PL379626A1 - Nowy proces syntezy estrów N-[(S)-1-karboksybutylo]-(S)-alaniny i ich zastosowanie do syntezy perindoprilu - Google Patents

Nowy proces syntezy estrów N-[(S)-1-karboksybutylo]-(S)-alaniny i ich zastosowanie do syntezy perindoprilu

Info

Publication number
PL379626A1
PL379626A1 PL379626A PL37962604A PL379626A1 PL 379626 A1 PL379626 A1 PL 379626A1 PL 379626 A PL379626 A PL 379626A PL 37962604 A PL37962604 A PL 37962604A PL 379626 A1 PL379626 A1 PL 379626A1
Authority
PL
Poland
Prior art keywords
synthesizing
carboxybutyl
alanine
novel method
perindopril
Prior art date
Application number
PL379626A
Other languages
English (en)
Other versions
PL211801B1 (pl
Inventor
Fabienne Breard
Claude Fugier
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of PL379626A1 publication Critical patent/PL379626A1/pl
Publication of PL211801B1 publication Critical patent/PL211801B1/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30Preparation of optical isomers
    • C07C227/32Preparation of optical isomers by stereospecific synthesis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/301,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/321,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL379626A 2003-09-01 2004-08-31 Sposób otrzymywania estrów N-[(S)-1-karboksybutylo]-(S)-alaniny, związki pośrednie i ich zastosowanie do syntezy perindoprilu PL211801B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03292145A EP1362845B1 (fr) 2003-09-01 2003-09-01 Nouveau procédé de synthèse des esters de la N-((S)-1-carboxybutyl)-(S)-alanine et application à la synthèse du perindopril

Publications (2)

Publication Number Publication Date
PL379626A1 true PL379626A1 (pl) 2006-10-30
PL211801B1 PL211801B1 (pl) 2012-06-29

Family

ID=29266057

Family Applications (1)

Application Number Title Priority Date Filing Date
PL379626A PL211801B1 (pl) 2003-09-01 2004-08-31 Sposób otrzymywania estrów N-[(S)-1-karboksybutylo]-(S)-alaniny, związki pośrednie i ich zastosowanie do syntezy perindoprilu

Country Status (28)

Country Link
US (1) US7361757B2 (pl)
EP (1) EP1362845B1 (pl)
JP (1) JP4616833B2 (pl)
KR (1) KR100735198B1 (pl)
CN (2) CN100577652C (pl)
AR (1) AR045545A1 (pl)
AT (1) ATE445588T1 (pl)
AU (1) AU2004270432B8 (pl)
BR (1) BRPI0413901B1 (pl)
CA (1) CA2536926C (pl)
CY (1) CY1109822T1 (pl)
DE (1) DE60329648D1 (pl)
DK (1) DK1362845T3 (pl)
EA (1) EA009980B1 (pl)
EG (1) EG25738A (pl)
ES (1) ES2334900T3 (pl)
GE (1) GEP20094650B (pl)
MA (1) MA28018A1 (pl)
MX (1) MXPA06002229A (pl)
MY (1) MY139073A (pl)
NO (1) NO20061152L (pl)
NZ (1) NZ545337A (pl)
PL (1) PL211801B1 (pl)
PT (1) PT1362845E (pl)
SI (1) SI1362845T1 (pl)
UA (1) UA81179C2 (pl)
WO (1) WO2005023755A1 (pl)
ZA (1) ZA200601427B (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20161602T1 (hr) * 2004-03-29 2016-12-30 Les Laboratoires Servier Postupak priprave čvrstog farmaceutskog pripravka
SI21800A (sl) 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
EP1792896A1 (en) 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2620699B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2807037B1 (fr) * 2000-03-31 2002-05-10 Adir NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2807430B1 (fr) * 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Also Published As

Publication number Publication date
WO2005023755A1 (fr) 2005-03-17
CA2536926A1 (fr) 2005-03-17
JP2007504203A (ja) 2007-03-01
HK1096378A1 (zh) 2007-06-01
AR045545A1 (es) 2005-11-02
EA009980B1 (ru) 2008-04-28
AU2004270432B8 (en) 2008-02-21
SI1362845T1 (sl) 2010-01-29
EG25738A (en) 2012-06-20
BRPI0413901A (pt) 2006-10-24
CN100577652C (zh) 2010-01-06
CN1835911A (zh) 2006-09-20
JP4616833B2 (ja) 2011-01-19
ES2334900T3 (es) 2010-03-17
KR20060060710A (ko) 2006-06-05
AU2004270432B2 (en) 2007-12-06
NO20061152L (no) 2006-03-10
UA81179C2 (en) 2007-12-10
US20060252958A1 (en) 2006-11-09
DK1362845T3 (da) 2010-01-18
NZ545337A (en) 2009-12-24
DE60329648D1 (de) 2009-11-26
EP1362845B1 (fr) 2009-10-14
MY139073A (en) 2009-08-28
CY1109822T1 (el) 2014-09-10
US7361757B2 (en) 2008-04-22
CN100460382C (zh) 2009-02-11
KR100735198B1 (ko) 2007-07-03
EP1362845A2 (fr) 2003-11-19
CA2536926C (fr) 2010-06-22
GEP20094650B (en) 2009-03-25
BRPI0413901B1 (pt) 2016-11-29
HK1118285A1 (zh) 2009-02-06
ATE445588T1 (de) 2009-10-15
MXPA06002229A (es) 2006-05-17
PL211801B1 (pl) 2012-06-29
MA28018A1 (fr) 2006-07-03
EP1362845A3 (fr) 2004-03-31
ZA200601427B (en) 2007-05-30
AU2004270432A1 (en) 2005-03-17
EA200600501A1 (ru) 2006-08-25
PT1362845E (pt) 2009-11-05
CN101143855A (zh) 2008-03-19

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