PL405697A1 - Process for producing 7,4'-dihydroxy-5-methoxy-8-prenyloflavone - Google Patents
Process for producing 7,4'-dihydroxy-5-methoxy-8-prenyloflavoneInfo
- Publication number
- PL405697A1 PL405697A1 PL405697A PL40569713A PL405697A1 PL 405697 A1 PL405697 A1 PL 405697A1 PL 405697 A PL405697 A PL 405697A PL 40569713 A PL40569713 A PL 40569713A PL 405697 A1 PL405697 A1 PL 405697A1
- Authority
- PL
- Poland
- Prior art keywords
- prenyloflavone
- dihydroxy
- methoxy
- producing
- isoxanthohumol
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 2
- YKGCBLWILMDSAV-GOSISDBHSA-N Isoxanthohumol Natural products O(C)c1c2C(=O)C[C@H](c3ccc(O)cc3)Oc2c(C/C=C(\C)/C)c(O)c1 YKGCBLWILMDSAV-GOSISDBHSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- YKGCBLWILMDSAV-SFHVURJKSA-N isoxanthohumol Chemical compound C1([C@H]2OC=3C(CC=C(C)C)=C(O)C=C(C=3C(=O)C2)OC)=CC=C(O)C=C1 YKGCBLWILMDSAV-SFHVURJKSA-N 0.000 abstract 2
- 239000011541 reaction mixture Substances 0.000 abstract 2
- 239000012043 crude product Substances 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Sposób wytwarzania 7,4'-dihydroksy-5-metoksy-8-prenyloflawonu, o wzorze 2, charakteryzuje się tym, że do mieszaniny reakcyjnej składającej się z pirydyny i jodu dodaje się izoksantohumol i ogrzewa się z jednoczesnym mieszaniem do całkowitego przereagowania izoksantohumolu, po czym mieszaninę poreakcyjną rozcieńcza się wodą, usuwa pozostałości jodu, zobojętnia i ekstrahuje rozpuszczalnikiem organicznym, nie mieszającym się z wodą, oddziela frakcję organiczną, osusza i odparowuje rozpuszczalnik i tak otrzymany surowy produkt oczyszcza się znaną metodą.The method of producing 7,4'-dihydroxy-5-methoxy-8-prenyloflavone, of formula II, is characterized in that isoxanthohumol is added to the reaction mixture consisting of pyridine and iodine and heated with simultaneous stirring until the isoxanthohumol has completely reacted the reaction mixture is diluted with water, the iodine residue is removed, neutralized and extracted with a water-immiscible organic solvent, the organic fraction is separated, dried and the solvent is evaporated and the crude product thus obtained is purified by a known method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL405697A PL219968B1 (en) | 2013-10-21 | 2013-10-21 | Process for producing 7,4'-dihydroxy-5-methoxy-8-prenyloflavone |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL405697A PL219968B1 (en) | 2013-10-21 | 2013-10-21 | Process for producing 7,4'-dihydroxy-5-methoxy-8-prenyloflavone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL405697A1 true PL405697A1 (en) | 2014-04-14 |
| PL219968B1 PL219968B1 (en) | 2015-08-31 |
Family
ID=50442242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL405697A PL219968B1 (en) | 2013-10-21 | 2013-10-21 | Process for producing 7,4'-dihydroxy-5-methoxy-8-prenyloflavone |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL219968B1 (en) |
-
2013
- 2013-10-21 PL PL405697A patent/PL219968B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL219968B1 (en) | 2015-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LICE | Declarations of willingness to grant licence |
Effective date: 20150209 |