PL375344A1 - Nowe związki karboksyamidowe działające antagonistycznie wobec MCH, środki medyczne zawierające te związki oraz sposoby ich wytwarzania - Google Patents
Nowe związki karboksyamidowe działające antagonistycznie wobec MCH, środki medyczne zawierające te związki oraz sposoby ich wytwarzaniaInfo
- Publication number
- PL375344A1 PL375344A1 PL03375344A PL37534403A PL375344A1 PL 375344 A1 PL375344 A1 PL 375344A1 PL 03375344 A PL03375344 A PL 03375344A PL 37534403 A PL37534403 A PL 37534403A PL 375344 A1 PL375344 A1 PL 375344A1
- Authority
- PL
- Poland
- Prior art keywords
- compounds
- mch
- production
- methods
- antagonistic effect
- Prior art date
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- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| DE10238865A DE10238865A1 (de) | 2002-08-24 | 2002-08-24 | Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
Publications (1)
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| PL375344A1 true PL375344A1 (pl) | 2005-11-28 |
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| PL03375344A PL375344A1 (pl) | 2002-08-24 | 2003-08-16 | Nowe związki karboksyamidowe działające antagonistycznie wobec MCH, środki medyczne zawierające te związki oraz sposoby ich wytwarzania |
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| UA (1) | UA82853C2 (pl) |
| WO (1) | WO2004024702A1 (pl) |
| ZA (1) | ZA200500086B (pl) |
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| US7351719B2 (en) | 2002-10-31 | 2008-04-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds |
| EP1593667A4 (en) * | 2003-02-12 | 2009-03-04 | Takeda Pharmaceutical | Amine derivative |
| JP2007508303A (ja) | 2003-10-01 | 2007-04-05 | ザ プロクター アンド ギャンブル カンパニー | メラニン凝集ホルモン拮抗物質 |
| MXPA06003951A (es) * | 2003-10-07 | 2006-06-27 | Renovis Inc | Derivados de amida como ligandos del canal de ion y composiciones farmaceuticas y sus metodos de uso. |
| US7592373B2 (en) | 2003-12-23 | 2009-09-22 | Boehringer Ingelheim International Gmbh | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds |
| US7605176B2 (en) | 2004-03-06 | 2009-10-20 | Boehringer Ingelheim International Gmbh | β-ketoamide compounds with MCH antagonistic activity |
| US7524862B2 (en) | 2004-04-14 | 2009-04-28 | Boehringer Ingelheim International Gmbh | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds |
| DE102004017934A1 (de) | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
| CN1956719A (zh) * | 2004-05-25 | 2007-05-02 | 辉瑞产品公司 | 用于治疗负能量平衡的特定 ppar激动剂 |
| TW200613272A (en) * | 2004-08-13 | 2006-05-01 | Astrazeneca Ab | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators |
| DE102004039789A1 (de) * | 2004-08-16 | 2006-03-02 | Sanofi-Aventis Deutschland Gmbh | Arylsubstituierte polycyclische Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| BRPI0519424B8 (pt) | 2004-12-28 | 2021-05-25 | Athenex Inc | compostos, composição e uso dos ditos compostos para a preparação de um medicamento para prevenção ou tratamento de um distúrbio de proliferação celular ou infecção microbiana |
| US7968574B2 (en) | 2004-12-28 | 2011-06-28 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
| EP1912939A1 (en) * | 2005-08-12 | 2008-04-23 | AstraZeneca AB | Metabotropic glutamate-receptor-potentiating isoindolones |
| US7807706B2 (en) | 2005-08-12 | 2010-10-05 | Astrazeneca Ab | Metabotropic glutamate-receptor-potentiating isoindolones |
