PL377220A1 - Nowy proces syntezy związków kwasu (2S, 3aS, 7aS)-1-[(S)-alanilo]-oktahydro-1H-indolo-2-karboksylowego i zastosowanie w syntezie perindoprylu - Google Patents

Nowy proces syntezy związków kwasu (2S, 3aS, 7aS)-1-[(S)-alanilo]-oktahydro-1H-indolo-2-karboksylowego i zastosowanie w syntezie perindoprylu

Info

Publication number
PL377220A1
PL377220A1 PL377220A PL37722004A PL377220A1 PL 377220 A1 PL377220 A1 PL 377220A1 PL 377220 A PL377220 A PL 377220A PL 37722004 A PL37722004 A PL 37722004A PL 377220 A1 PL377220 A1 PL 377220A1
Authority
PL
Poland
Prior art keywords
synthesis
alanil
octahydro
indole
carboxylic acid
Prior art date
Application number
PL377220A
Other languages
English (en)
Other versions
PL211506B1 (pl
Inventor
Thierry Dubuffet
Pascal Langlois
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of PL377220A1 publication Critical patent/PL377220A1/pl
Publication of PL211506B1 publication Critical patent/PL211506B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Catalysts (AREA)
PL377220A 2003-02-28 2004-02-27 Sposób otrzymywania związków kwasu (2S, 3aS, 7aS)-1-[(S)-alanilo]-oktahydro-1H-indolo-2-karboksylowego i ich zastosowanie w syntezie perindoprilu oraz związek przejściowy PL211506B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03290486A EP1403277B1 (fr) 2003-02-28 2003-02-28 Nouveau procédé de synthèse de dérives de l'acide (2S, 3aS, 7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylique, et application à la synthèse du perindopril

Publications (2)

Publication Number Publication Date
PL377220A1 true PL377220A1 (pl) 2006-01-23
PL211506B1 PL211506B1 (pl) 2012-05-31

Family

ID=31970534

Family Applications (1)

Application Number Title Priority Date Filing Date
PL377220A PL211506B1 (pl) 2003-02-28 2004-02-27 Sposób otrzymywania związków kwasu (2S, 3aS, 7aS)-1-[(S)-alanilo]-oktahydro-1H-indolo-2-karboksylowego i ich zastosowanie w syntezie perindoprilu oraz związek przejściowy

Country Status (18)

Country Link
US (1) US7157485B2 (pl)
EP (1) EP1403277B1 (pl)
JP (1) JP4279871B2 (pl)
CN (1) CN1331883C (pl)
AR (1) AR043410A1 (pl)
AT (1) ATE305939T1 (pl)
AU (1) AU2004218202B2 (pl)
DE (1) DE60301774T2 (pl)
DK (1) DK1403277T3 (pl)
EA (1) EA009062B1 (pl)
ES (1) ES2249691T3 (pl)
MY (1) MY136851A (pl)
NZ (1) NZ541423A (pl)
PL (1) PL211506B1 (pl)
PT (1) PT1403277E (pl)
SI (1) SI1403277T1 (pl)
WO (1) WO2004078708A2 (pl)
ZA (1) ZA200505780B (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE307801T1 (de) * 2003-02-28 2005-11-15 Servier Lab Verfahren zur synthese des (2s,3as,7as)- perhydroindol-2-carbonsäures und seiner estern, verwendung in der synthese von perindopril
DK1403277T3 (da) * 2003-02-28 2005-11-21 Servier Lab Fremgangsmåde til syntest af (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse heraf ved syntese i perindopril
WO2009050041A1 (en) * 2007-10-17 2009-04-23 Dsm Ip Assets B.V. Novel carbamoylglycine derivatives
WO2009098251A1 (en) * 2008-02-07 2009-08-13 Dsm Ip Assets B.V. NOVEL CYCLOALKANONE β-SUBSTITUTED ALANINE DERIVATIVES
US8558023B2 (en) * 2010-04-20 2013-10-15 Chiral Quest, Inc. Enantioselective process for cycloalkenyl β-substituted alanines
CN106657507B (zh) * 2015-11-03 2019-07-02 中移（杭州）信息技术有限公司 一种声学回声消除方法及装置

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE55867B1 (en) * 1981-12-29 1991-02-14 Hoechst Ag New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation
NL1008302C2 (nl) * 1998-02-13 1999-08-16 Dsm Nv Werkwijze voor de bereiding van een optisch actief indoline-2-carbonzuur of derivaat daarvan.
WO2001016336A1 (en) * 1999-09-02 2001-03-08 Lexicon Genetics Incorporated Human calcium dependent proteases and polynucleotides encoding the same
FR2807431B1 (fr) * 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
DK1403277T3 (da) * 2003-02-28 2005-11-21 Servier Lab Fremgangsmåde til syntest af (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse heraf ved syntese i perindopril

