BRPI0413901A - processo de sìntese dos ésteres da n-[(s)-1-carboxibutil]-(s)-alanina e aplicação à sìntese do perindopril - Google Patents

processo de sìntese dos ésteres da n-[(s)-1-carboxibutil]-(s)-alanina e aplicação à sìntese do perindopril

Info

Publication number
BRPI0413901A
BRPI0413901A BRPI0413901-1A BRPI0413901A BRPI0413901A BR PI0413901 A BRPI0413901 A BR PI0413901A BR PI0413901 A BRPI0413901 A BR PI0413901A BR PI0413901 A BRPI0413901 A BR PI0413901A
Authority
BR
Brazil
Prior art keywords
synthesis
application
perindopril
carboxybutyl
alanine ester
Prior art date
Application number
BRPI0413901-1A
Other languages
English (en)
Inventor
Fabienne Breard
Claude Fugier
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of BRPI0413901A publication Critical patent/BRPI0413901A/pt
Publication of BRPI0413901B1 publication Critical patent/BRPI0413901B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)

Abstract

"PROCESSO DE SìNTESE DOS éSTERES DA N-¢(S)-1-CARBOXIBUTIL!-(S)-ALANINA E APLICAçãO à SìNTESE DO PERINDOPRIL". A presente invenção refere-se a um processo de síntese de derivados de fórmula (I) na qual R representa um grupo alquila (C~ 1~-C~ 6~) linear ou ramificado. Aplicação à síntese do perindopril e de seus sais farmaceuticamente aceitáveis.
BRPI0413901A 2003-09-01 2004-08-31 processo de síntese dos ésteres da n-[(s)-1-carboxibutil]-(s)-alanina e aplicação à síntese do perindopril BRPI0413901B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03292145A EP1362845B1 (fr) 2003-09-01 2003-09-01 Nouveau procédé de synthèse des esters de la N-((S)-1-carboxybutyl)-(S)-alanine et application à la synthèse du perindopril
PCT/FR2004/002213 WO2005023755A1 (fr) 2003-09-01 2004-08-31 Nouveau procede de synthese des esters de la n-[(s)-1-carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Publications (2)

Publication Number Publication Date
BRPI0413901A true BRPI0413901A (pt) 2006-10-24
BRPI0413901B1 BRPI0413901B1 (pt) 2016-11-29

Family

ID=29266057

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413901A BRPI0413901B1 (pt) 2003-09-01 2004-08-31 processo de síntese dos ésteres da n-[(s)-1-carboxibutil]-(s)-alanina e aplicação à síntese do perindopril

Country Status (28)

Country Link
US (1) US7361757B2 (pt)
EP (1) EP1362845B1 (pt)
JP (1) JP4616833B2 (pt)
KR (1) KR100735198B1 (pt)
CN (2) CN100577652C (pt)
AR (1) AR045545A1 (pt)
AT (1) ATE445588T1 (pt)
AU (1) AU2004270432B8 (pt)
BR (1) BRPI0413901B1 (pt)
CA (1) CA2536926C (pt)
CY (1) CY1109822T1 (pt)
DE (1) DE60329648D1 (pt)
DK (1) DK1362845T3 (pt)
EA (1) EA009980B1 (pt)
EG (1) EG25738A (pt)
ES (1) ES2334900T3 (pt)
GE (1) GEP20094650B (pt)
MA (1) MA28018A1 (pt)
MX (1) MXPA06002229A (pt)
MY (1) MY139073A (pt)
NO (1) NO20061152L (pt)
NZ (1) NZ545337A (pt)
PL (1) PL211801B1 (pt)
PT (1) PT1362845E (pt)
SI (1) SI1362845T1 (pt)
UA (1) UA81179C2 (pt)
WO (1) WO2005023755A1 (pt)
ZA (1) ZA200601427B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4948392B2 (ja) * 2004-03-29 2012-06-06 レ ラボラトア セルビエ 固形薬学的組成物を調製するためのプロセス
SI21800A (sl) 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
EP1792896A1 (en) 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2620699B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2807037B1 (fr) * 2000-03-31 2002-05-10 Adir NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2807430B1 (fr) * 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Also Published As

Publication number Publication date
HK1096378A1 (zh) 2007-06-01
WO2005023755A1 (fr) 2005-03-17
EA009980B1 (ru) 2008-04-28
EP1362845A2 (fr) 2003-11-19
MA28018A1 (fr) 2006-07-03
JP4616833B2 (ja) 2011-01-19
NZ545337A (en) 2009-12-24
ATE445588T1 (de) 2009-10-15
CA2536926A1 (fr) 2005-03-17
AU2004270432B2 (en) 2007-12-06
SI1362845T1 (sl) 2010-01-29
PL379626A1 (pl) 2006-10-30
DK1362845T3 (da) 2010-01-18
CN1835911A (zh) 2006-09-20
DE60329648D1 (de) 2009-11-26
PT1362845E (pt) 2009-11-05
NO20061152L (no) 2006-03-10
ES2334900T3 (es) 2010-03-17
GEP20094650B (en) 2009-03-25
KR20060060710A (ko) 2006-06-05
CN100577652C (zh) 2010-01-06
BRPI0413901B1 (pt) 2016-11-29
ZA200601427B (en) 2007-05-30
US7361757B2 (en) 2008-04-22
AU2004270432B8 (en) 2008-02-21
CN101143855A (zh) 2008-03-19
HK1118285A1 (zh) 2009-02-06
CN100460382C (zh) 2009-02-11
KR100735198B1 (ko) 2007-07-03
CA2536926C (fr) 2010-06-22
JP2007504203A (ja) 2007-03-01
EP1362845B1 (fr) 2009-10-14
PL211801B1 (pl) 2012-06-29
EG25738A (en) 2012-06-20
EA200600501A1 (ru) 2006-08-25
CY1109822T1 (el) 2014-09-10
EP1362845A3 (fr) 2004-03-31
US20060252958A1 (en) 2006-11-09
UA81179C2 (en) 2007-12-10
AU2004270432A1 (en) 2005-03-17
AR045545A1 (es) 2005-11-02
MY139073A (en) 2009-08-28
MXPA06002229A (es) 2006-05-17

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 29/11/2016, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 15A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2529 DE 25-06-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.