PL377791A1 - Pochodne 3-aminopiperydyny i sposoby ich wytwarzania - Google Patents
Pochodne 3-aminopiperydyny i sposoby ich wytwarzaniaInfo
- Publication number
- PL377791A1 PL377791A1 PL377791A PL37779103A PL377791A1 PL 377791 A1 PL377791 A1 PL 377791A1 PL 377791 A PL377791 A PL 377791A PL 37779103 A PL37779103 A PL 37779103A PL 377791 A1 PL377791 A1 PL 377791A1
- Authority
- PL
- Poland
- Prior art keywords
- amino
- processes
- preparation
- piperidine derivatives
- piperidine
- Prior art date
Links
- PEUGKEHLRUVPAN-UHFFFAOYSA-N piperidin-3-amine Chemical class NC1CCCNC1 PEUGKEHLRUVPAN-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4462—Non condensed piperidines, e.g. piperocaine only substituted in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42832402P | 2002-11-21 | 2002-11-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL377791A1 true PL377791A1 (pl) | 2006-02-20 |
Family
ID=32326635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL377791A PL377791A1 (pl) | 2002-11-21 | 2003-11-10 | Pochodne 3-aminopiperydyny i sposoby ich wytwarzania |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7084277B2 (pl) |
| EP (1) | EP1572649A2 (pl) |
| JP (1) | JP2006508976A (pl) |
| KR (2) | KR100742012B1 (pl) |
| CN (2) | CN101353321A (pl) |
| AU (1) | AU2003278529A1 (pl) |
| BR (1) | BR0316470A (pl) |
| CA (1) | CA2506016C (pl) |
| MX (1) | MXPA05005403A (pl) |
| PL (1) | PL377791A1 (pl) |
| RS (1) | RS20050380A (pl) |
| RU (2) | RU2309147C9 (pl) |
| WO (1) | WO2004046112A2 (pl) |
| ZA (1) | ZA200504068B (pl) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA006227B1 (ru) | 1999-12-10 | 2005-10-27 | Пфайзер Продактс Инк. | СОЕДИНЕНИЯ ПИРРОЛО[2,3-d]ПИРИМИДИНА |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| BR0313059B8 (pt) | 2002-07-29 | 2021-07-27 | Rigel Pharmaceuticals | composto, e, composição farmacêutica |
| CN102358738A (zh) | 2003-07-30 | 2012-02-22 | 里格尔药品股份有限公司 | 2,4-嘧啶二胺化合物及其预防和治疗自体免疫疾病的用途 |
| MXPA06012663A (es) * | 2004-05-03 | 2007-01-16 | Novartis Ag | Combinaciones que comprenden un agonista del receptor s1p y un inhibidor de quinasa jak3. |
| US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| EP1904457B1 (en) | 2005-06-08 | 2017-09-06 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| CN101233138A (zh) | 2005-07-29 | 2008-07-30 | 辉瑞产品公司 | 吡咯并[2，3-d]嘧啶衍生物、其中间体和合成方法 |
| JP2009528295A (ja) | 2006-02-24 | 2009-08-06 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ｊａｋ経路の阻害のための組成物および方法 |
| ATE497496T1 (de) | 2006-10-19 | 2011-02-15 | Rigel Pharmaceuticals Inc | 2,4-pyridimediamon-derivate als hemmer von jak- kinasen zur behandlung von autoimmunerkrankungen |
| HUE030912T2 (en) | 2008-02-15 | 2017-06-28 | Rigel Pharmaceuticals Inc | Pyrimidine-2-amine compounds and their use as inhibitors of yak kinases |
| US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| MX2010011463A (es) | 2008-04-16 | 2011-06-03 | Portola Pharm Inc | 2,6-diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o jak quinasas. |
| JP2011518219A (ja) | 2008-04-22 | 2011-06-23 | ポートラ ファーマシューティカルズ， インコーポレイテッド | タンパク質キナーゼの阻害剤 |
| CN101565397B (zh) * | 2009-04-07 | 2011-08-10 | 浙江医药股份有限公司新昌制药厂 | N-Boc-3-氨基哌啶及其光学异构体的合成方法 |
| EP3026052A1 (en) | 2009-04-20 | 2016-06-01 | Auspex Pharmaceuticals, Inc. | Preparation of deuterated piperidine inhibitors of janus kinase 3 |
| IN2012DN02577A (pl) | 2009-10-15 | 2015-08-28 | Pfizer | |
| PT3252057T (pt) * | 2009-12-04 | 2024-06-04 | Sunovion Pharmaceuticals Inc | Compostos multicíclicos e métodos de utilização dos mesmos |
