PL401706A1 - Superparamagnetyczne nanocząstki tlenku żelaza z ultracienkimi warstwami polimerowymi, sposób ich wytwarzania i zastosowanie - Google Patents

Superparamagnetyczne nanocząstki tlenku żelaza z ultracienkimi warstwami polimerowymi, sposób ich wytwarzania i zastosowanie

Info

Publication number
PL401706A1
PL401706A1 PL401706A PL40170612A PL401706A1 PL 401706 A1 PL401706 A1 PL 401706A1 PL 401706 A PL401706 A PL 401706A PL 40170612 A PL40170612 A PL 40170612A PL 401706 A1 PL401706 A1 PL 401706A1
Authority
PL
Poland
Prior art keywords
iron oxide
superparamagnetic iron
ultra
production
oxide nanoparticles
Prior art date
Application number
PL401706A
Other languages
English (en)
Other versions
PL227182B1 (pl
Inventor
Szczepan Zapotoczny
Gabriela Kania
Agnieszka Szpak
Maria Nowakowska
Original Assignee
Uniwersytet Jagielloński
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Jagielloński filed Critical Uniwersytet Jagielloński
Priority to PL401706A priority Critical patent/PL227182B1/pl
Priority to PL13818529T priority patent/PL2922577T3/pl
Priority to EP13818529.3A priority patent/EP2922577B1/en
Priority to PCT/PL2013/050031 priority patent/WO2014081322A1/en
Publication of PL401706A1 publication Critical patent/PL401706A1/pl
Publication of PL227182B1 publication Critical patent/PL227182B1/pl

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0089—Particulate, powder, adsorbate, bead, sphere
    • A61K49/0091—Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
    • A61K49/0093—Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1851—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
    • A61K49/1863—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule the organic macromolecular compound being a polysaccharide or derivative thereof, e.g. chitosan, chitin, cellulose, pectin, starch
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G49/00—Compounds of iron
    • C01G49/02—Oxides; Hydroxides
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G49/00—Compounds of iron
    • C01G49/02—Oxides; Hydroxides
    • C01G49/08—Ferroso-ferric oxide [Fe3O4]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2002/00—Crystal-structural characteristics
    • C01P2002/60—Compounds characterised by their crystallite size
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2002/00—Crystal-structural characteristics
    • C01P2002/80—Crystal-structural characteristics defined by measured data other than those specified in group C01P2002/70
    • C01P2002/82—Crystal-structural characteristics defined by measured data other than those specified in group C01P2002/70 by IR- or Raman-data
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2002/00—Crystal-structural characteristics
    • C01P2002/80—Crystal-structural characteristics defined by measured data other than those specified in group C01P2002/70
    • C01P2002/84—Crystal-structural characteristics defined by measured data other than those specified in group C01P2002/70 by UV- or VIS- data
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2002/00—Crystal-structural characteristics
    • C01P2002/80—Crystal-structural characteristics defined by measured data other than those specified in group C01P2002/70
    • C01P2002/86—Crystal-structural characteristics defined by measured data other than those specified in group C01P2002/70 by NMR- or ESR-data
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/01—Particle morphology depicted by an image
    • C01P2004/03—Particle morphology depicted by an image obtained by SEM
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/01—Particle morphology depicted by an image
    • C01P2004/04—Particle morphology depicted by an image obtained by TEM, STEM, STM or AFM
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/60—Particles characterised by their size
    • C01P2004/64—Nanometer sized, i.e. from 1-100 nanometer
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/42—Magnetic properties

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Materials Engineering (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Thin Magnetic Films (AREA)
  • Compounds Of Iron (AREA)

Abstract

Przedmiotem wynalazku są superparamagnetyczne nanocząstki tlenku żelaza z ultracienkimi warstwami polimerowymi charakteryzujące się tym, że składają się z superparamagnetycznych rdzeni z tlenków żelaza współstrąconych z polikationem oraz hydrofilowej powłoki złożonej z przynajmniej jednej ultracienkiej warstwy polielektrolitu. Przedmiotem wynalazku jest także sposób wytwarzania superparamagnetycznych nanocząstek oraz zastosowanie superparamagnetycznych nanocząstek jako środka kontrastowego w obrazowaniu rezonansem magnetycznym i/lub fluorescencyjnym i/lub mikroskopii fluorescencyjnej.
PL401706A 2012-11-21 2012-11-21 Superparamagnetyczne nanoczastki tlenku zelaza z ultracienkimi warstwami polimerowymi, sposób ich wytwarzania i zastosowanie PL227182B1 (pl)

