PL375344A1 - Novel carboxamide compounds having an mch-antagonistic effect, medicaments containing said compounds, and methods for the production thereof - Google Patents
Novel carboxamide compounds having an mch-antagonistic effect, medicaments containing said compounds, and methods for the production thereofInfo
- Publication number
- PL375344A1 PL375344A1 PL03375344A PL37534403A PL375344A1 PL 375344 A1 PL375344 A1 PL 375344A1 PL 03375344 A PL03375344 A PL 03375344A PL 37534403 A PL37534403 A PL 37534403A PL 375344 A1 PL375344 A1 PL 375344A1
- Authority
- PL
- Poland
- Prior art keywords
- compounds
- mch
- production
- methods
- antagonistic effect
- Prior art date
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- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
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| US7592373B2 (en) | 2003-12-23 | 2009-09-22 | Boehringer Ingelheim International Gmbh | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds |
| US7605176B2 (en) | 2004-03-06 | 2009-10-20 | Boehringer Ingelheim International Gmbh | β-ketoamide compounds with MCH antagonistic activity |
| DE102004017934A1 (en) | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New alkyne compounds having MCH antagonist activity and medicaments containing these compounds |
| US7524862B2 (en) | 2004-04-14 | 2009-04-28 | Boehringer Ingelheim International Gmbh | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds |
| WO2005115389A2 (en) * | 2004-05-25 | 2005-12-08 | Pfizer Products Inc. | Specific ppar agonists for treating negative energy balance |
| TW200613272A (en) | 2004-08-13 | 2006-05-01 | Astrazeneca Ab | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators |
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| US7968574B2 (en) | 2004-12-28 | 2011-06-28 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
| US7807706B2 (en) | 2005-08-12 | 2010-10-05 | Astrazeneca Ab | Metabotropic glutamate-receptor-potentiating isoindolones |
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| ES2412007T3 (en) | 2005-12-21 | 2013-07-09 | Janssen Pharmaceutica, N.V. | Novel substituted pyrazinone derivatives for use in diseases mediated by MCH-1 |
| TW200804347A (en) | 2006-01-10 | 2008-01-16 | Janssen Pharmaceutica Nv | Urotensin II receptor antagonists |
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| RU2008136898A (en) * | 2006-02-15 | 2010-03-20 | Санофи-Авентис (Fr) | AZACYCLYL-SUBSTITUTED ARYLDIGIDROISOCHINOLINONES, METHOD FOR PRODUCING THEM AND THEIR USE AS MEDICINES |
| TWI398440B (en) * | 2006-06-29 | 2013-06-11 | Kinex Pharmaceuticals Llc | Biaryl compositions and methods for modulating a kinase cascade |
| JP5564251B2 (en) * | 2006-06-29 | 2014-07-30 | キネックス ファーマシューティカルズ, エルエルシー | Biaryl compositions and methods for modulating kinase cascades |
| CA2659412A1 (en) | 2006-07-31 | 2008-02-07 | Janssen Pharmaceutica N.V. | Urotensin ii receptor antagonists |
| JP5073746B2 (en) | 2006-08-25 | 2012-11-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Novel pyridone derivative having MCH antagonistic action and drug containing this compound |
| ES2483866T3 (en) | 2006-12-05 | 2014-08-08 | Janssen Pharmaceutica Nv | Novel substituted diaza-spiro-pyridinone derivatives for use in diseases mediated by MCH-1 |
| CA2671984A1 (en) | 2006-12-11 | 2008-06-19 | Boehringer Ingelheim International Gmbh | New pyridazine derivatives with mch antagonistic activity and medicaments comprising these compounds |
| US7935697B2 (en) | 2006-12-28 | 2011-05-03 | Kinex Pharmaceuticals, Llc | Compositions for modulating a kinase cascade and methods of use thereof |
| CA2674321A1 (en) * | 2007-01-03 | 2008-07-17 | Cortex Pharmaceuticals, Inc. | 3-substituted-[1,2,3]benzotriazinone compounds for enhancing glutamatergic synaptic responses |
| US8093265B2 (en) | 2007-03-09 | 2012-01-10 | Renovis, Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
