PL3898637T3 - Pochodne rapamycyny - Google Patents
Pochodne rapamycynyInfo
- Publication number
- PL3898637T3 PL3898637T3 PL19836546.2T PL19836546T PL3898637T3 PL 3898637 T3 PL3898637 T3 PL 3898637T3 PL 19836546 T PL19836546 T PL 19836546T PL 3898637 T3 PL3898637 T3 PL 3898637T3
- Authority
- PL
- Poland
- Prior art keywords
- rapamicin
- derivatives
- rapamicin derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862781242P | 2018-12-18 | 2018-12-18 | |
| PCT/IB2019/060957 WO2020128861A1 (en) | 2018-12-18 | 2019-12-17 | Rapamycin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3898637T3 true PL3898637T3 (pl) | 2025-05-19 |
Family
ID=69165426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL19836546.2T PL3898637T3 (pl) | 2018-12-18 | 2019-12-17 | Pochodne rapamycyny |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US12281125B2 (pl) |
| EP (1) | EP3898637B1 (pl) |
| JP (1) | JP7618553B2 (pl) |
| KR (1) | KR20210105397A (pl) |
| CN (1) | CN113260619B (pl) |
| AU (1) | AU2019409366B2 (pl) |
| BR (1) | BR112021011325A2 (pl) |
| CA (1) | CA3122922A1 (pl) |
| DK (1) | DK3898637T3 (pl) |
| ES (1) | ES3014225T3 (pl) |
| FI (1) | FI3898637T3 (pl) |
| HR (1) | HRP20250197T1 (pl) |
| HU (1) | HUE070859T2 (pl) |
| LT (1) | LT3898637T (pl) |
| MX (1) | MX2021007247A (pl) |
| PL (1) | PL3898637T3 (pl) |
| PT (1) | PT3898637T (pl) |
| RS (1) | RS66527B1 (pl) |
| SI (1) | SI3898637T1 (pl) |
| WO (1) | WO2020128861A1 (pl) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR112834A1 (es) | 2017-09-26 | 2019-12-18 | Novartis Ag | Derivados de rapamicina |
| BR112020025283A2 (pt) | 2018-06-15 | 2021-03-09 | Navitor Pharmaceuticals, Inc. | Análogos de rapamicina e usos dos mesmos |
| EA202191983A1 (ru) | 2019-01-22 | 2021-12-01 | Аеовиан Фармасьютикалз, Инк. | МОДУЛЯТОРЫ mTORC И ИХ ПРИМЕНЕНИЕ |
| AU2020397938A1 (en) | 2019-12-05 | 2022-06-23 | Janssen Pharmaceutica Nv | Rapamycin analogs and uses thereof |
| IL296828A (en) | 2020-03-27 | 2022-11-01 | Aeovian Pharmaceuticals Inc | mtorc1 modulators and their uses |
| WO2024211738A1 (en) * | 2023-04-07 | 2024-10-10 | Regeneron Pharmaceuticals, Inc. | Selective rapamycin analogs and uses thereof |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
| US4316885A (en) | 1980-08-25 | 1982-02-23 | Ayerst, Mckenna And Harrison, Inc. | Acyl derivatives of rapamycin |
| US4650803A (en) | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
| US5120842A (en) | 1991-04-01 | 1992-06-09 | American Home Products Corporation | Silyl ethers of rapamycin |
| US5151413A (en) | 1991-11-06 | 1992-09-29 | American Home Products Corporation | Rapamycin acetals as immunosuppressant and antifungal agents |
| ZA935112B (en) | 1992-07-17 | 1994-02-08 | Smithkline Beecham Corp | Rapamycin derivatives |
| GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
| US5302584A (en) | 1992-10-13 | 1994-04-12 | American Home Products Corporation | Carbamates of rapamycin |
| US5258389A (en) | 1992-11-09 | 1993-11-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives |
| US5527907A (en) | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
| US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
| CA2219080A1 (en) * | 1995-06-07 | 1996-12-27 | Ariad Gene Therapeutics, Inc. | Rapamycin-based regulation of biological events |
| JP2002514893A (ja) | 1995-06-07 | 2002-05-21 | アリアド・ジーン・セラピューティクス・インコーポレイテッド | 生物学的事象のラパマイシンに基づく調節 |
| KR100400620B1 (ko) | 1995-06-09 | 2004-02-18 | 노파르티스 아게 | 라파마이신유도체 |
| GB9606452D0 (en) | 1996-03-27 | 1996-06-05 | Sandoz Ltd | Organic compounds |
| CA2257803C (en) | 1996-07-12 | 2008-12-02 | Ariad Pharmaceuticals, Inc. | Non immunosuppressive antifungal rapalogs |
| AU755784B2 (en) | 1998-01-15 | 2002-12-19 | Ariad Pharmaceuticals, Inc. | Regulation of biological events using multimeric chimeric proteins |
| ES2219388T3 (es) | 1999-08-24 | 2004-12-01 | Ariad Gene Therapeutics, Inc. | 28-epi-rapalogos. |
