PL377791A1 - Pochodne 3-aminopiperydyny i sposoby ich wytwarzania - Google Patents
Pochodne 3-aminopiperydyny i sposoby ich wytwarzaniaInfo
- Publication number
- PL377791A1 PL377791A1 PL377791A PL37779103A PL377791A1 PL 377791 A1 PL377791 A1 PL 377791A1 PL 377791 A PL377791 A PL 377791A PL 37779103 A PL37779103 A PL 37779103A PL 377791 A1 PL377791 A1 PL 377791A1
- Authority
- PL
- Poland
- Prior art keywords
- amino
- processes
- preparation
- piperidine derivatives
- piperidine
- Prior art date
Links
- PEUGKEHLRUVPAN-UHFFFAOYSA-N piperidin-3-amine Chemical class NC1CCCNC1 PEUGKEHLRUVPAN-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4462—Non condensed piperidines, e.g. piperocaine only substituted in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42832402P | 2002-11-21 | 2002-11-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL377791A1 true PL377791A1 (pl) | 2006-02-20 |
Family
ID=32326635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL377791A PL377791A1 (pl) | 2002-11-21 | 2003-11-10 | Pochodne 3-aminopiperydyny i sposoby ich wytwarzania |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7084277B2 (pl) |
| EP (1) | EP1572649A2 (pl) |
| JP (1) | JP2006508976A (pl) |
| KR (2) | KR100742012B1 (pl) |
| CN (2) | CN101353321A (pl) |
| AU (1) | AU2003278529A1 (pl) |
| BR (1) | BR0316470A (pl) |
| CA (1) | CA2506016C (pl) |
| MX (1) | MXPA05005403A (pl) |
| PL (1) | PL377791A1 (pl) |
| RS (1) | RS20050380A (pl) |
| RU (2) | RU2309147C9 (pl) |
| WO (1) | WO2004046112A2 (pl) |
| ZA (1) | ZA200504068B (pl) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60037345T2 (de) | 1999-12-10 | 2008-11-13 | Pfizer Products Inc., Groton | Pyrrolo(2,3-d)pyrimidin-Verbindungen |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| HRP20050089B1 (hr) | 2002-07-29 | 2015-06-19 | Rigel Pharmaceuticals | Upotreba 2,4 pirimidindiaminskog spoja za proizvodnju lijeka za lijeäśenje ili sprjeäśavanje autoimunosne bolesti |
| WO2005012294A1 (en) | 2003-07-30 | 2005-02-10 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases |
| AU2005237254B2 (en) * | 2004-05-03 | 2010-02-04 | Novartis Ag | Combinations comprising a S1P receptor agonist and a JAK3 kinase inhibitor |
| BRPI0610876B8 (pt) | 2005-06-08 | 2021-05-25 | Rigel Pharmaceuticals Inc | composto, formulação farmacêutica, e métodos de inibir uma atividade de uma jak cinase, e de inibir uma cascata de transdução de sinal em que jak3 cinase desempenha um papel |
| US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| EP1913000B1 (en) | 2005-07-29 | 2012-01-11 | Pfizer Products Inc. | Pyrrolo[2,3-d]pyrimidine derivatives; their intermediates and synthesis |
| ES2622493T3 (es) | 2006-02-24 | 2017-07-06 | Rigel Pharmaceuticals, Inc. | Composiciones y métodos para la inhibición de la ruta de JAK |
| JP5161233B2 (ja) | 2006-10-19 | 2013-03-13 | ライジェル ファーマシューティカルズ， インコーポレイテッド | 自己免疫疾患の処置のためのｊａｋキナーゼの阻害剤としての２，４−ピリミジンアミン誘導体 |
| HUE030912T2 (en) | 2008-02-15 | 2017-06-28 | Rigel Pharmaceuticals Inc | Pyrimidine-2-amine compounds and their use as inhibitors of yak kinases |
| US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| US8063058B2 (en) | 2008-04-16 | 2011-11-22 | Portola Pharmaceuticals, Inc. | Inhibitors of syk and JAK protein kinases |
| AU2009238590A1 (en) | 2008-04-22 | 2009-10-29 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| CN101565397B (zh) * | 2009-04-07 | 2011-08-10 | 浙江医药股份有限公司新昌制药厂 | N-Boc-3-氨基哌啶及其光学异构体的合成方法 |
| AU2010239396B2 (en) * | 2009-04-20 | 2016-06-23 | Auspex Pharmaceuticals, Llc | Piperidine inhibitors of Janus Kinase 3 |
| ES2426407T3 (es) | 2009-10-15 | 2013-10-23 | Pfizer Inc. | Compuestos de pirrolo[2,3-d]pirimidina |