| ES2412007T3 (es) | 2005-12-21 | 2013-07-09 | Janssen Pharmaceutica, N.V. | Derivados de pirazinona sustituida novedosos para uso en enfermedades mediadas por MCH-1 |
| TW200804347A (en) | 2006-01-10 | 2008-01-16 | Janssen Pharmaceutica Nv | Urotensin II receptor antagonists |
| CN101384583A (zh) * | 2006-02-15 | 2009-03-11 | 塞诺菲-安万特股份有限公司 | 氮杂环基-取代的芳基二氢异喹啉酮、它们的制备方法和它们作为药物的用途 |
| CA2636617A1 (en) | 2006-02-15 | 2007-08-23 | Lothar Schwink | Novel aminoalcohol-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments |
| JP2009526792A (ja) * | 2006-02-15 | 2009-07-23 | サノフィ−アベンティス | 新規なアザシクリル置換アリールチエノピリミジノン、それらの製造方法及び薬剤としてのそれらの使用 |
| WO2007093365A2 (en) * | 2006-02-15 | 2007-08-23 | Sanofi-Aventis | Novel amino alcohol-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments |
| TWI398440B (zh) * | 2006-06-29 | 2013-06-11 | Kinex Pharmaceuticals Llc | 雙芳基組成物與調節激酶級聯之方法 |
| EP2041071B1 (en) * | 2006-06-29 | 2014-06-18 | Kinex Pharmaceuticals, LLC | Biaryl compositions and methods for modulating a kinase cascade |
| CA2659412A1 (en) | 2006-07-31 | 2008-02-07 | Janssen Pharmaceutica N.V. | Urotensin ii receptor antagonists |
| CN101506195A (zh) | 2006-08-25 | 2009-08-12 | 贝林格尔.英格海姆国际有限公司 | 具有mch拮抗活性的新颖吡啶酮衍生物及包含这些化合物的药物 |
| AU2007328979B2 (en) | 2006-12-05 | 2013-05-09 | Janssen Pharmaceutica N.V. | Novel substituted diaza spiro pyridinone derivatives for use in MCH-1 mediated diseases |
| EP2102171A1 (en) | 2006-12-11 | 2009-09-23 | Boehringer Ingelheim International GmbH | New pyridazine derivatives with mch antagonistic activity and medicaments comprising these compounds |
| US7935697B2 (en) | 2006-12-28 | 2011-05-03 | Kinex Pharmaceuticals, Llc | Compositions for modulating a kinase cascade and methods of use thereof |
| WO2008085505A1 (en) * | 2007-01-03 | 2008-07-17 | Cortex Pharmaceuticals, Inc. | 3-substituted-[1,2,3]benzotriazinone compounds for enhancing glutamatergic synaptic responses |
| JP2010520875A (ja) | 2007-03-09 | 2010-06-17 | レノビス, インコーポレイテッド | P2x7調節因子としてのビシクロヘテロアリール化合物およびその使用 |
| TWI417100B (zh) | 2007-06-07 | 2013-12-01 | Astrazeneca Ab | 二唑衍生物及其作為代謝型麩胺酸受體增效劑-842之用途 |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| CN101412682B (zh) * | 2007-10-19 | 2012-06-27 | 上海药明康德新药开发有限公司 | 芳基氨茴酸及其衍生物的合成方法 |
| EA021119B1 (ru) * | 2008-04-23 | 2015-04-30 | Райджел Фармасьютикалз, Инк. | Карбоксамидные соединения для лечения метаболических расстройств |
| SA109300358B1 (ar) | 2008-06-06 | 2012-11-03 | استرازينيكا ايه بي | مقويات مستقبل جلوتامات ذي انتحاء أيضي من أيزو إندولون |
| EP2326644B1 (en) | 2008-08-02 | 2012-02-22 | Janssen Pharmaceutica N.V. | Urotensin ii receptor antagonists |
| TW201040154A (en) | 2009-02-13 | 2010-11-16 | Sanofi Aventis | Novel substituted indanes, process for preparation thereof and use thereof as a medicament |
| AR075402A1 (es) | 2009-02-13 | 2011-03-30 | Sanofi Aventis | Derivados heterociclicos oxigenados y/o nitrogenados de tetrahidronaftaleno, medicamentos que los contienen y uso de los mismos en el tratamiento de trastornos metabolicos, tales como obesidad,entre otros. |
| CN107441097A (zh) | 2010-04-16 | 2017-12-08 | 阿西纳斯公司 | 用于预防和治疗癌症的组合物以及方法 |
| GB201009853D0 (en) | 2010-06-11 | 2010-07-21 | Chroma Therapeutics Ltd | HSP90 inhibitors |
| EP2707361B1 (en) | 2011-05-10 | 2017-08-23 | Gilead Sciences, Inc. | Fused heterocyclic compounds as sodium channel modulators |
