PL379629A1 - Nowy sposób syntezy perindoprylu oraz jego farmaceutycznie dopuszczalnych soli - Google Patents

Nowy sposób syntezy perindoprylu oraz jego farmaceutycznie dopuszczalnych soli

Info

Publication number
PL379629A1
PL379629A1 PL379629A PL37962904A PL379629A1 PL 379629 A1 PL379629 A1 PL 379629A1 PL 379629 A PL379629 A PL 379629A PL 37962904 A PL37962904 A PL 37962904A PL 379629 A1 PL379629 A1 PL 379629A1
Authority
PL
Poland
Prior art keywords
perindopril
pharmaceutically
synthesis
acceptable salts
novel method
Prior art date
Application number
PL379629A
Other languages
English (en)
Other versions
PL211509B1 (pl
Inventor
Thierry Dubuffet
Jean-Pierre Lecouve
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of PL379629A1 publication Critical patent/PL379629A1/pl
Publication of PL211509B1 publication Critical patent/PL211509B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PL379629A 2003-08-29 2004-08-27 Sposób otrzymywania perindoprilu oraz jego farmaceutycznie dopuszczalnych soli PL211509B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03292131A EP1380590B1 (fr) 2003-08-29 2003-08-29 Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables

Publications (2)

Publication Number Publication Date
PL379629A1 true PL379629A1 (pl) 2006-10-30
PL211509B1 PL211509B1 (pl) 2012-05-31

Family

ID=29724623

Family Applications (1)

Application Number Title Priority Date Filing Date
PL379629A PL211509B1 (pl) 2003-08-29 2004-08-27 Sposób otrzymywania perindoprilu oraz jego farmaceutycznie dopuszczalnych soli

Country Status (19)

Country Link
US (1) US7183308B1 (pl)
EP (1) EP1380590B1 (pl)
JP (1) JP4331205B2 (pl)
CN (1) CN100395264C (pl)
AR (1) AR045515A1 (pl)
AT (1) ATE338766T1 (pl)
AU (1) AU2004270427B2 (pl)
CY (1) CY1105790T1 (pl)
DE (1) DE60308102T2 (pl)
DK (1) DK1380590T3 (pl)
EA (1) EA008485B1 (pl)
ES (1) ES2272922T3 (pl)
MY (1) MY139348A (pl)
NZ (1) NZ545335A (pl)
PL (1) PL211509B1 (pl)
PT (1) PT1380590E (pl)
SI (1) SI1380590T1 (pl)
WO (1) WO2005023841A1 (pl)
ZA (1) ZA200601428B (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE310012T1 (de) * 2003-08-29 2005-12-15 Servier Lab Verfahren für die synthese von perindopril und seiner pharmazeutisch annehmbaren salzen
WO2005108365A1 (en) * 2004-05-07 2005-11-17 Glenmark Pharmaceuticals Limited Processes for the preparation of alpha polymorph of perindopril erbumine
EP1987828A1 (en) 2005-01-06 2008-11-05 IPCA Laboratories Limited salts of perindopril and their use in the therapy of hypertension
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
PH12018502155B1 (en) 2016-04-20 2024-03-27 Servier Lab Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid
CN108752259A (zh) * 2018-07-04 2018-11-06 南京方生和医药科技有限公司 培哚普利消旋体及其中间体的制备方法
CN112047998B (zh) * 2020-09-07 2024-01-09 上海阿达玛斯试剂有限公司 一种培哚普利的制备方法
CN113980096A (zh) * 2021-11-29 2022-01-28 绍兴市上虞区武汉理工大学高等研究院 一种吨级培哚普利叔丁胺的合成工艺方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
ES2240919T3 (es) * 2003-03-12 2005-10-16 Les Laboratoires Servier Nuevo procedimiento para la sintesis de perindopril y de sus sales farmaceuticamente aceptables.
PT1319668E (pt) * 2003-03-12 2005-02-28 Servier Lab Novo processo de sintese de derivados do acido (2s,3as,7as)-1-[(s)-alanil]-octa-hidro-1h-indole-2-carboxilico e aplicacao a sintese de perindopril
EP1371659B1 (fr) * 2003-08-29 2005-10-12 Les Laboratoires Servier Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables

Also Published As

Publication number Publication date
AU2004270427B2 (en) 2008-08-21
ZA200601428B (en) 2007-05-30
EA008485B1 (ru) 2007-06-29
CN1839147A (zh) 2006-09-27
JP2007526901A (ja) 2007-09-20
CN100395264C (zh) 2008-06-18
AR045515A1 (es) 2005-11-02
SI1380590T1 (sl) 2006-12-31
ATE338766T1 (de) 2006-09-15
AU2004270427A1 (en) 2005-03-17
MY139348A (en) 2009-09-30
US7183308B1 (en) 2007-02-27
EP1380590B1 (fr) 2006-09-06
PT1380590E (pt) 2006-12-29
US20070043103A1 (en) 2007-02-22
PL211509B1 (pl) 2012-05-31
HK1096409A1 (en) 2007-06-01
DE60308102T2 (de) 2007-06-21
NZ545335A (en) 2009-08-28
CY1105790T1 (el) 2011-02-02
EA200600456A1 (ru) 2006-08-25
JP4331205B2 (ja) 2009-09-16
EP1380590A1 (fr) 2004-01-14
ES2272922T3 (es) 2007-05-01
WO2005023841A1 (fr) 2005-03-17
DE60308102D1 (de) 2006-10-19
DK1380590T3 (da) 2007-01-08

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