PL377501A1 - Adamantyloacetamidy jako inhibitory dehydrogenazy 11-beta hydroksysteroidowej - Google Patents

Adamantyloacetamidy jako inhibitory dehydrogenazy 11-beta hydroksysteroidowej

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Publication number
PL377501A1
PL377501A1 PL377501A PL37750103A PL377501A1 PL 377501 A1 PL377501 A1 PL 377501A1 PL 377501 A PL377501 A PL 377501A PL 37750103 A PL37750103 A PL 37750103A PL 377501 A1 PL377501 A1 PL 377501A1
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PL
Poland
Prior art keywords
4alkyl
independently hydrogen
substituted
het1
4alkyloxy
Prior art date
Application number
PL377501A
Other languages
English (en)
Other versions
PL210615B1 (pl
Inventor
Joannes Theodorus Maria Linders
Gustaaf Henri Maria Willemsens
Ronaldus Arnodus Hendrika Joseph Gilissen
Christophe Francis Robert Nestor Buyck
Greta Constantia Peter Vanhoof
Der Veken Louis Jozef Elisabeth Van
Libuse Jaroskova
Original Assignee
Janssen Pharmaceutica N.V.
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Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of PL377501A1 publication Critical patent/PL377501A1/pl
Publication of PL210615B1 publication Critical patent/PL210615B1/pl

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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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Abstract

Formy N-tlenków, farmaceutycznie dopuszczalne sole addycyjne i ich stereochemiczne formy izomeryczne, w których n oznacza liczbę całkowitą 1 lub 2; każdy R1 i R2 niezależnie oznacza atom wodoru, C1-4alkil, NR9R10, C3-6-alkilooksy; lub R1 i R2 razem z atom węgla, z którym są połączone tworzą C3-6cykloalkil; i w którym n ma wartość 2, albo R1 lub R2 mogą nie występować dając wiązanie nienasycone; R3 oznacza C6-12cykloalkil, korzystnie wybrany spośród takich jak cylooctanyl i cykloheksyl lub R3 oznacza jednowartościowy rodnik o jednym z następujących wzorów, przy czym ten C6-12cykloalkil lub jednowartościowy rodnik może być ewentualnie podstawiony przez jeden, lub gdzie to możliwe dwa, trzy lub więcej podstawników wybranych z grupy obejmującej C1-4alkil, C1-4alkilooksy, atom fluorowca lub hydroksykl; Q oznacza Het1 lub Ar2 przy czym ten C3-8cykloalkil, Het1 lub Ar2 są ewentualnie podstawione przez jeden lub gdzie to możliwe dwa lub więcej podstawników wybranych spośród takich jak atom fluorowca, C1-4alkil, C1-4alkilooksy, hydroksyl, nitro, NR5R6, C1-4alkilooksy podstawiony przez jeden lub gdzie to możliwe dwa, trzy lub więcej podstawników, przy czym każdy jest niezależnie wybrany spośród takich jak hydroksykarbonyl, Het2 i NR7R8, i C1-4alkil podstawiony przez jeden lub gdzie to możliwe dwa lub trzy atomy fluorowca, korzystnie trifluorometyl; każdy R5 i R6 niezależnie oznacza atom wodoru, C1-4alkil, lub C1-4alkil podstawiony przez fenyl; każdy R1 i R8 niezależnie oznacza atom wodoru lub C1-4alkil; każdy R9 i R10 niezależnie oznacza atom wodoru, C1-4alkil lub C1-4alkilooksykarbonyl; L oznacza C1-4alkil; Het1 oznacza heterocykl wybrany spośród takich jak pirydynyl, tiofenyl, lub 1,3-benzodioksolil; Het2 oznacza piperydynyl, pirolidynyl lub morfolinyl; Ar2 oznacza fenyl, naftyl lub indenyl.
PL377501A 2002-12-23 2003-12-16 Pochodna adamantyloacetamidu i jej zastosowanie oraz kompozycja farmaceutyczna i sposób jej wytwarzania PL210615B1 (pl)

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