-26 | Procedimiento de obtencion de un compuesto farmaceuticamente activo. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL374447A1 true PL374447A1 (pl) | 2005-10-17 |
| PL211464B1 PL211464B1 (pl) | 2012-05-31 |
Family
ID=28051970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL374447A PL211464B1 (pl) | 2002-03-26 | 2003-03-21 | Sposób wytwarzania granisetronu, lub jego farmaceutycznie dopuszczalnej soli |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7071209B2 (pl) |
| EP (1) | EP1487833B1 (pl) |
| JP (1) | JP4560293B2 (pl) |
| KR (1) | KR100835553B1 (pl) |
| AT (1) | ATE299144T1 (pl) |
| AU (1) | AU2003208552A1 (pl) |
| CA (1) | CA2481703A1 (pl) |
| DE (1) | DE60300986D1 (pl) |
| ES (1) | ES2197001B1 (pl) |
| IL (1) | IL164742A0 (pl) |
| PL (1) | PL211464B1 (pl) |
| PT (1) | PT1487833E (pl) |
| TW (1) | TWI291959B (pl) |
| WO (1) | WO2003080606A1 (pl) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2499128C (en) | 2002-09-25 | 2012-07-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof |
| PL1697378T3 (pl) | 2003-12-22 | 2008-04-30 | Memory Pharm Corp | Indole, 1h-indazole, 1,2-benzoizoksazole i 1,2-benzoizotiazole oraz ich wytwarzanie i zastosowania |
| WO2005092890A2 (en) | 2004-03-25 | 2005-10-06 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof |
| DE602005024677D1 (de) | 2004-04-22 | 2010-12-23 | Memory Pharm Corp | Indole, 1h-indazole, 1,2-benzisoxazole, 1,2-benzoisothiazole, deren herstellung und verwendungen |
| RU2386633C2 (ru) | 2004-05-07 | 2010-04-20 | Мемори Фармасьютиклз Корпорейшн | 1h-индазолы, бензотиазолы, 1, 2-бензоизоксазолы, 1, 2-бензоизотиазолы и хромоны и их получение и применения |
| JP2008525464A (ja) | 2004-12-22 | 2008-07-17 | メモリー・ファーマシューティカルズ・コーポレイション | α−７ニコチン性受容体リガンド並びにその製造及び使用 |
| RU2420525C2 (ru) * | 2005-07-11 | 2011-06-10 | Мицубиси Танабе Фарма Корпорейшн | Производные оксимов и их получение |
| US8911751B2 (en) | 2005-10-11 | 2014-12-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions for nasal delivery |
| WO2007088557A1 (en) * | 2006-02-01 | 2007-08-09 | Natco Pharma Limited | Process for highly pure crystalline granisetron base |
| US20080242696A1 (en) * | 2007-03-27 | 2008-10-02 | Chemagis Ltd. | Crystalline granisetron base and production process therefor |
| EP2164848B1 (en) | 2007-06-13 | 2016-02-24 | Inke, S.A. | Polymorphic form of granisetron base, methods for obtaining it and formulation containing it |
| CA2734900A1 (en) * | 2008-08-19 | 2010-02-25 | Shu-Ping Chen | Polymorphic form of granisetron hydrochloride and methods of making the same |
| US20120101089A1 (en) * | 2010-10-26 | 2012-04-26 | Ashwani Agarwal | Anti-Emetic Substance |
| CN112778203B (zh) * | 2021-01-29 | 2022-02-15 | 兰州交通大学 | 1h-吲唑-3-羧酸衍生物及格拉斯琼和氯尼达明的制备方法 |
| CN115372487B (zh) * | 2021-05-18 | 2023-10-10 | 成都倍特得诺药业有限公司 | 盐酸格拉司琼中杂质e的hplc测定方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3687080T2 (de) | 1985-04-27 | 1993-03-25 | Beecham Group Plc | Azabicyclononyl-indazol-carboxamid mit 5-ht-antagonistischer wirkung. |
| GB9404055D0 (en) | 1994-03-03 | 1994-04-20 | Smithkline Beecham Plc | Novel process |
| GB9602862D0 (en) * | 1996-02-13 | 1996-04-10 | Smithkline Beecham Plc | Novel process |
| GB9602866D0 (en) * | 1996-02-13 | 1996-04-10 | Smithkline Beecham Plc | Novel process |
-
2002
- 2002-03-26 ES ES200200713A patent/ES2197001B1/es not_active Expired - Fee Related
-
2003
- 2003-03-21 CA CA002481703A patent/CA2481703A1/en not_active Abandoned
- 2003-03-21 PL PL374447A patent/PL211464B1/pl not_active IP Right Cessation
- 2003-03-21 US US10/508,493 patent/US7071209B2/en not_active Expired - Fee Related
- 2003-03-21 PT PT03706845T patent/PT1487833E/pt unknown
- 2003-03-21 EP EP03706845A patent/EP1487833B1/en not_active Expired - Lifetime
- 2003-03-21 WO PCT/IB2003/001058 patent/WO2003080606A1/en not_active Ceased
- 2003-03-21 JP JP2003578360A patent/JP4560293B2/ja not_active Expired - Fee Related
- 2003-03-21 AT AT03706845T patent/ATE299144T1/de not_active IP Right Cessation
- 2003-03-21 DE DE60300986T patent/DE60300986D1/de not_active Expired - Lifetime
- 2003-03-21 AU AU2003208552A patent/AU2003208552A1/en not_active Abandoned
- 2003-03-21 KR KR1020047015135A patent/KR100835553B1/ko not_active Expired - Fee Related
- 2003-03-26 TW TW092106806A patent/TWI291959B/zh active
-
2004
- 2004-10-20 IL IL16474204A patent/IL164742A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1487833B1 (en) | 2005-07-06 |
| ES2197001A1 (es) | 2003-12-16 |
| TW200305572A (en) | 2003-11-01 |
| KR100835553B1 (ko) | 2008-06-09 |
| AU2003208552A1 (en) | 2003-10-08 |
| IL164742A0 (en) | 2005-12-18 |
| US7071209B2 (en) | 2006-07-04 |
| PT1487833E (pt) | 2005-11-30 |
| JP4560293B2 (ja) | 2010-10-13 |
| PL211464B1 (pl) | 2012-05-31 |
| ATE299144T1 (de) | 2005-07-15 |
| JP2006511439A (ja) | 2006-04-06 |
| WO2003080606A1 (en) | 2003-10-02 |
| TWI291959B (en) | 2008-01-01 |
| DE60300986D1 (de) | 2005-08-11 |
| EP1487833A1 (en) | 2004-12-22 |
| CA2481703A1 (en) | 2003-10-02 |
| WO2003080606A8 (en) | 2005-03-17 |
| KR20040099361A (ko) | 2004-11-26 |
| US20050124650A1 (en) | 2005-06-09 |
| ES2197001B1 (es) | 2004-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Decisions on the lapse of the protection rights |
Effective date: 20140321 |