Priority Applications (4)

Application Number Priority Date Filing Date Title
PL401706A PL227182B1 (pl) 2012-11-21 2012-11-21 Superparamagnetyczne nanoczastki tlenku zelaza z ultracienkimi warstwami polimerowymi, sposób ich wytwarzania i zastosowanie
PL13818529T PL2922577T3 (pl) 2012-11-21 2013-11-19 Superparamagnetyczne nanocząstki tlenku żelaza z ultracienkimi warstwami polimerowymi
EP13818529.3A EP2922577B1 (en) 2012-11-21 2013-11-19 Superparamagnetic iron oxide nanoparticles with ultra-thin polymer layers
PCT/PL2013/050031 WO2014081322A1 (en) 2012-11-21 2013-11-19 Superparamagnetic iron oxide nanoparticles with ultra-thin polymer layers, the method of their preparation and application

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL401706A PL227182B1 (pl) 2012-11-21 2012-11-21 Superparamagnetyczne nanoczastki tlenku zelaza z ultracienkimi warstwami polimerowymi, sposób ich wytwarzania i zastosowanie

Publications (2)

Publication Number Publication Date
PL401706A1 true PL401706A1 (pl) 2014-05-26
PL227182B1 PL227182B1 (pl) 2017-11-30

Family

ID=49920587

Family Applications (2)

Application Number Title Priority Date Filing Date
PL401706A PL227182B1 (pl) 2012-11-21 2012-11-21 Superparamagnetyczne nanoczastki tlenku zelaza z ultracienkimi warstwami polimerowymi, sposób ich wytwarzania i zastosowanie
PL13818529T PL2922577T3 (pl) 2012-11-21 2013-11-19 Superparamagnetyczne nanocząstki tlenku żelaza z ultracienkimi warstwami polimerowymi

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL13818529T PL2922577T3 (pl) 2012-11-21 2013-11-19 Superparamagnetyczne nanocząstki tlenku żelaza z ultracienkimi warstwami polimerowymi

Country Status (3)

Country Link
EP (1) EP2922577B1 (pl)
PL (2) PL227182B1 (pl)
WO (1) WO2014081322A1 (pl)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112978803A (zh) * 2021-02-23 2021-06-18 四川大学 一种表面带正电的水溶性超顺磁性四氧化三铁微球的制备方法
CN115078579A (zh) * 2022-06-20 2022-09-20 湖北省农业科学院农业质量标准与检测技术研究所 萘基修饰的磁性四氧化三铁纳米萃取材料在多环芳烃富集和检测中的应用

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104386760B (zh) * 2014-10-31 2015-12-30 山东师范大学 一种快速大量制备磁性载体材料的方法
WO2017015659A1 (en) * 2015-07-23 2017-01-26 Novather, Inc. System and method for the treatment of disease using nanoparticles
CN109432451A (zh) * 2018-11-09 2019-03-08 南京大学 一种肾脏清除的超小双靶向双模态磁共振造影剂的制备方法
EP3653674A1 (en) * 2018-11-15 2020-05-20 Commissariat à l'Énergie Atomique et aux Énergies Alternatives Process for manufacturing omniphobic cosmetic pigments
CN114316141B (zh) * 2020-10-10 2024-03-29 中科院广州化学有限公司 一种磁性羧甲基壳聚糖/丙烯酸/衣康酸共聚水凝胶吸附剂及其制备方法与应用
CN114306650B (zh) * 2022-01-21 2022-12-06 南方医科大学 一种磁性四氧化三铁纳米粒及其制备方法和应用
CN117085506A (zh) * 2023-09-20 2023-11-21 哈尔滨工业大学水资源国家工程研究中心有限公司 一种Ti掺杂四氧化三铁复合纳米粒子共混改性催化聚醚砜超滤膜的制备方法
US11980937B1 (en) * 2023-12-21 2024-05-14 King Faisal University Electrical doping of iron with chitosan nanoemulsion

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5262176A (en) * 1986-07-03 1993-11-16 Advanced Magnetics, Inc. Synthesis of polysaccharide covered superparamagnetic oxide colloids
EP1088315B1 (en) * 1998-05-26 2003-06-25 Bar-Ilan University Nucleation and growth of magnetic metal oxide nanoparticles and its use
US20040146855A1 (en) * 2003-01-27 2004-07-29 Marchessault Robert H. Formation of superparamagnetic particles

