PL376483A1 - Sposób wytwarzania doustnej postaci leku o natychmiastowym rozpadzie i uwalnianiu substancji czynnych - Google Patents
Sposób wytwarzania doustnej postaci leku o natychmiastowym rozpadzie i uwalnianiu substancji czynnychInfo
- Publication number
- PL376483A1 PL376483A1 PL03376483A PL37648303A PL376483A1 PL 376483 A1 PL376483 A1 PL 376483A1 PL 03376483 A PL03376483 A PL 03376483A PL 37648303 A PL37648303 A PL 37648303A PL 376483 A1 PL376483 A1 PL 376483A1
- Authority
- PL
- Poland
- Prior art keywords
- release
- making
- active substances
- oral formulation
- immediate degradation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10304403A DE10304403A1 (de) | 2003-01-28 | 2003-01-28 | Verfahren zur Herstellung einer oralen Arzneiform mit unmittelbarem Zerfall und Wirkstofffreisetzung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL376483A1 true PL376483A1 (pl) | 2005-12-27 |
| PL206413B1 PL206413B1 (pl) | 2010-08-31 |
Family
ID=32667988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL376483A PL206413B1 (pl) | 2003-01-28 | 2003-11-21 | Sposób wytwarzania doustnej postaci leku o natychmiastowym rozpadzie i uwalnianiu substancji czynnej, proszek zawierający substancję czynną oraz jego zastosowanie |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8343542B2 (pl) |
| EP (1) | EP1587497B1 (pl) |
| JP (2) | JP5537756B2 (pl) |
| KR (1) | KR100983461B1 (pl) |
| AU (1) | AU2003292061A1 (pl) |
| BR (1) | BRPI0318049B8 (pl) |
| CA (1) | CA2512738C (pl) |
| DE (1) | DE10304403A1 (pl) |
| ES (1) | ES2528359T3 (pl) |
| IL (1) | IL169886A (pl) |
| MX (1) | MXPA05007643A (pl) |
| PL (1) | PL206413B1 (pl) |
| SI (1) | SI1587497T1 (pl) |
| WO (1) | WO2004066976A1 (pl) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10026698A1 (de) * | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
| US7527807B2 (en) | 2000-06-21 | 2009-05-05 | Cubist Pharmaceuticals, Inc. | Compositions and methods for increasing the oral absorption of antimicrobials |
| CA2359812C (en) | 2000-11-20 | 2004-02-10 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures |
| DE10304403A1 (de) * | 2003-01-28 | 2004-08-05 | Röhm GmbH & Co. KG | Verfahren zur Herstellung einer oralen Arzneiform mit unmittelbarem Zerfall und Wirkstofffreisetzung |
| US8377952B2 (en) * | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
| US8025899B2 (en) * | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| WO2005094812A1 (ja) * | 2004-04-01 | 2005-10-13 | Ajinomoto Co., Inc. | ナテグリニド含有製剤 |
| EP1814544A4 (en) * | 2004-11-05 | 2009-12-02 | Cephalon Inc | CANCER TREATMENTS |
| US8436190B2 (en) | 2005-01-14 | 2013-05-07 | Cephalon, Inc. | Bendamustine pharmaceutical compositions |
| FR2882655B1 (fr) * | 2005-03-07 | 2007-04-27 | Vetoquinol Sa Sa | Nouveau procede d'obtention d'une poudre d'imidapril a dissolution rapide |
| EP2974718A1 (en) * | 2005-04-29 | 2016-01-20 | Cubist Pharmaceuticals, Inc. | Therapeutic compositions |
