PL377220A1 - Nowy proces syntezy związków kwasu (2S, 3aS, 7aS)-1-[(S)-alanilo]-oktahydro-1H-indolo-2-karboksylowego i zastosowanie w syntezie perindoprylu - Google Patents

Nowy proces syntezy związków kwasu (2S, 3aS, 7aS)-1-[(S)-alanilo]-oktahydro-1H-indolo-2-karboksylowego i zastosowanie w syntezie perindoprylu

Info

Publication number
PL377220A1
PL377220A1 PL377220A PL37722004A PL377220A1 PL 377220 A1 PL377220 A1 PL 377220A1 PL 377220 A PL377220 A PL 377220A PL 37722004 A PL37722004 A PL 37722004A PL 377220 A1 PL377220 A1 PL 377220A1
Authority
PL
Poland
Prior art keywords
synthesis
alanil
octahydro
indole
carboxylic acid
Prior art date
Application number
PL377220A
Other languages
English (en)
Other versions
PL211506B1 (pl
Inventor
Thierry Dubuffet
Pascal Langlois
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of PL377220A1 publication Critical patent/PL377220A1/pl
Publication of PL211506B1 publication Critical patent/PL211506B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Catalysts (AREA)
PL377220A 2003-02-28 2004-02-27 Sposób otrzymywania związków kwasu (2S, 3aS, 7aS)-1-[(S)-alanilo]-oktahydro-1H-indolo-2-karboksylowego i ich zastosowanie w syntezie perindoprilu oraz związek przejściowy PL211506B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03290486A EP1403277B1 (fr) 2003-02-28 2003-02-28 Nouveau procédé de synthèse de dérives de l'acide (2S, 3aS, 7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylique, et application à la synthèse du perindopril

Publications (2)

Publication Number Publication Date
PL377220A1 true PL377220A1 (pl) 2006-01-23
PL211506B1 PL211506B1 (pl) 2012-05-31

Family

ID=31970534

Family Applications (1)

Application Number Title Priority Date Filing Date
PL377220A PL211506B1 (pl) 2003-02-28 2004-02-27 Sposób otrzymywania związków kwasu (2S, 3aS, 7aS)-1-[(S)-alanilo]-oktahydro-1H-indolo-2-karboksylowego i ich zastosowanie w syntezie perindoprilu oraz związek przejściowy

Country Status (18)

Country Link
US (1) US7157485B2 (pl)
EP (1) EP1403277B1 (pl)
JP (1) JP4279871B2 (pl)
CN (1) CN1331883C (pl)
AR (1) AR043410A1 (pl)
AT (1) ATE305939T1 (pl)
AU (1) AU2004218202B2 (pl)
DE (1) DE60301774T2 (pl)
DK (1) DK1403277T3 (pl)
EA (1) EA009062B1 (pl)
ES (1) ES2249691T3 (pl)
MY (1) MY136851A (pl)
NZ (1) NZ541423A (pl)
PL (1) PL211506B1 (pl)
PT (1) PT1403277E (pl)
SI (1) SI1403277T1 (pl)
WO (1) WO2004078708A2 (pl)
ZA (1) ZA200505780B (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60301774T2 (de) * 2003-02-28 2006-07-20 Les Laboratoires Servier Verfahren zur Synthese von (2S,3aS,7aS)-1-((S)-Alanyl)-octahydro-1H-indol-2-carbonsäurederivaten und Verwendung in der Synthese von Perindopril
ATE307801T1 (de) * 2003-02-28 2005-11-15 Servier Lab Verfahren zur synthese des (2s,3as,7as)- perhydroindol-2-carbonsäures und seiner estern, verwendung in der synthese von perindopril
WO2009050041A1 (en) * 2007-10-17 2009-04-23 Dsm Ip Assets B.V. Novel carbamoylglycine derivatives
WO2009098251A1 (en) * 2008-02-07 2009-08-13 Dsm Ip Assets B.V. NOVEL CYCLOALKANONE β-SUBSTITUTED ALANINE DERIVATIVES
CN102984945B (zh) * 2010-04-20 2014-08-20 凯瑞斯德生化(苏州)有限公司 一种环烯基在β位取代的丙氨酸的不对称合成方法
CN106657507B (zh) * 2015-11-03 2019-07-02 中移（杭州）信息技术有限公司 一种声学回声消除方法及装置

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ202903A (en) * 1981-12-29 1988-01-08 Hoechst Ag 1-- pe pyrrol-2-yl-carboxylic acid derivatives and pharmaceutical compositions
NL1008302C2 (nl) * 1998-02-13 1999-08-16 Dsm Nv Werkwijze voor de bereiding van een optisch actief indoline-2-carbonzuur of derivaat daarvan.
WO2001016336A1 (en) * 1999-09-02 2001-03-08 Lexicon Genetics Incorporated Human calcium dependent proteases and polynucleotides encoding the same
FR2807431B1 (fr) * 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
DE60301774T2 (de) * 2003-02-28 2006-07-20 Les Laboratoires Servier Verfahren zur Synthese von (2S,3aS,7aS)-1-((S)-Alanyl)-octahydro-1H-indol-2-carbonsäurederivaten und Verwendung in der Synthese von Perindopril

Also Published As

Publication number Publication date
EP1403277A1 (fr) 2004-03-31
JP4279871B2 (ja) 2009-06-17
WO2004078708A3 (fr) 2004-10-14
DE60301774T2 (de) 2006-07-20
SI1403277T1 (sl) 2005-12-31
PT1403277E (pt) 2005-11-30
US20060149082A1 (en) 2006-07-06
HK1086280A1 (zh) 2006-09-15
EP1403277B1 (fr) 2005-10-05
ATE305939T1 (de) 2005-10-15
WO2004078708A2 (fr) 2004-09-16
AR043410A1 (es) 2005-07-27
AU2004218202B2 (en) 2009-07-30
ES2249691T3 (es) 2006-04-01
PL211506B1 (pl) 2012-05-31
NZ541423A (en) 2008-03-28
CN1331883C (zh) 2007-08-15
EA009062B1 (ru) 2007-10-26
DK1403277T3 (da) 2005-11-21
EA200501257A1 (ru) 2006-04-28
CN1753907A (zh) 2006-03-29
DE60301774D1 (de) 2006-02-16
JP2006519176A (ja) 2006-08-24
AU2004218202A1 (en) 2004-09-16
US7157485B2 (en) 2007-01-02
ZA200505780B (en) 2006-09-27
MY136851A (en) 2008-11-28

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