| ES2461967T3 (es) | 2009-12-18 | 2014-05-21 | Pfizer Inc. | Compuestos de pirrolo[2,3-d]pirimidina |
| EP2531508A1 (en) | 2010-02-05 | 2012-12-12 | Pfizer Inc. | Pyrrolo [ 2, 3 - d]pyrimidine urea compounds as jak inhibitors |
| EP2635557A2 (en) | 2010-11-01 | 2013-09-11 | Portola Pharmaceuticals, Inc. | Nicotinamides as jak kinase modulators |
| SG11201402570QA (en) | 2011-11-23 | 2014-06-27 | Portola Pharm Inc | Pyrazine kinase inhibitors |
| CN104837817B (zh) | 2012-07-25 | 2017-03-22 | 力奇制药公司 | 制备3‑氨基‑哌啶化合物的合成路线 |
| RU2499793C1 (ru) * | 2012-08-24 | 2013-11-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный технический университет" (ВолгГТУ) | Способ получения третичных аминов |
| US9676756B2 (en) | 2012-10-08 | 2017-06-13 | Portola Pharmaceuticals, Inc. | Substituted pyrimidinyl kinase inhibitors |
| WO2014097150A1 (en) | 2012-12-17 | 2014-06-26 | Ranbaxy Laboratories Limited | Process for the preparation of tofacitinib and intermediates thereof |
| EP3290421B1 (en) | 2013-02-22 | 2019-01-02 | Pfizer Inc | Combination of pyrrolo [2, 3 -d]pyrimidine derivatives with one or more additional agents as inhibitors of janus- related kinases (jak) |
| ES2654051T3 (es) | 2013-12-05 | 2018-02-12 | Pfizer Inc. | Pirrolo[2,3-d]pirimidinilo, pirrolo[2,3-b]pirazinilo y pirrolo[2,3-d]piridinil acrilamidas |
| CN103755624B (zh) * | 2014-01-20 | 2018-10-09 | 上海博氏医药科技有限公司 | 一种哌啶衍生物的合成方法 |
| EP3180344B1 (en) | 2014-08-12 | 2019-09-18 | Pfizer Inc | Pyrrolo[2,3-d]pyrimidine derivatives useful for inhibiting janus kinase |
| ES2928757T3 (es) | 2015-05-01 | 2022-11-22 | Pfizer | Acrilamidas de pirrolo[2,3-b]pirazinilo y epóxidos de las mismas como inhibidores de la Janus Quinasa |
| EP3421455B1 (en) * | 2017-06-29 | 2019-03-27 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Improved process for the preparation of chiral 3-amino-piperidins, useful intermediates for the preparation of tofacitinib |
| MX2020008537A (es) | 2018-02-16 | 2021-01-08 | Sunovion Pharmaceuticals Inc | Sales, formas cristalinas y metodos de produccion de las mismas. |
| WO2020198583A1 (en) | 2019-03-27 | 2020-10-01 | Insilico Medicine Ip Limited | Bicyclic jak inhibitors and uses thereof |
| CA3180115A1 (en) | 2020-04-14 | 2021-10-21 | Sunovion Pharmaceuticals Inc. | (s)-(4,5-dihydro-7h-thieno[2,3-c]pyran-7-yl)-n-methylmethanamine for treating neurological and psychiatric disorders |
| KR102897364B1 (ko) * | 2024-03-19 | 2025-12-05 | 인천대학교 산학협력단 | 아실하이드라지드 화합물로부터 옥사다이아진 화합물의 원포트 합성방법 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE640616A (pl) * | 1962-12-19 | |||
| US3492397A (en) * | 1967-04-07 | 1970-01-27 | Warner Lambert Pharmaceutical | Sustained release dosage in the pellet form and process thereof |
| US4060598A (en) * | 1967-06-28 | 1977-11-29 | Boehringer Mannheim G.M.B.H. | Tablets coated with aqueous resin dispersions |
| US3538214A (en) * | 1969-04-22 | 1970-11-03 | Merck & Co Inc | Controlled release medicinal tablets |
| US4173626A (en) * | 1978-12-11 | 1979-11-06 | Merck & Co., Inc. | Sustained release indomethacin |
| JPS59112984A (ja) * | 1982-12-21 | 1984-06-29 | Shionogi & Co Ltd | １，４−ベンゾジアゼピン誘導体 |
| US4725599A (en) * | 1986-09-08 | 1988-02-16 | Pfizer Inc. | Heterocyclic ring fused pyrimidine-4 (3H)-ones as anticoccidial agents |
| FR2619111B1 (fr) * | 1987-08-07 | 1991-01-11 | Synthelabo | Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique |
| NZ239846A (en) * | 1990-09-27 | 1994-11-25 | Merck & Co Inc | Sulphonamide derivatives and pharmaceutical compositions thereof |
| JPH0794440B2 (ja) * | 1991-03-26 | 1995-10-11 | フアイザー・インコーポレイテツド | 置換ピペリジンの立体選択的製造 |