| GB0518129D0 (en) * | 2005-09-06 | 2005-10-12 | Arrow Int Ltd | Ramipril formulation |
| CN100336816C (zh) * | 2005-12-14 | 2007-09-12 | 广州大学 | 一种舒巴坦制备方法 |
| CN100402030C (zh) * | 2006-01-05 | 2008-07-16 | 珠海联邦制药股份有限公司 | 一种含阿莫西林的药物组合物及其制备方法 |
| CA2641351C (en) * | 2006-02-03 | 2014-05-06 | Evonik Operations Gmbh | Pharmaceutical compositions containing mixtures of polymers and active agents poorly soluble in water |
| DE102007026550A1 (de) | 2007-06-08 | 2008-12-11 | Bayer Healthcare Ag | Extrudate mit verbesserter Geschmacksmaskierung |
| US20090036414A1 (en) * | 2007-08-02 | 2009-02-05 | Mutual Pharmaceutical Company, Inc. | Mesalamine Formulations |
| US8198277B2 (en) * | 2007-12-19 | 2012-06-12 | Sunovion Pharmaceuticals Inc. | L-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine |
| US8268832B2 (en) * | 2007-12-19 | 2012-09-18 | Sunovion Pharmaceuticals Inc. | Maleate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine |
| US8212036B2 (en) * | 2007-12-19 | 2012-07-03 | Sunovion Pharmaceuticals Inc. | Maleate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine |
| US8198278B2 (en) * | 2007-12-19 | 2012-06-12 | Sunovion Pharmaceuticals Inc. | Besylate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine |
| AR072777A1 (es) | 2008-03-26 | 2010-09-22 | Cephalon Inc | Formas solidas de clorhidrato de bendamustina |
| AU2009296734B2 (en) * | 2008-09-25 | 2016-02-18 | Cephalon Llc | Liquid formulations of bendamustine |
| AU2010204765A1 (en) | 2009-01-15 | 2011-07-28 | Cephalon, Inc. | Novel forms of bendamustine free base |
| CN102471523A (zh) * | 2009-07-30 | 2012-05-23 | 赢创罗姆有限公司 | 包含共聚物、二羧酸和脂肪单羧酸的粉末状或粒状组合物 |
| JP5817715B2 (ja) * | 2010-03-03 | 2015-11-18 | ライオン株式会社 | 固形医薬組成物、医薬製剤及び固形医薬組成物の製造方法 |
| CN102985074B (zh) | 2010-05-10 | 2015-09-02 | 赢创罗姆有限公司 | 包含一种或多种抗逆转录病毒活性成分的药物剂型 |
| JO3659B1 (ar) * | 2010-06-02 | 2020-08-27 | Astellas Deutschland Gmbh | أشكال جرعات بينداموستين عن طريق الفم وإستخداماته العلاجية |
| CN102078322B (zh) * | 2011-02-17 | 2013-10-30 | 武汉同源药业有限公司 | 注射用哌拉西林钠他唑巴坦钠的医药用途 |
| RU2013139247A (ru) | 2011-02-23 | 2015-03-27 | Церулеус Лтд. | Комплексы флумазенила, содержащие их композиции и их применения |
| SI3616695T1 (sl) | 2011-09-09 | 2025-01-31 | Merck Sharp & Dohme Llc | Ceftolozan/tazobaktam za zdravljenje intrapulmonalnih okužb |
| US8809314B1 (en) | 2012-09-07 | 2014-08-19 | Cubist Pharmacueticals, Inc. | Cephalosporin compound |
| US8476425B1 (en) | 2012-09-27 | 2013-07-02 | Cubist Pharmaceuticals, Inc. | Tazobactam arginine compositions |
| UA121298C2 (uk) | 2013-03-15 | 2020-05-12 | Мерк Шарп І Доум Корп. | Антибіотична композиція на основі цефтолозану і тазобактаму |
| US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
| US20140274997A1 (en) | 2013-03-15 | 2014-09-18 | Cubist Pharmaceuticals, Inc. | Cephalosporin pharmaceutical compositions |
| AU2014233637A1 (en) | 2013-09-09 | 2015-03-26 | Merck Sharp & Dohme Corp. | Treating infections with ceftolozane/tazobactam in subjects having impaired renal function |