| SG10201510665WA (en) * | 2009-12-04 | 2016-01-28 | Sunovion Pharmaceuticals Inc | Multicycle Compounds And Pharmaceutical Compositions Useful For The Treatment Of Neurological Disorders |
| WO2011075334A1 (en) | 2009-12-18 | 2011-06-23 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidine compounds |
| MX2012009074A (es) | 2010-02-05 | 2012-08-23 | Pfizer | Compuestos de urea pirrolo [2, 3-d] pirimidina como inhibidores de janus quinasa. |
| EP2975027A1 (en) | 2010-11-01 | 2016-01-20 | Portola Pharmaceuticals, Inc. | Nicotinamides as jak kinase modulators |
| MX363551B (es) | 2011-11-23 | 2019-03-27 | Portola Pharmaceuticals Inc Star | Compuestos derivados de pirazina como inhibidores de cinasa. |
| WO2014016338A1 (en) | 2012-07-25 | 2014-01-30 | Lek Pharmaceuticals D.D. | New synthetic route for the preparation of 3-amino-piperidine compounds |
| RU2499793C1 (ru) * | 2012-08-24 | 2013-11-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный технический университет" (ВолгГТУ) | Способ получения третичных аминов |
| WO2014058921A2 (en) | 2012-10-08 | 2014-04-17 | Portola Pharmaceuticals, Inc. | Substituted pyrimidinyl kinase inhibitors |
| WO2014097150A1 (en) | 2012-12-17 | 2014-06-26 | Ranbaxy Laboratories Limited | Process for the preparation of tofacitinib and intermediates thereof |
| GEP201606600B (en) | 2013-02-22 | 2017-01-10 | Pfizer | Pyrrolo [2, 3 -d]pyrimidine derivatives as inhibitors of janus- related kinases (jak) |
| SI3077395T1 (en) | 2013-12-05 | 2018-03-30 | Pfizer Inc. | Pyrrolo(2,3-d)pyrimidinyl, pyrrolo(2,3-b)pyrazinyl and pyrrolo(2,3-d)pyridinyl acrylamides |
| CN103755624B (zh) * | 2014-01-20 | 2018-10-09 | 上海博氏医药科技有限公司 | 一种哌啶衍生物的合成方法 |
| WO2016024185A1 (en) | 2014-08-12 | 2016-02-18 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidine derivatives useful for inhibiting janus kinase |
| EP3288943B1 (en) | 2015-05-01 | 2022-09-28 | Pfizer Inc. | Pyrrolo[2,3-b]pyrazinyl acrylamides and epoxides thereof as inhibitors of janus kinase |
| EP3421455B1 (en) * | 2017-06-29 | 2019-03-27 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Improved process for the preparation of chiral 3-amino-piperidins, useful intermediates for the preparation of tofacitinib |
| UA130249C2 (uk) | 2018-02-16 | 2025-12-31 | Сумітомо Фарма Америка, Інк. | Солі, кристалічні форми і способи їх отримання |
| WO2020198583A1 (en) | 2019-03-27 | 2020-10-01 | Insilico Medicine Ip Limited | Bicyclic jak inhibitors and uses thereof |
| CA3180115A1 (en) | 2020-04-14 | 2021-10-21 | Sunovion Pharmaceuticals Inc. | (s)-(4,5-dihydro-7h-thieno[2,3-c]pyran-7-yl)-n-methylmethanamine for treating neurological and psychiatric disorders |
| KR102897364B1 (ko) * | 2024-03-19 | 2025-12-05 | 인천대학교 산학협력단 | 아실하이드라지드 화합물로부터 옥사다이아진 화합물의 원포트 합성방법 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE640616A (pl) | 1962-12-19 | |||
| US3492397A (en) | 1967-04-07 | 1970-01-27 | Warner Lambert Pharmaceutical | Sustained release dosage in the pellet form and process thereof |
| US4060598A (en) | 1967-06-28 | 1977-11-29 | Boehringer Mannheim G.M.B.H. | Tablets coated with aqueous resin dispersions |
| US3538214A (en) | 1969-04-22 | 1970-11-03 | Merck & Co Inc | Controlled release medicinal tablets |
| US4173626A (en) | 1978-12-11 | 1979-11-06 | Merck & Co., Inc. | Sustained release indomethacin |
| JPS59112984A (ja) * | 1982-12-21 | 1984-06-29 | Shionogi & Co Ltd | １，４−ベンゾジアゼピン誘導体 |
| US4725599A (en) * | 1986-09-08 | 1988-02-16 | Pfizer Inc. | Heterocyclic ring fused pyrimidine-4 (3H)-ones as anticoccidial agents |
| FR2619111B1 (fr) | 1987-08-07 | 1991-01-11 | Synthelabo | Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique |
| NZ239846A (en) * | 1990-09-27 | 1994-11-25 | Merck & Co Inc | Sulphonamide derivatives and pharmaceutical compositions thereof |
| SK284565B6 (sk) * | 1991-03-26 | 2005-06-02 | Pfizer Inc. | Spôsob prípravy substituovaných piperidínov |
| US5461156A (en) * | 1993-03-31 | 1995-10-24 | Eli Lilly And Company | Stereocontrolled synthesis of cis-bicyclic compounds |
| US5559128A (en) * | 1995-04-18 | 1996-09-24 | Merck & Co., Inc. | 3-substituted piperidines promote release of growth hormone |
| AU734872B2 (en) * | 1996-12-02 | 2001-06-21 | Merck Sharp & Dohme Limited | Use of NK-1 receptor antagonists for treating movement disorders |
| CA2291734A1 (en) * | 1997-06-27 | 1999-01-07 | Merck Sharp & Dohme Limited | Substituted 3-(benzylamino)piperidine derivatives and their use as therapeutic agents |
| SK286420B6 (sk) | 1997-09-15 | 2008-09-05 | The Procter & Gamble Company | Zlúčenina so štruktúrou chinolónu, farmaceutický prostriedok s jej obsahom a jej použitie |
| JP4030164B2 (ja) * | 1997-12-01 | 2008-01-09 | 株式会社トクヤマ | テトラハイドロピリジン誘導体及びその製造方法 |
| DE60037345T2 (de) * | 1999-12-10 | 2008-11-13 | Pfizer Products Inc., Groton | Pyrrolo(2,3-d)pyrimidin-Verbindungen |
| IL151552A0 (en) * | 2000-03-17 | 2003-04-10 | Bristol Myers Squibb Pharma Co | Cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha |
| MY145722A (en) * | 2000-04-27 | 2012-03-30 | Abbott Lab | Diazabicyclic central nervous system active agents |
| JP3771128B2 (ja) * | 2000-12-28 | 2006-04-26 | 独立行政法人科学技術振興機構 | フェブリフジンおよびフェブリフジン化合物の新規合成方法 |
| WO2002057244A1 (en) * | 2001-01-19 | 2002-07-25 | Cytokinetics, Inc. | Phenothiazine kinesin inhibitors |
-
2003
- 2003-11-10 AU AU2003278529A patent/AU2003278529A1/en not_active Abandoned
- 2003-11-10 CN CNA2008101292567A patent/CN101353321A/zh active Pending
- 2003-11-10 RU RU2005115500/04A patent/RU2309147C9/ru active
- 2003-11-10 CA CA002506016A patent/CA2506016C/en not_active Expired - Fee Related
- 2003-11-10 WO PCT/IB2003/005151 patent/WO2004046112A2/en not_active Ceased
- 2003-11-10 EP EP03769829A patent/EP1572649A2/en not_active Withdrawn
- 2003-11-10 RS YUP-2005/0380A patent/RS20050380A/sr unknown
- 2003-11-10 JP JP2004553003A patent/JP2006508976A/ja not_active Withdrawn
- 2003-11-10 MX MXPA05005403A patent/MXPA05005403A/es active IP Right Grant
- 2003-11-10 BR BR0316470-5A patent/BR0316470A/pt not_active IP Right Cessation
- 2003-11-10 KR KR1020067021730A patent/KR100742012B1/ko not_active Expired - Fee Related
- 2003-11-10 KR KR1020057009058A patent/KR100678800B1/ko not_active Expired - Fee Related
- 2003-11-10 CN CNA2003801062274A patent/CN1726192A/zh active Pending
- 2003-11-10 PL PL377791A patent/PL377791A1/pl not_active Application Discontinuation
- 2003-11-20 US US10/717,958 patent/US7084277B2/en not_active Expired - Fee Related
-
2005
- 2005-05-19 ZA ZA200504068A patent/ZA200504068B/en unknown
-
2007
- 2007-04-28 RU RU2007116248/04A patent/RU2007116248A/ru not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004046112A2 (en) | 2004-06-03 |
| RU2005115500A (ru) | 2006-01-20 |
| ZA200504068B (en) | 2006-08-30 |
| EP1572649A2 (en) | 2005-09-14 |
| US7084277B2 (en) | 2006-08-01 |
| RS20050380A (sr) | 2007-11-15 |
| RU2007116248A (ru) | 2008-11-10 |
| AU2003278529A1 (en) | 2004-06-15 |
| JP2006508976A (ja) | 2006-03-16 |
| RU2309147C9 (ru) | 2008-03-20 |
| KR20060116873A (ko) | 2006-11-15 |
| CA2506016C (en) | 2009-03-17 |
| CA2506016A1 (en) | 2004-06-03 |
| KR100678800B1 (ko) | 2007-02-05 |
| CN1726192A (zh) | 2006-01-25 |
| BR0316470A (pt) | 2005-10-11 |
| WO2004046112A3 (en) | 2004-08-05 |
| US20040102627A1 (en) | 2004-05-27 |
| KR20050083905A (ko) | 2005-08-26 |
| CN101353321A (zh) | 2009-01-28 |
| MXPA05005403A (es) | 2005-08-03 |
| KR100742012B1 (ko) | 2007-07-23 |
| RU2309147C2 (ru) | 2007-10-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |