PL374504A1 - 1,3-diazadibenzoazuleny jako inhibitory wytwarzania czynnika martwiczego nowotworu i związki pośrednie do ich wytwarzania - Google Patents

1,3-diazadibenzoazuleny jako inhibitory wytwarzania czynnika martwiczego nowotworu i związki pośrednie do ich wytwarzania

Info

Publication number: PL374504A1
Authority: PL; Poland
Prior art keywords: dibenzoazulenes; diaza; intermediates; inhibitors; preparation
Prior art date: 2002-05-23

Application number

PL03374504A

Other languages

English (en)

Inventor

Mladen Mercep

Milan Mesic

Renata Rupcic

Dijana Pesic

Original Assignee

Pliva-Istrazivacki Institut D.O.O.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-23

Filing date

2003-05-20

Publication date

2005-10-31

2003-05-20 Application filed by Pliva-Istrazivacki Institut D.O.O. filed Critical Pliva-Istrazivacki Institut D.O.O.

2005-10-31 Publication of PL374504A1 publication Critical patent/PL374504A1/pl

Links

NKTGZAKMRRHEKM-UHFFFAOYSA-N 3,5-diazatetracyclo[12.4.0.02,6.08,13]octadeca-1(18),2,4,6,8,10,12,14,16-nonaene Chemical class N1=CN=C2C3=C(C4=C(C=C12)C=CC=C4)C=CC=C3 NKTGZAKMRRHEKM-UHFFFAOYSA-N 0.000 title 1
102000018594 Tumour necrosis factor Human genes 0.000 title 1
108050007852 Tumour necrosis factor Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
239000000543 intermediate Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PL03374504A 2002-05-23 2003-05-20 1,3-diazadibenzoazuleny jako inhibitory wytwarzania czynnika martwiczego nowotworu i związki pośrednie do ich wytwarzania PL374504A1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HR20020453A HRP20020453A2 (en)	2002-05-23	2002-05-23	1,3-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof

Publications (1)

Publication Number	Publication Date
PL374504A1 true PL374504A1 (pl)	2005-10-31

Family

ID=29559974

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL03374504A PL374504A1 (pl)	2002-05-23	2003-05-20	1,3-diazadibenzoazuleny jako inhibitory wytwarzania czynnika martwiczego nowotworu i związki pośrednie do ich wytwarzania

Country Status (15)

Country	Link
US (1)	US7166583B2 (pl)
EP (1)	EP1509528B1 (pl)
JP (1)	JP2005531586A (pl)
CN (1)	CN100354277C (pl)
AR (1)	AR040040A1 (pl)
AT (1)	ATE409191T1 (pl)
AU (1)	AU2003232372A1 (pl)
CA (1)	CA2487017A1 (pl)
DE (1)	DE60323748D1 (pl)
ES (1)	ES2314237T3 (pl)
HR (1)	HRP20020453A2 (pl)
IS (1)	IS7568A (pl)
PL (1)	PL374504A1 (pl)
RS (1)	RS100104A (pl)
WO (1)	WO2003099823A2 (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2288036T5 (es)	1998-11-13	2017-07-06	Immunex Corporation	ADN de TSLP humano y polipéptidos
DK1417231T3 (da)	2001-07-23	2013-07-22	Immunex Corp	Modificeret human thymisk stromal lymphopoietin
HRP20020304B1 (en) *	2002-04-10	2008-04-30	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	1-oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof
HRP20030958A2 (en) *	2003-11-21	2005-08-31	Pliva-Istra�iva�ki institut d.o.o.	USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
AU2005277236A1 (en) *	2004-08-20	2006-03-02	Amgen Inc.	Methods and compositions for treating allergic inflammation
JP2008532927A (ja) *	2005-01-13	2008-08-21	グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ	抗炎症マクロライド接合体
WO2007095753A1 (en) *	2006-02-24	2007-08-30	Merck Frosst Canada Ltd.	2-(phenyl or heterocyclic) - 1h-phenanthro [9,10-d] imidazoles
US7982016B2 (en)	2007-09-10	2011-07-19	Amgen Inc.	Antigen binding proteins capable of binding thymic stromal lymphopoietin

