PL410603A1 - Sposób wykrywania aglutynacji - Google Patents
Sposób wykrywania aglutynacjiInfo
- Publication number
- PL410603A1 PL410603A1 PL410603A PL41060314A PL410603A1 PL 410603 A1 PL410603 A1 PL 410603A1 PL 410603 A PL410603 A PL 410603A PL 41060314 A PL41060314 A PL 41060314A PL 410603 A1 PL410603 A1 PL 410603A1
- Authority
- PL
- Poland
- Prior art keywords
- drop
- microfluidic channel
- biological fluid
- agglutination
- immiscible
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
- G01N33/5304—Reaction vessels, e.g. agglutination plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/148—Specific details about calibrations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Dispersion Chemistry (AREA)
- Ecology (AREA)
- Clinical Laboratory Science (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
Sposób wykrywania aglutynacji w płynie biologicznym poprzez pomiar zmiany właściwości fizycznych płynu biologicznego przepływającego przez kanał mikroprzepływowy, charakteryzujący się tym, że obejmuje następujące kroki: (a) wypełnia się kanał mikroprzepływowy hydrofobową, płynną fazą ciągłą; (b) wprowadza się do kanału mikroprzepływowego co najmniej jedną pierwszą kroplę referencyjną, będącą kroplą płynu biologicznego połączoną z solą fizjologiczną lub buforowaną solą fizjologiczną lub wodą, niemieszalną z fazą ciągłą; (c) pozwala się na przepływ kropli referencyjnej przez kanał mikroprzepływowy; (d) wprowadza się do kanału mikroprzepływowego co najmniej jedną - drugą kroplę referencyjną taką jak w kroku (b), i co najmniej jedną kroplę testową będącą kroplą płynu biologicznego połączoną z reagentem wywołującym aglutynację, niemieszalną się z fazą ciągłą; (e) pozwala się na przepływ drugiej kropli referencyjnej i co najmniej jednej kropli testowej przez kanał mikroprzepływowy; (f) określa się wystąpienie aglutynacji w płynie biologicznym na podstawie porównania prędkości i/lub oporu hydrodynamicznego obliczonego dla pierwszej i drugiej kropli referencyjnej.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14461594 | 2014-11-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL410603A1 true PL410603A1 (pl) | 2016-06-06 |
Family
ID=52134092
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL410603A PL410603A1 (pl) | 2014-11-28 | 2014-12-21 | Sposób wykrywania aglutynacji |
| PL15196909T PL3025781T3 (pl) | 2014-11-28 | 2015-11-28 | Sposób wykrywania aglutynacji |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15196909T PL3025781T3 (pl) | 2014-11-28 | 2015-11-28 | Sposób wykrywania aglutynacji |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10473651B2 (pl) |
| EP (1) | EP3025781B1 (pl) |
| JP (1) | JP2016121994A (pl) |
| DK (1) | DK3025781T3 (pl) |
| ES (1) | ES2651482T3 (pl) |
| HU (1) | HUE036046T2 (pl) |
| PL (2) | PL410603A1 (pl) |
| PT (1) | PT3025781T (pl) |
| SI (1) | SI3025781T1 (pl) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113514646B (zh) * | 2021-08-26 | 2023-11-24 | 深圳市亚辉龙生物科技股份有限公司 | 检测蛋白抗原的微流控芯片、方法、试剂盒和系统 |
| CN116440971B (zh) * | 2023-05-24 | 2024-09-27 | 重庆大学 | 一种基于微流控的微型离心装置及应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7026131B2 (en) | 2000-11-17 | 2006-04-11 | Nagaoka & Co., Ltd. | Methods and apparatus for blood typing with optical bio-discs |
| EP2101917A1 (en) | 2007-01-10 | 2009-09-23 | Scandinavian Micro Biodevices A/S | A microfluidic device and a microfluidic system and a method of performing a test |
| US8318439B2 (en) | 2008-10-03 | 2012-11-27 | Micronics, Inc. | Microfluidic apparatus and methods for performing blood typing and crossmatching |
| AU2010300092B2 (en) | 2009-09-24 | 2016-02-04 | Monash University | Testing device for identifying antigens and antibodies in biofluids |
| GB201109203D0 (en) | 2011-06-01 | 2011-07-13 | Carclo Technical Plastics Ltd | Fluid flow control |
| PL219803B1 (pl) | 2011-09-30 | 2015-07-31 | Inst Chemii Fizycznej Polskiej Akademii Nauk | Sposób oznaczania grupy krwi i układ do oznaczania grupy krwi |
| FR2991457B1 (fr) * | 2012-06-01 | 2014-07-18 | Commissariat Energie Atomique | Procede et systeme de caracterisation de la vitesse de deplacement de particules contenues dans un liquide, telles que des particules sanguines |
-
2014
- 2014-12-21 PL PL410603A patent/PL410603A1/pl unknown
-
2015
- 2015-11-28 PT PT151969094T patent/PT3025781T/pt unknown
- 2015-11-28 ES ES15196909.4T patent/ES2651482T3/es active Active
- 2015-11-28 HU HUE15196909A patent/HUE036046T2/hu unknown
- 2015-11-28 EP EP15196909.4A patent/EP3025781B1/en not_active Not-in-force
- 2015-11-28 PL PL15196909T patent/PL3025781T3/pl unknown
- 2015-11-28 SI SI201530126T patent/SI3025781T1/en unknown
- 2015-11-28 DK DK15196909.4T patent/DK3025781T3/en active
- 2015-11-29 US US14/953,357 patent/US10473651B2/en active Active
- 2015-11-30 JP JP2015233621A patent/JP2016121994A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016121994A (ja) | 2016-07-07 |
| DK3025781T3 (en) | 2017-12-04 |
| SI3025781T1 (en) | 2018-03-30 |
| PL3025781T3 (pl) | 2018-04-30 |
| PT3025781T (pt) | 2017-11-27 |
| HUE036046T2 (hu) | 2018-06-28 |
| ES2651482T3 (es) | 2018-01-26 |
| US20160153971A1 (en) | 2016-06-02 |
| US10473651B2 (en) | 2019-11-12 |
| EP3025781B1 (en) | 2017-09-13 |
| EP3025781A1 (en) | 2016-06-01 |
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