| US20150094293A1 (en) | 2013-09-27 | 2015-04-02 | Calixa Therapeutics, Inc. | Solid forms of ceftolozane |
| CN104523430A (zh) * | 2014-12-17 | 2015-04-22 | 吉林敖东世航药业股份有限公司 | 中药材的冰冻低温超微粉碎方法 |
| CN104784125B (zh) * | 2015-04-14 | 2017-10-03 | 海南皇隆制药股份有限公司 | 一种注射用萘普生钠冻干粉针制剂及其制备方法 |
| US10624899B2 (en) | 2016-07-14 | 2020-04-21 | Achaogen, Inc. | Combination products for the treatment of bacterial infections and methods of producing or dosing of same |
| CN109364777B (zh) * | 2018-10-25 | 2021-08-06 | 瑞阳制药股份有限公司 | 美洛西林钠和舒巴坦钠混粉的制备方法及装置 |
| DE102019219184A1 (de) | 2019-12-09 | 2021-06-10 | Robert Bosch Gmbh | Elektrischer Leiter aus Graphen und/oder Kohlenstoffnanoröhren mit beschichteten Fügestellen |
| JP2023553010A (ja) | 2020-12-03 | 2023-12-20 | バテル・メモリアル・インスティテュート | 非ウイルス性送達のためのポリマーナノ粒子およびdnaナノ構造組成物ならびに方法 |
| EP4320233A4 (en) | 2021-04-07 | 2025-08-13 | Battelle Memorial Institute | RAPID DESIGN, BUILD, TEST, AND LEARNING TECHNOLOGIES TO IDENTIFY AND USE NON-VIRAL VECTORS |
| JP7817300B2 (ja) * | 2023-02-14 | 2026-02-18 | 沢井製薬株式会社 | コーティング顆粒、コーティング顆粒を含む製剤及びそれらの製造方法 |
| WO2025072751A1 (en) | 2023-09-29 | 2025-04-03 | Battelle Memorial Institute | Polymer nanoparticle compositions for in vivo expression of polypeptides |
| WO2025122954A1 (en) | 2023-12-08 | 2025-06-12 | Battelle Memorial Institute | Use of dna origami nanostructures for molecular information based data storage systems |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3930733A1 (de) | 1989-09-14 | 1991-03-28 | Roehm Gmbh | Verfahren zur herstellung eines komplexierten arzneimittels |
| JPH0674206B2 (ja) * | 1989-12-28 | 1994-09-21 | 田辺製薬株式会社 | 放出制御型製剤およびその製法 |
| DE29502547U1 (de) * | 1995-02-16 | 1995-03-30 | Röhm GmbH, 64293 Darmstadt | Thermoplastisches Überzugs- und Bindemittel für Arzneiformen |
| US5529800A (en) * | 1995-02-17 | 1996-06-25 | General Mills, Inc. | Low density ready-to-spread frosting and method of preparation |
| AUPN605795A0 (en) * | 1995-10-19 | 1995-11-09 | F.H. Faulding & Co. Limited | Analgesic pharmaceutical composition |
| CA2227314A1 (en) | 1997-01-24 | 1998-07-24 | Hoechst Aktiengesellschaft | Preparation of concealed taste preparations of antibacterially active quinolone derivatives |
| EP1027036A2 (en) | 1997-10-03 | 2000-08-16 | ELAN CORPORATION, Plc | Taste masked formulations |
| FR2781152B1 (fr) | 1998-07-20 | 2001-07-06 | Permatec Tech Ag | Utilisation d'un polymere de type acrylique en tant qu'agent de desagregation |
| DE19918435A1 (de) * | 1998-07-23 | 2000-01-27 | Roehm Gmbh | Überzugs- und Bindemittel für orale oder dermale Arzneiformen |
| DE19958007A1 (de) | 1999-12-02 | 2001-06-07 | Roehm Gmbh | Spritzgußverfahren für (Meth)acrylat-Copolymere mit teritiären Ammoniumgruppen |
| US6656492B2 (en) * | 2000-06-30 | 2003-12-02 | Yamanouchi Pharmaceutical Co., Ltd. | Quick disintegrating tablet in buccal cavity and manufacturing method thereof |
