PL413886A1 - Method for manufacturing the agent preventing blood coagulation, the agent preventing blood coagulation and its application - Google Patents
Method for manufacturing the agent preventing blood coagulation, the agent preventing blood coagulation and its applicationInfo
- Publication number
- PL413886A1 PL413886A1 PL413886A PL41388615A PL413886A1 PL 413886 A1 PL413886 A1 PL 413886A1 PL 413886 A PL413886 A PL 413886A PL 41388615 A PL41388615 A PL 41388615A PL 413886 A1 PL413886 A1 PL 413886A1
- Authority
- PL
- Poland
- Prior art keywords
- application
- blood coagulation
- agent
- range
- preventing blood
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 230000023555 blood coagulation Effects 0.000 title 2
- 239000003146 anticoagulant agent Substances 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 229920001282 polysaccharide Polymers 0.000 abstract 2
- 239000005017 polysaccharide Substances 0.000 abstract 2
- 238000002604 ultrasonography Methods 0.000 abstract 2
- 208000025494 Aortic disease Diseases 0.000 abstract 1
- 235000004385 Conyza canadensis Nutrition 0.000 abstract 1
- 206010014522 Embolism venous Diseases 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 208000018262 Peripheral vascular disease Diseases 0.000 abstract 1
- 241000264105 Senecio serra Species 0.000 abstract 1
- 206010047249 Venous thrombosis Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229940127090 anticoagulant agent Drugs 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000015271 coagulation Effects 0.000 abstract 1
- 238000005345 coagulation Methods 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 239000007857 degradation product Substances 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 238000000265 homogenisation Methods 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 229920002521 macromolecule Polymers 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 208000031225 myocardial ischemia Diseases 0.000 abstract 1
- 239000000419 plant extract Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 150000008442 polyphenolic compounds Chemical class 0.000 abstract 1
- 235000013824 polyphenols Nutrition 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- 238000000638 solvent extraction Methods 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- 201000005665 thrombophilia Diseases 0.000 abstract 1
- 230000001732 thrombotic effect Effects 0.000 abstract 1
- 230000008733 trauma Effects 0.000 abstract 1
- 208000004043 venous thromboembolism Diseases 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
Zgłoszenie dotyczy sposobu wytwarzania środka przeciwdziałającego koagulacji krwi, obejmującego ekstrakcję substancji aktywnych z przymiotna kanadyjskiego (Conyza canadensis), przy pomocy alkoholu lub ketonu, a następnie wody, oraz wyodrębnianie substancji aktywnych poprzez ekstrakcję rozpuszczalnikami w układach dwufazowych, zatężanie do konsystencji pasty i oddzielanie ekstraktu roślinnego od pozostałych składników. Sposób charakteryzuje się tym, że otrzymaną mieszaninę koniugatów polifenolowo-polisacharydowych, o wielkości cząsteczek w zakresie masy od 1 000 Da do 200 000 Da, poddaje się częściowej degradacji i homogenizacji na cząsteczki o masie cząsteczkowej, zawierającej się w przedziale 20 000 - 50 000 Da, przy użyciu ultradźwięków o częstotliwości 20 kHz i mocy w zakresie od 90 do 240 W. Otrzymaną mieszaninę poreakcyjną rozdziela się na membranie filtracyjnej, w celu usunięcia mniejszych niż 5 000 Da produktów degradacji. Uzyskane składniki aktywne, przekształca się do postaci soli sodowych lub soli wapniowych, a po uzyskaniu pH roztworu na poziomie 7,2 i po wysuszeniu uzyskuje się środek przeciwdziałający koagulacji krwi. Przedmiotem zgłoszenia jest również środek przeciwdziałający koagulacji krwi, który jest mieszaniną, koniugatów polifenoli z polisacharydami, o makrocząsteczkach częściowo zdegradowanych, a częściowo skondensowanych przy użyciu ultradźwięków, których masa cząsteczkowa wynosi od 20 000 Da do 50 000 Da, a współczynnik rozproszenia masy składników polimerowych wynosi od 3,5 do 1,1. Zgłoszenie dotyczy też zastosowania środka przeciwdziałającego koagulacji krwi, spowodowanej problemem nadmiernej krzepliwości krwi w układzie krwionośnym człowieka, w stężeniu od 0,005% do 95%, w kompozycjach farmaceutycznych, spożywczych i kosmetycznych, stosowanych do profilaktyki i leczenia w żylnej chorobie zakrzepowo-zatorowej, zakrzepicy żył głębokich, w chorobie niedokrwiennej serca, chorobie aorty i naczyń obwodowych, w powikłaniach zakrzepowych spowodowanych urazem lub zabiegiem operacyjnym.The application relates to a method for the production of an anti-coagulant agent, including the extraction of active substances from the Canadian attribute (Conyza canadensis), with the help of alcohol or ketone, followed by water, and the isolation of active substances by solvent extraction in two-phase systems, concentrating to a paste consistency and separating the plant extract from other ingredients. The method is characterized in that the obtained mixture of polyphenol-polysaccharide conjugates, with a particle size in the mass range from 1,000 Da to 200,000 Da, is subjected to partial degradation and homogenization into particles with a molecular mass in the range 20,000 - 50,000 Da , using ultrasound at a frequency of 20 kHz and power in the range from 90 to 240 W. The resulting reaction mixture is separated on a filtration membrane to remove less than 5,000 Da of degradation products. The resulting active ingredients are converted into the form of sodium salts or calcium salts, and after reaching a solution pH of 7.2 and after drying, an anti-coagulation agent is obtained. The subject of the application is also an anti-blood coagulation agent, which is a mixture of polyphenol conjugates with polysaccharides, with macromolecules partially degraded and partly condensed using ultrasound, whose molecular weight is from 20,000 Da to 50,000 Da, and the mass dispersion factor of polymer components from 3.5 to 1.1. The application also relates to the use of an anti-coagulation agent, caused by the problem of excessive blood clotting in the human circulatory system, at a concentration of 0.005% to 95%, in pharmaceutical, food and cosmetic compositions used for the prevention and treatment of venous thromboembolism, venous thrombosis deep, in ischemic heart disease, aortic and peripheral vascular disease, thrombotic complications due to trauma or surgery.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL413886A PL236149B1 (en) | 2015-09-09 | 2015-09-09 | Method for manufacturing the agent preventing blood coagulation, the agent preventing blood coagulation and its application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL413886A PL236149B1 (en) | 2015-09-09 | 2015-09-09 | Method for manufacturing the agent preventing blood coagulation, the agent preventing blood coagulation and its application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL413886A1 true PL413886A1 (en) | 2017-03-13 |
| PL236149B1 PL236149B1 (en) | 2020-12-14 |
Family
ID=58231144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL413886A PL236149B1 (en) | 2015-09-09 | 2015-09-09 | Method for manufacturing the agent preventing blood coagulation, the agent preventing blood coagulation and its application |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL236149B1 (en) |
-
2015
- 2015-09-09 PL PL413886A patent/PL236149B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL236149B1 (en) | 2020-12-14 |
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