PL400213A1 - Imidazo [1,2-b] pyridazine-6-amine derivatives as JAK-2 kinase inhibitors - Google Patents
Imidazo [1,2-b] pyridazine-6-amine derivatives as JAK-2 kinase inhibitorsInfo
- Publication number
- PL400213A1 PL400213A1 PL400213A PL40021312A PL400213A1 PL 400213 A1 PL400213 A1 PL 400213A1 PL 400213 A PL400213 A PL 400213A PL 40021312 A PL40021312 A PL 40021312A PL 400213 A1 PL400213 A1 PL 400213A1
- Authority
- PL
- Poland
- Prior art keywords
- group
- jak
- alkyl groups
- imidazo
- pyridazine
- Prior art date
Links
- 102100033444 Tyrosine-protein kinase JAK2 Human genes 0.000 title abstract 2
- 101710112791 Tyrosine-protein kinase JAK2 Proteins 0.000 title abstract 2
- DCLWNTIANRACSB-UHFFFAOYSA-N imidazo[1,2-b]pyridazin-6-amine Chemical class N1=C(N)C=CC2=NC=CN21 DCLWNTIANRACSB-UHFFFAOYSA-N 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 208000014767 Myeloproliferative disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Przedmiotem zgloszenia sa zwiazki przedstawione wzorem ogólnym (I), w którym R1 oznacza H lub C1-C4 alkil, R2 oznacza fenyl podstawiony jednym lub dwoma podstawnikami, wybranymi z grupy skladajacej sie z atomów chlorowca i grup -OC1-C4 alkilowych, R3 oznacza fenyl lub 5-10-czlonowy monocykliczny lub bicykliczny heteroaryl zawierajacy w pierscieniu od 1 do 4 heteroatomów wybranych z grupy skladajacej sie z N, S, i O, który moze byc ewentualnie podstawiony podstawnikiem wybranym z atomów chlorowców, grup C1-C4-alkilowych, i grup -C(O)O-C1-C4-alkil; i X oznacza grupe -CH2- lub grupe karbonylowa -C(O)-; oraz ich sole addycyjne z kwasami. Zwiazki sa inhibitorami kinazy JAK-2 i moga znalezc zastosowanie jako leki w chorobach mieloproliferacyjnych i nowotworowych.The subject of the application are compounds represented by the general formula (I), in which R1 is H or C1-C4 alkyl, R2 is phenyl substituted with one or two substituents selected from the group consisting of halogen atoms and -OC1-C4 alkyl groups, R3 is phenyl or a 5-10 membered monocyclic or bicyclic heteroaryl having 1 to 4 ring heteroatoms selected from the group consisting of N, S, and O, which may be optionally substituted with a substituent selected from halogen, C1-C4-alkyl groups, and -C (O) O-C1-C4-alkyl groups; and X is a -CH2- group or a carbonyl group -C (O) -; and their acid addition salts. The compounds are inhibitors of JAK-2 kinase and may find application as drugs in myeloproliferative diseases and neoplastic diseases.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL400213A PL400213A1 (en) | 2012-08-01 | 2012-08-01 | Imidazo [1,2-b] pyridazine-6-amine derivatives as JAK-2 kinase inhibitors |
| PCT/IB2013/056241 WO2014020531A1 (en) | 2012-08-01 | 2013-07-30 | Imidazo[1,2-b]pyridazin-6-amine derivatives as kinase jak-2 inhibitors |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL400213A PL400213A1 (en) | 2012-08-01 | 2012-08-01 | Imidazo [1,2-b] pyridazine-6-amine derivatives as JAK-2 kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL400213A1 true PL400213A1 (en) | 2014-02-03 |
Family
ID=49301568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL400213A PL400213A1 (en) | 2012-08-01 | 2012-08-01 | Imidazo [1,2-b] pyridazine-6-amine derivatives as JAK-2 kinase inhibitors |
Country Status (2)
| Country | Link |
|---|---|
| PL (1) | PL400213A1 (en) |
| WO (1) | WO2014020531A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022549506A (en) | 2019-09-27 | 2022-11-25 | ディスク・メディシン・インコーポレイテッド | Methods for treating myelofibrosis and related conditions |
| KR20230012539A (en) | 2020-05-13 | 2023-01-26 | 디스크 메디슨, 인크. | Anti-hemojuvelin (HJV) antibodies to treat myelofibrosis |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007292924A1 (en) | 2006-09-07 | 2008-03-13 | Biogen Idec Ma Inc. | IRAK modulators for treating an inflammatory condition, cell proliferative disorder, immune disorder |
| PA8851101A1 (en) | 2008-12-16 | 2010-07-27 | Lilly Co Eli | AMINO PIRAZOL COMPOUND |
-
2012
- 2012-08-01 PL PL400213A patent/PL400213A1/en not_active Application Discontinuation
-
2013
- 2013-07-30 WO PCT/IB2013/056241 patent/WO2014020531A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014020531A1 (en) | 2014-02-06 |
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| REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |