PL376793A1 - Spirocykliczne pochodne cykloheksanu - Google Patents

Spirocykliczne pochodne cykloheksanu

Info

Publication number
PL376793A1
PL376793A1 PL37679303A PL37679303A PL376793A1 PL 376793 A1 PL376793 A1 PL 376793A1 PL 37679303 A PL37679303 A PL 37679303A PL 37679303 A PL37679303 A PL 37679303A PL 376793 A1 PL376793 A1 PL 376793A1
Authority
PL
Poland
Prior art keywords
cyclohexane derivatives
spirocyclic cyclohexane
spirocyclic
derivatives
medicinal
Prior art date
Application number
PL37679303A
Other languages
English (en)
Other versions
PL215227B1 (pl
Inventor
Claudia Hinze
Otto Aulenbacher
Bernd Sundermann
Stefan Oberbörsch
Elmar Friderichs
Werner Englberger
Babette-Yvonne Kögel
Klaus Linz
Hans Schick
Helmut Sonnenschein
Brigitta Henkel
Valerie Sarah Rose
Michael Jonathan Lipkin
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32185555&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL376793(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of PL376793A1 publication Critical patent/PL376793A1/pl
Publication of PL215227B1 publication Critical patent/PL215227B1/pl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61P13/10—Drugs for disorders of the urinary system of the bladder
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    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
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    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/06—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing halogen atoms, or nitro or nitroso groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/265—Citric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Wynalazek dotyczy spirocyklicznych pochodnych cykloheksanu, sposobu ich wytwarzania, środka leczniczego, zawierającego te związki, oraz zastosowania spirocyklicznych pochodnych cykloheksanu do wytwarzania środków leczniczych.
PL376793A 2002-11-11 2003-11-05 Spirocykliczne pochodne cykloheksanu, sposoby ich wytwarzania, ich zastosowania oraz srodek leczniczy zawierajacy te zwiazki PL215227B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2002152667 DE10252667A1 (de) 2002-11-11 2002-11-11 Spirocyclische Cyclohexan-Derivate

Publications (2)

Publication Number Publication Date
PL376793A1 true PL376793A1 (pl) 2006-01-09
PL215227B1 PL215227B1 (pl) 2013-11-29

Family

ID=32185555

Family Applications (2)

Application Number Title Priority Date Filing Date
PL390420A PL217804B1 (pl) 2002-11-11 2003-11-05 Spirocykliczne pochodne cykloheksanu, sposoby ich wytwarzania, ich zastosowania oraz środek leczniczy zawierający te związki
PL376793A PL215227B1 (pl) 2002-11-11 2003-11-05 Spirocykliczne pochodne cykloheksanu, sposoby ich wytwarzania, ich zastosowania oraz srodek leczniczy zawierajacy te zwiazki

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL390420A PL217804B1 (pl) 2002-11-11 2003-11-05 Spirocykliczne pochodne cykloheksanu, sposoby ich wytwarzania, ich zastosowania oraz środek leczniczy zawierający te związki

Country Status (27)

Country Link
US (6) US7547707B2 (pl)
EP (4) EP2062898B1 (pl)
JP (4) JP4728645B2 (pl)
KR (2) KR101075817B1 (pl)
CN (2) CN100577664C (pl)
AR (2) AR041932A1 (pl)
AT (1) ATE441650T1 (pl)
AU (2) AU2003296563B2 (pl)
BR (2) BRPI0318811B8 (pl)
CA (1) CA2505555C (pl)
CO (1) CO5580765A2 (pl)
CY (2) CY1110558T1 (pl)
DE (2) DE10252667A1 (pl)
DK (2) DK2062898T3 (pl)
EC (1) ECSP055786A (pl)
ES (4) ES2587185T3 (pl)
IL (2) IL168473A (pl)
MX (1) MXPA05004959A (pl)
NO (2) NO331818B1 (pl)
NZ (1) NZ540575A (pl)
PE (1) PE20040830A1 (pl)
PL (2) PL217804B1 (pl)
PT (2) PT1560835E (pl)
RU (1) RU2354656C2 (pl)
SI (2) SI1560835T1 (pl)
WO (1) WO2004043967A1 (pl)
ZA (1) ZA200504725B (pl)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
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DK1560835T3 (da) 2010-01-04
CA2505555A1 (en) 2004-05-27
PL217804B1 (pl) 2014-08-29
US20100240897A1 (en) 2010-09-23
US9120797B2 (en) 2015-09-01
PL390420A1 (pl) 2010-04-26
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HK1080478A1 (zh) 2006-04-28
AU2010200219B2 (en) 2012-04-12
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EP2233487B1 (de) 2016-05-18
CA2505555C (en) 2011-01-04
CN100577664C (zh) 2010-01-06
CO5580765A2 (es) 2005-11-30
HK1130491A1 (en) 2009-12-31
RU2354656C2 (ru) 2009-05-10
US20090163716A1 (en) 2009-06-25
KR101075810B1 (ko) 2011-10-25
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US20150322080A1 (en) 2015-11-12
BR0315296A (pt) 2005-08-30
PL215227B1 (pl) 2013-11-29
KR20050074579A (ko) 2005-07-18
HK1146044A1 (zh) 2011-05-13
ES2587013T3 (es) 2016-10-20
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ES2333956T3 (es) 2010-03-03
DE10252667A1 (de) 2004-05-27
MXPA05004959A (es) 2005-08-02
BRPI0318811B8 (pt) 2021-05-25
DE50311874D1 (en) 2009-10-15
NO20093060L (no) 2005-06-07
JP5539821B2 (ja) 2014-07-02
US9862719B2 (en) 2018-01-09
EP2116544A2 (de) 2009-11-11
ES2587185T3 (es) 2016-10-21
EP2062898B1 (de) 2013-10-02
ATE441650T1 (de) 2009-09-15
PT1560835E (pt) 2009-12-10
WO2004043967A1 (de) 2004-05-27
EP2233487A1 (de) 2010-09-29
CY1110558T1 (el) 2015-04-29
AU2010200219A1 (en) 2010-02-11
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