| CA2403831C (en) * | 2001-02-27 | 2009-11-24 | Evonik Operations Gmbh | Coating and binding agent for pharmaceutical formulations having improved storage stability |
| HUP0401941A3 (en) | 2001-07-16 | 2008-04-28 | Astrazeneca Ab | Pharmaceutical formulation comprising a proton pomp inhibitor and antacids and process for its preparation |
| DE10208344A1 (de) | 2002-02-27 | 2003-09-04 | Roehm Gmbh | Schmelzextrusion von Wirkstoffsalzen |
| DE10239999A1 (de) * | 2002-08-27 | 2004-03-04 | Röhm GmbH & Co. KG | Granulat oder Pulver zur Herstellung von Überzugs- und Bindemitteln für Arzneiformen |
| DE10304403A1 (de) * | 2003-01-28 | 2004-08-05 | Röhm GmbH & Co. KG | Verfahren zur Herstellung einer oralen Arzneiform mit unmittelbarem Zerfall und Wirkstofffreisetzung |
-
2003
- 2003-01-28 DE DE10304403A patent/DE10304403A1/de not_active Withdrawn
- 2003-11-21 EP EP03767591.5A patent/EP1587497B1/de not_active Expired - Lifetime
- 2003-11-21 CA CA2512738A patent/CA2512738C/en not_active Expired - Lifetime
- 2003-11-21 AU AU2003292061A patent/AU2003292061A1/en not_active Abandoned
- 2003-11-21 KR KR1020057013779A patent/KR100983461B1/ko not_active Expired - Lifetime
- 2003-11-21 SI SI200332408T patent/SI1587497T1/sl unknown
- 2003-11-21 US US10/542,283 patent/US8343542B2/en active Active
- 2003-11-21 ES ES03767591.5T patent/ES2528359T3/es not_active Expired - Lifetime
- 2003-11-21 JP JP2004567296A patent/JP5537756B2/ja not_active Expired - Lifetime
- 2003-11-21 PL PL376483A patent/PL206413B1/pl unknown
- 2003-11-21 MX MXPA05007643A patent/MXPA05007643A/es active IP Right Grant
- 2003-11-21 WO PCT/EP2003/013059 patent/WO2004066976A1/de not_active Ceased
- 2003-11-21 BR BRPI0318049A patent/BRPI0318049B8/pt active IP Right Grant
-
2005
- 2005-07-26 IL IL169886A patent/IL169886A/en unknown
-
2012
- 2012-11-15 US US13/677,740 patent/US8999385B2/en not_active Expired - Lifetime
-
2014
- 2014-02-28 JP JP2014039093A patent/JP2014159424A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003292061A1 (en) | 2004-08-23 |
| KR20050096952A (ko) | 2005-10-06 |
| BR0318049A (pt) | 2005-12-20 |
| BRPI0318049B8 (pt) | 2021-05-25 |
| JP2014159424A (ja) | 2014-09-04 |
| DE10304403A1 (de) | 2004-08-05 |
| WO2004066976A1 (de) | 2004-08-12 |
| EP1587497B1 (de) | 2014-11-12 |
| SI1587497T1 (sl) | 2015-03-31 |
| BRPI0318049B1 (pt) | 2018-04-03 |
| CA2512738A1 (en) | 2004-08-12 |
| US20130071475A1 (en) | 2013-03-21 |
| CA2512738C (en) | 2013-08-13 |
| JP2006514660A (ja) | 2006-05-11 |
| IL169886A0 (en) | 2007-07-04 |
| KR100983461B1 (ko) | 2010-09-27 |
| US8999385B2 (en) | 2015-04-07 |
| JP5537756B2 (ja) | 2014-07-02 |
| MXPA05007643A (es) | 2005-09-30 |
| PL206413B1 (pl) | 2010-08-31 |
| IL169886A (en) | 2010-11-30 |
| ES2528359T3 (es) | 2015-02-09 |
| EP1587497A1 (de) | 2005-10-26 |
| US20060051412A1 (en) | 2006-03-09 |
| US8343542B2 (en) | 2013-01-01 |
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