| TWI417100B (en) | 2007-06-07 | 2013-12-01 | Astrazeneca Ab | Oxadiazole derivatives and their use as metabotropic glutamate receptor potentiators-842 |
| EP2025674A1 (en) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs |
| CN101412682B (en) * | 2007-10-19 | 2012-06-27 | 上海药明康德新药开发有限公司 | Process for synthesizing aryl anthranilic acid and derivatives thereof |
| WO2009132136A1 (en) * | 2008-04-23 | 2009-10-29 | Rigel Pharmaceuticals, Inc. | Carboxamide compounds for the treatment of metabolic disorders |
| SA109300358B1 (en) | 2008-06-06 | 2012-11-03 | استرازينيكا ايه بي | Isoindolone Metabotropic Glutamate receptor Potentiators |
| ES2379762T3 (en) | 2008-08-02 | 2012-05-03 | Janssen Pharmaceutica N.V. | Urotensin II receptor antagonists |
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| CN107441097A (en) | 2010-04-16 | 2017-12-08 | 阿西纳斯公司 | For preventing and treating the composition and method of cancer |
| GB201009853D0 (en) | 2010-06-11 | 2010-07-21 | Chroma Therapeutics Ltd | HSP90 inhibitors |
| WO2012154760A1 (en) * | 2011-05-10 | 2012-11-15 | Gilead Sciences, Inc. | Fused heterocyclic compounds as sodium channel modulators |
| UY34171A (en) | 2011-07-01 | 2013-01-31 | Gilead Sciences Inc | FUSIONED HETEROCYCLIC COMPOUNDS AS IONIC CHANNEL MODULATORS |
| NO3175985T3 (en) | 2011-07-01 | 2018-04-28 | ||
| UY34194A (en) * | 2011-07-15 | 2013-02-28 | Astrazeneca Ab | ? (3- (4- (SPIROHETEROCYCLIC) METHYL) PHENOXI) AZETIDIN-1-IL) (5- (PHENYL) -1,3,4-OXADIAZOL-2-IL) METHANONE IN THE TREATMENT OF OBESITY? |
| US8933079B2 (en) * | 2012-03-07 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Pyridone and pyridazinone derivatives as anti-obesity agents |
| US9926273B2 (en) | 2012-08-30 | 2018-03-27 | Athenex, Inc. | Composition and methods for modulating a kinase cascade |
| FR3000491B1 (en) * | 2012-09-27 | 2015-08-28 | Univ Lille Ii Droit & Sante | COMPOUNDS FOR USE IN THE TREATMENT OF MYCOBACTERIAL INFECTIONS |
| CN110407824B (en) * | 2019-08-08 | 2021-07-02 | 安徽医科大学 | Aryl formamide compound and preparation method, pharmaceutical composition and use thereof |
| CN114901652A (en) * | 2019-09-17 | 2022-08-12 | 比亚尔R&D投资股份公司 | Substituted saturated and unsaturated N-heterocyclic carboxamides and related compounds for the treatment of medical disorders |
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| EP1283199A4 (en) * | 2000-05-16 | 2003-12-17 | Takeda Chemical Industries Ltd | MELANIN CONCENTRATION HORMONE ANTAGONIST |
| EP1299362A4 (en) * | 2000-07-05 | 2004-11-03 | Synaptic Pharma Corp | SELECTIVE ANTAGONISTS OF MELANIN CONCENTRATION HORMONE-1 RECEPTORS (MCH1) AND USE THEREOF |
| US20030022891A1 (en) * | 2000-12-01 | 2003-01-30 | Anandan Palani | MCH antagonists and their use in the treatment of obesity |
| HUP0302582A2 (en) * | 2000-12-22 | 2003-12-29 | Schering Corp. | Piperidine mch antagonists and their use in the treatment of obesity and pharmaceutical compositions containing them |
| GB0124627D0 (en) * | 2001-10-15 | 2001-12-05 | Smithkline Beecham Plc | Novel compounds |
| GB0124931D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
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| NO20050068L (en) | 2005-03-04 |
| DE10238865A1 (en) | 2004-03-11 |
| CA2496563A1 (en) | 2004-03-25 |
| BR0313790A (en) | 2005-07-12 |
| ECSP055615A (en) | 2005-05-30 |
| UA82853C2 (en) | 2008-05-26 |
| CN1678591A (en) | 2005-10-05 |
| AR043046A1 (en) | 2005-07-13 |
| ZA200500086B (en) | 2006-07-26 |
| MXPA05002158A (en) | 2005-05-23 |
| WO2004024702A1 (en) | 2004-03-25 |
| HRP20050179A2 (en) | 2006-05-31 |
| TW200413332A (en) | 2004-08-01 |
| EP1534689A1 (en) | 2005-06-01 |
| EA012834B1 (en) | 2009-12-30 |
| JP2006507246A (en) | 2006-03-02 |
| AU2003258620A1 (en) | 2004-04-30 |
| KR20050040928A (en) | 2005-05-03 |
| PE20040974A1 (en) | 2005-01-12 |
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