PL406058A1 - Method for producing 15α-hydroxy-androst-1,4-diene-3,17-dione - Google Patents
Method for producing 15α-hydroxy-androst-1,4-diene-3,17-dioneInfo
- Publication number
- PL406058A1 PL406058A1 PL406058A PL40605813A PL406058A1 PL 406058 A1 PL406058 A1 PL 406058A1 PL 406058 A PL406058 A PL 406058A PL 40605813 A PL40605813 A PL 40605813A PL 406058 A1 PL406058 A1 PL 406058A1
- Authority
- PL
- Poland
- Prior art keywords
- carried out
- androst
- dione
- hydroxy
- producing
- Prior art date
Links
- OSVMTWJCGUFAOD-KZQROQTASA-N formestane Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1O OSVMTWJCGUFAOD-KZQROQTASA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 241001149507 Penicillium urticae Species 0.000 abstract 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 230000036983 biotransformation Effects 0.000 abstract 1
- RSIHSRDYCUFFLA-DYKIIFRCSA-N boldenone Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 RSIHSRDYCUFFLA-DYKIIFRCSA-N 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 239000012043 crude product Substances 0.000 abstract 1
- RSIHSRDYCUFFLA-UHFFFAOYSA-N dehydrotestosterone Natural products O=C1C=CC2(C)C3CCC(C)(C(CC4)O)C4C3CCC2=C1 RSIHSRDYCUFFLA-UHFFFAOYSA-N 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Abstract
Sposób wytwarzania 15?-hydroksy-androst-1,4-dien-3,17-dionu, charakteryzuje się tym, że wodną pożywkę zaszczepia się szczepem Penicillium urticae AM84 i hodowlę prowadzi się przez 3 doby, następnie dodaje się propionian 1-dehydrotestosteronu rozpuszczony w acetonie, w ilości od 10 do 25 mg na 100 cm3 pożywki, transformację prowadzi się przez kolejne 7 dni, przy czym proces biotransformacji substratu prowadzi się przy ciągłym wstrząsaniu reagentów i temperaturze od 18 do 27°C, następnie tak powstały roztwór ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą, osusza i odparowuje rozpuszczalnik, zaś surowy produkt oczyszcza się chromatograficznie.The method of producing 15'-hydroxy-androst-1,4-dien-3,17-dione is characterized by the fact that the aqueous medium is inoculated with the strain Penicillium urticae AM84 and the culture is carried out for 3 days, then dissolved 1-dehydrotestosterone propionate in acetone, in an amount of 10 to 25 mg per 100 cm3 of medium, transformation is carried out for a further 7 days, with the substrate biotransformation process carried out with continuous shaking of the reagents and a temperature of 18 to 27 ° C, then the resulting solution is extracted with solvent organic immiscible with water, drying and evaporating the solvent, and the crude product is purified by chromatography.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL406058A PL222711B1 (en) | 2013-11-14 | 2013-11-14 | Method for preparing 15α-hydroxy-androst-1,4-diene-3,17-dione |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL406058A PL222711B1 (en) | 2013-11-14 | 2013-11-14 | Method for preparing 15α-hydroxy-androst-1,4-diene-3,17-dione |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL406058A1 true PL406058A1 (en) | 2014-07-07 |
| PL222711B1 PL222711B1 (en) | 2016-08-31 |
Family
ID=51063157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL406058A PL222711B1 (en) | 2013-11-14 | 2013-11-14 | Method for preparing 15α-hydroxy-androst-1,4-diene-3,17-dione |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL222711B1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107652351A (en) * | 2017-10-26 | 2018-02-02 | 南京盖斯夫医药科技有限公司 | A kind of 2 ketone asiatic acid, preparation method and the application in stem cell field |
-
2013
- 2013-11-14 PL PL406058A patent/PL222711B1/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107652351A (en) * | 2017-10-26 | 2018-02-02 | 南京盖斯夫医药科技有限公司 | A kind of 2 ketone asiatic acid, preparation method and the application in stem cell field |
| CN107652351B (en) * | 2017-10-26 | 2020-04-17 | 北京泰盛生物科技有限公司 | 2-ketoasiatic acid, preparation method and application in stem cell field |
Also Published As
| Publication number | Publication date |
|---|---|
| PL222711B1 (en) | 2016-08-31 |
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