PL386416A1 - Sposób otrzymywania kwasu [1-hydroksy-2-(1H-imidazol-1-ilo)-etylideno] bisfosfonowego - Google Patents

Sposób otrzymywania kwasu [1-hydroksy-2-(1H-imidazol-1-ilo)-etylideno] bisfosfonowego

Info

Publication number
PL386416A1
PL386416A1 PL386416A PL38641608A PL386416A1 PL 386416 A1 PL386416 A1 PL 386416A1 PL 386416 A PL386416 A PL 386416A PL 38641608 A PL38641608 A PL 38641608A PL 386416 A1 PL386416 A1 PL 386416A1
Authority
PL
Poland
Prior art keywords
ethylidene
imidazole
hydroxy
obtaining
bisphosphonic acid
Prior art date
Application number
PL386416A
Other languages
English (en)
Other versions
PL213599B1 (pl
Inventor
Daniel Żyła
Robert Rynkiewicz
Mariusz Krzyżanowski
Leszek Dembkowski
Zdzisław Roznerski
Roman Szramka
Janusz Rachoń
Sławomir Makowiec
Original Assignee
Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna
Politechnika Gdańska
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna, Politechnika Gdańska filed Critical Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna
Priority to PL386416A priority Critical patent/PL213599B1/pl
Priority to PCT/PL2009/000092 priority patent/WO2010050830A1/en
Priority to US13/126,636 priority patent/US8524912B2/en
Priority to EP09753231A priority patent/EP2350102A1/en
Publication of PL386416A1 publication Critical patent/PL386416A1/pl
Publication of PL213599B1 publication Critical patent/PL213599B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL386416A 2008-10-31 2008-10-31 Sposób otrzymywania kwasu [1-hydroksy-2-(1H-imidazol-1-ilo)-etylideno] bisfosfonowego PL213599B1 (pl)

Priority Applications (4)

Application Number Priority Date Filing Date Title
PL386416A PL213599B1 (pl) 2008-10-31 2008-10-31 Sposób otrzymywania kwasu [1-hydroksy-2-(1H-imidazol-1-ilo)-etylideno] bisfosfonowego
PCT/PL2009/000092 WO2010050830A1 (en) 2008-10-31 2009-10-17 Process for the preparation of [1-hydroxy-2-(1h-imidazol-1-yl)- ethylidene]bisphosphonic acid
US13/126,636 US8524912B2 (en) 2008-10-31 2009-10-17 Process for the preparation of [1-hydroxy-2-(1H-imidazol-1-yl)- ethylidene]bisphosphonic acid
EP09753231A EP2350102A1 (en) 2008-10-31 2009-10-17 Process for the preparation of ý1-hydroxy-2-(1h-imidazol-1-yl)- ethylidene¨bisphosphonic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL386416A PL213599B1 (pl) 2008-10-31 2008-10-31 Sposób otrzymywania kwasu [1-hydroksy-2-(1H-imidazol-1-ilo)-etylideno] bisfosfonowego

Publications (2)

Publication Number Publication Date
PL386416A1 true PL386416A1 (pl) 2010-05-10
PL213599B1 PL213599B1 (pl) 2013-03-29

Family

ID=41426894

Family Applications (1)

Application Number Title Priority Date Filing Date
PL386416A PL213599B1 (pl) 2008-10-31 2008-10-31 Sposób otrzymywania kwasu [1-hydroksy-2-(1H-imidazol-1-ilo)-etylideno] bisfosfonowego

Country Status (4)

Country Link
US (1) US8524912B2 (pl)
EP (1) EP2350102A1 (pl)
PL (1) PL213599B1 (pl)
WO (1) WO2010050830A1 (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201270328A1 (ru) * 2009-08-28 2012-09-28 Синтон Б. В. Способ получения 1-гидроксиалкилиден-1,1-дифосфоновых кислот
JP2016524713A (ja) 2013-06-05 2016-08-18 ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク Ｍｅｍｓ式熱量計、その製造および使用
CN106699809A (zh) * 2016-12-07 2017-05-24 河北仁合益康药业有限公司 一种唑来膦酸的合成工艺

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3776880D1 (de) * 1986-11-21 1992-04-02 Ciba Geigy Ag Neue substituierte alkandiphosphonsaeuren.
ITMI20020908A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
KR100681282B1 (ko) 2002-05-17 2007-02-12 테바 파마슈티컬 인더스트리즈 리미티드 특정 희석제를 사용하는 비스포스폰산 및 그 염의 제조방법
JP4642762B2 (ja) 2003-08-21 2011-03-02 サン・ファーマシューティカル・インダストリーズ・リミテッド ビスホスホン酸化合物の製造方法
WO2005066188A1 (en) 2003-10-17 2005-07-21 Sun Pharmaceutical Industries Limited A process for the preparation of 2-(imidazol-1-yl)-1-hydroxyethane-1, 1-diphosphonic acid
CA2551230A1 (en) * 2003-12-23 2005-07-14 Lyogen Limited A process for the preparation of alkyl- and aryl-diphosphonic acids and salts thereof
WO2005063717A1 (en) 2003-12-26 2005-07-14 Natco Pharma Limited An improved process for the preparation of zoledronic acid
PL199215B1 (pl) * 2004-12-28 2008-08-29 Politechnika Gdanska Sposób wytwarzania kwasu [1-hydroksy-2-(3-pirydylo)etylidenobisfosfonowego] oraz jego soli monosodowej dwu i pół wodnej
WO2006134603A1 (en) 2005-06-13 2006-12-21 Jubilant Organosys Limited Process for producing bisphosphonic acids and forms thereof
EP1963345A2 (en) 2005-12-16 2008-09-03 Wockhardt Limited Processes for the preparation of pure zoledronic acid
WO2007083240A2 (en) 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
CA2642321A1 (en) 2006-02-20 2007-08-30 Alembic Limited An improved process for the preparation of biphosphonic derivatives
US20090137808A1 (en) 2006-03-21 2009-05-28 Albemarle Corporation Process for manufacturing bisphosphonic acids
WO2008035131A1 (en) 2006-09-19 2008-03-27 Orchid Chemicals And Pharmaceuticals Limited An improved process for the preparation of bisphosphonic acid
PT103600B (pt) 2006-11-06 2009-01-30 Hovione Farmaciencia Sa Processo para a preparação de ácidos biosfónicos e seus sais farmaceuticamente aceitáveis

Also Published As

Publication number Publication date
EP2350102A1 (en) 2011-08-03
PL213599B1 (pl) 2013-03-29
US20120116092A1 (en) 2012-05-10
WO2010050830A1 (en) 2010-05-06
US8524912B2 (en) 2013-09-03

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