PL377497A1 - Awermektyna B1 i pochodne monosacharydowe awermektyny B1 mające podstawnik alkoksymetylowy w pozycji 4" lub 4' - Google Patents
Awermektyna B1 i pochodne monosacharydowe awermektyny B1 mające podstawnik alkoksymetylowy w pozycji 4" lub 4'Info
- Publication number
- PL377497A1 PL377497A1 PL377497A PL37749703A PL377497A1 PL 377497 A1 PL377497 A1 PL 377497A1 PL 377497 A PL377497 A PL 377497A PL 37749703 A PL37749703 A PL 37749703A PL 377497 A1 PL377497 A1 PL 377497A1
- Authority
- PL
- Poland
- Prior art keywords
- alkyl
- avermectin
- compounds
- tautomers
- alkoxy
- Prior art date
Links
- IBSREHMXUMOFBB-JFUDTMANSA-N 5u8924t11h Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 IBSREHMXUMOFBB-JFUDTMANSA-N 0.000 title 1
- NJTGMYOUKBELLQ-NVQQORPBSA-N avermectin b1 monosaccharide Chemical class O1C(C)C(O)C(OC)CC1O[C@@H]1C(/C)=C/C[C@@H](O[C@]2(C3)C=C[C@H](C)[C@@H](C(C)C)O2)C[C@@H]3OC(=O)[C@@H]([C@]23O)C=C(C)[C@@H](O)[C@H]3OC\C2=C/C=C/[C@@H]1C NJTGMYOUKBELLQ-NVQQORPBSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 4
- 125000006710 (C2-C12) alkenyl group Chemical group 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
- 125000004642 (C1-C12) alkoxy group Chemical group 0.000 abstract 1
- 125000004643 (C1-C12) haloalkoxy group Chemical group 0.000 abstract 1
- 125000006711 (C2-C12) alkynyl group Chemical group 0.000 abstract 1
- 241000607479 Yersinia pestis Species 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000005844 heterocyclyloxy group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000003518 norbornenyl group Chemical group C12(C=CC(CC1)C2)* 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/22—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom rings with more than six members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Opisany został związek o wzorze (I), w którym n jest 0 lub 1; A-B jest -CH=CH- lub -CH2-CH2-; R1 jest C1-C12-alkilem, C3-C8-cykloalkilem lub C2-C12-alkenylem; R2 jest, na przykład, C1-C12-alkilem, C2-C12-alkenylem lub C2-C12-alkinylem; które są ewentualnie podstawione jednym do pięciu podstawników wybranych z grupy składającej się z OH, fluorowca, CN, -N3, -NO2, C3-C8-cykloalkilem, norbornenylem, C3-C8-cykloalkenylem, C3-C8-fluorowcocykloalkilem, C1-C12-alkoksylem, C1-C6-alkoksy-C1-C6-alkoksylem, C3-C8-cykloalkoksylem, C1-C12-fluorowcoalkoksylem, grupą C1-C12-alkilotio, C2-C8-cykloalkilotio, C1-C12-fluorowcoalkilotio, C1-C12-alkilosulfinylem, C3-C8-cykloalkilosulfinylem, C1-C12-fluorowcoalkilosulfinylem, C3-C8- fluorowco cykloalkilosulfinylem, C1-C12-alkilosulfonylem, C3-C8-cykloalkilosulfonylem, C1-C12-fluorowcoalkilosulfonylem, C3-C8-fluorowcocykloalkilosulfonylem, -NR4R6, -X-C(=Y)-R4, -X-C(=Y)-Z-R4, -P(=0) (OC1-C6-alkilo)2, arylem, heterocyklilem, aryloksylem, grupą arylotio i heterocykliloksy; R3 jest na przykład H, C1-C12-alkilem lub ewentualnie podstawionym C1-C12-alkilem i, gdzie występują, izomery E/Z, mieszaniny izomerów E/Z i/lub tautomerów, w każdym przypadku w postaci wolnej lub w postaci soli; sposób wytwarzania i stosowania tych związków i ich tautomerów; środki do niszczenia szkodników, w których składnik czynny wybrany jest spośród tych związków i ich tautomerów; oraz sposób wytwarzania tych związków i kompozycji oraz zastosowanie tych związków i kompozycji.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0229804.0A GB0229804D0 (en) | 2002-12-20 | 2002-12-20 | Avermection b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL377497A1 true PL377497A1 (pl) | 2006-02-06 |
