PL401408A1 - Genistein-nicotinamide monohydrate co-crystal and a method for preparing genistein-nicotinamide monohydrate co-crystal - Google Patents
Genistein-nicotinamide monohydrate co-crystal and a method for preparing genistein-nicotinamide monohydrate co-crystalInfo
- Publication number
- PL401408A1 PL401408A1 PL401408A PL40140812A PL401408A1 PL 401408 A1 PL401408 A1 PL 401408A1 PL 401408 A PL401408 A PL 401408A PL 40140812 A PL40140812 A PL 40140812A PL 401408 A1 PL401408 A1 PL 401408A1
- Authority
- PL
- Poland
- Prior art keywords
- genistein
- nicotinamide
- crystal
- monohydrate
- amount
- Prior art date
Links
- 229960003966 nicotinamide Drugs 0.000 title abstract 7
- 239000011570 nicotinamide Substances 0.000 title abstract 7
- 239000013078 crystal Substances 0.000 title abstract 6
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 abstract 6
- TZBJGXHYKVUXJN-UHFFFAOYSA-N genistein Natural products C1=CC(O)=CC=C1C1=COC2=CC(O)=CC(O)=C2C1=O TZBJGXHYKVUXJN-UHFFFAOYSA-N 0.000 abstract 5
- 235000005152 nicotinamide Nutrition 0.000 abstract 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- 229940045109 genistein Drugs 0.000 abstract 3
- 235000006539 genistein Nutrition 0.000 abstract 3
- ZCOLJUOHXJRHDI-CMWLGVBASA-N genistein 7-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 ZCOLJUOHXJRHDI-CMWLGVBASA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 2
- SLRCCWJSBJZJBV-BYNSBNAKSA-N genisteine Chemical compound C1N2CCCC[C@@H]2[C@@H]2CN3CCCC[C@@H]3[C@H]1C2 SLRCCWJSBJZJBV-BYNSBNAKSA-N 0.000 abstract 2
- 150000004682 monohydrates Chemical class 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 229910000831 Steel Inorganic materials 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 235000019256 formaldehyde Nutrition 0.000 abstract 1
- 239000013080 microcrystalline material Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 239000010959 steel Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
Wynalazek dotyczy kokrysztalu monohydratu genisteina-nikotynamid o wzorze 3 i jego zastosowania w przemysle farmaceutycznym i/lub kosmetycznym. Wynalazek ujawnia równiez sposób otrzymywania kokrysztalu monohydratu genisteina - nikotynamid o wzorze 3 charakteryzujacy sie tym, ze genisteine w ilosci od 25 do 50 mg oraz nikotynamid w ilosci od 150 do 300 mg rozpuszcza sie w od 5 do 10 ml, etanolu i metanalu, po czym calosc miesza sie, przesacza sie, a nastepnie pozostawia sie do powolnego odparowania w temperaturze pokojowej, a po 2 do 4 tygodni zbiera sie krysztaly. W innej metodzie sposobu otrzymywania kokrysztalu monohydratu genisteina - nikotynamid o wzorze 3, umieszcza sie genisteine i nikotynamid w ilosci stechiometrycznej 1:1 w stalowym naczyniu mlyna kulowego, po czym dodaje sie wode lub mieszanine acetonitryl z woda w ilosci 50 ?l na kazde 50 mg genisteiny, poddaje sie mieleniu przez 5-45 minut, przy czestosci drgan 50-60 Hz. Tak otrzymany material mikrokrystaliczny suszy sie w temperaturze pokojowej przez czas od 12 do 24 godzin i poddaje analizie na dyfraktometrze proszkowym.The invention relates to the genistein-nicotinamide monohydrate co-crystal of formula 3 and its use in the pharmaceutical and / or cosmetics industry. The invention also discloses a method for the preparation of the co-crystal monohydrate genistein - nicotinamide of formula 3 characterized in that genisteine in the amount of 25 to 50 mg and nicotinamide in the amount of 150 to 300 mg are dissolved in 5 to 10 ml, ethanol and methanal, after which the whole is mixed, filtered and then allowed to evaporate slowly at room temperature, and after 2 to 4 weeks the crystals collect. In another method of obtaining the co-crystal of monohydrate genistein - nicotinamide of formula 3, place genisteine and nicotinamide in a stoichiometric amount of 1: 1 in a steel ball mill vessel, after which water or a mixture of acetonitrile with water in the amount of 50 ml for each 50 mg is added genistein, milled for 5-45 minutes, with a vibration frequency of 50-60 Hz. The microcrystalline material thus obtained is dried at room temperature for 12 to 24 hours and analyzed on a powder diffractometer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL401408A PL401408A1 (en) | 2012-10-30 | 2012-10-30 | Genistein-nicotinamide monohydrate co-crystal and a method for preparing genistein-nicotinamide monohydrate co-crystal |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL401408A PL401408A1 (en) | 2012-10-30 | 2012-10-30 | Genistein-nicotinamide monohydrate co-crystal and a method for preparing genistein-nicotinamide monohydrate co-crystal |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL401408A1 true PL401408A1 (en) | 2013-06-10 |
Family
ID=48539640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL401408A PL401408A1 (en) | 2012-10-30 | 2012-10-30 | Genistein-nicotinamide monohydrate co-crystal and a method for preparing genistein-nicotinamide monohydrate co-crystal |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL401408A1 (en) |
-
2012
- 2012-10-30 PL PL401408A patent/PL401408A1/en not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |