ATE207492T1 - Difluoroavermectin-derivate - Google Patents

Difluoroavermectin-derivate

Info

Publication number: ATE207492T1
Authority: AT; Austria
Prior art keywords: derivatives; disclosed; avermectin; incorporate; compounds
Prior art date: 1992-04-29

Application number

AT93910687T

Other languages

English (en)

Inventor

Peter T Meinke

Helmut Mrozik

Michael H Fisher

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-29

Filing date

1993-04-20

Publication date

2001-11-15

1993-04-20 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2001-11-15 Application granted granted Critical

2001-11-15 Publication of ATE207492T1 publication Critical patent/ATE207492T1/de

Links

239000005660 Abamectin Substances 0.000 abstract 2
RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical class C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000001153 fluoro group Chemical group F* 0.000 abstract 2
TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 abstract 1
PLMKQQMDOMTZGG-UHFFFAOYSA-N Astrantiagenin E-methylester Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)CCC3(C(=O)OC)CCC21C PLMKQQMDOMTZGG-UHFFFAOYSA-N 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
239000000921 anthelmintic agent Substances 0.000 abstract 1
238000007385 chemical modification Methods 0.000 abstract 1
-1 difluoro avermectin analogs Chemical class 0.000 abstract 1
125000000600 disaccharide group Chemical group 0.000 abstract 1
PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 abstract 1
230000000749 insecticidal effect Effects 0.000 abstract 1
239000002917 insecticide Substances 0.000 abstract 1
150000002576 ketones Chemical class 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000001483 monosaccharide substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Agronomy & Crop Science (AREA)
Zoology (AREA)
Environmental Sciences (AREA)
Dentistry (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Plant Pathology (AREA)
Molecular Biology (AREA)
Pest Control & Pesticides (AREA)
Tropical Medicine & Parasitology (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT93910687T 1992-04-29 1993-04-20 Difluoroavermectin-derivate ATE207492T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/875,486 US5229416A (en)	1992-04-29	1992-04-29	Avermectin difluoro derivatives
PCT/US1993/003737 WO1993022307A1 (en)	1992-04-29	1993-04-20	Avermectin difluoro derivatives

Publications (1)

Publication Number	Publication Date
ATE207492T1 true ATE207492T1 (de)	2001-11-15

Family

ID=25365897

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93910687T ATE207492T1 (de)	1992-04-29	1993-04-20	Difluoroavermectin-derivate

Country Status (10)

Country	Link
US (2)	US5229416A (de)
EP (1)	EP0638078B1 (de)
JP (1)	JP3170283B2 (de)
AT (1)	ATE207492T1 (de)
AU (1)	AU4109393A (de)
CA (1)	CA2118491C (de)
DE (1)	DE69331007T2 (de)
ES (1)	ES2164660T3 (de)
WO (1)	WO1993022307A1 (de)
ZA (1)	ZA932981B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5229416A (en) *	1992-04-29	1993-07-20	Merck & Co., Inc.	Avermectin difluoro derivatives
CN1040113C (zh) *	1993-10-05	1998-10-07	美国辉瑞有限公司	抗寄生虫药物多哇麦汀(doramectin)的中间体及其制备方法
DE102007007750A1 (de) *	2006-08-17	2008-02-21	Bayer Cropscience Ag	Avermectinderivate
US8901163B2 (en)	2007-01-03	2014-12-02	Galderma S.A.	Method of treating hyperesthesia, paresthesia, dolor, and pruritus caused by insect stings or noxious weeds or plants using avermectin compound
DE102010064245A1 (de)	2010-12-28	2012-06-28	Bayer Animal Health Gmbh	Makrocylischen Lactone und deren Verwendung und deren Kombinationen mit anderen Wirkstoffen
WO2012028556A1 (en)	2010-08-31	2012-03-08	Bayer Animal Health Gmbh	Macrocyclic lactones and their use and their combinations with other active substances
EP2629772B1 (de)	2010-10-20	2016-05-18	Galderma S.A.	Ivermectin zur behandlung von hämorrhoiden
EP2629770B1 (de)	2010-10-20	2016-05-25	Galderma S.A.	Ivermectin zur behandlung von gehörgangsentzündungen
CN103360444B (zh)	2012-04-03	2016-05-11	浙江海正药业股份有限公司	抗寄生虫药赛拉菌素的合成新工艺
CN103896961A (zh) *	2014-03-25	2014-07-02	武汉大学	一种米尔贝肟类化合物及其制备方法
CN113563395B (zh) *	2021-08-09	2023-06-02	河北威远生物化工有限公司	一种阿维菌素b2衍生物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4171314A (en) *	1977-12-19	1979-10-16	Merck & Co., Inc.	13-Halo and 13-deoxy C-076 compounds
US4173571A (en) *	1977-12-19	1979-11-06	Merck & Co., Inc.	13-Halo and 13-deoxy derivatives of C-076 compounds
EP0180539A1 (de) *	1984-09-18	1986-05-07	Ciba-Geigy Ag	13-Halo- und 13-Hydroximilbemycine
JPS6289685A (ja) *	1985-05-31	1987-04-24	Sankyo Co Ltd	１３−ハロゲンミルベマイシン誘導体
NZ228866A (en) *	1988-05-02	1991-10-25	Merck & Co Inc	Fluoro-substituted milbemycins and avermectins for combatting parasites and insects
AU613521B2 (en) *	1988-09-02	1991-08-01	Sankyo Company Limited	13-substituted milbemycin derivatives, their preparation and use
EP0423445B1 (de) *	1989-09-11	1995-11-08	American Cyanamid Company	13-Alkyl-23-Imino und 13-Halo-23-Imino-Derivate von LL-F28249-Verbindungen und ihre Verwendung als Endo- und Ectoparasitizide, Insektizide, Akarizide und Nematozide Mittel
US5229415A (en) *	1992-03-24	1993-07-20	Merck & Co., Inc.	Alkylthio alkyl avermectins are active antiparasitic agents
US5229416A (en) *	1992-04-29	1993-07-20	Merck & Co., Inc.	Avermectin difluoro derivatives

1992
- 1992-04-29 US US07/875,486 patent/US5229416A/en not_active Expired - Lifetime
1993
- 1993-04-20 WO PCT/US1993/003737 patent/WO1993022307A1/en not_active Ceased
- 1993-04-20 EP EP93910687A patent/EP0638078B1/de not_active Expired - Lifetime
- 1993-04-20 JP JP51934993A patent/JP3170283B2/ja not_active Expired - Lifetime
- 1993-04-20 AU AU41093/93A patent/AU4109393A/en not_active Abandoned
- 1993-04-20 CA CA002118491A patent/CA2118491C/en not_active Expired - Lifetime
- 1993-04-20 DE DE69331007T patent/DE69331007T2/de not_active Expired - Lifetime
- 1993-04-20 AT AT93910687T patent/ATE207492T1/de not_active IP Right Cessation
- 1993-04-20 ES ES93910687T patent/ES2164660T3/es not_active Expired - Lifetime
- 1993-04-28 ZA ZA932981A patent/ZA932981B/xx unknown
- 1993-06-10 US US08/074,763 patent/US5350742A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2164660T3 (es)	2002-03-01
EP0638078A4 (en)	1995-03-22
US5229416A (en)	1993-07-20
AU4109393A (en)	1993-11-29
EP0638078B1 (de)	2001-10-24
DE69331007D1 (de)	2001-11-29
WO1993022307A1 (en)	1993-11-11
JP3170283B2 (ja)	2001-05-28
ZA932981B (en)	1993-11-10
US5350742A (en)	1994-09-27
CA2118491A1 (en)	1993-11-11
CA2118491C (en)	1999-09-14
DE69331007T2 (de)	2002-06-06
JPH07506361A (ja)	1995-07-13
EP0638078A1 (de)	1995-02-15

Legal Events

Date	Code	Title	Description
2002-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DK0388019T3 (da)	1994-05-24	Avermectin-ketal-derivater, der er egnede som antiparasitiske midler
ATE183883T1 (de)	1999-09-15	Synergistische pestizide zusammensetzungen
IL117226A (en)	2001-08-26	Compositions for controlling parasites and process for preparation thereof
NO307326B1 (no)	2000-03-20	Lipofile, oligosakkaride antibiotikasaltpreparater
ATE207492T1 (de)	2001-11-15	Difluoroavermectin-derivate
ATE173738T1 (de)	1998-12-15	Alkylthioalkylavermectine sind aktive antiparasitäre wirkstoffe
IL102567A0 (en)	1993-01-14	Stable compositions for parenteral administration and their use
DK0930077T3 (da)	2003-08-04	Cyclodextrinpræparater indeholdende et avermectin- eller milbemycinderivat
AP2004003106A0 (en)	2004-09-30	Synergistic insecticidal mixtures.
DE69128630D1 (de)	1998-02-12	Benzopyran derivat, seine darstellung und pharmazeutische zusammensetzung, welche dieses enthält
PT1197207E (pt)	2008-07-01	Composições estáveis para administração parentérica
IL97648A0 (en)	1992-06-21	Stabilized 4-ethyl-2-hydroxyimino-5-nitro-3-hexenamide pharmaceutical compositions and methods for the preparation thereof
ES2090779T3 (es)	1996-10-16	Agentes insecticidas, acaricidas y molusquicidas de n-oxi- y tioalquilcarboniloxialquilpirrol.