| TW201837023A (zh) | 2011-07-01 | 2018-10-16 | 美商基利科學股份有限公司 | 作為離子通道調節劑之稠合雜環化合物 |
| NO3175985T3 (pl) | 2011-07-01 | 2018-04-28 | ||
| UY34194A (es) * | 2011-07-15 | 2013-02-28 | Astrazeneca Ab | ?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad? |
| US8933079B2 (en) * | 2012-03-07 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Pyridone and pyridazinone derivatives as anti-obesity agents |
| TWI664167B (zh) | 2012-08-30 | 2019-07-01 | 美商艾瑟奈克斯公司 | 用於調節激酶級聯之組成物及方法 |
| FR3000491B1 (fr) * | 2012-09-27 | 2015-08-28 | Univ Lille Ii Droit & Sante | Composes utilisables dans le traitement des infections mycobacteriennes |
| CN110407824B (zh) * | 2019-08-08 | 2021-07-02 | 安徽医科大学 | 芳基甲酰胺类化合物及其制备方法、药物组合物及用途 |
| EP4031540A1 (en) * | 2019-09-17 | 2022-07-27 | Bial-R&D Investments, S.A. | Substituted, saturated and unsaturated n-heterocyclic carboxamides and related compounds for their use in the treatment of medical disorders |
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2003
- 2003-08-16 KR KR1020057003110A patent/KR20050040928A/ko not_active Ceased
- 2003-08-16 JP JP2004535098A patent/JP2006507246A/ja active Pending
- 2003-08-16 PL PL03375344A patent/PL375344A1/pl not_active Application Discontinuation
- 2003-08-16 HR HR20050179A patent/HRP20050179A2/hr not_active Application Discontinuation
- 2003-08-16 CA CA002496563A patent/CA2496563A1/en not_active Abandoned
- 2003-08-16 AU AU2003258620A patent/AU2003258620A1/en not_active Abandoned
- 2003-08-16 RS YUP-2005/0173A patent/RS20050173A/sr unknown
- 2003-08-16 EP EP03794886A patent/EP1534689A1/de not_active Withdrawn
- 2003-08-16 MX MXPA05002158A patent/MXPA05002158A/es unknown
- 2003-08-16 UA UAA200502601A patent/UA82853C2/uk unknown
- 2003-08-16 WO PCT/EP2003/009099 patent/WO2004024702A1/de not_active Ceased
- 2003-08-16 EA EA200500301A patent/EA012834B1/ru not_active IP Right Cessation
- 2003-08-16 CN CNA038200767A patent/CN1678591A/zh active Pending
- 2003-08-16 BR BR0313790-2A patent/BR0313790A/pt not_active IP Right Cessation
- 2003-08-21 PE PE2003000849A patent/PE20040974A1/es not_active Application Discontinuation
- 2003-08-22 AR ARP030103034A patent/AR043046A1/es unknown
- 2003-08-22 TW TW092123197A patent/TW200413332A/zh unknown
-
2005
- 2005-01-05 ZA ZA200500086A patent/ZA200500086B/xx unknown
- 2005-01-06 NO NO20050068A patent/NO20050068L/no not_active Application Discontinuation
- 2005-02-18 EC EC2005005615A patent/ECSP055615A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200500086B (en) | 2006-07-26 |
| UA82853C2 (en) | 2008-05-26 |
| NO20050068L (no) | 2005-03-04 |
| MXPA05002158A (es) | 2005-05-23 |
| AR043046A1 (es) | 2005-07-13 |
| RS20050173A (sr) | 2007-09-21 |
| EA012834B1 (ru) | 2009-12-30 |
| AU2003258620A1 (en) | 2004-04-30 |
| HRP20050179A2 (en) | 2006-05-31 |
| ECSP055615A (es) | 2005-05-30 |
| CN1678591A (zh) | 2005-10-05 |
| EA200500301A1 (ru) | 2006-02-24 |
| BR0313790A (pt) | 2005-07-12 |
| KR20050040928A (ko) | 2005-05-03 |
| TW200413332A (en) | 2004-08-01 |
| DE10238865A1 (de) | 2004-03-11 |
| WO2004024702A1 (de) | 2004-03-25 |
| CA2496563A1 (en) | 2004-03-25 |
| JP2006507246A (ja) | 2006-03-02 |
| PE20040974A1 (es) | 2005-01-12 |
| EP1534689A1 (de) | 2005-06-01 |
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| REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |