PL377525A1 - Sposób wytwarzania racemicznego diolu citalopramu i/lub dioli S- lub R- citalopramu i zastosowanie tych dioli do wytwarzania racemicznego citalopramu, R-citalopramu i/lub S-citalopramu - Google Patents

Sposób wytwarzania racemicznego diolu citalopramu i/lub dioli S- lub R- citalopramu i zastosowanie tych dioli do wytwarzania racemicznego citalopramu, R-citalopramu i/lub S-citalopramu

Info

Publication number: PL377525A1
Authority: PL; Poland
Prior art keywords: citalopram; diol; citalopram diol; preparation; racemic
Prior art date: 2002-12-23

Application number

PL377525A

Other languages

English (en)

Other versions

PL207847B1 (pl

Inventor

Hans Petersen

Robert Dancer

Brian Christiansen

Rikke Eva Humble

Original Assignee

H. Lundbeck A/S

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-23

Filing date

2003-12-18

Publication date

2006-02-06

2003-12-18 Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S

2006-02-06 Publication of PL377525A1 publication Critical patent/PL377525A1/pl

2011-02-28 Publication of PL207847B1 publication Critical patent/PL207847B1/pl

Links

229960001653 citalopram Drugs 0.000 title abstract 17
238000000034 method Methods 0.000 title abstract 5
-1 citalopram diol Chemical class 0.000 title abstract 4
238000002360 preparation method Methods 0.000 title abstract 4
WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 title abstract 2
150000002009 diols Chemical class 0.000 title 1
239000000203 mixture Substances 0.000 abstract 4
239000012458 free base Substances 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
239000002253 acid Substances 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
239000002244 precipitate Substances 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
238000001953 recrystallisation Methods 0.000 abstract 1
238000006798 ring closing metathesis reaction Methods 0.000 abstract 1
238000000926 separation method Methods 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
- C07C253/34—Separation; Purification

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PL377525A 2002-12-23 2003-12-18 Sposób wytwarzania racemicznego 4-[4-(dimetyloamino)-1-(4'-fluorofenylo)-1- hydroksybutylo]-3-(hydroksymetylo)-benzonitrylu) i /lub R-lub S-4-[4-(dimetyloamino)-1-(4'-fluorofenylo)-1-hydroksybutylo]-3-( hydroksymetylo)- benzonitrylu) i sposób wytwarzania racemicznego citalopramu, R-citalopramu i/lub S-citalopramu PL207847B1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US43611702P	2002-12-23	2002-12-23
DKPA200202004		2002-12-23

Publications (2)

Publication Number	Publication Date
PL377525A1 true PL377525A1 (pl)	2006-02-06
PL207847B1 PL207847B1 (pl)	2011-02-28

Family

ID=32683721

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL377525A PL207847B1 (pl)	2002-12-23	2003-12-18	Sposób wytwarzania racemicznego 4-[4-(dimetyloamino)-1-(4'-fluorofenylo)-1- hydroksybutylo]-3-(hydroksymetylo)-benzonitrylu) i /lub R-lub S-4-[4-(dimetyloamino)-1-(4'-fluorofenylo)-1-hydroksybutylo]-3-( hydroksymetylo)- benzonitrylu) i sposób wytwarzania racemicznego citalopramu, R-citalopramu i/lub S-citalopramu

Country Status (13)

Country	Link
US (1)	US7390913B2 (pl)
EP (2)	EP1581483B1 (pl)
JP (1)	JP4505335B2 (pl)
AU (1)	AU2003291960B2 (pl)
CA (1)	CA2511143C (pl)
CY (1)	CY1112937T1 (pl)
IL (1)	IL169330A0 (pl)
IS (1)	IS2862B (pl)
MX (1)	MXPA05006783A (pl)
NO (1)	NO331181B1 (pl)
NZ (1)	NZ540653A (pl)
PL (1)	PL207847B1 (pl)
WO (1)	WO2004056754A1 (pl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN100569765C (zh) *	2003-12-19	2009-12-16	杭州民生药业集团有限公司	西酞普兰中间体晶体碱
TWI339651B (en) *	2004-02-12	2011-04-01	Lundbeck & Co As H	Method for the separation of intermediates which may be used for the preparation of escitalopram
ITMI20041872A1 (it)	2004-10-01	2005-01-01	Adorkem Technology Spa	Processo per la preparazione di citalopram e di scitalopram
GB0425320D0 (en)	2004-11-17	2004-12-22	Johnson Matthey Plc	Diamines
US7939680B2 (en) *	2005-07-27	2011-05-10	Aurobindo Pharma Ltd.	Process for the preparation of Escitalopram
US8022232B2 (en)	2007-09-11	2011-09-20	H. Lundbeck A/S	Method for manufacture of escitalopram
FI121570B (fi)	2007-09-11	2011-01-14	Lundbeck & Co As H	Menetelmä essitalopraamin valmistamiseksi
WO2012149447A2 (en)	2011-04-29	2012-11-01	Saint-Gobain Performance Plastics Corporation	Maintenance-free slide bearing with fep or pfa in the adhesive layer
FR2985215B1 (fr)	2011-12-28	2014-09-19	Saint Gobain Performance Plast	Revetements polymeres deposes sur des substrats par des techniques de projection thermique
CN103182808A (zh)	2011-12-28	2013-07-03	圣戈班高功能塑料集团	一种包括含氟聚合物表面层以及非氟聚合物过渡层的多层复合物
WO2014001524A1 (en)	2012-06-29	2014-01-03	Saint-Gobain Performance Plastics Pampus Gmbh	Slide bearing comprising a primer system as adhesion promoter
EP2901031B1 (en)	2012-09-28	2022-02-23	Saint-Gobain Performance Plastics Pampus GmbH	Maintenance-free slide bearing with a combined adhesive sliding layer
DK201500520A1 (en) *	2015-08-31	2016-09-19	H Lundbeck As	Crystalline forms of (R)-4-[4-(dimethylamino)-1-(4'-fluorophenyl)-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile free base and (S)-4-[4-(dimethylamino)-1-(4'-fluoro-phenyl)-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile free base and of racemic 4-[4-(dimethylamino)-1-(4'-fluorophenyl)-hydroxybutyl]-3-(hydroxyl-methyl)-benzonitrile toluene hemisolvate

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8419963D0 (en)	1984-08-06	1984-09-12	Lundbeck & Co As H	Intermediate compound and method
GB8814057D0 (en) *	1988-06-14	1988-07-20	Lundbeck & Co As H	New enantiomers & their isolation
JP2001123239A (ja)	1999-10-21	2001-05-08	Daiki Aluminium Industry Co Ltd	高強度鋳造用アルミニウム合金及び同アルミニウム合金鋳物
AR034612A1 (es)	2001-06-25	2004-03-03	Lundbeck & Co As H	Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR034759A1 (es)	2001-07-13	2004-03-17	Lundbeck & Co As H	Metodo para la preparacion de escitalopram

2003
- 2003-12-18 WO PCT/DK2003/000907 patent/WO2004056754A1/en not_active Ceased
- 2003-12-18 AU AU2003291960A patent/AU2003291960B2/en not_active Ceased
- 2003-12-18 US US10/540,300 patent/US7390913B2/en not_active Expired - Fee Related
- 2003-12-18 EP EP03767476A patent/EP1581483B1/en not_active Expired - Lifetime
- 2003-12-18 PL PL377525A patent/PL207847B1/pl unknown
- 2003-12-18 EP EP11164841A patent/EP2363389A1/en not_active Withdrawn
- 2003-12-18 JP JP2004561086A patent/JP4505335B2/ja not_active Expired - Lifetime
- 2003-12-18 CA CA2511143A patent/CA2511143C/en not_active Expired - Fee Related
- 2003-12-18 MX MXPA05006783A patent/MXPA05006783A/es active IP Right Grant
- 2003-12-18 NZ NZ540653A patent/NZ540653A/en unknown
2005
- 2005-06-09 IS IS7886A patent/IS2862B/is unknown
- 2005-06-21 IL IL169330A patent/IL169330A0/en unknown
- 2005-07-25 NO NO20053613A patent/NO331181B1/no not_active IP Right Cessation
2012
- 2012-07-04 CY CY20121100594T patent/CY1112937T1/el unknown

Also Published As

Publication number	Publication date
WO2004056754A1 (en)	2004-07-08
MXPA05006783A (es)	2005-09-08
NO331181B1 (no)	2011-10-24
CA2511143C (en)	2011-06-28
IL169330A0 (en)	2009-02-11
JP4505335B2 (ja)	2010-07-21
NO20053613L (no)	2005-09-15
CY1112937T1 (el)	2016-04-13
JP2006511559A (ja)	2006-04-06
IS7886A (is)	2005-06-09
NO20053613D0 (no)	2005-07-25
EP2363389A1 (en)	2011-09-07
PL207847B1 (pl)	2011-02-28
IS2862B (is)	2013-12-15
US7390913B2 (en)	2008-06-24
US20060020140A1 (en)	2006-01-26
AU2003291960A1 (en)	2004-07-14
CA2511143A1 (en)	2004-07-08
AU2003291960B2 (en)	2009-11-19
EP1581483A1 (en)	2005-10-05
NZ540653A (en)	2008-02-29
EP1581483B1 (en)	2012-06-06
HK1087994A1 (en)	2006-10-27

Publication	Publication Date	Title
CY1112937T1 (el)	2016-04-13	Μεθοδος για την παρασκευη ρακεμικης διολης σιταλοπραμης ή/και διολων s- ή r- σιταλοπραμης και η χρηση τετοιων διολων για την παρασκευη ρακεμικης σιταλοπραμης, r-σιταλοπραμης ή/και s-σιταλοπραμης
CA2450890A1 (en)	2003-01-03	Process for the preparation of racemic citalopram and/or s- or r-citalopram by separation of a mixture of r- and s-citalopram
DK170280B1 (da)	1995-07-24	Fremgangsmåde til fremstilling af (+)-citalopram og forbindelser der kan anvendes som mellemprodukt ved fremgangsmåden
JP2004536093A5 (ja)	2006-01-05	Ｒ−及びｓ−シタロプラムの混合物を分離することによってラセミシタロプラム及びｓ−もしくはｒ−シタロプラムを製造する方法
MEP5708A (xx)	2010-02-10	Postupak pripremanja racemskog citalopram diola i/ili r-citalopram diola i upotreba takvih diola za pripremanje racemskog citaloprama , r-citaloprama i/ili s-citaloprama.
JP3856830B2 (ja)	2006-12-13	リポ酸の製造法
HRP20070454A2 (en)	2009-03-31	A process for the preparation of racemic citalopram diol and/or s- or r- citalopram diols and the use of such diols for the preparation of racemic citalopram, r-citalopram and/or s-citalopram
TH51620B (th)	2016-09-29	กรรมวิธีสำหรับการเตรียมราเซมิกซิทาโลแพรม และ/หรือ s- หรือ r-ซิทาโลแพรมด้วยการแยกของของผสมของ r- และ s- ซิทาโลแพรม