| US5461156A (en) * | 1993-03-31 | 1995-10-24 | Eli Lilly And Company | Stereocontrolled synthesis of cis-bicyclic compounds |
| US5559128A (en) * | 1995-04-18 | 1996-09-24 | Merck & Co., Inc. | 3-substituted piperidines promote release of growth hormone |
| EP0942732B1 (en) * | 1996-12-02 | 2004-11-17 | MERCK SHARP & DOHME LTD. | Use of nk-1 receptor antagonists for treating movement disorders |
| US6214846B1 (en) * | 1997-06-27 | 2001-04-10 | Merck Sharp & Dohme Limited | Substituted 3-(benzylamino)piperidine derivatives and their use as therapeutic agents |
| ES2321042T3 (es) | 1997-09-15 | 2009-06-01 | THE PROCTER & GAMBLE COMPANY | Quinolonas antimicrobianas, composiciones y usos de las mismas. |
| JP4030164B2 (ja) * | 1997-12-01 | 2008-01-09 | 株式会社トクヤマ | テトラハイドロピリジン誘導体及びその製造方法 |
| EA006227B1 (ru) * | 1999-12-10 | 2005-10-27 | Пфайзер Продактс Инк. | СОЕДИНЕНИЯ ПИРРОЛО[2,3-d]ПИРИМИДИНА |
| CN1481377A (zh) * | 2000-03-17 | 2004-03-10 | ����˹�ж�-����˹˹����ҩƷ��˾ | 作为基质金属蛋白酶和TNF-α的抑制剂的环β-氨基酸衍生物 |
| MY137020A (en) * | 2000-04-27 | 2008-12-31 | Abbott Lab | Diazabicyclic central nervous system active agents |
| JP3771128B2 (ja) * | 2000-12-28 | 2006-04-26 | 独立行政法人科学技術振興機構 | フェブリフジンおよびフェブリフジン化合物の新規合成方法 |
| US6992082B2 (en) * | 2001-01-19 | 2006-01-31 | Cytokinetics, Inc. | Phenothiazine kinesin inhibitors |
-
2003
- 2003-11-10 CN CNA2008101292567A patent/CN101353321A/zh active Pending
- 2003-11-10 EP EP03769829A patent/EP1572649A2/en not_active Withdrawn
- 2003-11-10 WO PCT/IB2003/005151 patent/WO2004046112A2/en not_active Ceased
- 2003-11-10 JP JP2004553003A patent/JP2006508976A/ja not_active Withdrawn
- 2003-11-10 KR KR1020067021730A patent/KR100742012B1/ko not_active Expired - Fee Related
- 2003-11-10 KR KR1020057009058A patent/KR100678800B1/ko not_active Expired - Fee Related
- 2003-11-10 AU AU2003278529A patent/AU2003278529A1/en not_active Abandoned
- 2003-11-10 MX MXPA05005403A patent/MXPA05005403A/es active IP Right Grant
- 2003-11-10 RS YUP-2005/0380A patent/RS20050380A/sr unknown
- 2003-11-10 CA CA002506016A patent/CA2506016C/en not_active Expired - Fee Related
- 2003-11-10 BR BR0316470-5A patent/BR0316470A/pt not_active IP Right Cessation
- 2003-11-10 PL PL377791A patent/PL377791A1/pl not_active Application Discontinuation
- 2003-11-10 RU RU2005115500/04A patent/RU2309147C9/ru active
- 2003-11-10 CN CNA2003801062274A patent/CN1726192A/zh active Pending
- 2003-11-20 US US10/717,958 patent/US7084277B2/en not_active Expired - Fee Related
-
2005
- 2005-05-19 ZA ZA200504068A patent/ZA200504068B/en unknown
-
2007
- 2007-04-28 RU RU2007116248/04A patent/RU2007116248A/ru not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US7084277B2 (en) | 2006-08-01 |
| ZA200504068B (en) | 2006-08-30 |
| RU2007116248A (ru) | 2008-11-10 |
| KR100742012B1 (ko) | 2007-07-23 |
| RS20050380A (sr) | 2007-11-15 |
| EP1572649A2 (en) | 2005-09-14 |
| AU2003278529A1 (en) | 2004-06-15 |
| BR0316470A (pt) | 2005-10-11 |
| WO2004046112A3 (en) | 2004-08-05 |
| WO2004046112A2 (en) | 2004-06-03 |
| RU2005115500A (ru) | 2006-01-20 |
| CN101353321A (zh) | 2009-01-28 |
| KR100678800B1 (ko) | 2007-02-05 |
| KR20060116873A (ko) | 2006-11-15 |
| MXPA05005403A (es) | 2005-08-03 |
| JP2006508976A (ja) | 2006-03-16 |
| CA2506016C (en) | 2009-03-17 |
| RU2309147C2 (ru) | 2007-10-27 |
| CN1726192A (zh) | 2006-01-25 |
| US20040102627A1 (en) | 2004-05-27 |
| RU2309147C9 (ru) | 2008-03-20 |
| KR20050083905A (ko) | 2005-08-26 |
| CA2506016A1 (en) | 2004-06-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |