PL400167A1 - Nowe pochodne 1,6-dipodstawione imidazo[1,2-a][1,3,5]triazyny oraz sposób ich otrzymywania - Google Patents
Nowe pochodne 1,6-dipodstawione imidazo[1,2-a][1,3,5]triazyny oraz sposób ich otrzymywaniaInfo
- Publication number
- PL400167A1 PL400167A1 PL400167A PL40016712A PL400167A1 PL 400167 A1 PL400167 A1 PL 400167A1 PL 400167 A PL400167 A PL 400167A PL 40016712 A PL40016712 A PL 40016712A PL 400167 A1 PL400167 A1 PL 400167A1
- Authority
- PL
- Poland
- Prior art keywords
- preparation
- triazine
- chlorobenzyl
- methoxyphenyl
- methylphenyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- -1 1,6-disubstituted imidazo [1,2-a] [1,3,5] triazine Chemical class 0.000 title 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- OIWAVYDCTUEOEC-UHFFFAOYSA-N 1h-imidazo[1,2-a][1,3,5]triazine-2,4-dione Chemical class O=C1NC(=O)NC2=NC=CN21 OIWAVYDCTUEOEC-UHFFFAOYSA-N 0.000 abstract 1
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 abstract 1
- 125000006283 4-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])* 0.000 abstract 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Przedmiotem wynalazku jest sposób otrzymywania 1-arylo-6-(4-chlorobenzylo)-5,7(1H)diokso-2,3-dihydroimidazo[1,2-a][1,3,5]triazyn o wzorze 1, gdzie R oznacza podstawnik aromatyczny korzystnie, fenyl oraz jego podstawione analogi, a zwlaszcza 2-metylofenyl, 4-metylofenyl, 2-metoksyfenyl, 4-metoksyfenyl, 2-chlorofenyl. Zwiazki bedace przedmiotem wynalazku otrzymuje sie w wyniku kondensacji odpowiednio podstawionych pochodnych 1-(1-aryloimidazolidyn-2-ylideno)-3-(4-chlorobenzylo) mocznika z karbonylodiimidazolem. Kondensacje prowadzi sie w srodowisku rozpuszczalnika organicznego, korzystnie dimetyloformamidu w temperaturze wrzenia rozpuszczalnika przez okres 6-8 godzin. Wydzielony produkt oczyszcza sie przez krystalizacje z rozpuszczalników polarnych, korzystnie mieszaniny metanol-propan-2-ol w stosunku 1:3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL400167A PL219640B1 (pl) | 2012-07-30 | 2012-07-30 | Pochodne 1,6-dipodstawione imidazo[1,2-a][1,3,5]triazyny oraz sposób ich otrzymywania |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL400167A PL219640B1 (pl) | 2012-07-30 | 2012-07-30 | Pochodne 1,6-dipodstawione imidazo[1,2-a][1,3,5]triazyny oraz sposób ich otrzymywania |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL400167A1 true PL400167A1 (pl) | 2014-02-03 |
| PL219640B1 PL219640B1 (pl) | 2015-06-30 |
Family
ID=50023122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL400167A PL219640B1 (pl) | 2012-07-30 | 2012-07-30 | Pochodne 1,6-dipodstawione imidazo[1,2-a][1,3,5]triazyny oraz sposób ich otrzymywania |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL219640B1 (pl) |
-
2012
- 2012-07-30 PL PL400167A patent/PL219640B1/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL219640B1 (pl) | 2015-06-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Demirayak et al. | Microwave supported synthesis of some novel 1, 3-Diarylpyrazino [1, 2-a] benzimidazole derivatives and investigation of their anticancer activities | |
| EP4295841A3 (en) | Sulfur (vi) fluoride compounds and their use in click-reaction | |
| EA201170771A1 (ru) | Органические соединения | |
| Elansary et al. | Synthesis and anticancer activity of some novel fused pyridine ring system | |
| ES2620668T3 (es) | Derivados de amidas y sulfonamidas amido espirocíclicas | |
| EA201490912A1 (ru) | Производные [1,2,3]триазоло[4,5-d]пиримидина в качестве агонистов каннабиноидного рецептора 2 | |
| EA201691934A1 (ru) | Замещенные 4,5,6,7-тетрагидро-пиразоло[1,5-альфа]пиримидиновые производные и 2,3-дигидро-1h-имидазо[1,2-бета]пиразольные производные в качестве ингибиторов ros1 | |
| Zhao et al. | One-pot, three component synthesis of novel 5H-[1, 3, 4] thiadiazolo [3, 2-a] pyrimidine-6-carboxylate derivatives by microwave irradiation | |
| Adib et al. | An efficient synthesis of fully substituted pyrazolo [3, 4-b] pyridin-5-amines from α-azidochalcones | |
| Ali et al. | Design and synthesis of novel fused heterocycles using 4-chromanone as synthon | |
| Alekseeva et al. | One-stage synthesis of highly functionalized N-substituted 1, 8-naphthyridines | |
| CY1118084T1 (el) | ΠΑΡΑΓΩΓΑ ΤΟΥ 7-(ΕΤΕΡΟΑΡΥΛ-ΑΜΙΝΟ)-6,7,8,9-ΤΕΤΡΑΫΔΡΟΠΥΡΙΔΟ[1,2-α]ΙΝΔΟΛΟ ΟΞΙΚΟΥ ΟΞΕΟΣ ΚΑΙ Η ΧΡΗΣΗ ΤΟΥΣ ΩΣ ΤΡΟΠΟΠΟΙΗΤΕΣ ΤΟΥ ΥΠΟΔΟΧΕΑ ΤΗΣ ΠΡΟΣΤΑΓΛΑΝΔΙΝΗΣ D2 | |
| Sanad et al. | Utility of Pyridine‐2 (1H)‐thiones in the Synthesis of Novel Bis‐Thieno [2, 3‐b] pyridines and Their Fused Azines | |
| Spasov et al. | The derivatives of imidazo [1, 2-a] benzimidazole as 5-HT2A receptor antagonists | |
| PL400167A1 (pl) | Nowe pochodne 1,6-dipodstawione imidazo[1,2-a][1,3,5]triazyny oraz sposób ich otrzymywania | |
| CN103483339A (zh) | 一种9H-吡啶并[2,3-b]吲哚的简易合成方法 | |
| Elneairy et al. | Novel fused thienopyridine and pyrazolopyridine derivatives: Synthesis, characterization and cytotoxicity | |
| Yurtaeva et al. | Synthesis of 5-(hetarylmethylidene) pyrimidine-2, 4, 6 (1 H, 3 H, 5 H)-triones. | |
| Gorelov et al. | Synthesis and properties of 4-(3-aminothieno-[2, 3-b] pyridin-2-yl) coumarins | |
| Nassar et al. | Synthesis, reactivity and antitumor activity of some new pyrazolo [3, 4-d] pyrimidine and their triazole derivatives | |
| Elneairy et al. | Reactions with dimethylformamide‐dimethylacetal: Synthesis and reactions of several new pyridine and pyrazolo [3, 4‐b] pyridine derivatives | |
| Begunov et al. | Co-synthesis of 1-(3-aminopyridin-2-yl)-1 H-benzimidazole and 3-(2-aminophenyl)-3 H-imidazo [4, 5-b] pyridine | |
| Onisko et al. | Synthesis and halogenation of allylthioethers of pyrazolo [3, 4-d] pyrimidine | |
| Kulkarni et al. | Mannich Reaction as a New Route for the Synthesis of Tetrahydro Pyrimido Benzimidazolyl Coumarins. | |
| El-Shareef et al. | Synthesis and antibacterial evaluation of some new pyrimidine, pyridine and thiophene derivatives |