PL4069691T3 - Podstawione tetrahydrofurany jako modulatory kanałów sodowych - Google Patents

Podstawione tetrahydrofurany jako modulatory kanałów sodowych

Info

Publication number
PL4069691T3
PL4069691T3 PL20825397.1T PL20825397T PL4069691T3 PL 4069691 T3 PL4069691 T3 PL 4069691T3 PL 20825397 T PL20825397 T PL 20825397T PL 4069691 T3 PL4069691 T3 PL 4069691T3
Authority
PL
Poland
Prior art keywords
modulators
sodium channels
substituted tetrahydrofurans
tetrahydrofurans
substituted
Prior art date
Application number
PL20825397.1T
Other languages
English (en)
Inventor
Steven John Durrant
Nadia AHMAD
Elizabeth Mary BECK
Lidio CARVALHO MEIRELES
Ewa Iwona CHUDYK
Gorka ETXEBARRIA JARDI
Bhairavi GALAN
Sara S. Hadida Ruah
Dennis James Hurley
Ronald Marcellus KNEGTEL
Timothy Donald Neubert
Joanne Louise Pinder
Joseph Pontillo
Robert PULLIN
Yvonne Schmidt
David Matthew Shaw
Sarah Skerratt
Dean Stamos
Stephen Andrew Thomson
Anisa Nizarali Virani
Christopher Wray
Original Assignee
Vertex Pharmaceuticals Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=73854989&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL4069691(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated
Publication of PL4069691T3 publication Critical patent/PL4069691T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Steroid Compounds (AREA)
  • Details Of Television Scanning (AREA)
  • Amplitude Modulation (AREA)
  • Amplifiers (AREA)
PL20825397.1T 2019-12-06 2020-12-04 Podstawione tetrahydrofurany jako modulatory kanałów sodowych PL4069691T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962944869P 2019-12-06 2019-12-06
PCT/US2020/063290 WO2021113627A1 (en) 2019-12-06 2020-12-04 Substituted tetrahydrofurans as modulators of sodium channels

Publications (1)

Publication Number Publication Date
PL4069691T3 true PL4069691T3 (pl) 2025-01-27

Family

ID=73854989

Family Applications (1)

Application Number Title Priority Date Filing Date
PL20825397.1T PL4069691T3 (pl) 2019-12-06 2020-12-04 Podstawione tetrahydrofurany jako modulatory kanałów sodowych

Country Status (36)

Country Link
US (4) US11834441B2 (pl)
EP (2) EP4506001A3 (pl)
JP (2) JP7664925B2 (pl)
KR (1) KR20220124176A (pl)
CN (1) CN114945566B (pl)
AR (1) AR120680A1 (pl)
AU (1) AU2020397059A1 (pl)
BR (1) BR112022010924A2 (pl)
CA (1) CA3164134A1 (pl)
CL (1) CL2022001489A1 (pl)
CO (1) CO2022008969A2 (pl)
CR (1) CR20220316A (pl)
DK (1) DK4069691T3 (pl)
DO (2) DOP2022000115A (pl)
EC (1) ECSP22052564A (pl)
ES (1) ES2998396T3 (pl)
FI (1) FI4069691T3 (pl)
HR (1) HRP20241695T1 (pl)
HU (1) HUE069128T2 (pl)
IL (1) IL293592A (pl)
JO (1) JOP20220130B1 (pl)
LT (1) LT4069691T (pl)
MA (1) MA57825B1 (pl)
MD (1) MD4069691T2 (pl)
MX (1) MX2022006865A (pl)
PE (1) PE20230300A1 (pl)
PH (1) PH12022551379A1 (pl)
PL (1) PL4069691T3 (pl)
PT (1) PT4069691T (pl)
RS (1) RS66307B1 (pl)
SI (1) SI4069691T1 (pl)
SM (1) SMT202400488T1 (pl)
TW (1) TWI891687B (pl)
UA (1) UA130303C2 (pl)
UY (1) UY38979A (pl)
WO (1) WO2021113627A1 (pl)

