PL407710A1 - Sposób wytwarzania preparatu kropli do oczu w postaci zawiesiny zawierającej brynzolamid i preparat wytworzony tym sposobem - Google Patents
Sposób wytwarzania preparatu kropli do oczu w postaci zawiesiny zawierającej brynzolamid i preparat wytworzony tym sposobemInfo
- Publication number
- PL407710A1 PL407710A1 PL407710A PL40771014A PL407710A1 PL 407710 A1 PL407710 A1 PL 407710A1 PL 407710 A PL407710 A PL 407710A PL 40771014 A PL40771014 A PL 40771014A PL 407710 A1 PL407710 A1 PL 407710A1
- Authority
- PL
- Poland
- Prior art keywords
- preparation
- suspension containing
- producing
- eye drops
- brinzolamidum
- Prior art date
Links
- 239000003889 eye drop Substances 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 4
- 239000000725 suspension Substances 0.000 title abstract 3
- 229940012356 eye drops Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 2
- HCRKCZRJWPKOAR-JTQLQIEISA-N brinzolamide Chemical compound CCN[C@H]1CN(CCCOC)S(=O)(=O)C2=C1C=C(S(N)(=O)=O)S2 HCRKCZRJWPKOAR-JTQLQIEISA-N 0.000 abstract 2
- 229960000722 brinzolamide Drugs 0.000 abstract 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 229920002125 Sokalan® Polymers 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 229960000686 benzalkonium chloride Drugs 0.000 abstract 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 235000011167 hydrochloric acid Nutrition 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
- 235000011121 sodium hydroxide Nutrition 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Przedmiotem wynalazku jest sposób wytwarzania preparatu kropli do oczu w postaci zawiesiny zawierającej brynzolamid, polegający na tym, że substancja czynna jest rozpuszczana, a następnie strącana za pomocą środka strącającego, w postaci cząstek o odpowiedniej wielkości w wyniku zmiany pH środowiska, która to operacja przeprowadzana jest w roztworze zawierającym główne składniki kompozycji połączone w warunkach aseptycznych. Ujawniono również preparat kropli do oczu w postaci zawiesiny zawierającej brynzolamid i substancje pomocnicze: polimer kwasu akrylowego, wersenian disodowy, chlorek benzalkoniowy, mannitol, wodorotlenek sodu, kwas solny, wodorowęglan sodu i wodę do sporządzania kropli do oczu, wolny od substancji zmniejszających napięcie powierzchniowe.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL407710A PL407710A1 (pl) | 2014-03-28 | 2014-03-28 | Sposób wytwarzania preparatu kropli do oczu w postaci zawiesiny zawierającej brynzolamid i preparat wytworzony tym sposobem |
| PCT/PL2015/000052 WO2015147665A1 (en) | 2014-03-28 | 2015-03-27 | Process for manufacturing brinzolamide ophthalmic suspension and eye drops formulation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL407710A PL407710A1 (pl) | 2014-03-28 | 2014-03-28 | Sposób wytwarzania preparatu kropli do oczu w postaci zawiesiny zawierającej brynzolamid i preparat wytworzony tym sposobem |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL407710A1 true PL407710A1 (pl) | 2015-10-12 |
Family
ID=53051892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL407710A PL407710A1 (pl) | 2014-03-28 | 2014-03-28 | Sposób wytwarzania preparatu kropli do oczu w postaci zawiesiny zawierającej brynzolamid i preparat wytworzony tym sposobem |
Country Status (2)
| Country | Link |
|---|---|
| PL (1) | PL407710A1 (pl) |
| WO (1) | WO2015147665A1 (pl) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3088196B1 (fr) * | 2018-11-08 | 2022-03-25 | Abdeslem Alain Kitkit | Dispositif permettant d'ameliorer la vue compose d'une solution dans un flacon avec un traitement et un lavage |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6071904A (en) | 1996-12-11 | 2000-06-06 | Alcon Laboratories, Inc. | Process for manufacturing ophthalmic suspensions |
| AU2010325632B2 (en) * | 2009-12-03 | 2014-01-30 | Lupin Limited | Process for preparing pharmaceutical ophthalmic compositions |
| WO2012053011A2 (en) * | 2010-10-18 | 2012-04-26 | Usv Limited | Ophthalmic compositions comprising brinzolamide |
| US20130065888A1 (en) * | 2011-08-15 | 2013-03-14 | Biserka Cetina-Cizmek | Ophthalmic formulations and processes for their preparation |
| US20150119386A1 (en) * | 2012-05-21 | 2015-04-30 | Aurobindo Pharma Limited | Process for preparing opthalmic suspension of brinzolamide |
-
2014
- 2014-03-28 PL PL407710A patent/PL407710A1/pl unknown
-
2015
- 2015-03-27 WO PCT/PL2015/000052 patent/WO2015147665A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015147665A1 (en) | 2015-10-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR132148A2 (es) | Método para mejorar la solubilidad de un compuesto poco soluble o insoluble en agua contenido en una formulación farmacéutica | |
| NZ608202A (en) | Agent for treatment of dry eye characterized by combining p2y2 receptor agonist and hyaluronic acid or salt thereof, method for treating dry eye, and use of the p2y2 receptor agonist and hyaluronic acid or salt thereof | |
| EA201501122A1 (ru) | Новые агонисты соматостатиновых рецепторов подтипа 4 (sstr4) | |
| EA201691692A1 (ru) | Терапевтические наночастицы, содержащие терапевтический агент, и способы их изготовления и применения | |
| SG10201811186XA (en) | Purification of proteins | |
| JP2014139241A5 (pl) | ||
| MX384021B (es) | Composiciones y metodos para aplicaciones oftalmicas y/u otras aplicaciones. | |
| MX2014002731A (es) | Forma polimorfica de clorhidrato de pridopidina. | |
| DOP2013000181A (es) | Moduladores del receptor de glucagon | |
| EA201691216A1 (ru) | Композиции линаклотида с замедленным высвобождением | |
| EA201790024A1 (ru) | Модуляторы toll-подобных рецепторов для лечения вич | |
| MX2016011358A (es) | Composiciones liquidas de lactasa. | |
| UA113962C2 (xx) | Фармацевтична композиція, яка містить апоморфін як активний інгредієнт | |
| MX2018013566A (es) | Aparato electroquimico para producir desinfectante. | |
| CL2017000773A1 (es) | Proceso para la producción de granulados de sulfato de potasio y el granulado de sulfato de potasio obtenido a partir del mismo, así como también su uso. | |
| TN2015000356A1 (en) | Bicyclic compounds | |
| MY182591A (en) | Compositions for use in treating eye disorders using dipyridamole | |
| EA201591704A1 (ru) | Новые устойчивые соли пентадекапептида, способ их получения, их применение в производстве фармацевтических составов и их применение в терапии | |
| PH12015502717B1 (en) | Anti-fibrogenic compounds, methods and uses thereof | |
| FR3022257B1 (fr) | Procede de fabrication d'une solution aqueuse stable de beta-amylase, solution aqueuse obtenue et ses utilisations | |
| MX370564B (es) | Un proceso para la preparacion de levotiroxina y sus sales. | |
| NZ728136A (en) | Method for producing aqueous ophthalmic composition, and aqueous ophthalmic composition | |
| PH12015500852A1 (en) | Method for treating eye disorders | |
| MX2016014261A (es) | Uso de acido 1,3-propandisulfonico o sales farmaceuticamente aceptables del mismo para el tratamiento de sarcoidosis. | |
| PL408208A1 (pl) | Sposób zagęszczania zestawu szklarskiego |