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3711489A (en) *	1971-03-31	1973-01-16	Pfizer	Certain 8,9-dihydro(3,4,7,8)cycloocta(1,2-d)imidazoles
FR2211218A1 (en) *	1972-12-21	1974-07-19	Pfizer	Dibenzocyclooctaimidazoles - useful as anti inflammatories
US4215135A (en) *	1979-06-08	1980-07-29	E. I. Du Pont De Nemours And Company	Antiinflammatory 2-substituted-1H-phenanthro[9,10-d]imidazoles
US4198421A (en) *	1978-11-30	1980-04-15	E. I. Du Pont De Nemours And Company	Antiinflammatory 2-substituted-dibenzo[2,3:6,7]oxepino[4,5-d]imidazoles
US4305954A (en) *	1981-02-11	1981-12-15	E. I. Du Pont De Nemours And Company	Antiinflammatory 3,4-dihydro(or 1,4-dihydro)-2-[(substituted)thio]-[1]benzopyrano[3,4-d]imidazoles and their corresponding sulfoxides and sulfones
US5166214A (en)	1988-12-05	1992-11-24	Du Pont Merck Pharmaceutical Company	Use of imidazoles for the treatment of atherosclerosis
CA2003283A1 (en)	1988-12-05	1990-06-05	C. Anne Higley	Imidazoles for the treatment of atherosclerosis
CA2297176A1 (en)	1997-04-24	1998-10-29	Ortho-Mcneil Pharmaceutical, Inc.	Substituted imidazoles useful in the treatment of inflammatory diseases
HRP20000310A2 (en)	2000-05-17	2002-02-28	Pliva Farmaceutska Ind Dioniko	New dibenzoazulene compounds as tumor necrosis factor inhibitors

2002
- 2002-05-23 HR HR20020453A patent/HRP20020453A2/hr not_active Application Discontinuation
2003
- 2003-05-20 US US10/515,711 patent/US7166583B2/en not_active Expired - Fee Related
- 2003-05-20 CN CNB038161214A patent/CN100354277C/zh not_active Expired - Fee Related
- 2003-05-20 ES ES03755236T patent/ES2314237T3/es not_active Expired - Lifetime
- 2003-05-20 CA CA002487017A patent/CA2487017A1/en not_active Abandoned
- 2003-05-20 WO PCT/HR2003/000025 patent/WO2003099823A2/en not_active Ceased
- 2003-05-20 AT AT03755236T patent/ATE409191T1/de not_active IP Right Cessation
- 2003-05-20 RS YU100104A patent/RS100104A/sr unknown
- 2003-05-20 JP JP2004507480A patent/JP2005531586A/ja active Pending
- 2003-05-20 AU AU2003232372A patent/AU2003232372A1/en not_active Abandoned
- 2003-05-20 PL PL03374504A patent/PL374504A1/pl not_active Application Discontinuation
- 2003-05-20 EP EP03755236A patent/EP1509528B1/en not_active Expired - Lifetime
- 2003-05-20 DE DE60323748T patent/DE60323748D1/de not_active Expired - Fee Related
- 2003-05-23 AR ARP030101804A patent/AR040040A1/es not_active Application Discontinuation
2004
- 2004-11-29 IS IS7568A patent/IS7568A/is unknown

Also Published As

Publication number	Publication date
RS100104A (sr)	2006-10-27
HRP20020453A2 (en)	2003-12-31
DE60323748D1 (de)	2008-11-06
EP1509528A2 (en)	2005-03-02
CA2487017A1 (en)	2003-12-04
US20050227963A1 (en)	2005-10-13
US7166583B2 (en)	2007-01-23
ATE409191T1 (de)	2008-10-15
CN1665513A (zh)	2005-09-07
AR040040A1 (es)	2005-03-09
AU2003232372A1 (en)	2003-12-12
JP2005531586A (ja)	2005-10-20
ES2314237T3 (es)	2009-03-16
EP1509528B1 (en)	2008-09-24
WO2003099823A3 (en)	2004-04-29
IS7568A (is)	2004-11-29
WO2003099823A2 (en)	2003-12-04
CN100354277C (zh)	2007-12-12

Legal Events

Date	Code	Title	Description
2011-04-29	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)

Publication	Publication Date	Title
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AU2002334321A1 (en)	2003-09-29	Method for the production of phytoalexins
AU2003206803A1 (en)	2003-09-02	Production of alkenones
HRP20020440A2 (en)	2004-06-30	1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof
AU2003299227A1 (en)	2004-07-14	Synthesis of amines and intermediates for the synthesis thereof
AU2003232372A1 (en)	2003-12-12	1,3-diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
PL374385A1 (pl)	2005-10-17	1-tia-3-azadibenzoazuleny jako inhibitory wytwarzania czynnika martwiczego nowotworu i związki pośrednie do ich wytwarzania
AU2003232371A8 (en)	2003-12-02	1-oxa-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof
AU2003228450A1 (en)	2003-10-27	Inhibition of tumor growth via peroxiredoxin 3
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