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US12441703B2 (en) 2019-01-10 2025-10-14 Vertex Pharmaceuticals Incorporated Carboxamides as modulators of sodium channels
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WO2020243423A1 (en) 2019-05-31 2020-12-03 Ikena Oncology, Inc. Tead inhibitors and uses thereof
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CA3138560A1 (en) 2019-07-16 2021-01-21 Shaomeng Wang Imidazopyrimidines as eed inhibitors and the use thereof
CA3164134A1 (en) 2019-12-06 2021-06-10 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofurans as modulators of sodium channels
JP2024520643A (ja) 2021-06-04 2024-05-24 バーテックス ファーマシューティカルズ インコーポレイテッド ナトリウムチャネルの調節因子としてのヒドロキシ及び（ハロ）アルコキシ置換テトラヒドロフラン
CA3221788A1 (en) 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofuran-2-carboxamides as modulators of sodium channels
MA64856B1 (fr) 2021-06-04 2026-02-27 Vertex Pharmaceuticals Incorporated Formes de dosage solides et regimens de dosage comprenant le [[3-(3,4-difluoro-2-méthoxy-phényl)-4,5-diméthyl-5-(trifluorométhyl) tétrahydrofuranne-2-carbonyl]amino]pyridine-2-carboxamide
SI4347031T1 (sl) 2021-06-04 2026-01-30 Vertex Pharmaceuticals Incorporated N-(hidroksialkil (hetero)aril) tetrahidrofuran karboksamidi kot modulatorji natrijevih kanalčkov
WO2022256660A1 (en) * 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels
WO2022256676A1 (en) 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofuran analogs as modulators of sodium channels
JP2024520646A (ja) 2021-06-04 2024-05-24 バーテックス ファーマシューティカルズ インコーポレイテッド ナトリウムチャネルのモジュレーターとしてのｎ－（ヒドロキシアルキル（ヘテロ）アリール）テトラヒドロフランカルボキサミド類似体
TW202317520A (zh) 2021-06-15 2023-05-01 德商歌林達有限公司 經取代之吡唑醯胺
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UY40234A (es) 2022-04-22 2023-11-15 Vertex Pharma Compuestos heteroarilo para el tratamiento del dolor
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CN119585260A (zh) * 2022-08-24 2025-03-07 江苏恒瑞医药股份有限公司 杂环类化合物、其制备方法及其在医药上的应用
JP2025529931A (ja) * 2022-08-28 2025-09-09 シャンハイ ホイルン ファーマシューティカル カンパニー リミテッド ナトリウムチャネル調節剤及びその応用
CN119365451A (zh) * 2022-08-31 2025-01-24 江苏恒瑞医药股份有限公司 杂环类化合物、其制备方法及其在医药上的应用
AU2023391870A1 (en) * 2022-12-06 2025-06-05 Vertex Pharmaceuticals Incorporated Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels
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WO2025067219A1 (zh) * 2023-09-25 2025-04-03 江苏恒瑞医药股份有限公司 杂环类化合物、其制备方法及其在医药上的应用
TW202535352A (zh) * 2023-11-02 2025-09-16 大陸商陽光安津（南京）生物醫藥科技有限公司 化合物、組合物及其方法
WO2025108234A1 (zh) * 2023-11-20 2025-05-30 四川科伦药物研究院有限公司 化合物、其制备方法及用途
WO2025113633A1 (zh) * 2023-12-01 2025-06-05 南京清普生物科技有限公司 一种新的钠通道调节剂
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TW202545937A (zh) * 2024-02-01 2025-12-01 大陸商海思科醫藥集團股份有限公司 含硫雜環衍生物及其在醫藥上的應用
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WO2025252109A1 (zh) * 2024-06-04 2025-12-11 成都苑东生物制药股份有限公司 一种取代四氢呋喃类衍生物、其制备方法及用途
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WO2026037326A1 (zh) * 2024-08-16 2026-02-19 四川科伦药物研究院有限公司 吡啶酰胺类化合物的盐和晶型及其制备方法
CN119613390B (zh) * 2024-11-11 2025-10-28 广州楷石医药有限公司 氘代四氢呋喃类NaV1.8抑制剂及其用途
CN119143737B (zh) * 2024-11-18 2025-07-18 嘉兴安帝康生物科技有限公司 四氢呋喃甲酰胺类钠通道调节剂及其在医药上的应用
CN119241522B (zh) * 2024-11-28 2025-02-25 四川科伦药物研究院有限公司 杂环化合物的晶型及其药物组合物
CN119285621B (zh) * 2024-12-13 2025-07-18 嘉兴安帝康生物科技有限公司 作为钠通道调节剂的四氢呋喃甲酰胺类化合物及其在医药上的应用

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