| PL211483B1 PL211483B1 (pl) | 2012-05-31 |
Family
ID=9950151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL377497A PL211483B1 (pl) | 2002-12-20 | 2003-12-19 | Awermektyna B1 i jej pochodne monosacharydowe, środek do zwalczania szkodników, sposób zwalczania szkodników i zastosowanie kompozycji |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US7737261B2 (pl) |
| EP (1) | EP1581546B1 (pl) |
| JP (2) | JP4851094B2 (pl) |
| KR (1) | KR101109500B1 (pl) |
| CN (1) | CN1738828B (pl) |
| AR (1) | AR042533A1 (pl) |
| AU (1) | AU2003302284B2 (pl) |
| BR (1) | BR0317601A (pl) |
| CA (1) | CA2507774C (pl) |
| CO (1) | CO5690647A1 (pl) |
| ES (1) | ES2742899T3 (pl) |
| GB (1) | GB0229804D0 (pl) |
| IL (1) | IL169092A (pl) |
| MA (1) | MA27646A1 (pl) |
| MX (1) | MXPA05006036A (pl) |
| PE (1) | PE20040713A1 (pl) |
| PL (1) | PL211483B1 (pl) |
| RU (1) | RU2330857C2 (pl) |
| TW (1) | TW200512214A (pl) |
| UA (1) | UA81281C2 (pl) |
| WO (1) | WO2004056844A1 (pl) |
| ZA (1) | ZA200504353B (pl) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0229804D0 (en) * | 2002-12-20 | 2003-01-29 | Syngenta Participations Ag | Avermection b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position |
| JP2010006703A (ja) * | 2006-11-07 | 2010-01-14 | Hokko Chem Ind Co Ltd | アベルメクチンモノ配糖体誘導体 |
| RU2453553C1 (ru) * | 2011-05-11 | 2012-06-20 | Игорь Викторович Заварзин | 5-о-сукциноилавермектин, способ его получения и антипаразитарное средство на его основе |
| RU2472801C1 (ru) * | 2011-05-11 | 2013-01-20 | Игорь Викторович Заварзин | 5-о-производные авермектина, способ их получения и антипаразитарные средства на их основе |
| CN103613625B (zh) * | 2013-12-02 | 2016-03-02 | 兰州大学 | 一种阿维菌素类化合物及其制备方法和在农药中的用途 |
| CN104402953B (zh) * | 2014-11-28 | 2017-07-28 | 大庆志飞生物化工有限公司 | 阿维菌素单糖化合物及其制备方法和用途 |
| CN104402954A (zh) * | 2014-11-28 | 2015-03-11 | 大庆志飞生物化工有限公司 | 甲胺基阿维菌素单糖化合物及其制备方法和用途 |
| JP6577184B2 (ja) | 2014-12-24 | 2019-09-18 | Ntn株式会社 | 転がり軸受 |
| CN107501368B (zh) * | 2017-09-30 | 2020-02-21 | 中国科学院成都生物研究所 | 一种多拉菌素衍生物的合成及其杀虫应用 |
| CN113150053B (zh) * | 2020-01-22 | 2024-10-01 | 华东理工大学 | 偶氮苯类阿维菌素衍生物及其制备方法和应用 |
| CN113817008B (zh) * | 2021-07-15 | 2023-05-23 | 湖州师范学院 | 新型琥珀酰基十六元大环内酯的制备方法及用途 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US87519A (en) * | 1869-03-02 | Improvement in furnace-stoves and registers | ||
| US148520A (en) * | 1874-03-10 | Improvement in faucets | ||
| US18993A (en) * | 1857-12-29 | Cider-mill | ||
| SE434277B (sv) * | 1976-04-19 | 1984-07-16 | Merck & Co Inc | Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis |
| US4874749A (en) * | 1987-07-31 | 1989-10-17 | Merck & Co., Inc. | 4"-Deoxy-4-N-methylamino avermectin Bla/Blb |
| GB8811037D0 (en) * | 1988-05-10 | 1988-06-15 | Glaxo Group Ltd | Chemical compounds |
| EP0353959A2 (en) | 1988-08-02 | 1990-02-07 | Beecham Group Plc | Antihelmintic macrolide antibiotics |
| SE465605B (sv) * | 1990-02-26 | 1991-10-07 | Harry Nilsson | Skivfilter |
| JP2622197B2 (ja) * | 1990-03-01 | 1997-06-18 | 三共株式会社 | １３−エーテル置換ミルベマイシン誘導体 |
| US5169839A (en) | 1990-05-11 | 1992-12-08 | Merck & Co., Inc. | Derivatives of 3'- and 3"-o-desmethyl avermectin compounds, compositions and methods of treating melmintic and parasitic infections |