| EP3342411B1 (en) | 2001-02-19 | 2019-08-21 | Novartis Pharma AG | Rapamycin derivative for treating pancreas cancer |
| JP4547911B2 (ja) | 2002-02-01 | 2010-09-22 | アリアド・ファーマシューティカルズ・インコーポレイテッド | リン含有化合物およびその用途 |
| GB0601406D0 (en) | 2006-01-24 | 2006-03-08 | Novartis Ag | Organic Compounds |
| US20090023768A1 (en) | 2006-02-24 | 2009-01-22 | Novartis Ag | Rapamycin derivatives for treating neuroblastoma |
| RU2010104916A (ru) | 2006-08-16 | 2011-08-20 | Михаил В. Благосклонный (US) | Способ профилактики и лечения возрастных заболеваний |
| US8906374B2 (en) | 2010-04-20 | 2014-12-09 | Cedars-Sinai Medical Center | Combination therapy with CD4 lymphocyte depletion and mTOR inhibitors |
| WO2012103959A1 (en) | 2011-02-04 | 2012-08-09 | Synthon Bv | Process for making everolimus |
| WO2012110953A1 (en) | 2011-02-16 | 2012-08-23 | Novartis Ag | Combinations of therapeutic agents for use in the treatment of neurodegenerative diseases |
| WO2013078440A2 (en) | 2011-11-23 | 2013-05-30 | Intellikine, Llc | Enhanced treatment regimens using mtor inhibitors |
| ES2716685T3 (es) | 2014-01-24 | 2019-06-14 | Dana Farber Cancer Inst Inc | Moléculas de anticuerpo para PD-1 y usos de las mismas |
| EP3109250A1 (en) | 2015-06-23 | 2016-12-28 | Synbias Pharma AG | Method for the synthesis of rapamycin derivatives |
| WO2017044720A1 (en) * | 2015-09-11 | 2017-03-16 | Navitor Pharmaceuticals, Inc. | Rapamycin analogs and uses thereof |
| IL303660A (en) * | 2017-05-02 | 2023-08-01 | Revolution Medicines Inc | Rapamycin analogs as mtor inhibitors |
| AR112834A1 (es) | 2017-09-26 | 2019-12-18 | Novartis Ag | Derivados de rapamicina |
| EP3947392B1 (en) | 2019-03-26 | 2024-02-28 | Novartis AG | Isothiazolidine 1,1-dioxide and 1,4-butan sultone containing rapamycin derivatives and uses thereof |
-
2019
- 2019-12-17 LT LTEPPCT/IB2019/060957T patent/LT3898637T/lt unknown
- 2019-12-17 PL PL19836546.2T patent/PL3898637T3/pl unknown
- 2019-12-17 ES ES19836546T patent/ES3014225T3/es active Active
- 2019-12-17 AU AU2019409366A patent/AU2019409366B2/en active Active
- 2019-12-17 RS RS20250163A patent/RS66527B1/sr unknown
- 2019-12-17 HR HRP20250197TT patent/HRP20250197T1/hr unknown
- 2019-12-17 CN CN201980087363.4A patent/CN113260619B/zh active Active
- 2019-12-17 MX MX2021007247A patent/MX2021007247A/es unknown
- 2019-12-17 CA CA3122922A patent/CA3122922A1/en active Pending
- 2019-12-17 PT PT198365462T patent/PT3898637T/pt unknown
- 2019-12-17 FI FIEP19836546.2T patent/FI3898637T3/fi active
- 2019-12-17 JP JP2021534201A patent/JP7618553B2/ja active Active
- 2019-12-17 EP EP19836546.2A patent/EP3898637B1/en active Active
- 2019-12-17 WO PCT/IB2019/060957 patent/WO2020128861A1/en not_active Ceased
- 2019-12-17 DK DK19836546.2T patent/DK3898637T3/da active
- 2019-12-17 SI SI201930897T patent/SI3898637T1/sl unknown
- 2019-12-17 BR BR112021011325A patent/BR112021011325A2/pt unknown
- 2019-12-17 US US17/414,696 patent/US12281125B2/en active Active
- 2019-12-17 KR KR1020217022532A patent/KR20210105397A/ko active Pending
- 2019-12-17 HU HUE19836546A patent/HUE070859T2/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SI3898637T1 (sl) | 2025-04-30 |
| AU2019409366A1 (en) | 2021-06-10 |
| ES3014225T3 (en) | 2025-04-21 |
| RS66527B1 (sr) | 2025-03-31 |
| KR20210105397A (ko) | 2021-08-26 |
| EP3898637A1 (en) | 2021-10-27 |
| PT3898637T (pt) | 2025-02-24 |
| EP3898637B1 (en) | 2024-11-20 |
| CN113260619B (zh) | 2026-02-03 |
| CN113260619A (zh) | 2021-08-13 |
| DK3898637T3 (da) | 2025-02-17 |
| WO2020128861A1 (en) | 2020-06-25 |
| AU2019409366B2 (en) | 2022-10-27 |
| MX2021007247A (es) | 2021-07-15 |
| HRP20250197T1 (hr) | 2025-04-11 |
| JP2022514254A (ja) | 2022-02-10 |
| BR112021011325A2 (pt) | 2021-11-16 |
| US20220064185A1 (en) | 2022-03-03 |
| JP7618553B2 (ja) | 2025-01-21 |
| US12281125B2 (en) | 2025-04-22 |
| FI3898637T3 (fi) | 2025-02-24 |
| LT3898637T (lt) | 2025-03-10 |
| CA3122922A1 (en) | 2020-06-25 |
| HUE070859T2 (hu) | 2025-07-28 |
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