Also Published As

Publication number Publication date
EP1403277A1 (fr) 2004-03-31
US7157485B2 (en) 2007-01-02
AR043410A1 (es) 2005-07-27
DK1403277T3 (da) 2005-11-21
PL211506B1 (pl) 2012-05-31
WO2004078708A3 (fr) 2004-10-14
US20060149082A1 (en) 2006-07-06
AU2004218202A1 (en) 2004-09-16
WO2004078708A2 (fr) 2004-09-16
CN1753907A (zh) 2006-03-29
ZA200505780B (en) 2006-09-27
DE60301774D1 (de) 2006-02-16
EA200501257A1 (ru) 2006-04-28
PT1403277E (pt) 2005-11-30
JP2006519176A (ja) 2006-08-24
EA009062B1 (ru) 2007-10-26
AU2004218202B2 (en) 2009-07-30
EP1403277B1 (fr) 2005-10-05
JP4279871B2 (ja) 2009-06-17
HK1086280A1 (zh) 2006-09-15
CN1331883C (zh) 2007-08-15
MY136851A (en) 2008-11-28
DE60301774T2 (de) 2006-07-20
ES2249691T3 (es) 2006-04-01
NZ541423A (en) 2008-03-28
ATE305939T1 (de) 2005-10-15
SI1403277T1 (sl) 2005-12-31

Similar Documents

Publication Publication Date Title
NO329884B1 (no) Indolderivater, farmasoytisk formulering, anvendelse av forbindelsene, fremgangsmate for fremstilling derav samt mellomprodukter for anvendelse i fremgangsmaten
ATE501118T1 (de) Substituierte indole
IS7755A (is) Aðferð við framleiðslu á (S,S)-cis-2-benshýdríl-3-bensýlamínókínuklídín
SI1256590T1 (sl) NOV POSTOPEK ZA SINTEZO DERIVATOV (2S, 3aS, 7aS)-1-(S)-ALANIL-OKTAHIDRO-1H-INDOL-2-KARBOKSILNE KISLINE IN UPORABA ZA SINTEZO PERINDOPRILA
DE60303904D1 (de) Verfahren zur Synthese von (2S)-Indolin-2-carbonsäure, und Verwendung in der Synthese von Perindopril
PL377220A1 (pl) Nowy proces syntezy związków kwasu (2S, 3aS, 7aS)-1-[(S)-alanilo]-oktahydro-1H-indolo-2-karboksylowego i zastosowanie w syntezie perindoprylu
DE60220877D1 (de) Verfahren zur Herstellung von hochreinem Perindopril und Zwischenverbindungen nützlich in der Synthese
ZA200510324B (en) Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
DK1354876T3 (da) Fremgangsmåde til syntese af (2S,3aS,7aS)-perhydroindol-2-carboxylsyre og dennes estere og anvendelse heraf i syntesen af perindopril
DK1319668T3 (da) Fremgangsmåde til syntese af (2S, 3aS, 7aS)-1-((S)-alanyl)-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse heraf ved syntese af perindopril
SI1338591T1 (sl) NOV POSTOPEK ZA SINTEZO (2S,3aS,7aS)-PERHIDROINDOL-2-KARBOKSILNE KISLINE IN NJENIH ESTROV TER UPORABA PRI SINTEZI PERINDOPRILA
DK1323729T3 (da) Fremgangsmåde til syntese af (2S, 3aS, 7aS)-perhydroindol-2-carboxylsyre og estere heraf, samt anvendelse heraf ved syntese af perindopril
MY136288A (en) New process for the synthesis of perindopril and its pharmaceutically acceptable salts
MY136937A (en) NEW PROCESS FOR THE SYNTHESIS OF (2S, 3aS, 7aS)-1-[(S)-ALANYL]-OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID COMPOUNDS AND APPLICATION IN THE SYNTHESIS OF PERINDOPRIL
DK1420029T3 (da) Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
SI1354874T1 (en) Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof; and use in the synthesis of perindopril
SI1354875T1 (en) Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof; and use in the synthesis of perindopril
PL377238A1 (pl) Nowy proces syntezy perindoprylu i jego farmaceutycznie dopuszczalnej soli
AU2002247949A1 (en) Process for synthesis of trans-alkenoic acid, use thereof
SI1400531T1 (sl) Postopek za sintezo n-((s)-1-karbetoksibutil)-(s)-alanina in uporaba pri sintezi perindoprila
SI1403278T1 (en) Process for the synthesis of N-((S)-1-(ethoxycarbonyl)butyl)-(S)-alanine and use in the synthese of perindopril
PL379625A1 (pl) Nowy sposób syntezy perindoprilu i jego farmaceutycznie dopuszczalnych soli
PL379631A1 (pl) Nowy sposób syntezy perindoprilu i jego farmaceutycznie dopuszczalnych soli