| US5262400A (en) * | 1991-06-20 | 1993-11-16 | Merck & Co., Inc. | 4α-substituted avermectin derivatives |
| US5411737A (en) * | 1991-10-15 | 1995-05-02 | Merck & Co., Inc. | Slow release syneresing polymeric drug delivery device |
| US5602107A (en) * | 1993-05-10 | 1997-02-11 | Merck & Co., Inc. | Pour-on formulations consisting of gylcols, glycerides and avermectin compounds |
| PL174488B1 (pl) * | 1993-05-10 | 1998-08-31 | Merck & Co Inc | Preparat do zwalczania pasożytów zwierząt oraz sposób wytwarzania preparatu do zwalczania pasożytów zwierząt |
| DK0714400T3 (da) * | 1993-08-19 | 2000-04-10 | Merck & Co Inc | Termodynamisk stabil krystalform af 4''-deoxy-4''-epi-methylaminoavermectin B1a/B1b-benzoesyresalt og fremgangsmåder til de |
| US5436355A (en) * | 1994-02-03 | 1995-07-25 | Merck & Co., Inc. | Process for making avermectin/zein compositions |
| TW327125B (en) * | 1994-02-07 | 1998-02-21 | Merck & Co Inc | Composition and method for protecting against pine exhausted |
| CA2418968C (en) | 2000-08-09 | 2009-11-24 | The Kitasato Institute | Avermectin derivatives |
| JPWO2002012248A1 (ja) | 2000-08-09 | 2004-01-15 | 社団法人北里研究所 | エバーメクチン誘導体 |
| WO2003075742A2 (en) * | 2002-03-05 | 2003-09-18 | Merck & Co., Inc. | Biomarker for efficacy of appetite suppressant drugs |
| GB0229804D0 (en) * | 2002-12-20 | 2003-01-29 | Syngenta Participations Ag | Avermection b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position |
-
2002
- 2002-12-20 GB GBGB0229804.0A patent/GB0229804D0/en not_active Ceased
-
2003
- 2003-12-12 PE PE2003001284A patent/PE20040713A1/es active IP Right Grant
- 2003-12-18 TW TW092135927A patent/TW200512214A/zh unknown
- 2003-12-18 AR ARP030104712A patent/AR042533A1/es active IP Right Grant
- 2003-12-19 BR BR0317601-0A patent/BR0317601A/pt not_active Application Discontinuation
- 2003-12-19 PL PL377497A patent/PL211483B1/pl unknown
- 2003-12-19 CN CN2003801088575A patent/CN1738828B/zh not_active Expired - Lifetime
- 2003-12-19 WO PCT/EP2003/014613 patent/WO2004056844A1/en not_active Ceased
- 2003-12-19 AU AU2003302284A patent/AU2003302284B2/en not_active Ceased
- 2003-12-19 RU RU2005122943/04A patent/RU2330857C2/ru active
- 2003-12-19 EP EP03810843.7A patent/EP1581546B1/en not_active Expired - Lifetime
- 2003-12-19 ES ES03810843T patent/ES2742899T3/es not_active Expired - Lifetime
- 2003-12-19 JP JP2004561378A patent/JP4851094B2/ja not_active Expired - Fee Related
- 2003-12-19 KR KR1020057011622A patent/KR101109500B1/ko not_active Expired - Fee Related
- 2003-12-19 CA CA2507774A patent/CA2507774C/en not_active Expired - Fee Related
- 2003-12-19 US US10/539,274 patent/US7737261B2/en active Active
- 2003-12-19 UA UAA200507209A patent/UA81281C2/uk unknown
- 2003-12-19 MX MXPA05006036A patent/MXPA05006036A/es active IP Right Grant
-
2005
- 2005-06-09 IL IL169092A patent/IL169092A/en active IP Right Grant
- 2005-06-17 CO CO05059203A patent/CO5690647A1/es not_active Application Discontinuation
- 2005-06-17 MA MA28349A patent/MA27646A1/fr unknown
-
2006
- 2006-01-06 ZA ZA200504353A patent/ZA200504353B/en unknown
-
2010
- 2010-04-27 US US12/768,280 patent/US8017589B2/en not_active Expired - Fee Related
- 2010-12-22 JP JP2010286151A patent/JP5302297B2/ja not_active Expired - Fee Related
-
2011
- 2011-05-27 US US13/117,292 patent/US8263566B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RECP | Rectifications of patent specification |