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112978803A (zh) * 2021-02-23 2021-06-18 四川大学 一种表面带正电的水溶性超顺磁性四氧化三铁微球的制备方法
CN115078579A (zh) * 2022-06-20 2022-09-20 湖北省农业科学院农业质量标准与检测技术研究所 萘基修饰的磁性四氧化三铁纳米萃取材料在多环芳烃富集和检测中的应用

Also Published As

Publication number Publication date
PL227182B1 (pl) 2017-11-30
EP2922577B1 (en) 2019-08-28
PL2922577T3 (pl) 2020-09-07
EP2922577A1 (en) 2015-09-30
WO2014081322A1 (en) 2014-05-30

Similar Documents

Publication Publication Date Title
PL401706A1 (pl) Superparamagnetyczne nanocząstki tlenku żelaza z ultracienkimi warstwami polimerowymi, sposób ich wytwarzania i zastosowanie
EP2673006A2 (en) Method of preparing iron oxide nanoparticles coated with hydrophilic material, and magnetic resonance imaging contrast agent using the same
EP2990382A4 (en) Magnetic iron oxide nanoparticle powder, process for producing same, thin film of magnetic iron oxide nanoparticles comprising said magnetic iron oxide nanoparticle powder, and process for producing same
CL2016000144A1 (es) Partículas de pigmento magnetizables o magnéticas y capas de efecto óptico.
WO2012110835A3 (en) Prussian blue based nanoparticle as multimodal imaging contrast material
EP2981294A4 (en) METAL OXIDE NANOPARTICLES BASED T1-T2 DOUBLE MODE RESONANCE IMAGING CONTRAST
EP2779259A3 (en) Magnetoresistive structures and magnetic random-access memory devices including the same
SG10201805073VA (en) Multilayered nanoparticle and methods of manufacturing and using the same
WO2017131604A3 (en) Magnetic nanoparticles and magnetorheological fluid comprising same
MX2017015669A (es) Nuevos compuestos de quelato de gadolinio para usar en imagenes de resonancia magnetica.
WO2012018240A3 (en) Preparation of extremely small and uniform sized, iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles and mri t1 contrast agents using the same
EP2753321A4 (en) EPINEPHRINNANOPARTICLES, METHOD OF MANUFACTURING THEREOF AND METHOD FOR USE THEREOF FOR TREATING SUFFICIENT AS A RESPONSE TO EPINEPHRIN
EP2723392A4 (en) MRI CONTRAST AGENT FOR LYMPHOGRAPHY BASED ON IRON OXIDE NANOPARTICLES AND METHOD FOR ILLUSTRATING LYMPHOTIC NODES THEREWITH
WO2016044068A3 (en) Nanoparticles for magnetic resonance imaging applications
EA033112B1 (ru) Медицинское устройство, визуализируемое при исследовании методом мрт
EP3603855A4 (en) PROCESS FOR THE PRODUCTION OF ATOMIZED POWDER AND PROCESS FOR MANUFACTURING A MAGNETIC CORE
ZA201504445B (en) Method for coating metallic surfaces with nanocrystalline zinc oxide layers, aqueous compositions therefor and use of the surfaces coated in this way
EP2703517A3 (en) Vehicular disc brake rotor and manufacturing method of vehicular disc brake rotor
EP3012332A4 (en) CORNORATED ELECTROBLECH AND TRACKING CORE THEREFORE
FR2989280B1 (fr) Nanoparticules ultrafines comme agent de contraste multimodal
EP3948989A4 (en) NANOPARTICLES WITH POLYTHIONATE CORE
WO2010094043A3 (en) Gadolinium expressed lipid nanoparticles for magnetic resonance imaging
EP2621541A4 (en) FORMS-STORING MAGNETIC NANOPARTICLES AS T1-CONTRASTING AGENTS FOR MAGNETIC RESONANCE TOMOGRAPHY
WO2014152042A3 (en) Improved techniques, systems and machine readable programs for magnetic resonance
DE112012004621A5 (de) Verfahren zur Herstellung hochfester Bauteile aus Stahlguss mit TRIP/TWIP Eigenschaften und Verwendung der hergestellten Bauteile